| MERNUM |
Species |
Sequence length |
Peptidase unit |
Active site residues |
Metal ligands |
Source |
| MER1078465 |
Acanthaster planci |
819 |
413-522 |
D445, E491 |
H443, D453, E492, D520, missing |
GENBANK:XP_022097951 |
| MER0195567 |
Ailuropoda melanoleuca |
771 |
284-599 |
D398, E444 |
H396, D406, E445, D473, H576 |
UNIPROT:D2H4R6 |
| MER0195567 |
Ailuropoda melanoleuca |
771 |
284-599 |
D398, E444 |
H396, D406, E445, D473, H576 |
UNIPROT:D2H4R6 |
| MER0290129 |
Alligator mississippiensis |
743 |
299-579 |
D381, E427 |
H379, D389, E428, D456, H556 |
GENBANK:XP_006260865 |
| MER0302206 |
Alligator sinensis |
737 |
293-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_006030776 |
| MER1109574 |
Anolis carolinensis |
737 |
300-588 |
V390, F435 |
T388, G398, S436, P464, P564 |
UNIPROT:H9GBB3 |
| MER0556605 |
Astatotilapia burtoni |
819 |
363-643 |
D445, E491 |
H443, D453, E492, D520, H620 |
GENBANK:XP_005924573 |
| MER0374856 |
Astyanax mexicanus |
445 |
283-423 |
D373, missing |
H371, D381, missing, missing, missing |
GENBANK:XP_007237311 |
| MER1080664 |
Astyanax mexicanus |
685 |
291-413 |
D316, E362 |
H314, D324, E363, D391, missing |
GENBANK:XP_022523989 |
| MER0397521 |
Balaenoptera acutorostrata |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_007174338 |
| MER0679386 |
Bison bison |
771 |
292-600 |
D375, E421 |
H373, D383, E422, D477, H577 |
GENBANK:XP_010836332 |
| MER0435445 |
Bos grunniens |
744 |
292-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_005894135 |
| MER0100840 |
Bos taurus |
744 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:A6QPB7 |
| MER0100840 |
Bos taurus |
744 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:A6QPB7 |
| MER0139414 |
Branchiostoma floridae |
616 |
213-498 |
D299, E345 |
H297, D307, E346, D374, H475 |
GENBANK:EEA35572 |
| MER0140878 |
Branchiostoma floridae |
1009 |
671-918 |
A684, D723 |
E682, V689, T724, V773, P852 |
GENBANK:XP_002236259 |
| MER0579646 |
Bubalus bubalis |
744 |
292-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_006056564 |
| MER0195705 |
Callithrix jacchus |
493 |
85-321 |
D123, E169 |
H121, D131, E170, D198, H298 |
GENBANK:XP_002755645 |
| MER0678005 |
Camelus dromedarius |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_010994327 |
| MER0316575 |
Camelus ferus |
737 |
285-565 |
D375, E413 |
H373, X383, E414, D442, H542 |
GENBANK:XP_006179613 |
| MER0598802 |
Canis lupus familiaris |
777 |
283-605 |
missing, E453 |
missing, missing, E454, D482, H582 |
GENBANK:XP_005631809 |
| MER0522381 |
Capra hircus |
742 |
292-571 |
D375, E421 |
H373, D383, E422, D450, H548 |
GENBANK:XP_005699931 |
| MER0519119 |
Ceratotherium simum |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_004437641 |
| MER0584458 |
Cercopithecus sabaeus |
775 |
315-603 |
D405, E451 |
H403, D413, E452, D480, H580 |
GENBANK:XP_007989595 |
| MER0592115 |
Chelonia mydas |
752 |
305-585 |
D387, E433 |
H385, D395, E434, D462, H562 |
UNIPROT:M7B185 |
| MER0592115 |
Chelonia mydas |
752 |
305-585 |
D387, E433 |
H385, D395, E434, D462, H562 |
UNIPROT:M7B185 |
| MER0583165 |
Chinchilla lanigera |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_005384581 |
| MER0576264 |
Chrysemys picta |
746 |
298-578 |
D380, E426 |
H378, D388, E427, D455, H555 |
