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Literature for peptidase S14.009: ClpP2 peptidase (Streptomyces-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Bhardwaj,S. and Roy,K.K.
    Elucidating the structural basis of ClpP activation and dynamics in Mycobacterium tuberculosis
    J Biomol Struct Dyn (2026) , 1-28. PubMed  Europe PubMed DOI
    2. 2023
  2. Yang,Y., Zhao,N., Xu,X., Zhou,Y., Luo,B., Zhang,J., Sui,J., Huang,J., Qiu,Z., Zhang,X., Zeng,J., Bai,L., Bao,R. and Luo,Y.
    Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors
    J Med Chem (2023) 66, 16597-16614. PubMed  Europe PubMed DOI  I
    3. 2022
  3. Cobongela,S.Z.Z., Makatini,M.M., Mdluli,P.S. and Sibuyi,N.R.S.
    Acyldepsipeptide Analogues: A Future Generation Antibiotics for Tuberculosis Treatment
    Pharmaceutics (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  4. d'Andrea,F.B., Poulton,N.C., Froom,R., Tam,K., Campbell,E.A. and Rock,J.M.
    The essential M. tuberculosis Clp protease is functionally asymmetric in vivo
    Sci Adv (2022) 8, eabn7943-eabn7943. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Hawkins,P.M.E., Hoi,D.M., Cheung,C.Y., Wang,T., Quan,D., Sasi,V.M., Liu,D.Y., Linington,R.G., Jackson,C.J., Oehlers,S.H., Cook,G.M., Britton,W.J., Clausen,T. and Payne,R.J.
    Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A
    J Med Chem (2022) 65, 4893-4908. PubMed  Europe PubMed DOI
  6. Taylor,G., Frommherz,Y., Katikaridis,P., Layer,D., Sinning,I., Carroni,M., Weber-Ban,E. and Mogk,A.
    Antibacterial peptide CyclomarinA creates toxicity by deregulating the Mycobacterium tuberculosis ClpC1-ClpP1P2 protease
    J Biol Chem (2022) 298, 102202-102202. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2020
  7. Vahidi,S., Ripstein,Z.A., Juravsky,J.B., Rennella,E., Goldberg,A.L., Mittermaier,A.K., Rubinstein,J.L. and Kay,L.E.
    An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
    Proc Natl Acad Sci U S A (2020) 117, 5895-5906. PubMed  Europe PubMed DOI  S
    8. 2019
  8. Choules,M.P., Wolf,N.M., Lee,H., Anderson,J.R., Grzelak,E.M., Wang,Y., Ma,R., Gao,W., McAlpine,J.B., Jin,Y.Y., Cheng,J., Lee,H., Suh,J.W., Duc,N.M., Paik,S., Choe,J.H., Jo,E.K., Chang,C.L., Lee,J.S., Jaki,B.U., Pauli,G.F., Franzblau,S.G. and Cho,S.
    Rufomycin targets ClpC1 proteolysis in Mycobacterium tuberculosis and M. abscessus
    Antimicrob Agents Chemother (2019) 63, e02204-18-e02204-18. PubMed  Europe PubMed DOI
  9. Nagpal,J., Paxman,J.J., Zammit,J.E., Alhuwaider,A., Truscott,K.N., Heras,B. and Dougan,D.A.
    Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis
    Sci Rep (2019) 9, 18019-18019. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2018
  10. Liu,P., Yang,Y., Ju,Y., Tang,Y., Sang,Z., Chen,L., Yang,T., An,Q., Zhang,T. and Luo,Y.
    Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis
    Bioorg Chem (2018) 80, 422-432. PubMed  Europe PubMed DOI  I
    11. 2017
  11. Moreira,W., Santhanakrishnan,S., Ngan,G.J., Low,C.B., Sangthongpitag,K., Poulsen,A., Dymock,B.W. and Dick,T.
    Towards selective mycobacterial ClpP1P2 inhibitors with reduced activity against the human proteasome
    Antimicrob Agents Chemother (2017) 61, e02307-16-e02307-16. PubMed  Europe PubMed DOI  I
  12. Moreira,W., Santhanakrishnan,S., Dymock,B.W. and Dick,T.
    Bortezomib warhead-switch confers dual activity against mycobacterial caseinolytic protease and proteasome and selectivity against human proteasome
    Front Microbiol (2017) 8, 746-746. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Yamada,Y. and Dick,T.
    Mycobacterial caseinolytic protease gene regulator ClgR is a substrate of caseinolytic protease
    mSphere (2017) 2 PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2016
  14. Famulla,K., Sass,P., Malik,I., Akopian,T., Kandror,O., Alber,M., Hinzen,B., Ruebsamen-Schaeff,H., Kalscheuer,R., Goldberg,A.L. and Brotz-Oesterhelt,H.
    Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
    Mol Microbiol (2016) 101, 194-209. PubMed  Europe PubMed DOI
  15. Khandekar,N., Singh,S., Shukla,R., Tirumalaraju,S., Bandaru,S., Banerjee,T. and Nayarisseri,A.
    Structural basis for the in vitro known acyl-depsipeptide 2 (ADEP2) inhibition to Clp 2 protease from Mycobacterium tuberculosis
    Bioinformation (2016) 12, 92-97. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Li,M., Kandror,O., Akopian,T., Dharkar,P., Wlodawer,A., Maurizi,M.R. and Goldberg,A.L.
