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Inhibitors

Peptidase

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MEROPS SUBMISSIONS

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information

Sequence features for peptidase homologue M28.973: transferrin receptor 2 protein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0195950 Ailuropoda melanoleuca 820 354-548 D435, G480 Q433, K443, D481, D509, missing UNIPROT:D2HX08
MER0195950 Ailuropoda melanoleuca 820 354-548 D435, G480 Q433, K443, D481, D509, missing UNIPROT:D2HX08
MER0270506 Alligator mississippiensis 705 256-521 D339, G384 Q337, R347, D385, D413, S503 GENBANK:XP_006262974
MER0301417 Alligator sinensis 705 256-521 D339, G384 Q337, R347, D385, D413, S503 GENBANK:XP_006029653
MER0607318 Anolis carolinensis 333 1-161 missing, G20 missing, missing, D21, D49, H139 GENBANK:XP_008121626
MER0375231 Astyanax mexicanus 786 344-597 D429, G474 Q427, K437, E475, D503, N592 UNIPROT:W5L3X8
MER0375231 Astyanax mexicanus 786 344-597 D429, G474 Q427, K437, E475, D503, N592 UNIPROT:W5L3X8
MER0397043 Balaenoptera acutorostrata 839 354-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_007186686
MER0679370 Bison bison 817 353-630 D434, A485, Q432, K442, E486, D535, H612, GENBANK:XP_010836230
MER0079940 Bos grunniens 803 353-609 D434, G479 Q432, K442, D480, D508, H598 GENBANK:ELR58222
MER0112903 Bos taurus 803 353-621 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_875342
MER0579965 Bubalus bubalis 803 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_006046531
MER0195917 Callithrix jacchus 801 353-609 D434, S479 Q432, K442, D480, D508, H598 UNIPROT:U3EIN0
MER0195917 Callithrix jacchus 801 353-609 D434, S479 Q432, K442, D480, D508, H598 UNIPROT:U3EIN0
MER0593551 Callorhinchus milii 142 14-67 missing, missing missing, missing, missing, missing, N50 GENBANK:XP_007884545
MER0676735 Camelus dromedarius 807 354-617 D435, G480 Q433, K443, D481, D509, H599 GENBANK:XP_010977736
MER0356207 Camelus ferus 809 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_006188012
MER0555385 Capra hircus 770 418-654 D499, G544 Q497, K507, D545, D573, missing GENBANK:XP_005698132
MER0103726 Cavia porcellus 801 350-601 D430, G475 Q428, K438, D476, D504, H594 GENBANK:XP_003470195
MER0188481 Ceratotherium simum 807 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_004442935
MER0587962 Cercopithecus sabaeus 798 350-613 D431, G476 Q429, K439, D477, D505, H595 GENBANK:XP_008016717
MER0582760 Chinchilla lanigera 799 347-610 D428, G473 Q426, K436, D474, D502, H592 GENBANK:XP_005413763
MER0575665 Chrysemys picta 680 283-423 D366, E411 Q364, S374, D412, missing, missing GENBANK:XP_008176157
MER0574607 Chrysochloris asiatica 806 354-620 D435, G480 Q433, K443, D481, D509, N598 GENBANK:XP_006859702
MER0669782 Colobus angolensis 766 318-581 D399, G444 Q397, K407, D445, D473, H563 GENBANK:XP_011799348
MER0573454 Condylura cristata 805 352-615 D433, G478 Q431, K441, D479, D507, H597 GENBANK:XP_004691941
MER0195902 Cricetulus griseus 799 353-609 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_003510681
MER0107984 Danio rerio 783 341-606 D427, G472 Q425, K435, E473, D501, N589 UNIPROT:Q5MPX2
MER0107984 Danio rerio 783 341-606 D427, G472 Q425, K435, E473, D501, N589 UNIPROT:Q5MPX2
MER0606335 Dasypus novemcinctus 192 89-170 A167, missing Q165, missing, missing, missing, missing GENBANK:XP_004457237
