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Literature for peptidase T02.004: taspase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, V Review, M Mutation, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bietti,A.L.F., Kauth,A.A., Hommel,K., Blueggel,M., Mohr,L., Niemeyer,F.C., Beuck,C., Bayer,P., Knauer,S.K., Jan Ravoo,B. and Schrader,T.<br>Photoresponsive molecular tweezers modulate Taspase 1 activity<br>RSC Chem Biol (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  2. Hommel,K., Theisen,S., Blueggel,M., Niemeyer,F.C., Beuck,C., Bayer,P., Zadmard,R., Schrader,T. and Knauer,S.K.<br>Highly Preorganized Calixarene Tweezers for Protein Recognition<br>Biomacromolecules (2025) PubMed  Europe PubMed DOI
    3. 2024
  3. Hommel,K., Kauth,A.A., Kirupakaran,A., Theisen,S., Hayduk,M., Niemeyer,F.C., Beuck,C., Zadmard,R., Bayer,P., Ravoo,B.J., Voskuhl,J., Schrader,T. and Knauer,S.K.<br>Functional Linkers Support Targeting of Multivalent Tweezers to Taspase1<br>Chemistry (2024) , e202401542-e202401542. PubMed  Europe PubMed DOI
    4. 2022
  4. Hensel,A., Stahl,P., Moews,L., Konig,L., Patwardhan,R., Hoing,A., Schulze,N., Nalbant,P., Stauber,R.H. and Knauer,S.K.<br>The Taspase1/Myosin1f-axis regulates filopodia dynamics<br>iScience (2022) 25, 104355-104355. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Hoing,A., Kirupakaran,A., Beuck,C., Porschke,M., Niemeyer,F.C., Seiler,T., Hartmann,L., Bayer,P., Schrader,T. and Knauer,S.K.<br>Recognition of a Flexible Protein Loop in Taspase 1 by Multivalent Supramolecular Tweezers<br>Biomacromolecules (2022) 23, 4504-4518. PubMed  Europe PubMed DOI
    6. 2021
  6. Hoing,A., Zimmermann,A., Moews,L., Killa,M., Heimann,M., Hensel,A., Voskuhl,J. and Knauer,S.K.<br>A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin alpha Interaction<br>ChemMedChem (2021) PubMed  Europe PubMed DOI
    7. 2020
  7. van den Boom,J., Hensel,A., Trusch,F., Matena,A., Siemer,S., Guel,D., Docter,D., Hoing,A., Bayer,P., Stauber,R.H. and Knauer,S.K.<br>The other side of the corona: nanoparticles inhibit the protease taspase1 in a size-dependent manner<br>Nanoscale (2020) 12, 19093-19103. PubMed  Europe PubMed DOI
  8. Wang,F., Li,P., Shao,Y., Li,Y., Zhang,K., Li,M., Wang,R., Zheng,S., Wang,Y., Song,S., Feng,S., Liu,F., Xiao,W. and Li,X.<br>Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase zeta<br>Nucleic Acids Res (2020) 48, 3619-3637. PubMed  Europe PubMed DOI
  9. Zhang,Y., Du,P., Li,Y., Zhu,Q., Song,X., Liu,S., Hao,J., Liu,L., Liu,F., Hu,Y., Jiang,L., Ma,Q., Lu,W. and Liu,Y.<br>TASP1 Promotes gallbladder cancer cell proliferation and metastasis by up-regulating FAM49B via PI3K/AKT pathway<br>Int J Biol Sci (2020) 16, 739-751. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2019
  10. Balkin,D.M., Poranki,M., Forester,C.M., Dorsey,M.J., Slavotinek,A. and Pomerantz,J.H.<br>TASP1 mutation in a female with craniofacial anomalies, anterior segment dysgenesis, congenital immunodeficiency and macrocytic anemia<br>Mol Genet Genomic Med (2019) , e818-e818. PubMed  Europe PubMed DOI  M
