Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00459

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site Peptidase Residue range Cleavage type Description Evidence Reference
1 methionyl aminopeptidase 1 (Escherichia-type) 1-290 P release of an initiating methionine NT Hausinger & Howard, 1982
4 trypsin 1 1-290 N Hausinger et al., 1982
11 trypsin 1 1-290 N Hausinger et al., 1982
16 trypsin 1 1-290 N Hausinger et al., 1982
29 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
33 trypsin 1 1-290 N Hausinger et al., 1982
42 trypsin 1 1-290 N Hausinger et al., 1982
44 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
47 trypsin 1 1-290 N Hausinger et al., 1982
53 trypsin 1 1-290 N Hausinger et al., 1982
60 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
74 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
78 trypsin 1 1-290 N Hausinger et al., 1982
85 trypsin 1 1-290 N Hausinger et al., 1982
88 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
101 trypsin 1 1-290 N Hausinger et al., 1982
111 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
141 trypsin 1 1-290 N Hausinger et al., 1982
144 trypsin 1 1-290 N Hausinger et al., 1982
167 trypsin 1 1-290 N Hausinger et al., 1982
171 trypsin 1 1-290 N Hausinger et al., 1982
179 trypsin 1 1-290 N Hausinger et al., 1982
188 trypsin 1 1-290 N Hausinger et al., 1982
195 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
203 trypsin 1 1-290 N Hausinger et al., 1982
214 trypsin 1 1-290 N Hausinger et al., 1982
220 trypsin 1 1-290 N Hausinger et al., 1982
222 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
224 trypsin 1 1-290 N Hausinger et al., 1982
225 trypsin 1 1-290 N Hausinger et al., 1982
230 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
234 trypsin 1 1-290 N Hausinger et al., 1982
236 trypsin 1 1-290 N Hausinger et al., 1982
240 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
242 trypsin 1 1-290 N Hausinger et al., 1982
246 trypsin 1 1-290 N Hausinger et al., 1982
250 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
252 trypsin 1 1-290 N Hausinger et al., 1982
264 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
280 glutamyl endopeptidase I 1-290 N Hausinger et al., 1982
285 trypsin 1 1-290 N Hausinger et al., 1982