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Literature for peptidase T01.005: bacterial proteasome, beta component

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Turner,M., Uday,A.B., Velyvis,A., Rennella,E., Zeytuni,N. and Vahidi,S.<br>Structural basis for allosteric modulation of M. tuberculosis proteasome core particle<br>Nat Commun (2025) 16, 3138-3138. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Rozman,K., Alexander,E.M., Ogorevc,E., Bozovicar,K., Sosic,I., Aldrich,C.C. and Gobec,S.<br>Psoralen derivatives as inhibitors of Mycobacterium tuberculosis proteasome<br>Molecules (2020) 25 PubMed  Europe PubMed DOI  I
  3. Vimer,S., Ben-Nissan,G., Morgenstern,D., Kumar-Deshmukh,F., Polkinghorn,C., Quintyn,R.S., Vasil'ev,Y.V., Beckman,J.S., Elad,N., Wysocki,V.H. and Sharon,M.<br>Comparative structural analysis of 20S proteasome ortholog protein complexes by native mass spectrometry<br>ACS Cent Sci (2020) 6, 573-588. PubMed  Europe PubMed DOI  PMC  EPMC  S
    4. 2019
  4. Becker,S.H., Jastrab,J.B., Dhabaria,A., Chaton,C.T., Rush,J.S., Korotkov,K.V., Ueberheide,B. and Darwin,K.H.<br>The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway<br>Proc Natl Acad Sci U S A (2019) 116, 3202-3210. PubMed  Europe PubMed DOI
  5. Becker,S.H., Li,H. and Heran Darwin,K.<br>Biology and Biochemistry of Bacterial Proteasomes<br>Subcell Biochem (2019) 93, 339-358. PubMed  Europe PubMed DOI
  6. Muller,A.U. and Weber-Ban,E.<br>The bacterial proteasome at the core of diverse degradation pathways<br>Front Mol Biosci (2019) 6, 23-23. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2017
  7. Hsu,H.C., Singh,P.K., Fan,H., Wang,R., Sukenick,G., Nathan,C., Lin,G. and Li,H.<br>Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome<br>Biochemistry (2017) 56, 324-333. PubMed  Europe PubMed DOI
  8. Jastrab,J.B., Samanovic,M.I., Copin,R., Shopsin,B. and Darwin,K.H.<br>Loss-of-function mutations in HspR rescue the growth defect of a Mycobacterium tuberculosis proteasome activator E (pafE) mutant<br>J Bacteriol (2017) 199, e00850-16-e00850-16. PubMed  Europe PubMed DOI
  9. Moreira,W., Santhanakrishnan,S., Dymock,B.W. and Dick,T.<br>Bortezomib warhead-switch confers dual activity against mycobacterial caseinolytic protease and proteasome and selectivity against human proteasome<br>Front Microbiol (2017) 8, 746-746. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Totaro,K.A., Barthelme,D., Simpson,P.T., Jiang,X., Lin,G., Nathan,C.F., Sauer,R.T. and Sello,J.K.<br>Rational design of selective and bioactive inhibitors of the Mycobacterium tuberculosis proteasome<br>ACS Infect Dis (2017) 3, 176-181. PubMed  Europe PubMed DOI  I
  11. Wu,Y., Hu,K., Li,D., Bai,L., Yang,S., Jastrab,J.B., Xiao,S., Hu,Y., Zhang,S., Darwin,K.H., Wang,T. and Li,H.<br>Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease<br>Mol Microbiol (2017) 105, 227-241. PubMed  Europe PubMed DOI
    12. 2016
  12. Bai,L., Hu,K., Wang,T., Jastrab,J.B., Darwin,K.H. and Li,H.<br>Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis<br>Proc Natl Acad Sci U S A (2016) 113, E1983-E1992. PubMed  Europe PubMed DOI
  13. Bolten,M., Delley,C.L., Leibundgut,M., Boehringer,D., Ban,N. and Weber-Ban,E.<br>Structural analysis of the bacterial proteasome activator Bpa in complex with the 20S proteasome<br>Structure (2016) 24, 2138-2151. PubMed  Europe PubMed DOI  S
  14. dela Pena,A.H. and Lander,G.C.<br>What's the key to unlocking the proteasome's gate?<br>Structure (2016) 24, 2037-2038. PubMed  Europe PubMed DOI
