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Literature for peptidase S24.001: repressor LexA

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. He,R., Zuo,Y., Li,Q., Yan,Q. and Huang,L.
    Cooperative mechanisms of LexA and HtpG in the regulation of virulence gene expression in Pseudomonas plecoglossicida
    Curr Res Microb Sci (2025) 8, 100351-100351. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Vascon,F., De Felice,S., Gasparotto,M., Huber,S.T., Catalano,C., Chinellato,M., Mezzetti,R., Grinzato,A., Filippini,F., Maso,L., Jakobi,A.J. and Cendron,L.
    Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis
    iScience (2025) 28, 111726-111726. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Chatterjee,C., Mohan,G.R., C,H.V., Biswas,B., Sundaram,V., Srivastava,A. and Matheshwaran,S.
    Anti-mutagenic agent targeting LexA to combat antimicrobial resistance in mycobacteria
    J Biol Chem (2024) , 107650-107650. PubMed  Europe PubMed DOI
  4. Cory,M.B., Li,A., Hurley,C.M., Carman,P.J., Pumroy,R.A., Hostetler,Z.M., Perez,R.M., Venkatesh,Y., Li,X., Gupta,K., Petersson,E.J. and Kohli,R.M.
    The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation
    Nat Struct Mol Biol (2024) 31, 1522-1531. PubMed  Europe PubMed DOI
  5. Shi,X., Yan,H., Yuan,F., Li,G., Liu,J., Li,C., Yu,X., Li,Z., Zhu,Y. and Wang,W.
    LexA, an SOS response repressor, activates TGase synthesis in Streptomyces mobaraensis
    Front Microbiol (2024) 15, 1397314-1397314. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Gao,B., Liang,L., Su,L., Wen,A., Zhou,C. and Feng,Y.
    Structural basis for regulation of SOS response in bacteria
    Proc Natl Acad Sci U S A (2023) 120, e2217493120-e2217493120. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Schuurs,Z.P., McDonald,J.P., Croft,L.V., Richard,D.J., Woodgate,R. and Gandhi,N.S.
    Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis
    Front Cell Infect Microbiol (2023) 13, 1051602-1051602. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Srivastava,A., Kumar,A., Biswas,S., Kumar,R., Srivastava,V., Rajaram,H. and Mishra,Y.
    Gamma (gamma)-radiation stress response of the cyanobacterium Anabaena sp. PCC7120: Regulatory role of LexA and photophysiological changes
    Plant Sci (2023) 326, 111529-111529. PubMed  Europe PubMed DOI
    9. 2022
  9. Bastet,L., Bustos-Sanmamed,P., Catalan-Moreno,A., Caballero,C.J., Cuesta,S., Matilla-Cuenca,L., Villanueva,M., Valle,J., Lasa,I. and Toledo-Arana,A.
    Regulation of Heterogenous LexA Expression in Staphylococcus aureus by an Antisense RNA Originating from Transcriptional Read-Through upon Natural Mispairings in the sbrB Intrinsic Terminator
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  K
  10. Cory,M.B., Li,A., Hurley,C.M., Hostetler,Z.M., Venkatesh,Y., Jones,C.M., Petersson,E.J. and Kohli,R.M.
    Engineered RecA Constructs Reveal the Minimal SOS Activation Complex
    Biochemistry (2022) 61, 2884-2896. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Jaramillo,A.V.C., Cory,M.B., Li,A., Kohli,R.M. and Wuest,W.M.
    Exploration of inhibitors of the bacterial LexA repressor-protease
    Bioorg Med Chem Lett (2022) 65, 128702-128702. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Sasi,V.M., Ullrich,S., Ton,J., Fry,S.E., Johansen-Leete,J., Payne,R.J., Nitsche,C. and Jackson,C.J.
    Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening
    Biochemistry (2022) 61, 2495-2505. PubMed  Europe PubMed DOI
  13. Van Alstine,S. and Sandler,S.J.
    Positive Charges Are Important for the SOS Constitutive Phenotype in recA730 and recA1202 Mutants of Escherichia coli K-12
    J Bacteriol (2022) 204, e0008122-e0008122. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2021
  14. Akkaya,O., Aparicio,T., Perez-Pantoja,D. and de Lorenzo,V.
    The faulty SOS response of Pseudomonas putida KT2440 stems from an inefficient RecA-LexA interplay
    Environ Microbiol (2021) PubMed  Europe PubMed DOI
  15. Blanchard,L. and de Groot,A.
    Coexistence of SOS-Dependent and SOS-Independent Regulation of DNA Repair Genes in Radiation-Resistant Deinococcus Bacteria
    Cells (2021) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  16. Chatterjee,C., Majumdar,S., Deshpande,S., Pant,D. and Matheshwaran,S.