  11. Suleiman,J., Riedhammer,K.M., Jicinsky,T., Mundt,M., Werner,L., Gusic,M., Burgemeister,A.L., Alsaif,H.S., Abdulrahim,M., Moghrabi,N.N., Nicolas-Jilwan,M., AlSayed,M., Bi,W., Sampath,S., Alkuraya,F.S. and El-Hattab,A.W.<br>Homozygous loss-of-function variants of TASP1, a gene encoding an activator of the histone methyltransferases KMT2A and KMT2D, cause a syndrome of developmental delay, happy demeanor, distinctive facial features, and congenital anomalies<br>Hum Mutat (2019) 40, 1985-1992. PubMed  Europe PubMed DOI  M
  12. Zhao,Z., Wang,L., Volk,A.G., Birch,N.W., Stoltz,K.L., Bartom,E.T., Marshall,S.A., Rendleman,E.J., Nestler,C.M., Shilati,J., Schiltz,G.E., Crispino,J.D. and Shilatifard,A.<br>Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia<br>Genes Dev (2019) 33, 61-74. PubMed  Europe PubMed DOI  K
    13. 2018
  13. Schrenk,C., Fetz,V., Vallet,C., Heiselmayer,C., Schroder,E., Hensel,A., Hahlbrock,A., Wunsch,D., Goesswein,D., Bier,C., Habtemichael,N., Schneider,G., Stauber,R.H. and Knauer,S.K.<br>TFIIA transcriptional activity is controlled by a 'cleave-and-run' exportin-1/taspase 1-switch<br>J Mol Cell Biol (2018) 10, 33-47. PubMed  Europe PubMed DOI
  14. Suleiman,J., Mundt,M., Sampath,S. and El-Hattab,A.W.<br>TASP1 is deleted in an infant with developmental delay, microcephaly, distinctive facial features, and multiple congenital anomalies<br>Clin Genet (2018) 94, 170-173. PubMed  Europe PubMed DOI  M
    15. 2017
  15. Gribko,A., Hahlbrock,A., Strieth,S., Becker,S., Hagemann,J., Deichelbohrer,M., Hildebrandt,A., Habtemichael,N. and Wu Nsch,D.<br>Disease-relevant signalling-pathways in head and neck cancer: taspase1's proteolytic activity fine-tunes TFIIA function<br>Sci Rep (2017) 7, 14937-14937. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2016
  16. Hahlbrock,A., Goesswein,D., Kunzel,J., Wunsch,D. and Stauber,R.H.<br>Threonine aspartase1: an unexplored protease with relevance for oral oncology?<br>Oral Oncol (2016) 54, e10-e12. PubMed  Europe PubMed DOI  I
  17. Stauber,R.H., Hahlbrock,A., Knauer,S.K. and Wunsch,D.<br>Cleaving for growth: threonine aspartase 1-a protease relevant for development and disease<br>FASEB J (2016) 30, 1012-1022. PubMed  Europe PubMed DOI  V
  18. van den Boom,J., Trusch,F., Hoppstock,L., Beuck,C. and Bayer,P.<br>Structural characterization of the loop at the alpha-subunit C-terminus of the mixed lineage leukemia protein activating protease taspase1<br>PLoS ONE (2016) 11, e0151431-e0151431. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Wunsch,D., Hahlbrock,A., Jung,S., Schirmeister,T., van den Boom,J., Schilling,O., Knauer,S.K. and Stauber,R.H.<br>Taspase1: a 'misunderstood' protease with translational cancer relevance<br>Oncogene (2016) 35, 3351-3364. PubMed  Europe PubMed DOI  V
    20. 2015
  20. Malecova,B., Caputo,V.S., Lee,D.F., Hsieh,J.J. and Oelgeschlager,T.<br>Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID<br>Transcription (2015) 6, 21-32. PubMed  Europe PubMed DOI
