Literature for peptidase homologue S54.953: iRhom2

(Topics flags: M Mutation, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Azzopardi,S.A., Lu,H.Y., Monette,S., Rabinowitsch,A.I., Salmon,J.E., Matsunami,H. and Blobel,C.P.
   Role of iRhom2 in Olfaction: Implications for Odorant Receptor Regulation and Activity-Dependent Adaptation
   Int J Mol Sci25, PubMed  Europe PubMed DOI
2. Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M., Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
   Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation
   Cell Commun Signal22, 322-322. PubMed  Europe PubMed DOI
3. Calligaris,M., Spano,D.P., Bonelli,S., Muller,S.A., Carcione,C., D'Apolito,D., Amico,G., Miele,M., Di Bella,M., Zito,G., Nuti,E., Rossello,A., Blobel,C.P., Lichtenthaler,S.F. and Scilabra,S.D.
   iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
   Cell Mol Life Sci81, 163-163. PubMed  Europe PubMed DOI
4. Dulloo,I., Tellier,M., Levet,C., Chikh,A., Zhang,B., Blaydon,D.C., Webb,C.M., Kelsell,D.P. and Freeman,M.
   Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway
   Mol Cell84, 277-292. PubMed  Europe PubMed DOI
5. Liu,J., Su,G., Duan,C., Sun,Z., Xiao,S., Zhou,Y. and Fang,L.
   Porcine reproductive and respiratory syndrome virus infection activates ADAM17 to induce inflammatory responses
   Vet Microbiol292, 110066-110066. PubMed  Europe PubMed DOI
6. Lu,F., Zhao,H., Dai,Y., Wang,Y., Lee,C.H. and Freeman,M.
   Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
   Mol Cell84, 2152-2165. PubMed  Europe PubMed DOI
2023
7. Dwivedi,S.D., Shukla,R., Yadav,K., Rathor,L.S., Singh,D. and Singh,M.R.
   Mechanistic insight on the role of iRhom2-TNF-alpha-BAFF signaling pathway in various autoimmune disorders
   Adv Biol Regul92, 101011-101011. PubMed  Europe PubMed DOI
8. Gong,H., Xie,H., Huangfu,Z., Zhang,S., Tang,Y., Xiao,M., Li,M. and Wang,Y.
   RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker
   FEBS Open Bio13, 881-897. PubMed  Europe PubMed DOI
9. Schumacher,N., Thomsen,I., Brundert,F., Hejret,V., Dusterhoft,S., Tichy,B., Schmidt-Arras,D., Voss,M. and Rose-John,S.
   EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
   Biochim Biophys Acta Mol Cell Res1870, 119489-119489. PubMed  Europe PubMed DOI
10. Xu,M., Tan,J., Zhu,L., Ge,C., Dong,W., Dai,X., Kuang,Q., Zhong,S., Lai,L., Yi,C., Li,Q., Lou,D., Hu,L., Liu,X., Kuang,G., Luo,J., Feng,J. and Wang,B.
    The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway
    Acta Pharm Sin B13, 1071-1092. PubMed  Europe PubMed DOI
11. Xu,M., Tan,J., Zhu,L., Ge,C., Zhang,Y., Gao,F., Dai,X., Kuang,Q., Chai,J., Zou,B. and Wang,B.
    Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2
    Adv Sci (Weinh)10, e2302130-e2302130. PubMed  Europe PubMed DOI
2022
12. Liu,Y., Kuang,Q., Dai,X., Zhan,M., Zhou,L., Zhu,L. and Wang,B.
    Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress
    Int J Mol Sci23, PubMed  Europe PubMed DOI
13. Louis,T.J., Qasem,A. and Naser,S.A.
    Attenuation of Excess TNF-alpha Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-beta Mediated Immunosuppression Through Modulation of TACE Trafficking
    Front Immunol13, 887830-887830. PubMed  Europe PubMed DOI  K
14. Sieber,B., Lu,F., Stribbling,S.M., Grieve,A.G., Ryan,A.J. and Freeman,M.
    iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells
    J Cell Sci135, PubMed  Europe PubMed DOI
15. Xu,M., Tan,J., Dong,W., Zou,B., Teng,X., Zhu,L., Ge,C., Dai,X., Kuang,Q., Zhong,S., Lai,L., Yi,C., Tang,T., Zhao,J., Wang,L., Liu,J., Wei,H., Sun,Y., Yang,Q., Li,Q., Lou,D., Hu,L., Liu,X., Kuang,G., Luo,J., Xiong,M., Feng,J., Zhang,C. and Wang,B.