    Real-time kinetic studies of Mycobacterium tuberculosis LexA-DNA interaction
    Biosci Rep (2021) PubMed  Europe PubMed DOI
  17. Jones,E.C. and Uphoff,S.
    Single-molecule imaging of LexA degradation in Escherichia coli elucidates regulatory mechanisms and heterogeneity of the SOS response
    Nat Microbiol (2021) 6, 981-990. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Lanyon-Hogg,T.
    Targeting the bacterial SOS response for new antimicrobial agents: drug targets, molecular mechanisms and inhibitors
    Future Med Chem (2021) 13, 143-155. PubMed  Europe PubMed DOI  V
  19. Lewis,E.B., Chen,E. and Culyba,M.J.
    DNA cytosine methylation at the lexA promoter of Escherichia coli is stationary phase specific
    G3 (Bethesda) (2021) PubMed  Europe PubMed DOI
  20. Lu,Y. and Cheng,L.
    Computational analysis of LexA regulons in Proteus species
    3 Biotech (2021) 11, 131-131. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Sheng,D.H., Wang,Y., Wu,S.G., Duan,R.X. and Li,Y.Z.
    The regulation of LexA on UV induced SOS response in Myxococcus xanthus based on transcriptome analysis
    J Microbiol Biotechnol (2021) 31 PubMed  Europe PubMed DOI
    22. 2020
  22. Bellio,P., Mancini,A., Di Pietro,L., Cracchiolo,S., Franceschini,N., Reale,S., De Angelis,F., Perilli,M., Amicosante,G., Spyrakis,F., Tondi,D., Cendron,L. and Celenza,G.
    Inhibition of the transcriptional repressor LexA: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials
    Life Sci (2020) 241, 117116-117116. PubMed  Europe PubMed DOI  I
  23. Das,A., Mandal,S., Hemmadi,V., Ratre,V. and Biswas,M.
    Studies on the gene regulation involved in the lytic-lysogenic switch in Staphylococcus aureus temperate bacteriophage Phi11
    J Biochem (2020) PubMed  Europe PubMed DOI
  24. Hostetler,Z.M., Cory,M.B., Jones,C.M., Petersson,E.J. and Kohli,R.M.
    The kinetic and molecular basis for the interaction of LexA and activated RecA revealed by a fluorescent amino acid probe
    ACS Chem Biol (2020) 15, 1127-1133. PubMed  Europe PubMed DOI
  25. Pant,A., Bag,S., Saha,B., Verma,J., Kumar,P., Banerjee,S., Kumar,B., Kumar,Y., Desigamani,A., Maiti,S., Maiti,T.K., Banerjee,S.K., Bhadra,R.K., Koley,H., Dutta,S., Nair,G.B., Ramamurthy,T. and Das,B.
    Molecular insights into the genome dynamics and interactions between core and acquired genomes of Vibrio cholerae
    Proc Natl Acad Sci U S A (2020) 117, 23762-23773. PubMed  Europe PubMed DOI
    26. 2019
  26. Caveney,N.A., Pavlin,A., Caballero,G., Bahun,M., Hodnik,V., de Castro,L., Fornelos,N., Butala,M. and Strynadka,N.C.J.
    Structural insights into bacteriophage GIL01 gp7 inhibition of host LexA repressor
    Structure (2019) 27, 1094-1102. PubMed  Europe PubMed DOI
  27. Chandran,A.V., Srikalaivani,R., Paul,A. and Vijayan,M.
    Biochemical characterization of Mycobacterium tuberculosis LexA and structural studies of its C-terminal segment
    Acta Crystallogr D Struct Biol (2019) 75, 41-55. PubMed  Europe PubMed DOI
  28. Ojha,D. and Neelakanteshwar Patil,K.
    Molecular and functional characterization of the Listeria monocytogenes RecA protein: insights into the homologous recombination process
    Int J Biochem Cell Biol (2019) , 105642-105642. PubMed  Europe PubMed DOI
    29. 2018
  29. Fornelos,N., Browning,D.F., Pavlin,A., Podlesek,Z., Hodnik,V., Salas,M. and Butala,M.
    Lytic gene expression in the temperate bacteriophage GIL01 is activated by a phage-encoded LexA homologue
    Nucleic Acids Res (2018) 46, 9432-9443. PubMed  Europe PubMed DOI
  30. Mo,C.Y., Culyba,M.J., Selwood,T., Kubiak,J.M., Hostetler,Z.M., Jurewicz,A.J., Keller,P.M., Pope,A.J., Quinn,A., Schneck,J., Widdowson,K.L. and Kohli,R.M.