GENBANK:XP_005307958 |
| MER0574700 |
Chrysochloris asiatica |
740 |
280-568 |
D370, K416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_006861013 |
| MER0669726 |
Colobus angolensis |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_011797937 |
| MER0574511 |
Condylura cristata |
739 |
279-567 |
D369, E415 |
H367, D377, E416, D444, H544 |
GENBANK:XP_004682701 |
| MER0195554 |
Cricetulus griseus |
746 |
287-574 |
D376, E422 |
H374, D384, E423, D451, H551 |
UNIPROT:G3IJ23 |
| MER0195554 |
Cricetulus griseus |
746 |
287-574 |
D376, E422 |
H374, D384, E423, D451, H551 |
UNIPROT:G3IJ23 |
| MER1079748 |
Crocodylus porosus |
740 |
331-475 |
D378, E424 |
H376, D386, E425, D453, missing |
GENBANK:XP_019411957 |
| MER0567663 |
Cynoglossus semilaevis |
721 |
273-554 |
D356, E402 |
H354, D364, E403, D431, H531 |
GENBANK:XP_008334625 |
| MER0080566 |
Danio rerio |
740 |
283-571 |
D373, E419 |
H371, D381, E420, D448, H548 |
UNIPROT:A2BGQ8 |
| MER0080566 |
Danio rerio |
740 |
283-571 |
D373, E419 |
H371, D381, E420, D448, H548 |
UNIPROT:A2BGQ8 |
| MER0605579 |
Dasypus novemcinctus |
690 |
284-518 |
D374, E420 |
H372, D382, E421, E432, H495 |
GENBANK:XP_004478693 |
| MER0565451 |
Elephantulus edwardii |
742 |
282-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
GENBANK:XP_006901520 |
| MER0563383 |
Eptesicus fuscus |
744 |
292-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
GENBANK:XP_008157319 |
| MER0608021 |
Equus caballus |
662 |
202-490 |
D292, E338 |
H290, D300, E339, D367, H467 |
GENBANK:XP_005615274 |
| MER0561920 |
Equus przewalskii |
718 |
346-546 |
D359, E405 |
H357, D367, E406, D434, H523 |
GENBANK:XP_008530767 |
| MER0615727 |
Erinaceus europaeus |
742 |
282-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
GENBANK:XP_007518649 |
| MER0662146 |
Esox lucius |
742 |
292-573 |
D374, E420 |
H372, D382, E421, D449, H550 |
GENBANK:XP_010887772 |
| MER0208010 |
Felis catus |
745 |
349-561 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_003993631 |
| MER1125658 |
Felis catus |
748 |
301-592 |
L391, S440 |
A389, G399, K441, P469, G569 |
UNIPROT:M3W5J6 |
| MER0655644 |
Fukomys damarensis |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
UNIPROT:A0A091DBH1 |
| MER0655644 |
Fukomys damarensis |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
UNIPROT:A0A091DBH1 |
| MER0558008 |
Galeopterus variegatus |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_008578202 |
| MER0208357 |
Gorilla gorilla |
741 |
280-569 |
D370, E416 |
H368, D378, E417, D445, H546 |
GENBANK:XP_004051526 |
| MER0195559 |
Heterocephalus glaber |
728 |
270-557 |
D359, E405 |
H357, D367, E406, D434, H534 |
UNIPROT:G5B6M5 |
| MER0195559 |
Heterocephalus glaber |
728 |
270-557 |
D359, E405 |
H357, D367, E406, D434, H534 |
UNIPROT:G5B6M5 |
| MER0005239 |
Homo sapiens |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:BAI45353 |
| MER0005239 |
Homo sapiens |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:BAI45353 |
| MER1250960 |
Hyalella azteca |
647 |
252-366 |
D273, E319, |
H271, D281, E320, D348, missing, |
GENBANK:XP_018013472 |
| MER0106257 |
Ictidomys tridecemlineatus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:I3M1X7 |
| MER0106257 |
Ictidomys tridecemlineatus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:I3M1X7 |
