Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O75475

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
30	caspase-3	1-530	P	normal turnover		Wu et al., 2002
30	caspase-7	1-530	P			Wu et al., 2002
46	cathepsin L	40-56	N		MS	Biniossek et al., 2011
75	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
80	meprin alpha subunit	77-89	N		MS	Becker-Pauly et al., 2011
85	caspase-3	1-530	P	normal turnover		Wu et al., 2002
85	caspase-7	1-530	P			Wu et al., 2002
89	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
100	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
113	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
135	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
143	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
424	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
442	trypsin 1	1-530	N		MS	Schilling & Overall, 2008
486	caspase-3	1-530	P	normal turnover		Wu et al., 2002
486	caspase-7	1-530	P			Wu et al., 2002