    Inhibitors of LexA autoproteolysis and the bacterial SOS response discovered by an academic-industry partnership
    ACS Infect Dis (2018) 4, 349-359. PubMed  Europe PubMed DOI  I
  31. Selwood,T., Larsen,B.J., Mo,C.Y., Culyba,M.J., Hostetler,Z.M., Kohli,R.M., Reitz,A.B. and Baugh,S.D.P.
    Advancement of the 5-amino-1-(carbamoylmethyl)-1H-1,2,3-triazole-4-carboxamide scaffold to disarm the bacterial SOS response
    Front Microbiol (2018) 9, 2961-2961. PubMed  Europe PubMed DOI  PMC  EPMC  I
    32. 2015
  32. Kumar,A., Kirti,A. and Rajaram,H.
    LexA protein of cyanobacterium Anabaena sp. strain PCC7120 exhibits in vitro pH-dependent and RecA-independent autoproteolytic activity
    Int J Biochem Cell Biol (2015) 59C, 84-93. PubMed  Europe PubMed DOI
    33. 2014
  33. Mo,C.Y., Birdwell,L.D. and Kohli,R.M.
    Specificity determinants for autoproteolysis of LexA, a key regulator of bacterial SOS mutagenesis
    Biochemistry (2014) 53, 3158-3168. PubMed  Europe PubMed DOI  P
    34. 2013
  34. Kovacic,L., Paulic,N., Leonardi,A., Hodnik,V., Anderluh,G., Podlesek,Z., Zgur-Bertok,D., Krizaj,I. and Butala,M.
    Structural insight into LexA-RecA* interaction
    Nucleic Acids Res (2013) 41, 9901-9910. PubMed  Europe PubMed DOI
    35. 2012
  35. Little,J.W.
    Repressor LexA
    [ISSN:978-0-12-407742-3] (2012) 3, 3484-3487. DOI
    36. 2010
  36. Chandran,A.V., Prabu,J.R., Manjunath,G.P., Patil,K.N., Muniyappa,K. and Vijayan,M.
    Crystallization and preliminary X-ray studies of the C-terminal domain of Mycobacterium tuberculosis LexA
    Acta Crystallograph Sect F Struct Biol Cryst Commun (2010) 66, 1093-1095. PubMed  Europe PubMed DOI  S
  37. Zhang,A.P., Pigli,Y.Z. and Rice,P.A.
    Structure of the LexA-DNA complex and implications for SOS box measurement
    Nature (2010) 466, 883-886. PubMed  Europe PubMed DOI  PMC  EPMC  S
    38. 2009
  38. Butala,M., Zgur-Bertok,D. and Busby,S.J.
    The bacterial LexA transcriptional repressor
    Cell Mol Life Sci (2009) 66, 82-93. PubMed  Europe PubMed DOI
    39. 2008
  39. Giese,K.C., Michalowski,C.B. and Little,J.W.
    RecA-dependent cleavage of LexA dimers
    J Mol Biol (2008) 377, 148-161. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2004
  40. Little,J.W.
    Repressor LexA
    [ISSN:0-12-079610-4] (2004) 2, 1974-1976.  V
    41. 2003
  41. [YEAR:1-5-2003]Neher,S.B., Flynn,J.M., Sauer,R.T. and Baker,T.A.
    Latent ClpX-recognition signals ensure LexA destruction after DNA damage
    Genes Dev (1-5-2003) 17, 1084-1089. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2001
  42. [YEAR:7-9-2001]Luo,Y., Pfuetzner,R.A., Mosimann,S., Paetzel,M., Frey,E.A., Cherney,M., Kim,B., Little,J.W. and Strynadka,N.C.
    Crystal structure of LexA: a conformational switch for regulation of self-cleavage
    Cell (7-9-2001) 106, 585-594. PubMed  Europe PubMed DOI  S
  43. [YEAR:1-3-2001]Yasuda,T., Morimatsu,K., Kato,R., Usukura,J., Takahashi,M. and Ohmori,H.
    Physical interactions between DinI and RecA nucleoprotein filament for the regulation of SOS mutagenesis
    EMBO J (1-3-2001) 20, 1192-1202. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 1998
  44. [YEAR:20-2-1998]Konola,J.T., Guzzo,A., Gow,J.B., Walker,G.C. and Knight,K.L.