| MER0548336 |
Jaculus jaculus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_004656705 |
| MER0649640 |
Larimichthys crocea |
742 |
292-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_010741084 |
| MER0553455 |
Lepisosteus oculatus |
698 |
357-529 |
missing, E376 |
missing, missing, E377, D405, H506 |
GENBANK:XP_006626738 |
| MER0552538 |
Leptonychotes weddellii |
743 |
283-571 |
D373, E419 |
H371, D381, E420, D448, H548 |
GENBANK:XP_006737167 |
| MER0549615 |
Lipotes vexillifer |
742 |
285-570 |
D375, E421 |
H373, D383, E422, D450, H547 |
GENBANK:XP_007462087 |
| MER0102851 |
Loxodonta africana |
740 |
281-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
UNIPROT:G3SN18 |
| MER0102851 |
Loxodonta africana |
740 |
281-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
UNIPROT:G3SN18 |
| MER0195556 |
Macaca fascicularis |
740 |
282-569 |
D371, E417 |
H369, D379, E418, D446, H546 |
UNIPROT:G7PPK0 |
| MER0195556 |
Macaca fascicularis |
740 |
282-569 |
D371, E417 |
H369, D379, E418, D446, H546 |
UNIPROT:G7PPK0 |
| MER0646582 |
Mandrillus leucophaeus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_011848921 |
| MER0542178 |
Maylandia zebra |
749 |
293-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_004546980 |
| MER0545100 |
Mesocricetus auratus |
578 |
210-406 |
missing, E254 |
missing, missing, E255, D283, H383 |
GENBANK:XP_005063363 |
| MER0320699 |
Metaseiulus occidentalis |
812 |
400-496 |
D422, S468 |
H420, D430, H469, D496, missing |
GENBANK:XP_003745370 |
| MER0537981 |
Microtus ochrogaster |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_005351841 |
| MER0113317 |
Monodelphis domestica |
743 |
284-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
GENBANK:XP_001380124 |
| MER0030289 |
Mus musculus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:Q7M758 |
| MER0030289 |
Mus musculus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:Q7M758 |
| MER0030289 |
Mus musculus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:Q7M758 |
| MER0196193 |
Mustela putorius |
743 |
283-571 |
D373, E419 |
H371, D381, E420, D448, H548 |
GENBANK:XP_004770155 |
| MER0562893 |
Myotis brandtii |
744 |
292-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
GENBANK:XP_005864278 |
| MER0230859 |
Myotis davidii |
347 |
33-292 |
D96, E140 |
F94, C102, E141, D169, H269 |
UNIPROT:L5LDS9 |
| MER0230859 |
Myotis davidii |
347 |
33-292 |
D96, E140 |
F94, C102, E141, D169, H269 |
UNIPROT:L5LDS9 |
| MER0613513 |
Myotis davidii |
579 |
158-452 |
H241, E300 |
F239, G249, E301, D329, H429 |
GENBANK:XP_006771778 |
| MER0144689 |
Myotis lucifugus |
744 |
292-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
UNIPROT:G1PC45 |
| MER0144689 |
Myotis lucifugus |
744 |
292-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
UNIPROT:G1PC45 |
| MER0641031 |
Nannospalax galili |
744 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_008837109 |
| MER1070718 |
Nanorana parkeri |
736 |
323-466 |
D369, E415 |
H367, D377, E416, D444, missing |
GENBANK:XP_018422310 |
| MER0535299 |
Neolamprologus brichardi |
819 |
363-643 |
D445, E491 |
H443, D453, E492, D520, H620 |
GENBANK:XP_006790087 |
| MER0634939 |
Notothenia coriiceps |
597 |
139-428 |
D229, E275 |
H227, D237, E276, D304, H405 |
