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Inhibitors

Peptidase

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MEROPS SUBMISSIONS

Other
information

Sequence features for peptidase homologue M16.982: insulysin unit 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0689583 Acanthisitta chloris 986 466-655 E78, G757, E149, S828 H75, N754, I758, H79, K835, E156 GENBANK:XP_009082009
MER0380100 Aedes aegypti 1003 479-665 E90, K548, E161, I619 H87, E545, P549, H91, D626, E168 UNIPROT:Q16P73
MER0380100 Aedes aegypti 1003 479-665 E90, K548, E161, I619 H87, E545, P549, H91, D626, E168 UNIPROT:Q16P73
MER0924844 Amblyomma cajennense 605 131-278 missing, missing missing, missing, missing UNIPROT:A0A023FNN0
MER0924844 Amblyomma cajennense 605 131-278 missing, missing missing, missing, missing UNIPROT:A0A023FNN0
MER0225309 Anolis carolinensis 494     GENBANK:XP_008114985
MER0927327 Anoplophora glabripennis 1015 504-685 missing, E109, missing, E180 H106, missing, missing, H110, missing, E187 UNIPROT:V5GIB3
MER0927327 Anoplophora glabripennis 1015 504-685 missing, E109, missing, E180 H106, missing, missing, H110, missing, E187 UNIPROT:V5GIB3
MER0686414 Apaloderma vittatum 805 278-467 G569, S640 N566, I570, K647 GENBANK:XP_009877803
MER0687801 Aptenodytes forsteri 1056 536-725 E148, G827, S898, E219 N824, H145, I828, H149, E226, K905 GENBANK:XP_009276302
MER0686197 Aquila chrysaetos 907 387-576 missing, G678, E70, S749 N675, missing, missing, I679, E77, K756 GENBANK:XP_011574524
MER0686202 Aquila chrysaetos 613 458-579 E70, E141 H67, H71, E148 GENBANK:XP_011574526
MER0686204 Aquila chrysaetos 592 458-587 E70, E141 H67, H71, E148 GENBANK:XP_011574527
MER0684064 Atta cephalotes 1011 492-678 C783, E104, E175, K854 H101, K780, H105, T784, E182, D861 GENBANK:XP_012057716
MER0914820 Bactrocera oleae 264 4-174 missing, missing missing, missing, missing UNIPROT:E5L9G4
MER0914820 Bactrocera oleae 264 4-174 missing, missing missing, missing, missing UNIPROT:E5L9G4
MER0679495 Balearica regulorum 587 458-587 E70, E141 H67, H71, E148 GENBANK:XP_010305257
MER0682426 Balearica regulorum 391 1-60 G162, S233 N159, I163, K240 GENBANK:XP_010302375
MER0679623 Bison bison 1019 499-688 E111, G790, E182, S861 H108, N787, H112, I791, E189, I868 GENBANK:XP_010840502
MER0678474 Buceros rhinoceros 986 466-655 E78, G757, E149, S828 N754, H75, H79, I758, E156, K835 GENBANK:XP_010144389
MER0677063 Camelus dromedarius 1019 499-688 G790, E111, E182, E860 H108, N787, H112, I791, E189, I868 GENBANK:XP_010972589
MER0382232 Camponotus floridanus 1002 500-666 E91, V549, V620, E162 E546, H88, P550, H92, E169, D627 UNIPROT:E2B270
MER0382232 Camponotus floridanus 1002 500-666 E91, V549, V620, E162 E546, H88, P550, H92, E169, D627 UNIPROT:E2B270
MER0555482 Capra hircus 978 458-647 G749, E70, E141, E819 N746, H67, I750, H71, I827, E148 GENBANK:XP_005698269
MER0675925 Cariama cristata 968 465-654 E77, G756, E148, S827 H74, N753, H78, I757, K834, E155 GENBANK:XP_009693895
MER0675195 Cerapachys biroi 1016 494-681 C785, E106, E177, K856 K782, H103, T786, H107, D863, E184 GENBANK:XP_011329458
MER0670814 Ceratosolen solmsi 1055 527-713 E139, C818, E210, K889 H136, V815, H140, T819, E217, E896 GENBANK:XP_011499186
MER0673176 Chaetura pelagica 1103 583-772 E195, G874, E266, S945 N871, H192, H196, I875, E273, K952 GENBANK:XP_009998424
MER0672014 Charadrius vociferus 993 473-662 G764, E85, E156, S835 H82, N761, H86, I765, E163, K842 GENBANK:XP_009887090
