Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O60256

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-369	P	release of an initiating methionine	MS
36	lysyl endopeptidase (bacteria)	2-369	N		MS
102	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
115	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
164	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
181	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
223	unknown peptidase	2-369	P		MS	Dix et al., 2008
236	matrix metallopeptidase-2	232-249	N		MS	Schilling & Overall, 2008
249	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
263	trypsin 1	2-369	N		MS	Schilling & Overall, 2008
317	HIV-1 retropepsin	309-330	N		MS	Schilling & Overall, 2008
317	glutamyl endopeptidase I	309-330	N		MS	Schilling & Overall, 2008
330	trypsin 1	2-369	N		MS	Schilling & Overall, 2008