GENBANK:XP_010775249 |
| MER0533505 |
Ochotona princeps |
735 |
279-565 |
D367, E413 |
H365, D375, E414, D442, H542 |
GENBANK:XP_004596913 |
| MER0532008 |
Octodon degus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_004643787 |
| MER0530637 |
Odobenus rosmarus |
743 |
283-571 |
D373, E419 |
H371, D381, E420, D448, H548 |
GENBANK:XP_004394020 |
| MER0529049 |
Orcinus orca |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_004264380 |
| MER0195709 |
Oreochromis niloticus |
744 |
286-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:I3KJV0 |
| MER0195709 |
Oreochromis niloticus |
744 |
286-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:I3KJV0 |
| MER0528169 |
Orycteropus afer |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_007942980 |
| MER0605361 |
Oryctolagus cuniculus |
429 |
222-257 |
missing, missing |
missing, missing, missing, missing, H234 |
GENBANK:XP_008250023 |
| MER0230967 |
Otolemur garnettii |
745 |
286-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:H0XCB0 |
| MER0230967 |
Otolemur garnettii |
745 |
286-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:H0XCB0 |
| MER0208581 |
Ovis aries |
744 |
353-553 |
D375, E421 |
H373, D383, E422, D450, H523 |
GENBANK:XP_004019709 |
| MER0230992 |
Pan paniscus |
740 |
281-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_003828649 |
| MER0053252 |
Pan troglodytes |
694 |
241-555 |
Y331, A408 |
V329, V339, S409, S420, I532 |
GENBANK:XP_508540 |
| MER0212216 |
Pan troglodytes |
732 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_003951990 |
| MER1128835 |
Pan troglodytes |
713 |
294-582 |
L384, N430 |
A382, G392, K431, P459, G559 |
UNIPROT:H2Q417 |
| MER0518330 |
Panthera tigris |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_007091960 |
| MER0516872 |
Pantholops hodgsonii |
744 |
292-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_005959374 |
| MER0208099 |
Papio anubis |
745 |
350-586 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_003909644 |
| MER1079606 |
Paramormyrops kingsleyae |
737 |
345-449 |
D370, E416 |
H368, D378, E417, D445, missing |
GENBANK:XP_023679806 |
| MER0524501 |
Pelodiscus sinensis |
748 |
300-580 |
D382, E428 |
H380, D390, E429, D457, H557 |
GENBANK:XP_006136628 |
| MER0520757 |
Physeter catodon |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_007119311 |
| MER0521554 |
Poecilia formosa |
741 |
291-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:A0A087XX70 |
| MER0521554 |
Poecilia formosa |
741 |
291-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:A0A087XX70 |
| MER0513992 |
Poecilia reticulata |
740 |
290-571 |
D372, E418 |
H370, D380, E419, D447, H548 |
GENBANK:XP_008416268 |
| MER0320647 |
Pongo abelii |
751 |
281-579 |
D370, V425 |
H368, D378, E426, D456, H556 |
GENBANK:XP_003777767 |
| MER0206769 |
Pteropus alecto |
742 |
283-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
GENBANK:ELK13368 |
| MER0438852 |
Python bivittatus |
546 |
233-514 |
D323, E369 |
H321, D331, E370, D398, H498 |
GENBANK:XP_007444503 |
| MER0004357 |
Rattus norvegicus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:O54697 |
| MER0004357 |
Rattus norvegicus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:O54697 |
| MER0004357 |
Rattus norvegicus |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