MER0583225 Chinchilla lanigera 1020 499-689 E111, G791, S862, E182 N788, H108, I792, H112, E189, I869 GENBANK:XP_005385882
MER0671448 Colius striatus 494 2-163 G265, E335 N262, I266, K343 GENBANK:XP_010197954
MER0669991 Colobus angolensis 1019 499-688 G790, S861 N787, I791, I868 GENBANK:XP_011803228
MER0669999 Colobus angolensis 464 1-133 G235, E305 N232, I236, I313 GENBANK:XP_011803230
MER0663362 Corvus cornix 1018 498-687 G789, E110, E181, E859 N786, H107, I790, H111, K867, E188 GENBANK:XP_010408756
MER0667240 Crassostrea gigas 979 461-647 E72, E143 H69, H73, E150 GENBANK:XP_011455386
MER0926317 Crassostrea gigas 1019 439-604 missing, E45, missing, E116 H42, missing, missing, H46, missing, E123 UNIPROT:K1R5G5
MER0926317 Crassostrea gigas 1019 439-604 missing, E45, missing, E116 H42, missing, missing, H46, missing, E123 UNIPROT:K1R5G5
MER0665221 Cuculus canorus 968 458-647 G749, E70, E141, S820 H67, N746, H71, I750, E148, K827 GENBANK:XP_009569049
MER0664219 Egretta garzetta 998 478-667 E90, G769, E161, E839 H87, N766, H91, I770, K847, E168 GENBANK:XP_009640221
MER0661668 Esox lucius 1015 496-684 G786, S857 N783, I787, K864 GENBANK:XP_010862163
MER0658651 Eurypyga helias 385 1-108 G210, S281 N207, I211, K288 GENBANK:XP_010151026
MER0658762 Eurypyga helias 538 458-538 E70, E141 H67, H71, E148 GENBANK:XP_010152867
MER0658234 Fopius arisanus 1013 488-676 C786, H100, I171, E857 K783, L97, T787, M101, E864, H178 GENBANK:XP_011312074
MER0658238 Fopius arisanus 309 1-38 C148, E219 K145, T149, E226 GENBANK:XP_011312090
MER0658317 Fopius arisanus 952 498-686 K111, C796, E867, V182 K793, H108, T797, H112, E189, E874 GENBANK:XP_011313568
MER0655266 Fukomys damarensis 1002 482-671 E94, G773, E165, S844 N770, H91, H95, I774, E172, I851 GENBANK:XP_010630400
MER0655113 Fulmarus glacialis 997 481-670 G772, E93, E164, S843 H90, N769, H94, I773, E171, K850 GENBANK:XP_009582856
MER0653492 Gavia stellata 981 465-654 E77, G756, E148, S827 H74, N753, H78, I757, K834, E155 GENBANK:XP_009814696
MER0652087 Haliaeetus albicilla 649 129-318 G420, E490 N417, I421, K498 GENBANK:XP_009914023
MER0651494 Haliaeetus leucocephalus 922 458-647 E70, missing, E141, S764 missing, H67, H71, missing, E148, K771 GENBANK:XP_010563220
MER0651497 Haliaeetus leucocephalus 907 387-576 missing, G678, E70, S749 missing, N675, missing, I679, K756, E77 GENBANK:XP_010563221
MER0651503 Haliaeetus leucocephalus 450 13-119 G221, S292 N218, I222, K299 GENBANK:XP_010563225
MER0651506 Haliaeetus leucocephalus 965 458-647 E70, G749, E141, E819 H67, N746, I750, H71, K827, E148 GENBANK:XP_010563219
MER0651508 Haliaeetus leucocephalus 592 458-587 E70, E141 H67, H71, E148 GENBANK:XP_010563224
MER0651510 Haliaeetus leucocephalus 596 458-587 E70, E141 H67, H71, E148 GENBANK:XP_010563223
MER0382369 Harpegnathos saltator 1050 549-707 E140, V598, E211, I669 H137, E595, H141, P599, E218, D676 UNIPROT:E2BPG0
MER0382369 Harpegnathos saltator 1050 549-707 E140, V598, E211, I669 H137, E595, H141, P599, E218, D676 UNIPROT:E2BPG0
MER0382370 Heterocephalus glaber 1020 501-688 E121, L570, I641, E192 K567, H118, P571, H122, E199, E648 UNIPROT:G5BV05
MER0382370 Heterocephalus glaber 1020 501-688 E121, L570, I641, E192 K567, H118, P571, H122, E199, E648 UNIPROT:G5BV05
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0046821 Homo sapiens 1019 499-688 E111, G790, S861, E182 N787, H108, I791, H112, E189, I868 GENBANK:XP_016871679
