Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P0DJI8

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-122	P	release of a signal peptide	NT	Benditt et al., 1971
19	cathepsin L	19-122	P		MS	Röcken et al., 2005
20	cathepsin B	19-94	P		MS	Röcken et al., 2005
21	cathepsin B	19-92	P		MS	Röcken et al., 2005
22	cathepsin L	20-55	N		MS	Röcken et al., 2005
22	cathepsin B	21-49	P		MS	Röcken et al., 2005
23	cathepsin B	20-69	N		MS	Röcken et al., 2005
24	cathepsin B	20-85	N		MS	Röcken et al., 2005
25	cathepsin L	19-122	P		MS	Röcken et al., 2005
25	matrix metallopeptidase-3	19-122	P	normal turnover	MS	Stix et al., 2001
26	cathepsin L	20-85	N		MS	Röcken et al., 2005
34	matrix metallopeptidase-3	19-104	P	normal turnover	MS	Stix et al., 2001
35	cathepsin B	20-38	N		MS	Röcken et al., 2005
37	cathepsin L	27-49	N		MS	Röcken et al., 2005
38	cathepsin B	20-44	N		MS	Röcken et al., 2005
40	cathepsin B	21-43	P		MS	Röcken et al., 2005
41	matrix metallopeptidase-1	19-122	P		MS	van der Hilst et al., 2008
41	matrix metallopeptidase-3	19-104	P	normal turnover	MS	Stix et al., 2001
42	cathepsin L	20-55	N		MS	Röcken et al., 2005
43	cathepsin B	21-44	P		MS	Röcken et al., 2005
44	cathepsin B	20-46	N		MS	Röcken et al., 2005
45	cathepsin B	21-49	P		MS	Röcken et al., 2005
46	cathepsin B	20-55	N		MS	Röcken et al., 2005
47	matrix metallopeptidase-1	19-122	P		MS	van der Hilst et al., 2008
49	cathepsin L	27-55	N		MS	Röcken et al., 2005
49	cathepsin B	19-122	P		MS	Röcken et al., 2005
54	cathepsin L	19-55	P		MS	Röcken et al., 2005
55	cathepsin L	19-122	P		MS	Röcken et al., 2005
55	cathepsin B	20-58	N		MS	Röcken et al., 2005
58	cathepsin B	20-62	N		MS	Röcken et al., 2005
61	cathepsin L	20-75	N		MS	Röcken et al., 2005
62	cathepsin B	20-65	N		MS	Röcken et al., 2005
64	cathepsin B	21-65	P		MS	Röcken et al., 2005
65	cathepsin B	20-66	N		MS	Röcken et al., 2005
66	cathepsin B	20-68	N		MS	Röcken et al., 2005
68	cathepsin B	20-69	N		MS	Röcken et al., 2005
69	cathepsin B	20-72	N		MS	Röcken et al., 2005
69	matrix metallopeptidase-3	19-104	P	normal turnover	MS	Stix et al., 2001
70	cathepsin B	19-122	P		MS	Röcken et al., 2005
72	cathepsin B	20-78	N		MS	Röcken et al., 2005
73	matrix metallopeptidase-3	19-122	P	normal turnover	MS	Stix et al., 2001
74	matrix metallopeptidase-3	19-104	P		MS	Stix et al., 2001
75	matrix metallopeptidase-3	19-104	P		MS	Stix et al., 2001
78	cathepsin B	20-79	N		MS	Röcken et al., 2005
79	cathepsin B	20-81	N		MS	Röcken et al., 2005
81	cathepsin B	20-82	N		MS	Röcken et al., 2005
85	cathepsin B	19-87	P		MS	Röcken et al., 2005
87	cathepsin B	19-92	P		MS	Röcken et al., 2005
87	meprin beta subunit	19-122	N		MS	Becker-Pauly et al., 2011
88	cathepsin L	19-122	P		MS	Röcken et al., 2005
92	cathepsin B	19-94	P		MS	Röcken et al., 2005
92	meprin alpha subunit	19-122	N		MS	Becker-Pauly et al., 2011
92	meprin beta subunit	19-122	N		MS	Becker-Pauly et al., 2011
94	cathepsin B	19-96	P		MS	Röcken et al., 2005
96	cathepsin B	19-100	P		MS	Röcken et al., 2005
100	cathepsin B	19-101	P		MS	Röcken et al., 2005
101	cathepsin B	19-103	P		MS	Röcken et al., 2005
103	cathepsin B	19-104	P		MS	Röcken et al., 2005
104	cathepsin B	19-105	P		MS	Röcken et al., 2005
105	cathepsin B	19-117	P		MS	Röcken et al., 2005
117	cathepsin B	19-122	P		MS	Röcken et al., 2005
119	unknown peptidase	1-122	P		NT	<%Agarwal et al., 2012[]%>
120	unknown peptidase	1-122	P		NT	<%Agarwal et al., 2012[]%>
121	unknown peptidase	1-122	P		NT	<%Agarwal et al., 2012[]%>