Literature for peptidase S54.006: rhomboid like 3 peptidase (Homo sapiens)

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2025
1. Bhaduri,S., Braza,M.K.E., Stanchev,S., Tauber,M., Al-Bawab,R., Liu,L.J., Trujillo,D.F., Solorio-Kirpichyan,K., Srivastava,A., Sanlley-Hernandez,J., O'Donoghue,A.J., Lemberg,M.K., Amaro,R., Strisovsky,K. and Neal,S.E.
   An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4
   J Biol Chem (2025) , 108275-108275. PubMed  Europe PubMed DOI
2. Penalva,Y.C.M., Paschkowsky,S., Yang,J., Recinto,S.J., Cinkornpumin,J.K., Ruelas,M., Xiao,B., Nitu,A., Kwon,S.Y., Wu,H.Y., Munter,H.M., Michalski,B., Fahnestock,M., Pastor,W.A., Bennett,D.A. and Munter,L.M.
   Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model
   Cell Death Dis (2025) 16, 280-280. PubMed  Europe PubMed DOI  PMC  EPMC
2024
3. Knopf,J.D., Steigleder,S.S., Korn,F., Kuhnle,N., Badenes,M., Tauber,M., Theobald,S.J., Rybniker,J., Adrain,C. and Lemberg,M.K.
   RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling
   Nat Commun (2024) 15, 1528-1528. PubMed  Europe PubMed DOI  PMC  EPMC
4. Penalva,Y.C.M., Paschkowsky,S., Recinto,S.J., Duchesne,A., Hammond,T., Spiegler,P., Jansen,G., Levet,C., Charron,F., Freeman,M., McKinney,R.A., Trempe,J.F. and Munter,L.M.
   Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4
   J Biol Chem (2024) , 107541-107541. PubMed  Europe PubMed DOI
5. Penalva,Y.C.M., Paschkowsky,S., Yang,J., Recinto,S.J., Cinkorpumin,J., Xiao,B., Nitu,A., Wu,H., Munter,H.M., Michalski,B., Fahnestock,M., Pastor,W., Bennett,D.A. and Munter,L.M.
   Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model
   bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
2022
6. Lastun,V.L., Levet,C. and Freeman,M.
   The mammalian rhomboid protein RHBDL4 protects against endoplasmic reticulum stress by regulating the morphology and distribution of ER sheets
   J Biol Chem (2022) 298, 101935-101935. PubMed  Europe PubMed DOI  PMC  EPMC
7. Shibuya,K., Ebihara,K., Ebihara,C., Sawayama,N., Isoda,M., Yamamuro,D., Takahashi,M., Nagashima,S. and Ishibashi,S.
   AAA-ATPase valosin-containing protein binds the transcription factor SREBP1 and promotes its proteolytic activation by rhomboid protease RHBDL4
   J Biol Chem (2022) 298, 101936-101936. PubMed  Europe PubMed DOI  PMC  EPMC  K
2020
8. Knopf,J.D., Landscheidt,N., Pegg,C.L., Schulz,B.L., Kuhnle,N., Chao,C.W., Huck,S. and Lemberg,M.K.
   Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation
   J Cell Sci (2020) PubMed  Europe PubMed DOI
2019
9. Ikeda,K.N. and Freeman,M.
   Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4
   J Biol Chem (2019) 294, 11486-11497. PubMed  Europe PubMed DOI
2018
10. Paschkowsky,S., Recinto,S.J., Young,J.C., Bondar,A.N. and Munter,L.M.
    Membrane cholesterol as regulator of human rhomboid protease RHBDL4
    J Biol Chem (2018) 293, 15556-15568. PubMed  Europe PubMed DOI
2016
11. Lim,J.J., Lee,Y., Ly,T.T., Kang,J.Y., Lee,J.G., An,J.Y., Youn,H.S., Park,K.R., Kim,T.G., Yang,J.K., Jun,Y. and Eom,S.H.
    Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4
    Biochem J (2016) 473, 2863-2880. PubMed  Europe PubMed DOI
12. Paschkowsky,S., Hamze,M., Oestereich,F. and Munter,L.M.
    Alternative processing of the amyloid precursor protein family by rhomboid protease RHBDL4
    J Biol Chem (2016) 291, 21903-21912. PubMed  Europe PubMed DOI
13. Wunderle,L., Knopf,J.D., Kuhnle,N., Morle,A., Hehn,B., Adrain,C., Strisovsky,K., Freeman,M. and Lemberg,M.K.
    Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFalpha
    Sci Rep (2016) 6, 27342-27342. PubMed  Europe PubMed DOI  PMC  EPMC
2013
14. Kumar,A., Gibbs,J.R., Beilina,A., Dillman,A., Kumaran,R., Trabzuni,D., Ryten,M., Walker,R., Smith,C., Traynor,B.J., Hardy,J., Singleton,A.B. and Cookson,M.R.
    Age-associated changes in gene expression in human brain and isolated neurons
    Neurobiol Aging (2013) 34, 1199-1209. PubMed  Europe PubMed DOI
2012
15. Fleig,L., Bergbold,N., Sahasrabudhe,P., Geiger,B., Kaltak,L. and Lemberg,M.K.
    Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins
    Mol Cell (2012) 47, 558-569. PubMed  Europe PubMed DOI
16. Greenblatt,E.J., Olzmann,J.A. and Kopito,R.R.
    Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD
    Nat Struct Mol Biol (2012) 19, 979-981. PubMed  Europe PubMed DOI
17. Tsai,Y.C. and Weissman,A.M.
    A ubiquitin-binding rhomboid protease aimed at ERADication
    Dev Cell (2012) 23, 454-456. PubMed  Europe PubMed DOI
18. Urban,S.
    Mammalian rhomboid proteases
    [ISSN:978-0-12-407742-3] (2012) 3, 3573-3581. DOI
2002
19. Jaszai,J. and Brand,M.
    Cloning and expression of Ventrhoid, a novel vertebrate homologue of the Drosophila EGF pathway gene rhomboid
    Mech Dev (2002) 113, 73-77. PubMed  Europe PubMed