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Literature for peptidase T01.005: bacterial proteasome, beta component

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Turner,M., Uday,A.B., Velyvis,A., Rennella,E., Zeytuni,N. and Vahidi,S.
    Structural basis for allosteric modulation of M. tuberculosis proteasome core particle
    Nat Commun (2025) 16, 3138-3138. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Rozman,K., Alexander,E.M., Ogorevc,E., Bozovicar,K., Sosic,I., Aldrich,C.C. and Gobec,S.
    Psoralen derivatives as inhibitors of Mycobacterium tuberculosis proteasome
    Molecules (2020) 25 PubMed  Europe PubMed DOI  I
  3. Vimer,S., Ben-Nissan,G., Morgenstern,D., Kumar-Deshmukh,F., Polkinghorn,C., Quintyn,R.S., Vasil'ev,Y.V., Beckman,J.S., Elad,N., Wysocki,V.H. and Sharon,M.
    Comparative structural analysis of 20S proteasome ortholog protein complexes by native mass spectrometry
    ACS Cent Sci (2020) 6, 573-588. PubMed  Europe PubMed DOI  PMC  EPMC  S
    4. 2019
  4. Becker,S.H., Jastrab,J.B., Dhabaria,A., Chaton,C.T., Rush,J.S., Korotkov,K.V., Ueberheide,B. and Darwin,K.H.
    The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway
    Proc Natl Acad Sci U S A (2019) 116, 3202-3210. PubMed  Europe PubMed DOI
  5. Becker,S.H., Li,H. and Heran Darwin,K.
    Biology and Biochemistry of Bacterial Proteasomes
    Subcell Biochem (2019) 93, 339-358. PubMed  Europe PubMed DOI
  6. Muller,A.U. and Weber-Ban,E.
    The bacterial proteasome at the core of diverse degradation pathways
    Front Mol Biosci (2019) 6, 23-23. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2017
  7. Hsu,H.C., Singh,P.K., Fan,H., Wang,R., Sukenick,G., Nathan,C., Lin,G. and Li,H.
    Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome
    Biochemistry (2017) 56, 324-333. PubMed  Europe PubMed DOI
  8. Jastrab,J.B., Samanovic,M.I., Copin,R., Shopsin,B. and Darwin,K.H.
    Loss-of-function mutations in HspR rescue the growth defect of a Mycobacterium tuberculosis proteasome activator E (pafE) mutant
    J Bacteriol (2017) 199, e00850-16-e00850-16. PubMed  Europe PubMed DOI
  9. Moreira,W., Santhanakrishnan,S., Dymock,B.W. and Dick,T.
    Bortezomib warhead-switch confers dual activity against mycobacterial caseinolytic protease and proteasome and selectivity against human proteasome
    Front Microbiol (2017) 8, 746-746. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Totaro,K.A., Barthelme,D., Simpson,P.T., Jiang,X., Lin,G., Nathan,C.F., Sauer,R.T. and Sello,J.K.
    Rational design of selective and bioactive inhibitors of the Mycobacterium tuberculosis proteasome
    ACS Infect Dis (2017) 3, 176-181. PubMed  Europe PubMed DOI  I
  11. Wu,Y., Hu,K., Li,D., Bai,L., Yang,S., Jastrab,J.B., Xiao,S., Hu,Y., Zhang,S., Darwin,K.H., Wang,T. and Li,H.
    Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease
    Mol Microbiol (2017) 105, 227-241. PubMed  Europe PubMed DOI
    12. 2016
  12. Bai,L., Hu,K., Wang,T., Jastrab,J.B., Darwin,K.H. and Li,H.
    Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis
    Proc Natl Acad Sci U S A (2016) 113, E1983-E1992. PubMed  Europe PubMed DOI
  13. Bolten,M., Delley,C.L., Leibundgut,M., Boehringer,D., Ban,N. and Weber-Ban,E.
    Structural analysis of the bacterial proteasome activator Bpa in complex with the 20S proteasome
    Structure (2016) 24, 2138-2151. PubMed  Europe PubMed DOI  S
  14. dela Pena,A.H. and Lander,G.C.
    What's the key to unlocking the proteasome's gate?
    Structure (2016) 24, 2037-2038. PubMed  Europe PubMed DOI
    15. 2015
  15. Jastrab,J.B., Wang,T., Murphy,J.P., Bai,L., Hu,K., Merkx,R., Huang,J., Chatterjee,C., Ovaa,H., Gygi,S.P., Li,H. and Darwin,K.H.