MER0612473 Ictidomys tridecemlineatus 1019 499-688 G790, E111, E182, S861 H108, N787, H112, I791, E189, I868 GENBANK:XP_005333788
MER0648915 Larimichthys crocea 1015 495-684 E107, G786, E178, S857 N783, H104, H108, I787, E185, C864 GENBANK:XP_010732888
MER0924506 Leptosomus discolor 543 63-245 missing, missing missing, missing, missing UNIPROT:A0A091PLP2
MER0924506 Leptosomus discolor 543 63-245 missing, missing missing, missing, missing UNIPROT:A0A091PLP2
MER0647881 Linepithema humile 1022 496-683 C788, E108, E179, K859 H105, K785, H109, T789, E186, D866 GENBANK:XP_012215276
MER0382258 Macaca mulatta 1019 500-687 E111, L569, E182, I640 H108, K566, P570, H112, E647, E189 UNIPROT:F7FKF0
MER0382258 Macaca mulatta 1019 500-687 E111, L569, E182, I640 H108, K566, P570, H112, E647, E189 UNIPROT:F7FKF0
MER0646502 Manacus vitellinus 999 479-668 E91, G770, E162, S841 H88, N767, H92, I771, K848, E169 GENBANK:XP_008928133
MER0645830 Mandrillus leucophaeus 1019 499-688 E111, G790, S861, E182 H108, N787, H112, I791, E189, I868 GENBANK:XP_011843871
MER0645838 Mandrillus leucophaeus 464 1-133 G235, S306 N232, I236, I313 GENBANK:XP_011843873
MER0382022 Megachile rotundata 1015 509-677 E102, L560, I631, E173 H99, E557, H103, P561, E180, D638 GENBANK:XP_003701355
MER0926628 Meleagris gallopavo 373 33-134 missing, missing missing, missing, missing UNIPROT:G3UQZ4
MER0926941 Meleagris gallopavo 350 2-111 missing, missing missing, missing, missing UNIPROT:G1NA95
MER0644520 Merops nubicus 794 278-467 G569, S640 N566, I570, K647 GENBANK:XP_008938615
MER0643884 Mesitornis unicolor 970 466-655 G757, E78, E149, S828 H75, N754, H79, I758, E156, K835 GENBANK:XP_010189995
MER0046321 Mus musculus 1019 500-689 H112, V183 F109, M113, H190 UNIPROT:Q9JHR7
MER0641317 Nannospalax galili 1019 499-688 E111, G790, E182, S861 H108, N787, H112, I791, L868, E189 GENBANK:XP_008847842
MER0382382 Nasonia vitripennis 1016 510-673 E99, L556, E170, V627 E553, H96, H100, P557, E177, D634 GENBANK:XP_003427813
MER0638691 Nestor notabilis 986 466-655 G757, E78, E149, E827 N754, H75, I758, H79, K835, E156 GENBANK:XP_010010062
MER0635820 Nipponia nippon 989 469-658 E81, G760, E152, S831 N757, H78, H82, I761, E159, K838 GENBANK:XP_009464668
MER0634759 Notothenia coriiceps 474 336-474 missing, E19 missing, missing, E26 GENBANK:XP_010765140
MER0633906 Opisthocomus hoazin 1000 481-670 E93, G772, S843, E164 N769, H90, I773, H94, E171, K850 GENBANK:XP_009934009
MER0382375 Pediculus humanus 1031 504-689 L572, L643 E569, P573, E650 UNIPROT:E0V946
MER0382375 Pediculus humanus 1031 504-689 L572, L643 E569, P573, E650 UNIPROT:E0V946
MER0633242 Pelecanus crispus 1035 508-697 E120, G799, E191, E869 H117, N796, H121, I800, E198, K877 GENBANK:XP_009484863
MER0631956 Phaethon lepturus 335     GENBANK:XP_010286945
MER0631257 Phalacrocorax carbo 363 2-110 G212, S283 N209, I213, K290 GENBANK:XP_009506156
MER0629563 Picoides pubescens 1006 501-690 E113, G792, E184, E862 N789, H110, H114, I793, E191, K870 GENBANK:XP_009896096
MER0603365 Plutella xylostella 1196 583-719 E98, E169 H95, H99, E176 GENBANK:XP_011569316
MER0926743 Podiceps cristatus 970 466-648 missing, E72, E143, missing H69, missing, H73, missing, missing, E150 UNIPROT:A0A094LDH6
MER0926743 Podiceps cristatus 970 466-648 missing, E72, E143, missing H69, missing, H73, missing, missing, E150 UNIPROT:A0A094LDH6
MER0616897 Pogonomyrmex barbatus 130     GENBANK:XP_011634995
