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Literature for peptidase T01.006: HslV component of HslUV peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Lu,Q., Tang,Z., Guan,G., Yang,D., Liu,C., Du,C., Zhi,K., Wang,H. and Lu,F.<br>Deletion of the hslV gene alleviates the virulence and lethality of Salmonella Typhimurium in hosts by modulating lon and T3SS-1<br>Virulence (2025) 16, 2580174-2580174. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Hamid,M., Salar,U., Rashid,Y., Azim,M.K., Khan,K.M., Naz,S., Aziz,T., Alharbi,M., Alshammari,A. and Alasmari,A.F.<br>Determining the 3-substituted Coumarins inhibitory potential against the HslV protease of E. coli<br>Eur Rev Med Pharmacol Sci (2023) 27, 9169-9182. PubMed  Europe PubMed DOI  I
    3. 2019
  3. Chang,C.Y., Weng,Y.T., Hwang,L.Y., Hu,H.T., Shih,P.S., Kuan,J.E., Wu,K.F. and Wu,W.F.<br>Specific regions of the SulA protein recognized and degraded by the ATP-dependent ClpYQ (HslUV) protease in Escherichia coli<br>Microbiol Res (2019) 220, 21-31. PubMed  Europe PubMed DOI
  4. Fuchs,A.C.D. and Hartmann,M.D.<br>On the origins of symmetry and modularity in the proteasome family: symmetry transitions are pivotal in the evolution and functional diversification of self-compartmentalizing proteases<br>Bioessays (2019) , e1800237-e1800237. PubMed  Europe PubMed DOI
    5. 2018
  5. Yu,Y., Yan,F., He,Y., Qin,Y., Chen,Y., Chai,Y. and Guo,J.H.<br>The ClpY-ClpQ protease regulates multicellular development in Bacillus subtilis<br>Microbiology (Reading) (2018) 164, 848-862. PubMed  Europe PubMed DOI
    6. 2017
  6. Baytshtok,V., Chen,J., Glynn,S.E., Nager,A.R., Grant,R.A., Baker,T.A. and Sauer,R.T.<br>Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation<br>J Biol Chem (2017) 292, 5695-5704. PubMed  Europe PubMed DOI
  7. Dong,S.L., Hu,W.L., Ge,Y.M., Ojcius,D.M., Lin,X. and Yan,J.<br>A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis<br>Emerg Microbes Infect (2017) 6, e105-e105. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Tsai,C.H., Ho,Y.H., Sung,T.C., Wu,W.F. and Chen,C.S.<br>Escherichia coli proteome microarrays identified the substrates of ClpYQ protease<br>Mol Cell Proteomics (2017) 16, 113-120. PubMed  Europe PubMed DOI  P
    9. 2016
  9. Chang,C.Y., Hu,H.T., Tsai,C.H. and Wu,W.F.<br>The degradation of RcsA by ClpYQ(HslUV) protease in Escherichia coli<br>Microbiol Res (2016) 184, 42-50. PubMed  Europe PubMed DOI
    10. 2014
  10. Hwang,L.-Y., Hu,H.-T., Tsai,C.-H. and Wu,W.-F.<br>The Escherichia coli ClpYQ protease recognizes the C-terminal tail of SulA<br>Taiwanese J Agric Chem Food Sci (2014) 52, 48-58.  P
  11. Shi,L. and Kay,L.E.<br>Tracing an allosteric pathway regulating the activity of the HslV protease<br>Proc Natl Acad Sci U S A (2014) 111, 2140-2145. PubMed  Europe PubMed DOI
    12. 2013
  12. Jain,S., Rathore,S., Asad,M., Hossain,M.E., Sinha,D., Datta,G. and Mohmmed,A.<br>The prokaryotic ClpQ protease plays a key role in growth and development of mitochondria in Plasmodium falciparum<br>Cell Microbiol (2013) 15, 1660-1673. PubMed  Europe PubMed DOI
  13. Park,E., Lee,J.W., Yoo,H.M., Ha,B.H., An,J.Y., Jeon,Y.J., Seol,J.H., Eom,S.H. and Chung,C.H.<br>Structural alteration in the pore motif of the bacterial 20S proteasome homolog HslV leads to uncontrolled protein degradation<br>J Mol Biol (2013) 425, 2940-2954. PubMed  Europe PubMed DOI
    14. 2012