MER0606336 Dasypus novemcinctus 334 1-162 missing, G20 missing, missing, D21, D49, H139 GENBANK:XP_004457203
MER0599264 Echinops telfairi 809 358-624 D438, G483 Q436, K446, D484, D512, H601 GENBANK:XP_004705655
MER0565742 Elephantulus edwardii 797 353-607 D433, G478 Q431, K441, D479, D507, H597 GENBANK:XP_006896525
MER0320833 Epinephelus bruneus 334 1-80 missing, G20 missing, missing, D21, D49, missing UNIPROT:F8U080
MER0320833 Epinephelus bruneus 334 1-80 missing, G20 missing, missing, D21, D49, missing UNIPROT:F8U080
MER0563647 Eptesicus fuscus 806 353-616 D434, G479 Q432, R442, D480, D508, H598 GENBANK:XP_008139637
MER0098836 Equus caballus 805 353-621 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_001505111
MER0561656 Equus przewalskii 805 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_008525563
MER0616138 Erinaceus europaeus 803 350-613 D431, G476 Q429, K439, D477, D505, H595 GENBANK:XP_007534871
MER0228700 Felis catus 805 352-608 D433, G478 Q431, K441, D479, D507, H597 UNIPROT:M3W6L1
MER0228700 Felis catus 805 352-608 D433, G478 Q431, K441, D479, D507, H597 UNIPROT:M3W6L1
MER0655921 Fukomys damarensis 856 409-672 D490, G535 Q488, K498, D536, D564, H654 GENBANK:XP_010607808
MER0558050 Galeopterus variegatus 806 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_008578935
MER0228611 Gorilla gorilla 731 283-539 D364, G409 Q362, K372, D410, D438, H528 GENBANK:XP_004045980
MER0195958 Heterocephalus glaber 808 342-611 D423, G468 Q421, K431, D469, D497, H599 UNIPROT:G5BBZ8
MER0195958 Heterocephalus glaber 808 342-611 D423, G468 Q421, K431, D469, D497, H599 UNIPROT:G5BBZ8
MER0583869 Heterocephalus glaber 825 361-639 D442, G487 Q440, K450, D488, D526, H616 GENBANK:XP_004890713
MER0005152 Homo sapiens 801 353-621 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:Q9UP52
MER0547418 Jaculus jaculus 799 350-612 D431, G476 Q429, K439, D477, D505, N594 GENBANK:XP_004666365
MER0650168 Larimichthys crocea 776 333-595 D417, G462 Q415, K425, D463, D491, N578 GENBANK:XP_010751343
MER0553501 Lepisosteus oculatus 785 368-642 D455, G500 Q453, K463, D501, D529, N619 GENBANK:XP_006627468
MER0554465 Lepisosteus oculatus 774 336-594 D417, G463 Q415, K425, D464, D492, G580 UNIPROT:W5MJ70
MER0554465 Lepisosteus oculatus 774 336-594 D417, G463 Q415, K425, D464, D492, G580 UNIPROT:W5MJ70
MER0553392 Leptonychotes weddellii 641 188-451 D269, G314 Q267, K277, D315, D343, H433 GENBANK:XP_006751511
MER0549974 Lipotes vexillifer 805 353-616 D434, G479 Q432, R442, D480, D508, H598 GENBANK:XP_007468908
MER0195929 Loxodonta africana 806 354-605 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_003422538
MER0195965 Macaca fascicularis 555 124-363 D192, G237 Q190, K200, D238, D266, H352 UNIPROT:G8F4D6
MER0195965 Macaca fascicularis 555 124-363 D192, G237 Q190, K200, D238, D266, H352 UNIPROT:G8F4D6
MER0195887 Macaca mulatta 798 350-606 D431, G476 Q429, K439, D477, D505, H595 UNIPROT:G7MNV2
MER0195887 Macaca mulatta 798 350-606 D431, G476 Q429, K439, D477, D505, H595 UNIPROT:G7MNV2
MER0195939 Macaca mulatta 672 350-538 D431, G476 Q429, K439, D477, D505, missing GENBANK:XP_001113151
MER0645703 Mandrillus leucophaeus 798 350-613 D431, G476 Q429, K439, D477, D505, H595 GENBANK:XP_011841063
MER0543150 Maylandia zebra 780 337-599 D421, G466 Q419, K429, D467, D495, N582 GENBANK:XP_004575796
MER0544613 Mesocricetus auratus 803 354-613 D434, G479 Q432, R442, D480, D508, H598 GENBANK:XP_005080476