    An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis
    Proc Natl Acad Sci U S A (2015) 112, E1763-E1772. PubMed  Europe PubMed DOI
  16. Mehra,R., Chib,R., Munagala,G., Yempalla,K.R., Khan,I.A., Singh,P.P., Khan,F.G. and Nargotra,A.
    Discovery of new Mycobacterium tuberculosis proteasome inhibitors using a knowledge-based computational screening approach
    Mol Divers (2015) 19, 1003-1019. PubMed  Europe PubMed DOI  I
  17. Russo,F., Gising,J., Akerbladh,L., Roos,A.K., Naworyta,A., Mowbray,S.L., Sokolowski,A., Henderson,I., Alling,T., Bailey,M.A., Files,M., Parish,T., Karlen,A. and Larhed,M.
    Optimization and evaluation of 5-styryl-oxathiazol-2-one Mycobacterium tuberculosis proteasome inhibitors as potential antitubercular agents
    ChemistryOpen (2015) 4, 342-362. PubMed  Europe PubMed DOI  I
    18. 2014
  18. Anandan,T., Han,J., Baun,H., Nyayapathy,S., Brown,J.T., Dial,R.L., Moltalvo,J.A., Kim,M.S., Yang,S.H., Ronning,D.R., Husson,R.N., Suh,J. and Kang,C.M.
    Phosphorylation regulates mycobacterial proteasome
    J Microbiol (2014) 52, 743-754. PubMed  Europe PubMed DOI
  19. Delley,C.L., Laederach,J., Ziemski,M., Bolten,M., Boehringer,D. and Weber-Ban,E.
    Bacterial proteasome activator Bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasome
    PLoS ONE (2014) 9, e114348-e114348. PubMed  Europe PubMed DOI
    20. 2013
  20. Lin,G., Chidawanyika,T., Tsu,C., Warrier,T., Vaubourgeix,J., Blackburn,C., Gigstad,K., Sintchak,M., Dick,L. and Nathan,C.
    N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets
    J Am Chem Soc (2013) 135, 9968-9971. PubMed  Europe PubMed DOI  I
  21. Maldonado,A.Y., Burz,D.S., Reverdatto,S. and Shekhtman,A.
    Fate of Pup inside the Mycobacterium proteasome studied by in-cell NMR
    PLoS ONE (2013) 8, e74576-e74576. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Samanovic,M.I., Li,H. and Darwin,K.H.
    The Pup-proteasome system of Mycobacterium tuberculosis
    Subcell Biochem (2013) 66, 267-295. PubMed  Europe PubMed DOI
  23. Song,J.X. and Jiang,X.
    [Establishment of a Mycobacterium tuberculosis proteasome inhibitor model in vitro]
    Zhonghua Jie He He Hu Xi Za Zhi (2013) 36, 363-366. PubMed  Europe PubMed  A  I
    24. 2012
  24. Burns,K.E., McAllister,F.E., Schwerdtfeger,C., Mintseris,J., Cerda-Maira,F., Noens,E.E., Wilmanns,M., Hubbard,S.R., Melandri,F., Ovaa,H., Gygi,S.P. and Darwin,K.H.
    Mycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase
    J Biol Chem (2012) 287, 37522-37529. PubMed  Europe PubMed DOI
  25. Lin,G., Li,H. and Nathan,C.F.
    Bacterial proteasome
    [ISSN:978-0-12-407742-3] (2012) 3, 3671-3677. DOI
    26. 2011
  26. Kale,A.J., McGlinchey,R.P., Lechner,A. and Moore,B.S.
    Bacterial self-resistance to the natural proteasome inhibitor salinosporamide A
    ACS Chem Biol (2011) 6, 1257-1264. PubMed  Europe PubMed DOI  I
    27. 2010
  27. Burns,K.E., Cerda-Maira,F.A., Wang,T., Li,H., Bishai,W.R. and Darwin,K.H.
    "Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates
    Mol Cell (2010) 39, 821-827. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Cerda-Maira,F.A., Pearce,M.J., Fuortes,M., Bishai,W.R., Hubbard,S.R. and Darwin,K.H.
    Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis
    Mol Microbiol (2010) 77, 1123-1135. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Cheng,Y. and Pieters,J.