MER0382213 Pongo abelii 1019 500-687 E111, L569, E182, I640 H108, K566, H112, P570, E189, E647 UNIPROT:H2NB07
MER0382213 Pongo abelii 1019 500-687 E111, L569, E182, I640 H108, K566, H112, P570, E189, E647 UNIPROT:H2NB07
MER0588933 Pterocles gutturalis 340 1-23 G125, S196 N122, I126, K203 GENBANK:XP_010082766
MER0591820 Pterocles gutturalis 647 458-632 E70, E141 H67, H71, E148 GENBANK:XP_010076413
MER0926005 Pygoscelis adeliae 975 466-648 E72, missing, missing, E143 missing, H69, missing, H73, missing, E150 UNIPROT:A0A093NX76
MER0926005 Pygoscelis adeliae 975 466-648 E72, missing, missing, E143 missing, H69, missing, H73, missing, E150 UNIPROT:A0A093NX76
MER0046939 Rattus norvegicus 1019 - H112, G790, V183, S861 F109, N787, I791, M113, I868, H190 PIR:S29509
MER0046939 Rattus norvegicus 1019 - H112, G790, V183, S861 F109, N787, I791, M113, I868, H190 PIR:S29509
MER0562491 Rhinopithecus roxellana 1019 499-688 G790, E860 N787, I791, I868 GENBANK:XP_010379621
MER0925757 Rhipicephalus pulchellus 1026 543-700 missing, E125, missing, E196 missing, H122, missing, H126, E203, missing UNIPROT:L7MEJ4
MER0925757 Rhipicephalus pulchellus 1026 543-700 missing, E125, missing, E196 missing, H122, missing, H126, E203, missing UNIPROT:L7MEJ4
MER0382349 Rhizopus oryzae 1090 497-659 E85, V547, V618, E156 H82, T544, H86, P548, E163, Q625 UNIPROT:I1C5U7
MER0382349 Rhizopus oryzae 1090 497-659 E85, V547, V618, E156 H82, T544, H86, P548, E163, Q625 UNIPROT:I1C5U7
MER0490781 Saccoglossus kowalevskii 111     GENBANK:XP_006823134
MER0490796 Saccoglossus kowalevskii 498     GENBANK:XP_006823135
MER0542479 Serinus canaria 978 458-647 E70, G749, E141, E819 N746, H67, H71, I750, E148, K827 GENBANK:XP_009085529
MER0528291 Solenopsis invicta 493 21-160 C265, K336 K262, T266, D343 GENBANK:XP_011172985
MER0522313 Struthio camelus 954 458-647 E70, G749, E141, S820 H67, N746, H71, I750, K827, E148 GENBANK:XP_009676076
MER0522332 Struthio camelus 494 2-163 G265, S336 N262, I266, K343 GENBANK:XP_009676079
MER0595739 Tarsius syrichta 1022 502-691 H115, G793, S864, V186 F112, N790, M116, I794, H193, I871 GENBANK:XP_008061852
MER0375022 Tauraco erythrolophus 958 458-647 E70, G749, S820, E141 N746, H67, I750, H71, E148, K827 GENBANK:XP_009986141
MER0388546 Tinamus guttatus 976 534-723 G825, E146, E217, S896 N822, H143, I826, H147, K903, E224 GENBANK:XP_010211466
MER0597950 Tupaia chinensis 978 458-647 H71, G749, V142, S820 F68, N746, M72, I750, H149, I827 GENBANK:XP_006147699
MER0927637 Tupaia chinensis 933 464-649 E70, missing, missing, E141 H67, missing, H71, missing, E148, missing UNIPROT:L9KUU7
MER0927637 Tupaia chinensis 933 464-649 E70, missing, missing, E141 H67, missing, H71, missing, E148, missing UNIPROT:L9KUU7
MER0271300 Ursus maritimus 978 458-647 E70, G749, S820, E141 H67, N746, H71, I750, E148, I827 GENBANK:XP_008694470
MER0346537 Vollenhovia emeryi 1018 499-685 E111, C790, E182, K861 H108, K787, H112, T791, E189, D868 GENBANK:XP_011877956
MER0392115 Wasmannia auropunctata 1016 497-682 E109, C788, E180, R859 H106, K785, H110, T789, D866, E187 GENBANK:XP_011707871
MER0926517 Zootermopsis nevadensis 1011 511-670 E94, missing, missing, E165 H91, missing, H95, missing, E172, missing UNIPROT:A0A067RBB4
MER0926517 Zootermopsis nevadensis 1011 511-670 E94, missing, missing, E165 H91, missing, H95, missing, E172, missing UNIPROT:A0A067RBB4

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