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Literature for peptidase T02.004: taspase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bietti,A.L.F., Kauth,A.A., Hommel,K., Blueggel,M., Mohr,L., Niemeyer,F.C., Beuck,C., Bayer,P., Knauer,S.K., Jan Ravoo,B. and Schrader,T.
    Photoresponsive molecular tweezers modulate Taspase 1 activity
    RSC Chem Biol (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  2. Hommel,K., Theisen,S., Blueggel,M., Niemeyer,F.C., Beuck,C., Bayer,P., Zadmard,R., Schrader,T. and Knauer,S.K.
    Highly Preorganized Calixarene Tweezers for Protein Recognition
    Biomacromolecules (2025) PubMed  Europe PubMed DOI
    3. 2024
  3. Hommel,K., Kauth,A.A., Kirupakaran,A., Theisen,S., Hayduk,M., Niemeyer,F.C., Beuck,C., Zadmard,R., Bayer,P., Ravoo,B.J., Voskuhl,J., Schrader,T. and Knauer,S.K.
    Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1
    Chemistry (2024) , e202401542-e202401542. PubMed  Europe PubMed DOI
    4. 2022
  4. Hensel,A., Stahl,P., Moews,L., Konig,L., Patwardhan,R., Hoing,A., Schulze,N., Nalbant,P., Stauber,R.H. and Knauer,S.K.
    The Taspase1/Myosin1f-axis regulates filopodia dynamics
    iScience (2022) 25, 104355-104355. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Hoing,A., Kirupakaran,A., Beuck,C., Porschke,M., Niemeyer,F.C., Seiler,T., Hartmann,L., Bayer,P., Schrader,T. and Knauer,S.K.
    Recognition of a Flexible Protein Loop in Taspase 1 by Multivalent Supramolecular Tweezers
    Biomacromolecules (2022) 23, 4504-4518. PubMed  Europe PubMed DOI
    6. 2021
  6. Hoing,A., Zimmermann,A., Moews,L., Killa,M., Heimann,M., Hensel,A., Voskuhl,J. and Knauer,S.K.
    A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin alpha Interaction
    ChemMedChem (2021) PubMed  Europe PubMed DOI
    7. 2020
  7. van den Boom,J., Hensel,A., Trusch,F., Matena,A., Siemer,S., Guel,D., Docter,D., Hoing,A., Bayer,P., Stauber,R.H. and Knauer,S.K.
    The other side of the corona: nanoparticles inhibit the protease taspase1 in a size-dependent manner
    Nanoscale (2020) 12, 19093-19103. PubMed  Europe PubMed DOI
  8. Wang,F., Li,P., Shao,Y., Li,Y., Zhang,K., Li,M., Wang,R., Zheng,S., Wang,Y., Song,S., Feng,S., Liu,F., Xiao,W. and Li,X.
    Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase zeta
    Nucleic Acids Res (2020) 48, 3619-3637. PubMed  Europe PubMed DOI
  9. Zhang,Y., Du,P., Li,Y., Zhu,Q., Song,X., Liu,S., Hao,J., Liu,L., Liu,F., Hu,Y., Jiang,L., Ma,Q., Lu,W. and Liu,Y.
    TASP1 Promotes gallbladder cancer cell proliferation and metastasis by up-regulating FAM49B via PI3K/AKT pathway
    Int J Biol Sci (2020) 16, 739-751. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2019
  10. Balkin,D.M., Poranki,M., Forester,C.M., Dorsey,M.J., Slavotinek,A. and Pomerantz,J.H.
    TASP1 mutation in a female with craniofacial anomalies, anterior segment dysgenesis, congenital immunodeficiency and macrocytic anemia
    Mol Genet Genomic Med (2019) , e818-e818. PubMed  Europe PubMed DOI  M
  11. Suleiman,J., Riedhammer,K.M., Jicinsky,T., Mundt,M., Werner,L., Gusic,M., Burgemeister,A.L., Alsaif,H.S., Abdulrahim,M., Moghrabi,N.N., Nicolas-Jilwan,M., AlSayed,M., Bi,W., Sampath,S., Alkuraya,F.S. and El-Hattab,A.W.
    Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive facial features, and congenital anomalies
    Hum Mutat (2019) 40, 1985-1992. PubMed  Europe PubMed DOI  M
  12. Zhao,Z., Wang,L., Volk,A.G., Birch,N.W., Stoltz,K.L., Bartom,E.T., Marshall,S.A., Rendleman,E.J., Nestler,C.M., Shilati,J., Schiltz,G.E., Crispino,J.D. and Shilatifard,A.
    Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia
    Genes Dev (2019) 33, 61-74. PubMed  Europe PubMed DOI  K
    13. 2018
  13. Schrenk,C., Fetz,V., Vallet,C., Heiselmayer,C., Schroder,E., Hensel,A., Hahlbrock,A., Wunsch,D., Goesswein,D., Bier,C., Habtemichael,N., Schneider,G., Stauber,R.H. and Knauer,S.K.