MER0537703 Microtus ochrogaster 803 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_005371498
MER0015086 Mus musculus 798 348-616 D429, G474 Q427, K437, D475, D503, H593 UNIPROT:Q9JKX3
MER0601399 Mustela putorius 807 354-617 D435, G480 Q433, K443, D481, D509, H599 GENBANK:XP_004761591
MER0602903 Mustela putorius 843 390-653 D471, G516 Q469, K479, D517, D545, H635 GENBANK:XP_004761590
MER0571027 Myotis brandtii 806 353-616 D434, G479 Q432, R442, D480, D508, H598 GENBANK:XP_005879164
MER0228766 Myotis davidii 799 344-602 D425, G470 Q423, K433, D471, D499, H591 UNIPROT:L5LSY6
MER0228766 Myotis davidii 799 344-602 D425, G470 Q423, K433, D471, D499, H591 UNIPROT:L5LSY6
MER0233488 Myotis lucifugus 805 353-616 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:G1PF39
MER0233488 Myotis lucifugus 805 353-616 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:G1PF39
MER0640650 Nannospalax galili 795 347-610 D428, G473 Q426, K436, D474, D502, H592 GENBANK:XP_008830565
MER0534801 Neolamprologus brichardi 866 461-660 D545, G590 Q543, K553, D591, D619, missing GENBANK:XP_006806812
MER0532937 Octodon degus 809 346-621 L428, G484 H426, K443, E485, D513, H603 GENBANK:XP_004630647
MER0530944 Odobenus rosmarus 805 352-615 D433, G478 Q431, K441, D479, D507, H597 GENBANK:XP_004399094
MER0529328 Orcinus orca 805 353-616 D434, G479 Q432, R442, D480, D508, H598 GENBANK:XP_004268916
MER0195978 Oreochromis niloticus 782 338-535 D422, G467 Q420, K430, D468, D496, missing GENBANK:XP_003460204
MER0619812 Ornithorhynchus anatinus 182 11-80 missing, missing missing, missing, missing, missing, N62 GENBANK:XP_007660136
MER0528517 Orycteropus afer 785 353-608 D434, G479 Q432, R442, D480, D508, N598 GENBANK:XP_007954082
MER0110073 Oryctolagus cuniculus 797 353-610 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:G1TTY5
MER0110073 Oryctolagus cuniculus 797 353-610 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:G1TTY5
MER0229918 Oryzias latipes 771 327-530 D411, G456 Q409, K419, D457, D485, missing GENBANK:XP_004085392
MER0320757 Otolemur garnettii 805 352-604 D433, G478 Q431, Q441, D479, D507, H597 UNIPROT:H0WMN7
MER0320757 Otolemur garnettii 805 352-604 D433, G478 Q431, Q441, D479, D507, H597 UNIPROT:H0WMN7
MER0229074 Ovis aries 810 356-612 D437, G482 Q435, K445, A483, D511, H601 GENBANK:XP_004021058
MER0320760 Pan paniscus 707 259-515 D340, G385 Q338, K348, D386, D414, H504 GENBANK:XP_003812978
MER0053343 Pan troglodytes 1407 851-1150 D932, G977 Q930, K940, D978, D1035, H1125 GENBANK:XP_519265
MER0195865 Pan troglodytes 801 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:H2QV37
MER0195865 Pan troglodytes 801 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:H2QV37
MER0518947 Panthera tigris 803 350-613 D431, G476 Q429, K439, D477, D505, H595 GENBANK:XP_007073980
MER0516697 Pantholops hodgsonii 762 352-617 D433, G478 Q431, K441, D479, D509, H599 GENBANK:XP_005956301
MER0228467 Papio anubis 798 350-606 D431, G476 Q429, K439, D477, D505, H595 UNIPROT:A0A096NRN7
MER0228467 Papio anubis 798 350-606 D431, G476 Q429, K439, D477, D505, H595 UNIPROT:A0A096NRN7
MER0521124 Physeter catodon 805 353-616 D434, G479 Q432, K442, D480, D508, H598 GENBANK:XP_007110676
MER0523266 Poecilia formosa 763 324-579 D401, G446 Q399, K409, D447, D475, N562 UNIPROT:A0A087YD60
MER0523266 Poecilia formosa 763 324-579 D401, G446 Q399, K409, D447, D475, N562 UNIPROT:A0A087YD60