  14. Chrobak,M., Forster,S., Meisel,S., Pfefferkorn,R., Forster,F. and Clos,J.<br>Leishmania donovani HslV does not interact stably with HslU proteins<br>Int J Parasitol (2012) 42, 329-339. PubMed  Europe PubMed DOI
  15. Park,E., Yoo,S.J., Seong,I.S., Goldberg,A.L. and Chung,C.H.<br>HslVU protease<br>[ISSN:978-0-12-407742-3] (2012) 3, 3677-3683. DOI
  16. Rashid,Y., Kamran Azim,M., Saify,Z.S., Khan,K.M. and Khan,R.<br>Small molecule activators of proteasome-related HslV peptidase<br>Bioorg Med Chem Lett (2012) 22, 6089-6094. PubMed  Europe PubMed DOI  I
  17. Sundar,S., Baker,T.A. and Sauer,R.T.<br>The I domain of the AAA+ HslUV protease coordinates substrate binding, ATP hydrolysis, and protein degradation<br>Protein Sci (2012) 21, 188-198. PubMed  Europe PubMed DOI
    18. 2011
  18. Rathore,S., Jain,S., Sinha,D., Gupta,M., Asad,M., Srivastava,A., Narayanan,M.S., Ramasamy,G., Chauhan,V.S., Gupta,D. and Mohmmed,A.<br>Disruption of a mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death<br>Cell Death Dis (2011) 2, e231-e231. PubMed  Europe PubMed DOI
  19. Sauer,R.T. and Baker,T.A.<br>AAA+ Proteases: ATP-fueled machines of protein destruction<br>Annu Rev Biochem (2011) 80, 587-612. PubMed  Europe PubMed DOI
    20. 2010
  20. Sundar,S., McGinness,K.E., Baker,T.A. and Sauer,R.T.<br>Multiple sequence signals direct recognition and degradation of protein substrates by the AAA+ protease HslUV<br>J Mol Biol (2010) 403, 420-429. PubMed  Europe PubMed DOI  P
    21. 2009
  21. Koodathingal,P., Jaffe,N.E., Kraut,D.A., Prakash,S., Fishbain,S., Herman,C. and Matouschek,A.<br>ATP-dependent proteases differ substantially in their ability to unfold globular proteins<br>J Biol Chem (2009) 284, 18674-18684. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Lee,J.W., Park,E., Jeong,M.S., Jeon,Y.J., Eom,S.H., Seol,J.H. and Chung,C.H.<br>HslVU ATP-dependent protease utilizes maximally six among twelve threonine active sites during proteolysis<br>J Biol Chem (2009) 284, 33475-33484. PubMed  Europe PubMed DOI
    23. 2008
  23. Inobe,T. and Matouschek,A.<br>Protein targeting to ATP-dependent proteases<br>Curr Opin Struct Biol (2008) 18, 43-51. PubMed  Europe PubMed DOI  PMC  EPMC  V
  24. Park,E., Lee,J.W., Eom,S.H., Seol,J.H. and Chung,C.H.<br>Binding of MG132 or deletion of the Thr active sites in HslV subunits increases the affinity of HslV protease for HslU ATPase and makes this interaction nucleotide-independent<br>J Biol Chem (2008) 283, 33258-33266. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Yakamavich,J.A., Baker,T.A. and Sauer,R.T.<br>Asymmetric nucleotide transactions of the HslUV protease<br>J Mol Biol (2008) 380, 946-957. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2007
  26. Azim,M.K. and Noor,S.<br>Characterization of protomer interfaces in HslV protease; the bacterial homologue of 20S proteasome<br>Protein J (2007) 26, 213-219. PubMed  Europe PubMed DOI
  27. Lee,J.W., Park,E., Bang,O., Eom,S.H., Cheong,G.W., Chung,C.H. and Seol,J.H.<br>Nucleotide triphosphates inhibit the degradation of unfolded proteins by HslV peptidase<br>Mol Cells (2007) 23, 252-257. PubMed  Europe PubMed
    28. 2006
  28. [YEAR:4-10-2006]Ruiz-Gonzalez,M.X. and Marin,I.<br>Proteasome-related HslU and HslV genes typical of eubacteria are widespread in eukaryotes<br>J Mol Evol (4-10-2006) 63, 504-512. PubMed  Europe PubMed DOI
    29. 2005
