Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P23284

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
33	unknown peptidase	1-216	P	release of a signal peptide	NT	Price et al., 1991
59	trypsin 1	33-216	N		MS	Schilling & Overall, 2008
67	trypsin 1	33-216	N		MS	Schilling & Overall, 2008
99	glutamyl endopeptidase I	99-109	N		MS	Schilling & Overall, 2008
109	trypsin 1	33-216	N		MS	Schilling & Overall, 2008
119	astacin	116-129	N		MS	Becker-Pauly et al., 2011
119	meprin alpha subunit	116-129	N		MS	Becker-Pauly et al., 2011
121	glutamyl endopeptidase I	117-129	N		MS	Schilling & Overall, 2008
129	trypsin 1	33-216	N		MS	Schilling & Overall, 2008
144	peptidyl-Lys metallopeptidase	1-216	N		MS
157	peptidyl-Lys metallopeptidase	1-216	N		MS
170	peptidyl-Lys metallopeptidase	1-216	N		MS
194	cathepsin G	191-204	N		MS	Schilling & Overall, 2008
204	trypsin 1	33-216	N		MS	Schilling & Overall, 2008