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Literature for peptidase S26.012: mitochondrial inner membrane peptidase 2

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, P Specificity, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Clarke,R.A., Govindaraju,H., Beretta,M., Olzomer,E., Lawther,A.J., Walker,A.K., Fang,Z., Eapen,V., Hyams,T.C., Killingsworth,M., Bridge,W., Turner,N. and Siddiqui,K.S.
    Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  2. Ma,N., Luo,X., Wang,J., Sun,S., Liang,R., Zhang,Z., Cheng,Z., Wang,J. and Ma,Y.
    Inner Mitochondrial Membrane Peptidase 2-Like Deletion Aggravates Mitochondrial Apoptosis and Inhibits Autophagy After Hyperglycemia Stroke
    Mol Neurobiol PubMed  Europe PubMed DOI
    3. 2023
  3. Lawther,A.J., Zieba,J., Fang,Z., Furlong,T.M., Conn,I., Govindaraju,H., Choong,L.L.Y., Turner,N., Siddiqui,K.S., Bridge,W., Merlin,S., Hyams,T.C., Killingsworth,M., Eapen,V., Clarke,R.A. and Walker,A.K.
    Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse
    Genes (Basel)14, PubMed  Europe PubMed DOI
    4. 2022
  4. Yoshikawa,A., Kushima,I., Miyashita,M., Suzuki,K., Iino,K., Toriumi,K., Horiuchi,Y., Kawaji,H., Ozaki,N., Itokawa,M. and Arai,M.
    Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype
    PLoS ONE17, e0270506-e0270506. PubMed  Europe PubMed DOI
    5. 2020
  5. Bjerregaard,V.A., Schonewolf-Greulich,B., Juel Rasmussen,L., Desler,C. and Tumer,Z.
    Mitochondrial function in Gilles de la Tourette syndrome patients with and without intragenic IMMP2L deletions
    Front Neurol11, 163-163. PubMed  Europe PubMed DOI  M
  6. Pagliaroli,L., Vereczkei,A., Padmanabhuni,S.S., Tarnok,Z., Farkas,L., Nagy,P., Rizzo,R., Wolanczyk,T., Szymanska,U., Kapisyzi,M., Basha,E., Koumoula,A., Androutsos,C., Tsironi,V., Karagiannidis,I., Paschou,P. and Barta,C.
    Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome
    Front Neurol11, 803-803. PubMed  Europe PubMed DOI
    7. 2019
  7. Kreilaus,F., Chesworth,R., Eapen,V., Clarke,R. and Karl,T.
    First behavioural assessment of a novel Immp2l knockdown mouse model with relevance for Gilles de la Tourette syndrome and Autism spectrum disorder
    Behav Brain Res112057-112057. PubMed  Europe PubMed DOI  K
    8. 2018
  8. Sica,V. and Kroemer,G.
    IMMP2L: a mitochondrial protease suppressing cellular senescence
    Cell Res28, 607-608. PubMed  Europe PubMed DOI
  9. Yuan,L., Zhai,L., Qian,L., Huang, Ding,Y., Xiang,H., Liu,X., Thompson,J.W., Liu,J., He,Y.H., Chen,X.Q., Hu,J., Kong,Q.P., Tan,M. and Wang,X.F.
    Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death
    Cell Res28, 625-643. PubMed  Europe PubMed DOI
  10. Zhang,Y., Liu,Y., Zarrei,M., Tong,W., Dong,R., Wang,Y., Zhang,H., Yang,X., MacDonald,J.R., Uddin,M., Scherer,S.W. and Gai,Z.
    Association of IMMP2L deletions with autism spectrum disorder: a trio family study and meta-analysis
    Am J Med Genet B Neuropsychiatr Genet177, 93-100. PubMed  Europe PubMed DOI  M
    11. 2017
  11. Gokoolparsadh,A., Fang,Z., Braidy,N., Lin,P., Pardy,C.J., Eapen,V., Clarke,R. and Voineagu,I.
    Transcriptional response to mitochondrial protease IMMP2L knockdown in human primary astrocytes
    Biochem Biophys Res Commun482, 1252-1258. PubMed  Europe PubMed DOI  K
  12. Ma,Y., Zhang,Z., Chen,Z., Ma,N., Sun,S., Zhang,J., Ni,X., Zhang,J. and Li,P.A.
    Suppression of inner mitochondrial membrane peptidase 2-like (IMMP2L) gene exacerbates hypoxia-induced neural death under high glucose condition
    Neurochem Res42, 1504-1514. PubMed  Europe PubMed DOI  K
    13. 2016
  13. Liu,C., Li,X. and Lu,B.
    The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment
    Aging Cell15, 167-176. PubMed  Europe PubMed DOI  M
    14. 2014
  14. Bertelsen,B., Melchior,L., Jensen,L.R., Groth,C., Glenthoj,B., Rizzo,R., Debes,N.M., Skov,L., Brondum-Nielsen,K., Paschou,P., Silahtaroglu,A. and Tumer,Z.