    Novel proteasome inhibitors as potential drugs to combat tuberculosis
    J Mol Cell Biol (2010) 2, 173-175. PubMed  Europe PubMed DOI  I
  30. Gandotra,S., Lebron,M.B. and Ehrt,S.
    The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide
    PLoS Pathog (2010) 6, e1001040-e1001040. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Imkamp,F., Striebel,F., Sutter,M., Ozcelik,D., Zimmermann,N., Sander,P. and Weber-Ban,E.
    Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway
    EMBO Rep (2010) 11, 791-797. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Li,D., Li,H., Wang,T., Pan,H., Lin,G. and Li,H.
    Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome
    EMBO J (2010) 29, 2037-2047. PubMed  Europe PubMed DOI  S
  33. Lin,G., Li,D., Chidawanyika,T., Nathan,C. and Li,H.
    Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome
    Arch Biochem Biophys (2010) 501, 214-220. PubMed  Europe PubMed DOI  I
  34. Striebel,F., Hunkeler,M., Summer,H. and Weber-Ban,E.
    The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus
    EMBO J (2010) 29, 1262-1271. PubMed  Europe PubMed DOI
  35. Wang,T., Darwin,K.H. and Li,H.
    Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation
    Nat Struct Mol Biol (2010) 17, 1352-1357. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 2009
  36. Cerda-Maira,F. and Darwin,K.H.
    The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease
    Microbes Infect (2009) 11, 1150-1155. PubMed  Europe PubMed DOI
  37. Lin,G., Li,D., de Carvalho,L.P., Deng,H., Tao,H., Vogt,G., Wu,K., Schneider,J., Chidawanyika,T., Warren,J.D., Li,H. and Nathan,C.
    Inhibitors selective for mycobacterial versus human proteasomes
    Nature (2009) 461, 621-626. PubMed  Europe PubMed DOI  I
  38. Striebel,F., Imkamp,F., Sutter,M., Steiner,M., Mamedov,A. and Weber-Ban,E.
    Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes
    Nat Struct Mol Biol (2009) 16, 647-651. PubMed  Europe PubMed DOI
    39. 2008
  39. Lin,G., Tsu,C., Dick,L., Zhou,X.K. and Nathan,C.
    Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates
    J Biol Chem (2008) 283, 34423-34431. PubMed  Europe PubMed DOI  PMC  EPMC  P
    40. 2007
  40. De Mot,R.
    Actinomycete-like proteasomes in a Gram-negative bacterium
    Trends Microbiol (2007) 15, 335-338. PubMed  Europe PubMed DOI
  41. Gandotra,S., Schnappinger,D., Monteleone,M., Hillen,W. and Ehrt,S.
    In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice
    Nat Med (2007) 13, 1515-1520. PubMed  Europe PubMed DOI  T
  42. Kaganman,I.
    The dynamic proteasome
    Nat Methods (2007) 4, 202-203. DOI
  43. Sharon,M., Witt,S., Glasmacher,E., Baumeister,W. and Robinson,C.V.
    Mass spectrometry reveals the missing links in the assembly pathway of the bacterial 20S proteasome
    J Biol Chem (2007) 282, 18448-18457. PubMed  Europe PubMed DOI
    44. 2006
  44. Hu,G., Lin,G., Wang,M., Dick,L., Xu,R.M., Nathan,C. and Li,H.
    Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate
    Mol Microbiol (2006) 59, 1417-1428. PubMed  Europe PubMed DOI  S  I
  45. Lin,G., Hu,G., Tsu,C., Kunes,Y.Z., Li,H., Dick,L., Parsons,T., Li,P., Chen,Z., Zwickl,P., Weich,N. and Nathan,C.
    Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity
    Mol Microbiol (2006) 59, 1405-1416. PubMed  Europe PubMed DOI  P
  46. [YEAR:2-11-2006]Pearce,M.J., Arora,P., Festa,R.A., Butler-Wu,S.M., Gokhale,R.S. and Darwin,K.H.
    Identification of substrates of the Mycobacterium tuberculosis proteasome
    EMBO J (2-11-2006) 25, 5423-5432. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2005
  47. Hong,B., Wang,L., Lammertyn,E., Geukens,N., Van Mellaert,L., Li,Y. and Anne,J.
    Inactivation of the 20S proteasome in Streptomyces lividans and its influence on the production of heterologous proteins
    Microbiology (Reading) (2005) 151, 3137-3145. PubMed  Europe PubMed DOI  K
    48. 2004
  48. [YEAR:2-1-2004]Kwon,Y.D., Nagy,I., Adams,P.D., Baumeister,W. and Jap,B.K.
