Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence O75531

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-89	P	release of an initiating methionine	MS	Van Damme P et al., 2005
8	trypsin 1	1-89	N		MS	Schilling & Overall, 2008
12	meprin beta subunit	9-32	N		MS	Becker-Pauly et al., 2011
12	LAST_MAM peptidase (Limulus-type)	9-32	N		MS	Becker-Pauly et al., 2011
14	LAST_MAM peptidase (Limulus-type)	11-33	N		MS	Becker-Pauly et al., 2011
16	meprin alpha subunit	1-89	N		MS	Becker-Pauly et al., 2011
16	meprin beta subunit	1-89	N		MS	Becker-Pauly et al., 2011
17	peptidyl-Lys metallopeptidase	1-89	N		MS
21	cathepsin B	19-32	N		MS	Biniossek et al., 2011
21	astacin	18-32	N		MS	Becker-Pauly et al., 2011
31	peptidyl-Lys metallopeptidase	1-89	N		MS
32	trypsin 1	1-89	N		MS	Schilling & Overall, 2008