  21. Niizuma,H., Cheng,E.H. and Hsieh,J.J.<br>Taspase 1: a protease with many biological surprises<br>Mol Cell Oncol (2015) 2, e999513-e999513. PubMed  Europe PubMed DOI  PMC  EPMC  T
  22. Wunsch,D., Hahlbrock,A., Heiselmayer,C., Backer,S., Schrenk,C., Benne,F., Schilling,O. and Knauer,S.K.<br>Evolutionary divergence of threonine aspartase1 leads to species-specific substrate recognition<br>Biol Chem (2015) 396, 367-376. PubMed  Europe PubMed DOI
  23. Wunsch,D., Hahlbrock,A., Heiselmayer,C., Backer,S., Heun,P., Goesswein,D., Stocker,W., Schirmeister,T., Schneider,G., Kramer,O.H., Knauer,S.K. and Stauber,R.H.<br>Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's taspase1<br>FASEB J (2015) 29, 1973-1985. PubMed  Europe PubMed DOI
    24. 2014
  24. Dong,Y., Van Tine,B.A., Oyama,T., Wang,P.I., Cheng,E.H. and Hsieh,J.J.<br>Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis<br>Cell Res (2014) 24, 1354-1366. PubMed  Europe PubMed DOI  K
  25. van den Boom,J., Mamic,M., Baccelliere,D., Zweerink,S., Kaschani,F., Knauer,S., Bayer,P. and Kaiser,M.<br>Peptidyl succinimidyl peptides as taspase 1 inhibitors<br>Chembiochem (2014) 15, 2233-2237. PubMed  Europe PubMed DOI  I
    26. 2013
  26. Freiman,R.N.<br>Processing the complexities of transcription<br>Dev Cell (2013) 27, 123-124. PubMed  Europe PubMed DOI
  27. Oyama,T., Sasagawa,S., Takeda,S., Hess,R.A., Lieberman,P.M., Cheng,E.H. and Hsieh,J.J.<br>Cleavage of TFIIA by taspase1 activates TRF2-specified mammalian male germ cell programs<br>Dev Cell (2013) 27, 188-200. PubMed  Europe PubMed DOI
  28. Stauber,R.H. and Knauer,S.K.<br>Protease research: Taspase 1 - license to cut<br>BioSpektrum (2013) 19, 134-136. DOI
    29. 2012
  29. Bier,C., Knauer,S.K., Wunsch,D., Kunst,L., Scheiding,S., Kaiser,M., Ottmann,C., Kramer,O.H. and Stauber,R.H.<br>Allosteric inhibition of taspase1's pathobiological activity by enforced dimerization in vivo<br>FASEB J (2012) 26, 3421-3429. PubMed  Europe PubMed DOI
  30. Bier,C., Hecht,R., Kunst,L., Scheiding,S., Wunsch,D., Goesswein,D., Schneider,G., Kramer,O.H., Knauer,S.K. and Stauber,R.H.<br>Overexpression of the catalytically impaired taspase1 T234V or taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells<br>PLoS ONE (2012) 7, e34142-e34142. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Chen,D.Y., Lee,Y., Van Tine,B.A., Searleman,A.C., Westergard,T.D., Liu,H., Tu,H.C., Takeda,S., Dong,Y., Piwnica-Worms,D.R., Oh,K.J., Korsmeyer,S.J., Hermone,A., Gussio,R., Shoemaker,R.H., Cheng,E.H. and Hsieh,J.J.<br>A pharmacologic inhibitor of the protease taspase1 effectively inhibits breast and brain tumor growth<br>Cancer Res (2012) 72, 736-746. PubMed  Europe PubMed DOI  K  I
  32. Cunha,L., Tong,L. and Hsieh,J.J.D.<br>Taspase 1<br>[ISSN:978-0-12-407742-3] (2012) 3, 3723-3728. DOI
  33. Wunsch,D., Fetz,V., Heider,D., Tenzer,S., Bier,C., Kunst,L., Knauer,S. and Stauber,R.<br>Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1<br>Blood Cancer J (2012) 2, e77-e77. PubMed  Europe PubMed DOI  PMC  EPMC  I
    34. 2011
