Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P19999

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
17	unknown peptidase	1-238	P	release of a signal peptide	NT	Ikeda et al., 1987
56	membrane-type matrix metallopeptidase-1	18-238	P			Butler et al., 2002
62	matrix metallopeptidase-2	18-238	P	normal turnover		Butler et al., 2002
62	matrix metallopeptidase-9	18-238	P	normal turnover		Butler et al., 2002
68	matrix metallopeptidase-2	18-238	P			Butler et al., 2002
80	matrix metallopeptidase-2	18-238	P	normal turnover		Butler et al., 2002
80	matrix metallopeptidase-9	18-238	P	normal turnover		Butler et al., 2002
97	matrix metallopeptidase-2	18-238	P			Butler et al., 2002
97	matrix metallopeptidase-9	18-238	P			Butler et al., 2002
97	membrane-type matrix metallopeptidase-1	18-238	P			Butler et al., 2002