  29. [YEAR:31-3-2005]Azim,M.K., Goehring,W., Song,H.K., Ramachandran,R., Bochtler,M. and Goettig,P.<br>Characterization of the HslU chaperone affinity for HslV protease<br>Protein Sci (31-3-2005) 14, 1357-1362. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Azim,M.K., Goehring,W., Song,H.K., Ramachandran,R., Bochtler,M. and Goettig,P.<br>Characterization of the HsIU chaperone affinity for HsIV protease (vol 14, pg 1357, 2005)<br>Protein Sci (2005) 14, 2484-2484. PubMed  Europe PubMed DOI  PMC  EPMC
  31. [YEAR:6-2-2005]Burton,R.E., Baker,T.A. and Sauer,R.T.<br>Nucleotide-dependent substrate recognition by the AAA+ HslUV protease<br>Nat Struct Mol Biol (6-2-2005) 12, 245-251. PubMed  Europe PubMed DOI
  32. [YEAR:21-4-2005]Frees,D., Thomsen,L.E. and Ingmer,H.<br>Staphylococcus aureus ClpYQ plays a minor role in stress survival<br>Arch Microbiol (21-4-2005) 183, 286-291. PubMed  Europe PubMed DOI  K
  33. [YEAR:22-4-2005]Park,E., Rho,Y.M., Koh,O.J., Ahn,S.W., Seong,I.S., Song,J.J., Bang,O., Seol,J.H., Wang,J., Eom,S.H. and Chung,C.H.<br>Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase<br>J Biol Chem (22-4-2005) 280, 22892-22898. PubMed  Europe PubMed DOI
  34. Wang,J., Rho,S.H., Park,H.H. and Eom,S.H.<br>Correction of X-ray intensities from an HslV-HslU co-crystal containing lattice-translocation defects<br>Acta Crystallogr D Biol Crystallogr (2005) 61, 932-941. PubMed  Europe PubMed DOI  S
    35. 2004
  35. Huang,H.C., Goldberg,A.L., Yoo,S.J., Seong,I.S. and Chung,C.H.<br>HslVU protease<br>[ISSN:0-12-079610-4] (2004) 2, 2064-2068.  V
  36. Kwon,A.R., Trame,C.B. and McKay,D.B.<br>Kinetics of protein substrate degradation by HslUV<br>J Struct Biol (2004) 146, 141-147. PubMed  Europe PubMed DOI
    37. 2003
  37. [YEAR:4-7-2003]Kwon,A.R., Kessler,B.M., Overkleeft,H.S. and McKay,D.B.<br>Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome<br>J Mol Biol (4-7-2003) 330, 185-195. PubMed  Europe PubMed DOI
  38. Lee,Y.Y., Chang,C.F., Kuo,C.L., Chen,M.C., Yu,C.H., Lin,P.I. and Wu,W.F.<br>Subunit oligomerization and substrate recognition of the Escherichia coli ClpYQ (HslUV) protease implicated by in vivo protein-protein interactions in the yeast two-hybrid system<br>J Bacteriol (2003) 185, 2393-2401. PubMed  Europe PubMed DOI  PMC  EPMC
  39. [YEAR:23-10-2003]Nishii,W. and Takahashi,K.<br>Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli<br>FEBS Lett (23-10-2003) 553, 351-354. PubMed  Europe PubMed DOI
    40. 2002
  40. [YEAR:28-5-2002]Ramachandran,R., Hartmann,C., Song,H.K., Huber,R. and Bochtler,M.<br>Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY)<br>Proc Natl Acad Sci U S A (28-5-2002) 99, 7396-7401. PubMed  Europe PubMed DOI  PMC  EPMC
  41. [YEAR:19-7-2002]Seong,I.S., Kang,M.S., Choi,M.K., Lee,J.W., Koh,O.J., Wang,J., Eom,S.H. and Chung,C.H.<br>The C-terminal tails of HslU ATPase act as a molecular switch for activation of HslV peptidase<br>J Biol Chem (19-7-2002) 277, 25976-25982. PubMed  Europe PubMed DOI
  42. [YEAR:3-5-2002]Sousa,M.C., Kessler,B.M., Overkleeft,H.S. and McKay,D.B.<br>Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU<br>J Mol Biol (3-5-2002) 318, 779-785. PubMed  Europe PubMed DOI  S  I
    43. 2001
  43. Bochtler,M., Song,H.K., Hartmann,C., Ramachandran,R. and Huber,R.<br>The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale<br>J Struct Biol (2001) 135, 281-293. PubMed  Europe PubMed DOI  S
