Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O60812

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-293	P		NT	<%Agarwal et al., 2012[]%>
17	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
22	matrix metallopeptidase-2	17-30	N		MS	Schilling & Overall, 2008
29	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
30	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
37	chymotrypsin A (cattle-type)	1-293	N		MS	Schilling & Overall, 2008
39	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
110	granzyme B (Homo sapiens-type)	2-293	N		MS	Van Damme et al., 2010
112	granzyme B (Homo sapiens-type)	2-293	N		MS	Van Damme et al., 2010
174	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
184	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
191	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
196	matrix metallopeptidase-2	193-210	N		MS	Schilling & Overall, 2008
203	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
210	trypsin 1	1-293	N		MS	Schilling & Overall, 2008
230	peptidyl-Lys metallopeptidase	1-293	N		MS
270	peptidyl-Lys metallopeptidase	1-293	N		MS