    Differential cleavage of LexA and UmuD mediated by recA pro67 mutants: Implications for common LexA and UmuD binding sites on RecA
    J Mol Biol (20-2-1998) 276, 405-415. PubMed  Europe PubMed DOI
  45. [YEAR:1-6-1998]Yasuda,T., Morimatsu,K., Horii,T., Nagata,T. and Ohmori,H.
    Inhibition of Escherichia coli RecA coprotease activities by DinI
    EMBO J (1-6-1998) 17, 3207-3216. PubMed  Europe PubMed DOI  PMC  EPMC
    46. 1997
  46. Nastri,H.G., Guzzo,A., Lange,C.S., Walker,G.C. and Knight,K.L.
    Mutational analysis of the RecA protein L1 region identifies this area as a probable part of the co-protease substrate binding site
    Mol Microbiol (1997) 25, 967-978. PubMed  Europe PubMed
    47. 1996
  47. Rehrauer,W.M., Lavery,P.E., Palmer,E.L., Singh,R.N. and Kowalczykowski,S.C.
    Interaction of Escherichia coli RecA protein with LexA repressor. I. LexA repressor cleavage is competitive with binding of a secondary DNA molecule
    J Biol Chem (1996) 271, 23865-23873. PubMed  Europe PubMed DOI
  48. Shepley,D.P. and Little,J.W.
    Mutant LexA proteins with specific defects in autodigestion
    Proc Natl Acad Sci U S A (1996) 93, 11528-11533. PubMed  Europe PubMed DOI  PMC  EPMC
    49. 1994
  49. Little,J.W., Kim,B., Roland,K.L., Smith,M.H., Lin,L.L. and Slilaty,S.N.
    Cleavage of LexA repressor
    Methods Enzymol (1994) 244, 266-284. PubMed  Europe PubMed DOI  V
    50. 1993
  50. [YEAR:18-6-1993]Kim,B. and Little,J.W.
    LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction
    Cell (18-6-1993) 73, 1165-1173. PubMed  Europe PubMed DOI
  51. Little,J.W.
    LexA cleavage and other self-processing reactions
    J Bacteriol (1993) 175, 4943-4950. PubMed  Europe PubMed  PMC  EPMC
    52. 1992
  52. Koch,W.H., Ennis,D.G., Levine,A.S. and Woodgate,R.
    Escherichia coli umuDC mutants: DNA sequence alterations and UmuD cleavage
    Mol Gen Genet (1992) 233, 443-448. PubMed  Europe PubMed
  53. [YEAR:20-11-1992]Roland,K.L., Smith,M.H., Rupley,J.A. and Little,J.W.
    In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage
    J Mol Biol (20-11-1992) 228, 395-408. PubMed  Europe PubMed DOI
    54. 1991
  54. Slilaty,S.N. and Vu,H.K.
    The role of electrostatic interactions in the mechanism of peptide bond hydrolysis by a Ser-Lys catalytic dyad
    Protein Eng (1991) 4, 919-922. PubMed  Europe PubMed
    55. 1989
  55. [YEAR:5-12-1989]Lin,L.L. and Little,J.W.
    Autodigestion and RecA-dependent cleavage of Ind- mutant LexA proteins
    J Mol Biol (5-12-1989) 210, 439-452. PubMed  Europe PubMed DOI
    56. 1987
  56. Slilaty,S.N. and Little,J.W.
    Lysine-156 and serine-119 are required for LexA repressor cleavage: a possible mechanism
    Proc Natl Acad Sci U S A (1987) 84, 3987-3991. PubMed  Europe PubMed  PMC  EPMC  I
    57. 1986
  57. [YEAR:4-11-1986]Slilaty,S.N., Rupley,J.A. and Little,J.W.
    Intramolecular cleavage of LexA and phage lambda repressors: dependence of kinetics on repressor concentration, pH, temperature, and solvent
    Biochemistry (4-11-1986) 25, 6866-6875. PubMed  Europe PubMed
    58. 1984
  58. Little,J.W.
    Autodigestion of lexA and phage lambda repressors
    Proc Natl Acad Sci U S A (1984) 81, 1375-1379. PubMed  Europe PubMed  PMC  EPMC
    59. 1981
  59. Horii,T., Ogawa,T., Nakatani,T., Hase,T., Matsubara,H. and Ogawa,H.
    Regulation of SOS functions: purification of E. coli LexA protein and determination of its specific site cleaved by the RecA protein
    Cell (1981) 27, 515-522. PubMed  Europe PubMed

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