    15. 2015
  15. Jastrab,J.B., Wang,T., Murphy,J.P., Bai,L., Hu,K., Merkx,R., Huang,J., Chatterjee,C., Ovaa,H., Gygi,S.P., Li,H. and Darwin,K.H.<br>An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis<br>Proc Natl Acad Sci U S A (2015) 112, E1763-E1772. PubMed  Europe PubMed DOI
  16. Mehra,R., Chib,R., Munagala,G., Yempalla,K.R., Khan,I.A., Singh,P.P., Khan,F.G. and Nargotra,A.<br>Discovery of new Mycobacterium tuberculosis proteasome inhibitors using a knowledge-based computational screening approach<br>Mol Divers (2015) 19, 1003-1019. PubMed  Europe PubMed DOI  I
  17. Russo,F., Gising,J., Akerbladh,L., Roos,A.K., Naworyta,A., Mowbray,S.L., Sokolowski,A., Henderson,I., Alling,T., Bailey,M.A., Files,M., Parish,T., Karlen,A. and Larhed,M.<br>Optimization and evaluation of 5-styryl-oxathiazol-2-one Mycobacterium tuberculosis proteasome inhibitors as potential antitubercular agents<br>ChemistryOpen (2015) 4, 342-362. PubMed  Europe PubMed DOI  I
    18. 2014
  18. Anandan,T., Han,J., Baun,H., Nyayapathy,S., Brown,J.T., Dial,R.L., Moltalvo,J.A., Kim,M.S., Yang,S.H., Ronning,D.R., Husson,R.N., Suh,J. and Kang,C.M.<br>Phosphorylation regulates mycobacterial proteasome<br>J Microbiol (2014) 52, 743-754. PubMed  Europe PubMed DOI
  19. Delley,C.L., Laederach,J., Ziemski,M., Bolten,M., Boehringer,D. and Weber-Ban,E.<br>Bacterial proteasome activator Bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome<br>PLoS ONE (2014) 9, e114348-e114348. PubMed  Europe PubMed DOI
    20. 2013
  20. Lin,G., Chidawanyika,T., Tsu,C., Warrier,T., Vaubourgeix,J., Blackburn,C., Gigstad,K., Sintchak,M., Dick,L. and Nathan,C.<br>N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets<br>J Am Chem Soc (2013) 135, 9968-9971. PubMed  Europe PubMed DOI  I
  21. Maldonado,A.Y., Burz,D.S., Reverdatto,S. and Shekhtman,A.<br>Fate of Pup inside the Mycobacterium proteasome studied by in-cell NMR<br>PLoS ONE (2013) 8, e74576-e74576. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Samanovic,M.I., Li,H. and Darwin,K.H.<br>The Pup-proteasome system of Mycobacterium tuberculosis<br>Subcell Biochem (2013) 66, 267-295. PubMed  Europe PubMed DOI
  23. Song,J.X. and Jiang,X.<br>[Establishment of a Mycobacterium tuberculosis proteasome inhibitor model in vitro]<br>Zhonghua Jie He He Hu Xi Za Zhi (2013) 36, 363-366. PubMed  Europe PubMed  A  I
    24. 2012
  24. Burns,K.E., McAllister,F.E., Schwerdtfeger,C., Mintseris,J., Cerda-Maira,F., Noens,E.E., Wilmanns,M., Hubbard,S.R., Melandri,F., Ovaa,H., Gygi,S.P. and Darwin,K.H.<br>Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase<br>J Biol Chem (2012) 287, 37522-37529. PubMed  Europe PubMed DOI
  25. Lin,G., Li,H. and Nathan,C.F.<br>Bacterial proteasome<br>[ISSN:978-0-12-407742-3] (2012) 3, 3671-3677. DOI
    26. 2011
  26. Kale,A.J., McGlinchey,R.P., Lechner,A. and Moore,B.S.<br>Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A<br>ACS Chem Biol (2011) 6, 1257-1264. PubMed  Europe PubMed DOI  I
    27. 2010
  27. Burns,K.E., Cerda-Maira,F.A., Wang,T., Li,H., Bishai,W.R. and Darwin,K.H.<br>"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates<br>Mol Cell (2010) 39, 821-827. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Cerda-Maira,F.A., Pearce,M.J., Fuortes,M., Bishai,W.R., Hubbard,S.R. and Darwin,K.H.<br>Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis<br>Mol Microbiol (2010) 77, 1123-1135. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Cheng,Y. and Pieters,J.<br>Novel proteasome inhibitors as potential drugs to combat tuberculosis<br>J Mol Cell Biol (2010) 2, 173-175. PubMed  Europe PubMed DOI  I