  34. Bier,C., Knauer,S.K., Klapthor,A., Schweitzer,A., Rekik,A., Kramer,O.H., Marschalek,R. and Stauber,R.H.<br>Cell-based analysis of structure-function activity of threonine aspartase 1<br>J Biol Chem (2011) 286, 3007-3017. PubMed  Europe PubMed DOI
  35. Bier,C., Knauer,S.K., Docter,D., Schneider,G., Kramer,O.H. and Stauber,R.H.<br>The importin-alpha/nucleophosmin switch controls taspase1 protease function<br>Traffic (2011) 12, 703-714. PubMed  Europe PubMed DOI
  36. Knauer,S.K., Fetz,V., Rabenstein,J., Friedl,S., Hofmann,B., Sabiani,S., Schroder,E., Kunst,L., Proschak,E., Thines,E., Kindler,T., Schneider,G., Marschalek,R., Stauber,R.H. and Bier,C.<br>Bioassays to monitor taspase1 function for the identification of pharmacogenetic inhibitors<br>PLoS ONE (2011) 6, e18253-e18253. PubMed  Europe PubMed DOI  PMC  EPMC  A
    37. 2010
  37. Chen,D.Y., Liu,H., Takeda,S., Tu,H.C., Sasagawa,S., Van Tine,B.A., Lu,D., Cheng,E.H. and Hsieh,J.J.<br>Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis<br>Cancer Res (2010) 70, 5358-5367. PubMed  Europe PubMed DOI
    38. 2009
  38. Lee,J.T., Chen,D.Y., Yang,Z., Ramos,A.D., Hsieh,J.J. and Bogyo,M.<br>Design, syntheses, and evaluation of taspase1 inhibitors<br>Bioorg Med Chem Lett (2009) 19, 5086-5090. PubMed  Europe PubMed DOI  I
    39. 2007
  39. Capotosti,F., Hsieh,J.J. and Herr,W.<br>Species selectivity of Mixed-Lineage Leukemia/Trithorax and HCF proteolytic maturation pathways<br>Mol Cell Biol (2007) 27, 7063-7072. PubMed  Europe PubMed DOI  PMC  EPMC  P
  40. Hoiby,T., Zhou,H., Mitsiou,D.J. and Stunnenberg,H.G.<br>A facelift for the general transcription factor TFIIA<br>Biochim Biophys Acta (2007) 1769, 429-436. PubMed  Europe PubMed DOI
    41. 2006
  41. [YEAR:1-9-2006]Takeda,S., Chen,D.Y., Westergard,T.D., Fisher,J.K., Rubens,J.A., Sasagawa,S., Kan,J.T., Korsmeyer,S.J., Cheng,E.H. and Hsieh,J.J.<br>Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression<br>Genes Dev (1-9-2006) 20, 2397-2409. PubMed  Europe PubMed DOI  K  T
  42. Zhou,H., Spicuglia,S., Hsieh,J.J., Mitsiou,D.J., Hoiby,T., Veenstra,G.J., Korsmeyer,S.J. and Stunnenberg,H.G.<br>Uncleaved TFIIA is a substrate for taspase 1 and active in transcription<br>Mol Cell Biol (2006) 26, 2728-2735. PubMed  Europe PubMed DOI  PMC  EPMC  P
    43. 2005
  43. Khan,J.A., Dunn,B.M. and Tong,L.<br>Crystal structure of human taspase1, a crucial protease regulating the function of MLL<br>Structure (2005) 13, 1443-1452. PubMed  Europe PubMed DOI  S
    44. 2003
  44. [YEAR:31-10-2003]Gilliland,D.G.<br>Proteolytic processing in development and leukemogenesis<br>Cell (31-10-2003) 115, 248-250. PubMed  Europe PubMed
  45. [YEAR:31-10-2003]Hsieh,J.J., Cheng,E.H. and Korsmeyer,S.J.<br>Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression<br>Cell (31-10-2003) 115, 293-303. PubMed  Europe PubMed DOI
  46. Hsieh,J.J., Ernst,P., Erdjument-Bromage,H., Tempst,P. and Korsmeyer,S.J.<br>Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization<br>Mol Cell Biol (2003) 23, 186-194. PubMed  Europe PubMed DOI  PMC  EPMC

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