  44. Sousa,M.C. and McKay,D.B.<br>Structure of Haemophilus influenzae HslV protein at 1.9 A resolution, revealing a cation-binding site near the catalytic site<br>Acta Crystallogr D Biol Crystallogr (2001) 57, 1950-1954. PubMed  Europe PubMed DOI
  45. Wang,J.<br>A corrected quaternary arrangement of the peptidase HslV and ATPase HslU in a cocrystal structure<br>J Struct Biol (2001) 134, 15-24. PubMed  Europe PubMed DOI  S
  46. Wang,J., Song,J.J., Franklin,M.C., Kamtekar,S., Im,Y.J., Rho,S.H., Seong,I.S., Lee,C.S., Chung,C.H. and Eom,S.H.<br>Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism<br>Structure (2001) 9, 177-184. PubMed  Europe PubMed DOI  S
    47. 2000
  47. [YEAR:17-2-2000]Bochtler,M., Hartmann,C., Song,H.K., Bourenkov,G.P., Bartunik,H.D. and Huber,R.<br>The structures of HsIU and the ATP-dependent protease HsIU-HsIV<br>Nature (17-2-2000) 403, 800-805. PubMed  Europe PubMed DOI  S
  48. [YEAR:21-7-2000]Seong,I.S., Oh,J.Y., Lee,J.W., Tanaka,K. and Chung,C.H.<br>The HslU ATPase acts as a molecular chaperone in prevention of aggregation of SulA, an inhibitor of cell division in Escherichia coli<br>FEBS Lett (21-7-2000) 477, 224-229. PubMed  Europe PubMed DOI
  49. [YEAR:10-11-2000]Sousa,M.C., Trame,C.B., Tsuruta,H., Wilbanks,S.M., Reddy,V.S. and McKay,D.B.<br>Crystal and solution structures of an HslUV protease-chaperone complex<br>Cell (10-11-2000) 103, 633-643. PubMed  Europe PubMed  S
    50. 1999
  50. Kanemori,M., Yanagi,H. and Yura,T.<br>The ATP-dependent HslVU/ClpQY protease participates in turnover of cell division inhibitor SulA in Escherichia coli<br>J Bacteriol (1999) 181, 3674-3680. PubMed  Europe PubMed  PMC  EPMC
  51. Schmidt,M., Lupas,A.N. and Finley,D.<br>Structure and mechanism of ATP-dependent proteases<br>Curr Opin Chem Biol (1999) 3, 584-591. PubMed  Europe PubMed DOI
  52. [YEAR:30-7-1999]Seong,I.S., Oh,J.Y., Yoo,S.J., Seol,J.H. and Chung,C.H.<br>ATP-dependent degradation of SulA, a cell division inhibitor, by the HslVU protease in Escherichia coli<br>FEBS Lett (30-7-1999) 456, 211-214. PubMed  Europe PubMed DOI
  53. Wu,W.F., Zhou,Y. and Gottesman,S.<br>Redundant in vivo proteolytic activities of Escherichia coli lon and the ClpYQ (HslUV) protease<br>J Bacteriol (1999) 181, 3681-3687. PubMed  Europe PubMed  PMC  EPMC
    54. 1998
  54. [YEAR:2-1-1998]Hilliard,J.J., Maurizi,M.R. and Simon,L.D.<br>Isolation and characterization of the phage T4 PinA protein, an inhibitor of the ATP-dependent Lon protease of Escherichia coli<br>J Biol Chem (2-1-1998) 273, 518-523. PubMed  Europe PubMed DOI
  55. [YEAR:4-9-1998]Yoo,S.J., Kim,H.H., Shin,D.H., Lee,C.S., Seong,I.S., Seol,J.H., Shimbara,N., Tanaka,K. and Chung,C.H.<br>Effects of the Cys mutations on structure and function of the ATP-dependent HslVU protease in Escherichia coli. The Cys287 to Val mutation in HslU uncouples the ATP-dependent proteolysis by HslVU from ATP hydrolysis<br>J Biol Chem (4-9-1998) 273, 22929-22935. PubMed  Europe PubMed DOI
    56. 1997
  56. [YEAR:10-6-1997]Bochtler,M., Ditzel,L., Groll,M. and Huber,R.<br>Crystal structure of heat shock locus V (HslV) from Escherichia coli<br>Proc Natl Acad Sci U S A (10-6-1997) 94, 6070-6074. PubMed  Europe PubMed DOI  PMC  EPMC
  57. [YEAR:24-6-1997]Bogyo,M., McMaster,J.S., Gaczynska,M., Tortorella,D., Goldberg,A.L. and Ploegh,H.<br>Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors<br>Proc Natl Acad Sci U S A (24-6-1997) 94, 6629-6634. PubMed  Europe PubMed  PMC  EPMC  I
