Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O43290

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	granzyme A	1-800	N			Van Damme et al., 2010
20	cathepsin B	12-31	N		MS	Biniossek et al., 2011
154	granzyme B (Homo sapiens-type)	1-800	N		MS	Van Damme et al., 2010
230	granzyme B (Homo sapiens-type)	1-800	N		MS	Van Damme et al., 2010
256	matrix metallopeptidase-2	252-267	N		MS	Schilling & Overall, 2008
267	trypsin 1	1-800	N		MS	Schilling & Overall, 2008
421	granzyme B (Homo sapiens-type)	1-800	N		MS	Van Damme et al., 2010
492	meprin beta subunit	1-800	N		MS	Becker-Pauly et al., 2011