Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P12268

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-514	P		NT	<%Agarwal et al., 2012[]%>
7	cathepsin S	1-19	N		MS	Biniossek et al., 2011
86	cathepsin B	63-99	N		MS	Biniossek et al., 2011
89	cathepsin B	63-103	N		MS	Biniossek et al., 2011
91	cathepsin L	63-100	N		MS	Biniossek et al., 2011
92	cathepsin L	63-105	N		MS	Biniossek et al., 2011
110	meprin beta subunit	107-124	N		MS	Becker-Pauly et al., 2011
246	cathepsin L	243-257	N		MS	Biniossek et al., 2011
246	cathepsin S	243-257	N		MS	Biniossek et al., 2011
246	cathepsin B	243-259	N		MS	Biniossek et al., 2011
247	cathepsin B	243-259	N		MS	Biniossek et al., 2011
363	meprin beta subunit	360-375	N		MS	Becker-Pauly et al., 2011
462	cathepsin L	456-474	N		MS	Biniossek et al., 2011
462	cathepsin B	456-474	N		MS	Biniossek et al., 2011
463	cathepsin S	456-474	N		MS	Biniossek et al., 2011
463	cathepsin B	456-474	N		MS	Biniossek et al., 2011
465	cathepsin L	456-474	N		MS	Biniossek et al., 2011