UNIPROT:O54697 |
| MER0564834 |
Rhinopithecus roxellana |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_010362257 |
| MER0208829 |
Saimiri boliviensis |
755 |
295-583 |
D385, E431 |
H383, D393, E432, D460, H560 |
GENBANK:XP_003938058 |
| MER0320810 |
Sarcophilus harrisii |
587 |
283-362 |
missing, missing |
missing, missing, missing, missing, missing |
GENBANK:XP_003774173 |
| MER1057703 |
Scleropages formosus |
741 |
349-471 |
D374, E420 |
H372, D382, E421, D449, missing |
GENBANK:XP_018615582 |
| MER0597341 |
Sorex araneus |
742 |
285-571 |
D374, E420 |
H372, D382, E421, D449, H548 |
GENBANK:XP_004618460 |
| MER0473803 |
Stegastes partitus |
806 |
356-637 |
D438, E484 |
H436, D446, E485, D513, H614 |
GENBANK:XP_008281755 |
| MER0669276 |
Strongylocentrotus purpuratus |
424 |
294-401 |
D316, E361 |
H314, D324, E362, D390, missing |
GENBANK:XP_011662054 |
| MER0195560 |
Sus scrofa |
742 |
283-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
UNIPROT:F1RQT1 |
| MER0195560 |
Sus scrofa |
742 |
283-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
UNIPROT:F1RQT1 |
| MER0218648 |
Takifugu rubripes |
749 |
291-580 |
D381, E427 |
H379, D389, E428, D456, H557 |
UNIPROT:H2SBL7 |
| MER0596721 |
Tarsius syrichta |
742 |
282-570 |
D372, E418 |
H370, D380, E419, D447, H547 |
GENBANK:XP_008071194 |
| MER0107996 |
Tetraodon nigroviridis |
1321 |
285-577 |
D379, E425 |
H377, D387, E426, D454, H555 |
UNIPROT:Q4RSL1 |
| MER0107996 |
Tetraodon nigroviridis |
1321 |
285-577 |
D379, E425 |
H377, D387, E426, D454, H555 |
UNIPROT:Q4RSL1 |
| MER0480709 |
Trichechus manatus |
740 |
280-568 |
D370, E416 |
H368, D378, E417, D445, H545 |
GENBANK:XP_004383807 |
| MER0065806 |
Tupaia chinensis |
830 |
285-658 |
D374, E420 |
H372, D382, E421, D449, H635 |
UNIPROT:L9KQ85 |
| MER0065806 |
Tupaia chinensis |
830 |
285-658 |
D374, E420 |
H372, D382, E421, D449, H635 |
UNIPROT:L9KQ85 |
| MER0597571 |
Tupaia chinensis |
744 |
285-572 |
D374, E420 |
H372, D382, E421, D449, H549 |
GENBANK:XP_006149925 |
| MER0623037 |
Tursiops truncatus |
520 |
87-348 |
D177, E223 |
H175, D185, E224, D252, H325 |
GENBANK:XP_004329784 |
| MER0189491 |
Ursus maritimus |
743 |
331-571 |
D397, E443 |
H395, D405, E444, missing, H548 |
GENBANK:XP_008707351 |
| MER0616516 |
Vicugna pacos |
745 |
285-573 |
D375, E421 |
H373, D383, E422, D450, H550 |
GENBANK:XP_006216746 |
| MER0081236 |
Xenopus laevis |
743 |
284-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:A1L2N6 |
| MER0081236 |
Xenopus laevis |
743 |
284-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:A1L2N6 |
| MER0100844 |
Xenopus laevis |
739 |
283-568 |
D372, E418 |
H370, D380, E419, D447, H545 |
UNIPROT:A2VD75 |
| MER0100844 |
Xenopus laevis |
739 |
283-568 |
D372, E418 |
H370, D380, E419, D447, H545 |
UNIPROT:A2VD75 |
| MER0609936 |
Xenopus tropicalis |
273 |
2-221 |
D39, E85 |
H37, D47, E86, D114, H198 |
GENBANK:XP_004920550 |
| MER0848852 |
Xenopus tropicalis |
280 |
7-136 |
D39, E85 |
H37, D47, E86, D114, missing |
GENBANK:XP_012810682 |
| MER0454658 |
Xiphophorus maculatus |
741 |
291-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:M3ZL61 |
| MER0454658 |
Xiphophorus maculatus |
741 |
291-572 |
D373, E419 |
H371, D381, E420, D448, H549 |
UNIPROT:M3ZL61 |
