Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P16949

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-149	P		NT	<%Agarwal et al., 2012[]%>
4	meprin alpha subunit	2-149	N		MS	Becker-Pauly et al., 2011
4	meprin beta subunit	2-149	N		MS	Becker-Pauly et al., 2011
12	peptidyl-Lys metallopeptidase	1-149	N		MS
14	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
16	astacin	13-27	N		MS	Becker-Pauly et al., 2011
27	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
28	peptidyl-Lys metallopeptidase	1-149	N		MS
29	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
30	glutamyl endopeptidase I	29-41	N		MS	Schilling & Overall, 2008
31	meprin alpha subunit	28-41	N		MS	Becker-Pauly et al., 2011
41	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
42	peptidyl-Lys metallopeptidase	1-149	N		MS
43	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
52	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
53	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
64	meprin alpha subunit	2-149	N		MS	Becker-Pauly et al., 2011
64	meprin beta subunit	2-149	N		MS	Becker-Pauly et al., 2011
65	meprin alpha subunit	2-149	N		MS	Becker-Pauly et al., 2011
65	meprin beta subunit	2-149	N		MS	Becker-Pauly et al., 2011
84	peptidyl-Lys metallopeptidase	1-149	N		MS
85	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
94	peptidyl-Lys metallopeptidase	1-149	N		MS
95	trypsin 1	2-149	N		MS	Schilling & Overall, 2008
124	meprin alpha subunit	2-149	N		MS	Becker-Pauly et al., 2011