Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00533

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-628	P	release of a signal peptide	NT	Zhang & Henzel, 2004
356	peptidyl-Lys metallopeptidase	1-1210	N		MS
683	calpain-2	25-1210	P			Gregoriou et al., 1994
733	calpain-2	25-1210	P			Gregoriou et al., 1994
1006	caspase-3	25-1210	P			Bae et al., 2001
1009	caspase-3	25-1210	P			Bae et al., 2001
1030	calpain-2	25-1210	P			Gregoriou et al., 1994
1059	calpain-2	25-1210	P			Gregoriou et al., 1994
1086	calpain-2	25-1210	P			Gregoriou et al., 1994
1151	calpain-2	25-1210	P			Gregoriou et al., 1994
1185	calpain-2	25-1210	P			Gregoriou et al., 1994