    The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes
    Nat Commun13, 1052-1052. PubMed  Europe PubMed DOI
16. Zhao,Y., Davila,E.M., Li,X., Tang,B., Rabinowitsch,A.I., Perez-Aguilar,J.M. and Blobel,C.P.
    Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17
    Int J Mol Sci23, 12796-12796. PubMed  Europe PubMed DOI
2021
17. Burzenski,L.M., Low,B.E., Kohar,V., Shultz,L.D., Wiles,M.V. and Hosur,V.
    Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models
    Mamm Genome PubMed  Europe PubMed DOI  V
18. Hannemann,C., Schecker,J.H., Brettschneider,A., Grune,J., Rosener,N., Weller,A., Stangl,V., Fisher,E.A., Stangl,K., Ludwig,A. and Hewing,B.
    Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidemia and early atherogenesis
    Cardiovasc Res PubMed  Europe PubMed DOI
19. Tushaus,J., Muller,S.A., Shrouder,J., Arends,M., Simons,M., Plesnila,N., Blobel,C.P. and Lichtenthaler,S.F.
    The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system
    FASEB J35, e21962-e21962. PubMed  Europe PubMed DOI
20. Wang,L., Liu,X.X., Yang,Y.M., Wang,Y., Song,Y.Y., Gao,S., Li,L.Y. and Zhang,Z.S.
    RHBDF2 gene functions are correlated to facilitated renal clear cell carcinoma progression
    Cancer Cell Int21, 590-590. PubMed  Europe PubMed DOI
2020
21. Al-Salihi,M.A. and Lang,P.A.
    iRhom2: An Emerging Adaptor Regulating Immunity and Disease
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
22. Babendreyer,A., Rojas-Gonzalez,D.M., Giese,A.A., Fellendorf,S., Dusterhoft,S., Mela,P. and Ludwig,A.
    Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells
    Front Cardiovasc Med7, 610344-610344. PubMed  Europe PubMed DOI
23. Fang,R., Haxaire,C., Otero,M., Lessard,S., Weskamp,G., McIlwain,D.R., Mak,T.W., Lichtenthaler,S.F. and Blobel,C.P.
    Role of iRhoms 1 and 2 in Endochondral Ossification
    Int J Mol Sci21, PubMed  Europe PubMed DOI
24. Geesala,R., Issuree,P.D. and Maretzky,T.
    The Role of iRhom2 in Metabolic and Cardiovascular-Related Disorders
    Front Cardiovasc Med7, 612808-612808. PubMed  Europe PubMed DOI  V
25. Kim,J.H., Hwang,S.W., Koh,J., Chun,J., Lee,C., Im,J.P. and Kim,J.S.
    Inactive rhomboid protein 2 mediates intestinal inflammation by releasing tumor necrosis factor-alpha
    Inflamm Bowel Dis26, 242-253. PubMed  Europe PubMed DOI
26. Skurski,J., Penniman,C.M., Geesala,R., Dixit,G., Pulipati,P., Bhardwaj,G., Meyerholz,D.K., Issuree,P.D., O'Neill,B.T. and Maretzky,T.
    Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation
    Metabolism106, 154194-154194. PubMed  Europe PubMed DOI
27. Skurski,J., Dixit,G., Blobel,C.P., Issuree,P.D. and Maretzky,T.
    The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner
    Front Cell Infect Microbiol10, 620392-620392. PubMed  Europe PubMed DOI
28. Tang,B., Li,X., Maretzky,T., Perez-Aguilar,J.M., McIlwain,D., Xie,Y., Zheng,Y., Mak,T.W., Weinstein,H. and Blobel,C.P.
    Substrate-selective protein ectodomain shedding by ADAM17 and iRhom2 depends on their juxtamembrane and transmembrane domains
    FASEB J34, 4956-4969. PubMed  Europe PubMed DOI
29. Weskamp,G., Tushaus,J., Li,D., Feederle,R., Maretzky,T., Swendemann,S., Falck-Pedersen,E., McIlwain,D.R., Mak,T.W., Salmon,J.E., Lichtenthaler,S.F. and Blobel,C.P.
    ADAM17 stabilizes its interacting partner inactive rhomboid 2 (iRhom2) but not inactive rhomboid 1 (iRhom1)