  30. Gandotra,S., Lebron,M.B. and Ehrt,S.<br>The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide<br>PLoS Pathog (2010) 6, e1001040-e1001040. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Imkamp,F., Striebel,F., Sutter,M., Ozcelik,D., Zimmermann,N., Sander,P. and Weber-Ban,E.<br>Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway<br>EMBO Rep (2010) 11, 791-797. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Li,D., Li,H., Wang,T., Pan,H., Lin,G. and Li,H.<br>Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome<br>EMBO J (2010) 29, 2037-2047. PubMed  Europe PubMed DOI  S
  33. Lin,G., Li,D., Chidawanyika,T., Nathan,C. and Li,H.<br>Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome<br>Arch Biochem Biophys (2010) 501, 214-220. PubMed  Europe PubMed DOI  I
  34. Striebel,F., Hunkeler,M., Summer,H. and Weber-Ban,E.<br>The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus<br>EMBO J (2010) 29, 1262-1271. PubMed  Europe PubMed DOI
  35. Wang,T., Darwin,K.H. and Li,H.<br>Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation<br>Nat Struct Mol Biol (2010) 17, 1352-1357. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2009
  36. Cerda-Maira,F. and Darwin,K.H.<br>The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease<br>Microbes Infect (2009) 11, 1150-1155. PubMed  Europe PubMed DOI
  37. Lin,G., Li,D., de Carvalho,L.P., Deng,H., Tao,H., Vogt,G., Wu,K., Schneider,J., Chidawanyika,T., Warren,J.D., Li,H. and Nathan,C.<br>Inhibitors selective for mycobacterial versus human proteasomes<br>Nature (2009) 461, 621-626. PubMed  Europe PubMed DOI  I
  38. Striebel,F., Imkamp,F., Sutter,M., Steiner,M., Mamedov,A. and Weber-Ban,E.<br>Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes<br>Nat Struct Mol Biol (2009) 16, 647-651. PubMed  Europe PubMed DOI
    39. 2008
  39. Lin,G., Tsu,C., Dick,L., Zhou,X.K. and Nathan,C.<br>Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates<br>J Biol Chem (2008) 283, 34423-34431. PubMed  Europe PubMed DOI  PMC  EPMC  P
    40. 2007
  40. De Mot,R.<br>Actinomycete-like proteasomes in a Gram-negative bacterium<br>Trends Microbiol (2007) 15, 335-338. PubMed  Europe PubMed DOI
  41. Gandotra,S., Schnappinger,D., Monteleone,M., Hillen,W. and Ehrt,S.<br>In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice<br>Nat Med (2007) 13, 1515-1520. PubMed  Europe PubMed DOI  T
  42. Kaganman,I.<br>The dynamic proteasome<br>Nat Methods (2007) 4, 202-203. DOI
  43. Sharon,M., Witt,S., Glasmacher,E., Baumeister,W. and Robinson,C.V.<br>Mass spectrometry reveals the missing links in the assembly pathway of the bacterial 20S proteasome<br>J Biol Chem (2007) 282, 18448-18457. PubMed  Europe PubMed DOI
    44. 2006
  44. Hu,G., Lin,G., Wang,M., Dick,L., Xu,R.M., Nathan,C. and Li,H.<br>Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate<br>Mol Microbiol (2006) 59, 1417-1428. PubMed  Europe PubMed DOI  S  I
  45. Lin,G., Hu,G., Tsu,C., Kunes,Y.Z., Li,H., Dick,L., Parsons,T., Li,P., Chen,Z., Zwickl,P., Weich,N. and Nathan,C.<br>Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity<br>Mol Microbiol (2006) 59, 1405-1416. PubMed  Europe PubMed DOI  P