    TFIIA transcriptional activity is controlled by a 'cleave-and-run' exportin-1/taspase 1-switch
    J Mol Cell Biol (2018) 10, 33-47. PubMed  Europe PubMed DOI
  14. Suleiman,J., Mundt,M., Sampath,S. and El-Hattab,A.W.
    TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies
    Clin Genet (2018) 94, 170-173. PubMed  Europe PubMed DOI  M
    15. 2017
  15. Gribko,A., Hahlbrock,A., Strieth,S., Becker,S., Hagemann,J., Deichelbohrer,M., Hildebrandt,A., Habtemichael,N. and Wu Nsch,D.
    Disease-relevant signalling-pathways in head and neck cancer: taspase1's proteolytic activity fine-tunes TFIIA function
    Sci Rep (2017) 7, 14937-14937. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2016
  16. Hahlbrock,A., Goesswein,D., Kunzel,J., Wunsch,D. and Stauber,R.H.
    Threonine aspartase1: an unexplored protease with relevance for oral oncology?
    Oral Oncol (2016) 54, e10-e12. PubMed  Europe PubMed DOI  I
  17. Stauber,R.H., Hahlbrock,A., Knauer,S.K. and Wunsch,D.
    Cleaving for growth: threonine aspartase 1-a protease relevant for development and disease
    FASEB J (2016) 30, 1012-1022. PubMed  Europe PubMed DOI  V
  18. van den Boom,J., Trusch,F., Hoppstock,L., Beuck,C. and Bayer,P.
    Structural characterization of the loop at the alpha-subunit C-terminus of the mixed lineage leukemia protein activating protease taspase1
    PLoS ONE (2016) 11, e0151431-e0151431. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Wunsch,D., Hahlbrock,A., Jung,S., Schirmeister,T., van den Boom,J., Schilling,O., Knauer,S.K. and Stauber,R.H.
    Taspase1: a 'misunderstood' protease with translational cancer relevance
    Oncogene (2016) 35, 3351-3364. PubMed  Europe PubMed DOI  V
    20. 2015
  20. Malecova,B., Caputo,V.S., Lee,D.F., Hsieh,J.J. and Oelgeschlager,T.
    Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID
    Transcription (2015) 6, 21-32. PubMed  Europe PubMed DOI
  21. Niizuma,H., Cheng,E.H. and Hsieh,J.J.
    Taspase 1: a protease with many biological surprises
    Mol Cell Oncol (2015) 2, e999513-e999513. PubMed  Europe PubMed DOI  PMC  EPMC  T
  22. Wunsch,D., Hahlbrock,A., Heiselmayer,C., Backer,S., Schrenk,C., Benne,F., Schilling,O. and Knauer,S.K.
    Evolutionary divergence of threonine aspartase1 leads to species-specific substrate recognition
    Biol Chem (2015) 396, 367-376. PubMed  Europe PubMed DOI
  23. Wunsch,D., Hahlbrock,A., Heiselmayer,C., Backer,S., Heun,P., Goesswein,D., Stocker,W., Schirmeister,T., Schneider,G., Kramer,O.H., Knauer,S.K. and Stauber,R.H.
    Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's taspase1
    FASEB J (2015) 29, 1973-1985. PubMed  Europe PubMed DOI
    24. 2014
  24. Dong,Y., Van Tine,B.A., Oyama,T., Wang,P.I., Cheng,E.H. and Hsieh,J.J.
    Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis
    Cell Res (2014) 24, 1354-1366. PubMed  Europe PubMed DOI  K
  25. van den Boom,J., Mamic,M., Baccelliere,D., Zweerink,S., Kaschani,F., Knauer,S., Bayer,P. and Kaiser,M.
    Peptidyl succinimidyl peptides as taspase 1 inhibitors
    Chembiochem (2014) 15, 2233-2237. PubMed  Europe PubMed DOI  I
    26. 2013
  26. Freiman,R.N.
    Processing the complexities of transcription
    Dev Cell (2013) 27, 123-124. PubMed  Europe PubMed DOI
  27. Oyama,T., Sasagawa,S., Takeda,S., Hess,R.A., Lieberman,P.M., Cheng,E.H. and Hsieh,J.J.
    Cleavage of TFIIA by taspase1 activates TRF2-specified mammalian male germ cell programs
    Dev Cell (2013) 27, 188-200. PubMed  Europe PubMed DOI
  28. Stauber,R.H. and Knauer,S.K.
    Protease research: Taspase 1 - license to cut
    BioSpektrum (2013) 19, 134-136. DOI
    29. 2012
  29. Bier,C., Knauer,S.K., Wunsch,D., Kunst,L., Scheiding,S., Kaiser,M., Ottmann,C., Kramer,O.H. and Stauber,R.H.
    Allosteric inhibition of taspase1's pathobiological activity by enforced dimerization in vivo
    FASEB J (2012) 26, 3421-3429. PubMed  Europe PubMed DOI
  30. Bier,C., Hecht,R., Kunst,L., Scheiding,S., Wunsch,D., Goesswein,D., Schneider,G., Kramer,O.H., Knauer,S.K. and Stauber,R.H.
