Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O14818

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-248	P		NT	<%Agarwal et al., 2012[]%>
20	cathepsin S	6-28	N		MS	Biniossek et al., 2011
95	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
109	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
143	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
157	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
174	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
189	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
193	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
204	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
212	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
218	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
227	trypsin 1	2-248	N		MS	Schilling & Overall, 2008
241	trypsin 1	2-248	N		MS	Schilling & Overall, 2008