    Intragenic deletions affecting two alternative transcripts of the IMMP2L gene in patients with Tourette syndrome
    Eur J Hum Genet22, 1283-1289. PubMed  Europe PubMed DOI  M
  15. Bharadwaj,M.S., Zhou,Y., Molina,A.J., Criswell,T. and Lu,B.
    Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice
    Redox Biol2, 1008-1015. PubMed  Europe PubMed DOI  K
    16. 2013
  16. Han,C., Zhao,Q. and Lu,B.
    The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice
    Redox Biol1, 498-507. PubMed  Europe PubMed DOI  K
    17. 2012
  17. George,S.K., Jiao,Y., Bishop,C.E. and Lu,B.
    Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice
    Free Radic Biol Med52, 2223-2233. PubMed  Europe PubMed DOI  M
  18. Packer,J.C.L. and Howe,C.J.
    Organellar signal peptidases
    [ISSN:978-0-12-407742-3]3, 3508-3512. DOI
    19. 2011
  19. George,S.K., Jiao,Y., Bishop,C.E. and Lu,B.
    Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal
    Aging Cell10, 584-594. PubMed  Europe PubMed DOI  M
  20. Ma,Y., Mehta,S.L., Lu,B. and Li,P.A.
    Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function
    Neurobiol Dis44, 270-276. PubMed  Europe PubMed DOI  K
    21. 2008
  21. Lu,B., Poirier,C., Gaspar,T., Gratzke,C., Harrison,W., Busija,D., Matzuk,M.M., Andersson,K.E., Overbeek,P.A. and Bishop,C.E.
    A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice
    Biol Reprod78, 601-610. PubMed  Europe PubMed DOI  M
    22. 2006
  22. [YEAR:1-2-2006]Luo,W., Fang,H. and Green,N.
    Substrate specificity of inner membrane peptidase in yeast mitochondria
    Mol Genet Genomics275, 431-436. PubMed  Europe PubMed DOI  P
    23. 2005
  23. [YEAR:6-4-2005]Burri,L., Strahm,Y., Hawkins,C.J., Gentle,I.E., Puryer,M.A., Verhagen,A., Callus,B., Vaux,D. and Lithgow,T.
    Mature DIABLO/Smac Is produced by the IMP protease complex on the mitochondrial inner membrane
    Mol Biol Cell16, 2926-2933. PubMed  Europe PubMed DOI
    24. 2004
  24. [YEAR:30-4-2004]Esser,K., Jan,P.S., Pratje,E. and Michaelis,G.
    The mitochondrial IMP peptidase of yeast: functional analysis of domains and identification of Gut2 as a new natural substrate
    Mol Genet Genomics271, 616-626. PubMed  Europe PubMed DOI
  25. [YEAR:14-7-2004]Liang,H., Luo,W., Green,N. and Fang,H.
    Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria
    J Biol Chem279, 39396-39400. PubMed  Europe PubMed DOI
  26. Packer,J.C.L. and Howe,C.J.
    Organellar signal peptidases
    [ISSN:0-12-079610-4]2, 1988-1991.  V
    27. 2003
  27. [YEAR:14-2-2003]Luo,W., Chen,X., Fang,H. and Green,N.
    Factors governing nonoverlapping substrate specificity by mitochondrial inner membrane peptidase
    J Biol Chem278, 4943-4948. PubMed  Europe PubMed DOI
    28. 2002
  28. [YEAR:2-9-2002]Gakh,O., Cavadini,P. and Isaya,G.
    Mitochondrial processing peptidases
    Biochim Biophys Acta1592, 63-77. PubMed  Europe PubMed DOI
    29. 2001
  29. Petek,E., Windpassinger,C., Vincent,J.B., Cheung,J., Boright,A.P., Scherer,S.W., Kroisel,P.M. and Wagner,K.
    Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome
    Am J Hum Genet68, 848-858. PubMed  Europe PubMed DOI
    30. 2000
  30. Jan,P.S., Esser,K., Pratje,E. and Michaelis,G.
    Som1, a third component of the yeast mitochondrial inner membrane peptidase complex that contains Imp1 and Imp2
    Mol Gen Genet263, 483-491. PubMed  Europe PubMed DOI
    31. 1999
  31. [YEAR:31-12-1999]Chen,X., Van Valkenburgh,C., Fang,H. and Green,N.
    Signal peptides having standard and nonstandard cleavage sites can be processed by Imp1p of the mitochondrial inner membrane protease
    J Biol Chem274, 37750-37754. PubMed  Europe PubMed DOI
    32. 1994
  32. Schneider,A., Oppliger,W. and Jeno,P.
    Purified inner membrane protease I of yeast mitochondria is a heterodimer
    J Biol Chem269, 8635-8638. PubMed  Europe PubMed
    33. 1993
  33. Nunnari,J., Fox,T.D. and Walter,P.
    A mitochondrial protease with two catalytic subunits of nonoverlapping specificities
    Science262, 1997-2004. PubMed  Europe PubMed

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