Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O14980

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-1071	P	release of an initiating methionine	MS
22	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
44	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
423	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
442	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
446	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
455	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
491	peptidyl-Lys metallopeptidase	1-1071	N		MS
502	cathepsin S	493-515	N		MS	Biniossek et al., 2011
505	cathepsin L	493-514	N		MS	Biniossek et al., 2011
530	peptidyl-Lys metallopeptidase	1-1071	N		MS
543	matrix metallopeptidase-2	537-553	N		MS	Schilling & Overall, 2008
553	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
656	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
674	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
1016	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008
1023	trypsin 1	1-1071	N		MS	Schilling & Overall, 2008