    Crystal structures of the Rhodococcus proteasome with and without its pro-peptides: implications for the role of the pro-peptide in proteasome assembly
    J Mol Biol (2-1-2004) 335, 233-245. PubMed  Europe PubMed DOI
  49. Lupas,A., Kania,M. and Baumeister,W.
    Bacterial proteasome
    [ISSN:0-12-079610-4] (2004) 2, 2061-2063.  V
    50. 2003
  50. [YEAR:12-12-2003]Darwin,K.H., Ehrt,S., Gutierrez-Ramos,J.C., Weich,N. and Nathan,C.F.
    The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide
    Science (12-12-2003) 302, 1963-1966. PubMed  Europe PubMed DOI
    51. 2000
  51. Pouch,M.N., Cournoyer,B. and Baumeister,W.
    Characterization of the 20S proteasome from the actinomycete Frankia
    Mol Microbiol (2000) 35, 368-377. PubMed  Europe PubMed DOI
    52. 1999
  52. De Mot,R., Nagy,I., Walz,J. and Baumeister,W.
    Proteasomes and other self-compartmentalizing proteases in prokaryotes
    Trends Microbiol (1999) 7, 88-92. PubMed  Europe PubMed DOI
    53. 1998
  53. De Mot,R., Nagy,I. and Baumeister,W.
    A self-compartmentalizing protease in Rhodococcus: the 20S proteasome
    Antonie Van Leeuwenhoek (1998) 74, 83-87. PubMed  Europe PubMed DOI
  54. Mayr,J., Seemuller,E., Muller,S.A., Engel,A. and Baumeister,W.
    Late events in the assembly of 20S proteasomes
    J Struct Biol (1998) 124, 179-188. PubMed  Europe PubMed DOI
  55. Nagy,I., Tamura,T., Vanderleyden,J., Baumeister,W. and De Mot,R.
    The 20S proteasome of Streptomyces coelicolor
    J Bacteriol (1998) 180, 5448-5453. PubMed  Europe PubMed  PMC  EPMC
    56. 1997
  56. Knipfer,N. and Shrader,T.E.
    Inactivation of the 20S proteasome in Mycobacterium smegmatis
    Mol Microbiol (1997) 25, 375-383. PubMed  Europe PubMed  K
  57. [YEAR:17-10-1997]Mc Cormack,T., Baumeister,W., Grenier,L., Moomaw,C., Plamondon,L., Pramanik,B., Slaughter,C., Soucy,F., Stein,R., Zuhl,F. and Dick,L.
    Active site-directed inhibitors of Rhodococcus 20 S proteasome. Kinetics and mechanism
    J Biol Chem (17-10-1997) 272, 26103-26109. PubMed  Europe PubMed DOI  I
  58. [YEAR:2-1-1997]Zuhl,F., Tamura,T., Dolenc,I., Cejka,Z., Nagy,I., De Mot,R. and Baumeister,W.
    Subunit topology of the Rhodococcus proteasome
    FEBS Lett (2-1-1997) 400, 83-90. PubMed  Europe PubMed DOI
    59. 1996
  59. Aoyama,K., Zuhl,F., Tamura,T. and Baumeister,W.
    2-D crystallization of the Rhodococcus 20S proteasome
    J Struct Biol (1996) 116, 438-442. PubMed  Europe PubMed
    60. 1995
  60. [YEAR:1-7-1995]Tamura,T., Nagy,I., Lupas,A., Lottspeich,F., Cejka,Z., Schoofs,G., Tanaka,K., De Mot,R. and Baumeister,W.
    The first characterization of a eubacterial proteasome: the 20S complex of Rhodococcus
    Curr Biol (1-7-1995) 5, 766-774. PubMed  Europe PubMed
    61. 1992
  61. Benoist,P., Muller,A., Diem,H.G. and Schwencke,J.
    High-molecular-mass multicatalytic proteinase complexes produced by the nitrogen-fixing actinomycete Frankia strain BR
    J Bacteriol (1992) 174, 1495-1504. PubMed  Europe PubMed  PMC  EPMC

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