Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P0CG48

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
16	meprin alpha subunit	13-27	N		MS	Becker-Pauly et al., 2011
54	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
63	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
72	insulysin	1-74	P		MS	Ralat et al., 2011
74	insulysin	1-76	N		MS	<%21185309[]%>
76	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
82	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
87	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
103	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
109	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
118	trypsin 1	1-685	N		MS	Schilling & Overall, 2008
148	insulysin	77-150	P		MS	Ralat et al., 2011
150	insulysin	77-152	P		MS	Ralat et al., 2011
152	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
224	insulysin	153-226	P		MS	Ralat et al., 2011
226	insulysin	153-228	P		MS	Ralat et al., 2011
228	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
300	insulysin	229-302	P		MS	Ralat et al., 2011
302	insulysin	229-304	P		MS	Ralat et al., 2011
304	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
376	insulysin	305-378	P		MS	Ralat et al., 2011
378	insulysin	305-380	P		MS	Ralat et al., 2011
380	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
452	insulysin	381-454	P		MS	Ralat et al., 2011
454	insulysin	381-456	P		MS	Ralat et al., 2011
456	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
528	insulysin	457-530	P		MS	Ralat et al., 2011
530	insulysin	457-532	P		MS	Ralat et al., 2011
532	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
604	insulysin	533-606	P		MS	Ralat et al., 2011
606	insulysin	533-608	P		MS	Ralat et al., 2011
608	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>
680	insulysin	609-682	P		MS	Ralat et al., 2011
682	insulysin	609-684	P		MS	Ralat et al., 2011
684	unknown peptidase	1-685	P		NT	<%Agarwal et al., 2012[]%>