Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P25206

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-812	P		NT	<%Agarwal et al., 2012[]%>
21	granzyme B (Homo sapiens-type)	2-812	N			Van Damme et al., 2009
37	trypsin 1	2-812	N			Van Damme et al., 2009
516	granzyme B (Homo sapiens-type)	2-812	N		MS	Van Damme et al., 2009
525	granzyme B (Homo sapiens-type)	2-812	N		MS	Van Damme et al., 2009
530	caspase-1	2-812	P		MS	Lamkanfi et al., 2008
533	caspase-1	2-812	P		MS	Lamkanfi et al., 2008
737	granzyme B (Homo sapiens-type)	2-812	N		MS	Van Damme et al., 2009