    J Biol Chem295, 4350-4358. PubMed  Europe PubMed DOI
30. Xu,M., Ge,C., Qin,Y., Lou,D., Li,Q., Feng,J., Wu,Y., Hu,L., Wang,B. and Tan,J.
    Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation
    Mol Metab34, 112-123. PubMed  Europe PubMed DOI
31. Xu,M.X., Dai,X.L., Kuang,Q., Zhu,L.C., Hu,L.F., Lou,D.S., Li,Q., Feng,J., Wu,Y.K., Ge,C.X., Wang,B.C. and Tan,J.
    Dysfunctional Rhbdf2 of proopiomelanocortin mitigates ambient particulate matter exposure-induced neurological injury and neuron loss by antagonizing oxidative stress and inflammatory reaction
    J Hazard Mater400, 123158-123158. PubMed  Europe PubMed DOI
32. Zhou,C., Qin,Y., Chen,R., Gao,F., Zhang,J. and Lu,F.
    Fenugreek attenuates obesity-induced inflammation and improves insulin resistance through downregulation of iRhom2/TACE
    Life Sci258, 118222-118222. PubMed  Europe PubMed DOI
2019
33. Dulloo,I., Muliyil,S. and Freeman,M.
    The molecular, cellular and pathophysiological roles of iRhom pseudoproteases
    Open Biol9, 190003-190003. PubMed  Europe PubMed DOI
34. Geesala,R., Issuree,P.D. and Maretzky,T.
    Novel functions of inactive rhomboid proteins in immunity and disease
    J Leukoc Biol106, 823-835. PubMed  Europe PubMed DOI  V
35. Sundaram,B., Behnke,K., Belancic,A., Al-Salihi,M.A., Thabet,Y., Polz,R., Pellegrino,R., Zhuang,Y., Shinde,P.V., Xu,H.C., Vasilevska,J., Longerich,T., Herebian,D., Mayatepek,E., Bock,H.H., May,P., Kordes,C., Aghaeepour,N., Mak,T.W., Keitel,V., Haussinger,D., Scheller,J., Pandyra,A.A., Lang,K.S. and Lang,P.A.
    iRhom2 inhibits bile duct obstruction-induced liver fibrosis
    Sci Signal12, PubMed  Europe PubMed DOI
2018
36. Chaohui,C., Wei,H., Hongfeng,W., Yueliang,Z., Xiaoqin,P., Pingli,Z. and Zhibing,A.
    iRhom2 promotes atherosclerosis through macrophage inflammation and induction of oxidative stress
    Biochem Biophys Res Commun503, 1897-1904. PubMed  Europe PubMed DOI
37. Chenxu,G., Minxuan,X., Yuting,Q., Tingting,G., Jinxiao,L., Mingxing,W., Sujun,W., Yongjie,M., Deshuai,L., Qiang,L., Linfeng,H. and Jun,T.
    iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress
    Redox Biol19, 147-157. PubMed  Europe PubMed DOI  K
38. Kim,J.H., Kim,J., Chun,J., Lee,C., Im,J.P. and Kim,J.S.
    Role of iRhom2 in intestinal ischemia-reperfusion-mediated acute lung injury
    Sci Rep8, 3797-3797. PubMed  Europe PubMed DOI
39. Kunzel,U., Grieve,A.G., Meng,Y., Sieber,B., Cowley,S.A. and Freeman,M.
    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex
    elife7, e35012-e35012. PubMed  Europe PubMed DOI
40. Lee,M.Y., Kang,J.S., Go,R.E., Byun,Y.S., Wi,Y.J., Hwang,K.A., Choi,J.H., Kim,H.C., Choi,K.C. and Nam,K.H.
    Collagen-induced arthritis analysis in Rhbdf2 knockout mouse
    Biomol Ther (Seoul)26, 298-305. PubMed  Europe PubMed DOI  K
41. Qing,X., Chinenov,Y., Redecha,P., Madaio,M., Roelofs,J.J., Farber,G., Issuree,P.D., Donlin,L., Mcllwain,D.R., Mak,T.W., Blobel,C.P. and Salmon,J.E.
    iRhom2 promotes lupus nephritis through TNF-alpha and EGFR signaling
    J Clin Invest128, 1397-1412. PubMed  Europe PubMed DOI
42. Xu,M.X., Qin,Y.T., Ge,C.X., Gu,T.T., Lou,D.S., Li,Q., Hu,L.F., Li,Y.Y., Yang,W.W. and Tan,J.
    Activated iRhom2 drives prolonged PM2.5 exposure-triggered renal injury in Nrf2-defective mice
    Nanotoxicology12, 1045-1067. PubMed  Europe PubMed DOI
43. Xu,M.X., Ge,C.X., Qin,Y.T., Gu,T.T., Lou,D.S., Li,Q., Hu,L.F. and Tan,J.
    Multicombination approach suppresses Listeria monocytogenes-induced septicemia-associated acute hepatic failure: the role of iRhom2 signaling
    Adv Healthc Matere1800427-e1800427. PubMed  Europe PubMed DOI
2017
44. Cavadas,M., Oikonomidi,I., Gaspar,C.J., Burbridge,E., Badenes,M., Felix,I., Bolado,A., Hu,T., Bileck,A., Gerner,C., Domingos,P.M., von Kriegsheim,A. and Adrain,C.
    Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE
    Cell Rep21, 745-757. PubMed  Europe PubMed DOI
45. Ge,C.X., Qin,Y.T., Lou,D.S., Li,Q., Li,Y.Y., Wang,Z.M., Yang,W.W., Wang,M., Liu,N., Wang,Z., Zhang,P.X., Tu,Y.Y., Tan,J. and Xu,M.X.
    iRhom2 deficiency relieves TNF-alpha associated hepatic dyslipidemia in long-term PM2.5-exposed mice
    Biochem Biophys Res Commun493, 1402-1409. PubMed  Europe PubMed DOI
46. Hosur,V., Burzenski,L.M., Stearns,T.M., Farley,M.L., Sundberg,J.P., Wiles,M.V. and Shultz,L.D.
    Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing
    Exp Mol Pathol102, 337-346. PubMed  Europe PubMed DOI
47. Li,X., Maretzky,T., Perez-Aguilar,J.M., Monette,S., Weskamp,G., Le Gall,S., Beutler,B., Weinstein,H. and Blobel,C.P.
    Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis
    J Cell Sci130, 868-878. PubMed  Europe PubMed DOI
48. Luo,W.W., Li,S., Li,C., Zheng,Z.Q., Cao,P., Tong,Z., Lian,H., Wang,S.Y., Shu,H.B. and Wang,Y.Y.
    iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA
    PLoS Pathog13, e1006693-e1006693. PubMed  Europe PubMed DOI
49. Luo,W.W. and Shu,H.B.
    Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses
    FEBS Lett591, 3182-3189. PubMed  Europe PubMed DOI
50. Maruthappu,T., Chikh,A., Fell,B., Delaney,P.J., Brooke,M.A., Levet,C., Moncada-Pazos,A., Ishida-Yamamoto,A., Blaydon,D., Waseem,A., Leigh,I.M., Freeman,M. and Kelsell,D.P.
    Rhomboid family member 2 regulates cytoskeletal stress-associated keratin 16
    Nat Commun8, 14174-14174. PubMed  Europe PubMed DOI
51. Matthews,A.L., Noy,P.J., Reyat,J.S. and Tomlinson,M.G.
    Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: the emerging role of tetraspanins and rhomboids
    Platelets28, 333-341. PubMed  Europe PubMed DOI
2016
52. Lee,M.Y., Nam,K.H. and Choi,K.C.
    iRhoms; its functions and essential roles
    Biomol Ther (Seoul)24, 109-114. PubMed  Europe PubMed DOI
53. Lemberg,M.K. and Adrain,C.
    Inactive rhomboid proteins: new mechanisms with implications in health and disease
    Semin Cell Dev Biol60, 29-37. PubMed  Europe PubMed DOI
54. Luo,W.W., Li,S., Li,C., Lian,H., Yang,Q., Zhong,B. and Shu,H.B.
    iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
    Nat Immunol17, 1057-1066. PubMed  Europe PubMed DOI
55. Qing,X., D Rogers,L., Mortha,A., Lavin,Y., Redecha,P., Issuree,P.D., Maretzky,T., Merad,M., R McIlwain,D., Mak,T.W., Overall,C.M., Blobel,C.P. and Salmon,J.E.
    iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice
    Eur J Immunol46, 2737-2748. PubMed  Europe PubMed DOI
2015
56. Li,X., Maretzky,T., Weskamp,G., Monette,S., Qing,X., Issuree,P.D., Crawford,H.C., McIlwain,D.R., Mak,T.W., Salmon,J.E. and Blobel,C.P.
    iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
    Proc Natl Acad Sci U S A112, 6080-6085. PubMed  Europe PubMed DOI
2014
57. Leilei,Y., Bing,L., Yang,L., Shaoxia,W., Yuan,X., Dongping,W., Huahu,Y., Shichen,S., Guangzhou,Z., Ruiyun,P., Lin,Z. and Wenlong,L.
    iRhom2 mutation leads to aberrant hair follicle differentiation in mice
    PLoS ONE9, e115114-e115114. PubMed  Europe PubMed DOI  M
58. Siggs,O.M., Grieve,A., Xu,H., Bambrough,P., Christova,Y. and Freeman,M.
    Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice
    Biol Open3, 1151-1157. PubMed  Europe PubMed DOI  M
2011
59. Cao,S.S. and Kaufman,R.J.
    iRhoms: ERADicating the messenger in growth control signaling
    Dev Cell20, 414-416. PubMed  Europe PubMed DOI
60. Zettl,M., Adrain,C., Strisovsky,K., Lastun,V. and Freeman,M.
    Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling
    Cell145, 79-91. PubMed  Europe PubMed DOI