    Overexpression of the catalytically impaired taspase1 T234V or taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells
    PLoS ONE (2012) 7, e34142-e34142. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Chen,D.Y., Lee,Y., Van Tine,B.A., Searleman,A.C., Westergard,T.D., Liu,H., Tu,H.C., Takeda,S., Dong,Y., Piwnica-Worms,D.R., Oh,K.J., Korsmeyer,S.J., Hermone,A., Gussio,R., Shoemaker,R.H., Cheng,E.H. and Hsieh,J.J.
    A pharmacologic inhibitor of the protease taspase1 effectively inhibits breast and brain tumor growth
    Cancer Res (2012) 72, 736-746. PubMed  Europe PubMed DOI  K  I
  32. Cunha,L., Tong,L. and Hsieh,J.J.D.
    Taspase 1
    [ISSN:978-0-12-407742-3] (2012) 3, 3723-3728. DOI
  33. Wunsch,D., Fetz,V., Heider,D., Tenzer,S., Bier,C., Kunst,L., Knauer,S. and Stauber,R.
    Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1
    Blood Cancer J (2012) 2, e77-e77. PubMed  Europe PubMed DOI  PMC  EPMC  I
    34. 2011
  34. Bier,C., Knauer,S.K., Klapthor,A., Schweitzer,A., Rekik,A., Kramer,O.H., Marschalek,R. and Stauber,R.H.
    Cell-based analysis of structure-function activity of threonine aspartase 1
    J Biol Chem (2011) 286, 3007-3017. PubMed  Europe PubMed DOI
  35. Bier,C., Knauer,S.K., Docter,D., Schneider,G., Kramer,O.H. and Stauber,R.H.
    The importin-alpha/nucleophosmin switch controls taspase1 protease function
    Traffic (2011) 12, 703-714. PubMed  Europe PubMed DOI
  36. Knauer,S.K., Fetz,V., Rabenstein,J., Friedl,S., Hofmann,B., Sabiani,S., Schroder,E., Kunst,L., Proschak,E., Thines,E., Kindler,T., Schneider,G., Marschalek,R., Stauber,R.H. and Bier,C.
    Bioassays to monitor taspase1 function for the identification of pharmacogenetic inhibitors
    PLoS ONE (2011) 6, e18253-e18253. PubMed  Europe PubMed DOI  PMC  EPMC  A
    37. 2010
  37. Chen,D.Y., Liu,H., Takeda,S., Tu,H.C., Sasagawa,S., Van Tine,B.A., Lu,D., Cheng,E.H. and Hsieh,J.J.
    Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis
    Cancer Res (2010) 70, 5358-5367. PubMed  Europe PubMed DOI
    38. 2009
  38. Lee,J.T., Chen,D.Y., Yang,Z., Ramos,A.D., Hsieh,J.J. and Bogyo,M.
    Design, syntheses, and evaluation of taspase1 inhibitors
    Bioorg Med Chem Lett (2009) 19, 5086-5090. PubMed  Europe PubMed DOI  I
    39. 2007
  39. Capotosti,F., Hsieh,J.J. and Herr,W.
    Species selectivity of Mixed-Lineage Leukemia/Trithorax and HCF proteolytic maturation pathways
    Mol Cell Biol (2007) 27, 7063-7072. PubMed  Europe PubMed DOI  PMC  EPMC  P
  40. Hoiby,T., Zhou,H., Mitsiou,D.J. and Stunnenberg,H.G.
    A facelift for the general transcription factor TFIIA
    Biochim Biophys Acta (2007) 1769, 429-436. PubMed  Europe PubMed DOI
    41. 2006
  41. [YEAR:1-9-2006]Takeda,S., Chen,D.Y., Westergard,T.D., Fisher,J.K., Rubens,J.A., Sasagawa,S., Kan,J.T., Korsmeyer,S.J., Cheng,E.H. and Hsieh,J.J.
    Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression
    Genes Dev (1-9-2006) 20, 2397-2409. PubMed  Europe PubMed DOI  K  T
  42. Zhou,H., Spicuglia,S., Hsieh,J.J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G.
    Uncleaved TFIIA is a substrate for taspase 1 and active in transcription
    Mol Cell Biol (2006) 26, 2728-2735. PubMed  Europe PubMed DOI  PMC  EPMC  P
    43. 2005
  43. Khan,J.A., Dunn,B.M. and Tong,L.
    Crystal structure of human taspase1, a crucial protease regulating the function of MLL
    Structure (2005) 13, 1443-1452. PubMed  Europe PubMed DOI  S
    44. 2003
  44. [YEAR:31-10-2003]Gilliland,D.G.
    Proteolytic processing in development and leukemogenesis
    Cell (31-10-2003) 115, 248-250. PubMed  Europe PubMed
  45. [YEAR:31-10-2003]Hsieh,J.J., Cheng,E.H. and Korsmeyer,S.J.
    Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression
    Cell (31-10-2003) 115, 293-303. PubMed  Europe PubMed DOI
  46. Hsieh,J.J., Ernst,P., Erdjument-Bromage,H., Tempst,P. and Korsmeyer,S.J.
    Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
    Mol Cell Biol (2003) 23, 186-194. PubMed  Europe PubMed DOI  PMC  EPMC

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