  58. Goldberg,A.L., Akopian,T.N., Kisselev,A.F., Lee,D.H. and Rohrwild,M.<br>New insights into the mechanisms and importance of the proteasome in intracellular protein degradation<br>Biol Chem (1997) 378, 131-140. PubMed  Europe PubMed
  59. [YEAR:22-8-1997]Huang,H. and Goldberg,A.L.<br>Proteolytic activity of the ATP-dependent protease HslVU can be uncoupled from ATP hydrolysis<br>J Biol Chem (22-8-1997) 272, 21364-21372. PubMed  Europe PubMed DOI
  60. Khattar,M.M.<br>Overexpression of the hslVU operon suppresses SOS-mediated inhibition of cell division in Escherichia coli<br>FEBS Lett (1997) 414, 402-404. PubMed  Europe PubMed DOI
  61. Rohrwild,M., Pfeifer,G., Santarius,U., Muller,S.A., Huang,H.C., Engel,A., Baumeister,W. and Goldberg,A.L.<br>The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome<br>Nat Struct Biol (1997) 4, 133-139. PubMed  Europe PubMed DOI  S
  62. Yoo,S.J., Shim,Y.K., Seong,I.S., Seol,J.H., Kang,M.S. and Chung,C.H.<br>Mutagenesis of two N-terminal Thr and five Ser residues in HslV, the proteolytic component of the ATP-dependent HslVU protease<br>FEBS Lett (1997) 412, 57-60. PubMed  Europe PubMed DOI
    63. 1996
  63. Kessel,M., Wu,W., Gottesman,S., Kocsis,E., Steven,A.C. and Maurizi,M.R.<br>Six-fold rotational symmetry of ClpQ, the E. coli homolog of the 20S proteasome, and its ATP-dependent activator, ClpY<br>FEBS Lett (1996) 398, 274-278. PubMed  Europe PubMed DOI
  64. Missiakas,D., Schwager,F., Betton,J.M., Georgopoulos,C. and Raina,S.<br>Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli<br>EMBO J (1996) 15, 6899-6909. PubMed  Europe PubMed  PMC  EPMC
  65. Rohrwild,M., Coux,O., Huang,H.C., Moerschell,R.P., Yoo,S.J., Seol,J.H., Chung,C.H. and Goldberg,A.L.<br>HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome<br>Proc Natl Acad Sci U S A (1996) 93, 5808-5813. PubMed  Europe PubMed  PMC  EPMC
  66. Shin,D.H., Yoo,S.J., Shim,Y.K., Seol,J.H., Kang,M.S. and Chung,C.H.<br>Mutational analysis of the ATP-binding site in HslU, the ATPase component of HslVU protease in Escherichia coli<br>FEBS Lett (1996) 398, 151-154. PubMed  Europe PubMed DOI
  67. Yoo,S.J., Seol,J.H., Kang,M.S. and Chung,C.H.<br>Poly-L-lysine activates both peptide and ATP hydrolysis by the ATP-dependent HslVU protease in Escherichia coli<br>Biochem Biophys Res Commun (1996) 229, 531-535. PubMed  Europe PubMed DOI
  68. Yoo,S.J., Seol,J.H., Shin,D.H., Rohrwild,M., Kang,M.S., Tanaka,K., Goldberg,A.L. and Chung,C.H.<br>Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli<br>J Biol Chem (1996) 271, 14035-14040. PubMed  Europe PubMed DOI
    69. 1995
  69. Gottesman,S., Wickner,S., Jubete,Y., Singh,S.K., Kessel,M. and Maurizi,M.<br>Selective, energy-dependent proteolysis in Escherichia coli<br>Cold Spring Harb Symp Quant Biol (1995) 60, 533-548. PubMed  Europe PubMed
    70. 1993
  70. [YEAR:30-11-1993]Chuang,S.E., Burland,V., Plunkett,G., III, Daniels,D.L. and Blattner,F.R.<br>Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli<br>Gene (30-11-1993) 134, 1-6. PubMed  Europe PubMed DOI
  71. [YEAR:25-10-1993]Gottesman,S., Clark,W.P., de Crecy-Lagard,V. and Maurizi,M.R.<br>ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities<br>J Biol Chem (25-10-1993) 268, 22618-22626. PubMed  Europe PubMed

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