Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O75874

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-414	P	release of an initiating methionine	MS
123	matrix metallopeptidase-2	119-132	N		MS	Schilling & Overall, 2008
132	trypsin 1	2-414	N		MS	Schilling & Overall, 2008
140	trypsin 1	2-414	N		MS	Schilling & Overall, 2008
151	trypsin 1	2-414	N		MS	Schilling & Overall, 2008
249	trypsin 1	2-414	N		MS	Schilling & Overall, 2008
260	trypsin 1	2-414	N		MS	Schilling & Overall, 2008
379	matrix metallopeptidase-2	375-396	N		MS	Schilling & Overall, 2008
396	glutamyl endopeptidase I	2-414	N		MS	Schilling & Overall, 2008