MER0523734 Poecilia formosa 733 293-562 D377, G422 Q375, G385, D423, D451, N539 GENBANK:XP_006114727
MER0523735 Poecilia formosa 780 340-609 D424, G469 Q422, G432, D470, D498, N586 GENBANK:XP_006114726
MER0472293 Poecilia reticulata 419 143-324 D221, G266 Q219, K229, D267, D295, missing GENBANK:XP_008401444
MER0195899 Pongo abelii 801 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:H2PLP3
MER0195899 Pongo abelii 801 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:H2PLP3
MER0229842 Pteropus alecto 817 300-484 D381, G426 Q379, K389, D427, D455, missing UNIPROT:L5K848
MER0229842 Pteropus alecto 817 300-484 D381, G426 Q379, K389, D427, D455, missing UNIPROT:L5K848
MER0352491 Python bivittatus 679 237-507 D321, G366 Q319, R329, D367, D395, N485 GENBANK:XP_007440313
MER0026970 Rattus norvegicus 831 348-651 D429, G474 Q427, K437, D475, D503, H626 GENBANK:XP_222022
MER0026970 Rattus norvegicus 831 348-651 D429, G474 Q427, K437, D475, D503, H626 GENBANK:XP_222022
MER0026970 Rattus norvegicus 831 348-651 D429, G474 Q427, K437, D475, D503, H626 GENBANK:XP_222022
MER0026970 Rattus norvegicus 831 348-651 D429, G474 Q427, K437, D475, D503, H626 GENBANK:XP_222022
MER0557726 Rhinopithecus roxellana 798 350-613 D431, G476 Q429, K439, D477, D505, H595 GENBANK:XP_010376029
MER0229320 Saimiri boliviensis 828 380-632 D461, G506 Q459, K469, D507, D535, H625 GENBANK:XP_003934226
MER0320797 Sarcophilus harrisii 375 2-125 D10, G55 Q8, K18, D56, D84, missing GENBANK:XP_003770793
MER0597291 Sorex araneus 798 346-608 D426, G471 Q424, Q434, E472, D500, H590 GENBANK:XP_004617367
MER0471762 Stegastes partitus 777 336-598 D420, G465 Q418, K428, E466, D494, N581 GENBANK:XP_008303388
MER0195946 Sus scrofa 804 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:F1RMX9
MER0195946 Sus scrofa 804 353-609 D434, G479 Q432, K442, D480, D508, H598 UNIPROT:F1RMX9
MER0078911 Takifugu rubripes 749 307-504 D391, G436 Q389, K399, D437, D465, missing GENBANK:XP_003978666
MER0596620 Tarsius syrichta 776 259-521 D340, G385 Q338, K348, D386, D414, H503 GENBANK:XP_008047150
MER0195985 Tetraodon nigroviridis 647 206-403 D290, G335 Q288, K298, D336, D364, missing UNIPROT:Q4T355
MER0195985 Tetraodon nigroviridis 647 206-403 D290, G335 Q288, K298, D336, D364, missing UNIPROT:Q4T355
MER0196012 Tetraodon nigroviridis 232 68-231 H152, G197 H150, K160, D198, D226, missing UNIPROT:Q4TF97
MER0196012 Tetraodon nigroviridis 232 68-231 H152, G197 H150, K160, D198, D226, missing UNIPROT:Q4TF97
MER0481873 Trichechus manatus 808 356-622 D436, G481 Q434, K444, D482, D510, H600 GENBANK:XP_004386786
MER0080179 Tupaia chinensis 1303 829-1106 D910, G955 Q908, K918, D956, D984, H1095 UNIPROT:L9K4Y4
MER0080179 Tupaia chinensis 1303 829-1106 D910, G955 Q908, K918, D956, D984, H1095 UNIPROT:L9K4Y4
MER0598594 Tupaia chinensis 807 353-621 D434, G479 Q432, K442, D480, D508, H599 GENBANK:XP_006155756
MER0622685 Tursiops truncatus 720 363-532 missing, G395 missing, missing, D396, D424, H514 GENBANK:XP_004324042
MER0219304 Ursus maritimus 784 342-603 D423, G468 Q421, K431, D469, D497, H587 GENBANK:XP_008696730
MER0616597 Vicugna pacos 807 354-617 D435, G480 Q433, K443, D481, D509, H599 GENBANK:XP_006219198
MER0457607 Xiphophorus maculatus 526 173-428 D250, G295 Q248, K258, D296, D324, N411 GENBANK:XP_005817361

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Page created 8-September-2023

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