  46. [YEAR:2-11-2006]Pearce,M.J., Arora,P., Festa,R.A., Butler-Wu,S.M., Gokhale,R.S. and Darwin,K.H.<br>Identification of substrates of the Mycobacterium tuberculosis proteasome<br>EMBO J (2-11-2006) 25, 5423-5432. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2005
  47. Hong,B., Wang,L., Lammertyn,E., Geukens,N., Van Mellaert,L., Li,Y. and Anne,J.<br>Inactivation of the 20S proteasome in Streptomyces lividans and its influence on the production of heterologous proteins<br>Microbiology (Reading) (2005) 151, 3137-3145. PubMed  Europe PubMed DOI  K
    48. 2004
  48. [YEAR:2-1-2004]Kwon,Y.D., Nagy,I., Adams,P.D., Baumeister,W. and Jap,B.K.<br>Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly<br>J Mol Biol (2-1-2004) 335, 233-245. PubMed  Europe PubMed DOI
  49. Lupas,A., Kania,M. and Baumeister,W.<br>Bacterial proteasome<br>[ISSN:0-12-079610-4] (2004) 2, 2061-2063.  V
    50. 2003
  50. [YEAR:12-12-2003]Darwin,K.H., Ehrt,S., Gutierrez-Ramos,J.C., Weich,N. and Nathan,C.F.<br>The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide<br>Science (12-12-2003) 302, 1963-1966. PubMed  Europe PubMed DOI
    51. 2000
  51. Pouch,M.N., Cournoyer,B. and Baumeister,W.<br>Characterization of the 20S proteasome from the actinomycete Frankia<br>Mol Microbiol (2000) 35, 368-377. PubMed  Europe PubMed DOI
    52. 1999
  52. De Mot,R., Nagy,I., Walz,J. and Baumeister,W.<br>Proteasomes and other self-compartmentalizing proteases in prokaryotes<br>Trends Microbiol (1999) 7, 88-92. PubMed  Europe PubMed DOI
    53. 1998
  53. De Mot,R., Nagy,I. and Baumeister,W.<br>A self-compartmentalizing protease in Rhodococcus: the 20S proteasome<br>Antonie Van Leeuwenhoek (1998) 74, 83-87. PubMed  Europe PubMed DOI
  54. Mayr,J., Seemuller,E., Muller,S.A., Engel,A. and Baumeister,W.<br>Late events in the assembly of 20S proteasomes<br>J Struct Biol (1998) 124, 179-188. PubMed  Europe PubMed DOI
  55. Nagy,I., Tamura,T., Vanderleyden,J., Baumeister,W. and De Mot,R.<br>The 20S proteasome of Streptomyces coelicolor<br>J Bacteriol (1998) 180, 5448-5453. PubMed  Europe PubMed  PMC  EPMC
    56. 1997
  56. Knipfer,N. and Shrader,T.E.<br>Inactivation of the 20S proteasome in Mycobacterium smegmatis<br>Mol Microbiol (1997) 25, 375-383. PubMed  Europe PubMed  K
  57. [YEAR:17-10-1997]Mc Cormack,T., Baumeister,W., Grenier,L., Moomaw,C., Plamondon,L., Pramanik,B., Slaughter,C., Soucy,F., Stein,R., Zuhl,F. and Dick,L.<br>Active site-directed inhibitors of Rhodococcus 20 S proteasome. Kinetics and mechanism<br>J Biol Chem (17-10-1997) 272, 26103-26109. PubMed  Europe PubMed DOI  I
  58. [YEAR:2-1-1997]Zuhl,F., Tamura,T., Dolenc,I., Cejka,Z., Nagy,I., De Mot,R. and Baumeister,W.<br>Subunit topology of the Rhodococcus proteasome<br>FEBS Lett (2-1-1997) 400, 83-90. PubMed  Europe PubMed DOI
    59. 1996
  59. Aoyama,K., Zuhl,F., Tamura,T. and Baumeister,W.<br>2-D crystallization of the Rhodococcus 20S proteasome<br>J Struct Biol (1996) 116, 438-442. PubMed  Europe PubMed
    60. 1995
  60. [YEAR:1-7-1995]Tamura,T., Nagy,I., Lupas,A., Lottspeich,F., Cejka,Z., Schoofs,G., Tanaka,K., De Mot,R. and Baumeister,W.<br>The first characterization of a eubacterial proteasome: the 20S complex of Rhodococcus<br>Curr Biol (1-7-1995) 5, 766-774. PubMed  Europe PubMed
    61. 1992
  61. Benoist,P., Muller,A., Diem,H.G. and Schwencke,J.<br>High-molecular-mass multicatalytic proteinase complexes produced by the nitrogen-fixing actinomycete Frankia strain BR<br>J Bacteriol (1992) 174, 1495-1504. PubMed  Europe PubMed  PMC  EPMC

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