    Structure and functional properties of the active form of the proteolytic complex, ClpP1P2, from Mycobacterium tuberculosis
    J Biol Chem (2016) 291, 7465-7476. PubMed  Europe PubMed DOI  S
    17. 2015
  17. Akopian,T., Kandror,O., Tsu,C., Lai,J.H., Wu,W., Liu,Y., Zhao,P., Park,A., Wolf,L., Dick,L.R., Rubin,E.J., Bachovchin,W. and Goldberg,A.L.
    Cleavage specificity of Mycobacterium tuberculosis ClpP1P2 protease and identification of novel peptide substrates and boronate inhibitors with anti-bacterial activity
    J Biol Chem (2015) 290, 11008-11020. PubMed  Europe PubMed DOI  P  I
  18. Leodolter,J., Warweg,J. and Weber-Ban,E.
    The Mycobacterium tuberculosis ClpP1P2 protease interacts asymmetrically with its ATPase partners ClpX and ClpC1
    PLoS ONE (2015) 10, e0125345- PubMed  Europe PubMed DOI  PMC  EPMC
  19. Moreira,W., Ngan,G.J., Low,J.L., Poulsen,A., Chia,B.C., Ang,M.J., Yap,A., Fulwood,J., Lakshmanan,U., Lim,J., Khoo,A.Y., Flotow,H., Hill,J., Raju,R.M., Rubin,E.J. and Dick,T.
    Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria
    MBio (2015) 6, e00253-e00215. PubMed  Europe PubMed DOI  I
    20. 2014
  20. Gavrish,E., Sit,C.S., Cao,S., Kandror,O., Spoering,A., Peoples,A., Ling,L., Fetterman,A., Hughes,D., Bissell,A., Torrey,H., Akopian,T., Mueller,A., Epstein,S., Goldberg,A., Clardy,J. and Lewis,K.
    Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2
    Chem Biol (2014) 21, 509-518. PubMed  Europe PubMed DOI
  21. Li,D., Zhang,C., Lu,N., Mu,L., He,Y., Xu,L., Yang,J., Fan,Y., Kang,Y. and Yang,C.
    Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis
    Int J Clin Exp Pathol (2014) 7, 5674-5682. PubMed  Europe PubMed  PMC  EPMC
  22. Liu,J. and Chien,P.
    Structure and activation of a heteromeric protease complex
    Proc Natl Acad Sci U S A (2014) 111, 15289-15290. PubMed  Europe PubMed DOI
  23. Schmitz,K.R., Carney,D.W., Sello,J.K. and Sauer,R.T.
    Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery
    Proc Natl Acad Sci U S A (2014) 111, E4587-E4595. PubMed  Europe PubMed DOI  S
  24. Schmitz,K.R. and Sauer,R.T.
    Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase
    Mol Microbiol (2014) 93, 617-628. PubMed  Europe PubMed DOI
    25. 2013
  25. Compton,C.L., Schmitz,K.R., Sauer,R.T. and Sello,J.K.
    Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase
    ACS Chem Biol (2013) 8, 2669-2677. PubMed  Europe PubMed DOI  I
  26. Personne,Y., Brown,A.C., Schuessler,D.L. and Parish,T.
    Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities
    PLoS ONE (2013) 8, e60228-e60228. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2012
  27. Akopian,T., Kandror,O., Raju,R.M., Unnikrishnan,M., Rubin,E.J. and Goldberg,A.L.
    The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring
    EMBO J (2012) 31, 1529-1541. PubMed  Europe PubMed DOI
  28. Ollinger,J., O'Malley,T., Kesicki,E.A., Odingo,J. and Parish,T.
    Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target
    J Bacteriol (2012) 194, 663-668. PubMed  Europe PubMed DOI  T
  29. Raju,R.M., Unnikrishnan,M., Rubin,D.H., Krishnamoorthy,V., Kandror,O., Akopian,T.N., Goldberg,A.L. and Rubin,E.J.
    Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection
    PLoS Pathog (2012) 8, e1002511-e1002511. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2011
  30. Benaroudj,N., Raynal,B., Miot,M. and Ortiz-Lombardia,M.
    Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2
    BMC Biochem (2011) 12, 61-61. PubMed  Europe PubMed DOI
    31. 2004
  31. Bellier,A. and Mazodier,P.
    ClgR, a novel regulator of clp and lon expression in Streptomyces
    J Bacteriol (2004) 186, 3238-3248. PubMed  Europe PubMed DOI  PMC  EPMC
    32. 2002
  32. Viala,J. and Mazodier,P.
    ClpP-dependent degradation of PopR allows tightly regulated expression of the clpP3 clpP4 operon in Streptomyces lividans
    Mol Microbiol (2002) 44, 633-643. PubMed  Europe PubMed DOI
    33. 1999
  33. de Crecy-Lagard,V., Servant-Moisson,P., Viala,J., Grandvalet,C. and Mazodier,P.
    Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces
    Mol Microbiol (1999) 32, 505-517. PubMed  Europe PubMed DOI

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