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Literature for peptidase S14.001: peptidase Clp (type 1)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, V Review, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Dendene,S., Xue,S., Mohammedi,R., Vieillard,A., Nicoud,Q., Valette,O., Frascella,A., Bonnardel,A., Le Bars,R., Bourge,M., Mergaert,P., Brilli,M., Alunni,B. and Biondi,E.G.
    Sinorhizobium meliloti FcrX coordinates cell cycle and division during free-living growth and symbiosis by a ClpXP-dependent mechanism
    Proc Natl Acad Sci U S A122, e2412367122-e2412367122. PubMed  Europe PubMed DOI
  2. Ishikawa,F., Uchida,C., Ohnishi,R., Imai,T. and Tanabe,G.
    Degradation of Nonribosomal Peptide Synthetase Megasynthetases SrfAA and SrfAB by Acyldepsipeptide-Activated ClpP in Bacillus Subtilis
    Chembiocheme2500135-e2500135. PubMed  Europe PubMed DOI
  3. Jadhav,P., Roy,S., Butzin,X.Y. and Butzin,N.C.
    Engineering a New SsrA-Based Degradation Tag (LAA-LAA) and a Bacterial Synthetic Oscillator
    ACS Synth Biol PubMed  Europe PubMed DOI
  4. Li,S., Lv,H., Zhou,Y., Wang,J., Deng,X., Ma,H., Kong,L., Zhang,Y. and Zhang,Q.
    Anti-infective therapy of inhibiting Staphylococcus aureus ClpP by protocatechuic aldehyde
    Int Immunopharmacol157, 114802-114802. PubMed  Europe PubMed DOI  I
  5. Noskova,Y., Nedashkovskaya,O. and Balabanova,L.
    Production, Purification, and Biochemical Characterization of a Novel ATP-Dependent Caseinolytic Protease from the Marine Bacterium Cobetia amphilecti KMM 296
    Microorganisms13, PubMed  Europe PubMed DOI
  6. Wang,Y., Wang,L., Guo,D., Liu,X., Xu,Y., Wang,R., Sun,Y., Liu,Q., Guan,J., Liu,D., Wang,B., Zhao,Y. and Yan,M.
    Targeting ClpP: Unlocking a novel therapeutic approach of isochlorogenic acid A for methicillin-resistant Staphylococcus aureus-infected osteomyelitis
    Microbiol Res292, 128042-128042. PubMed  Europe PubMed DOI  I
  7. Zhang,T., Wu,W., Zhao,Y., Ding,Z., Wei,B., Yang,T., Li,J., Wang,P., Lan,L., Gan,J. and Yang,C.G.
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection
    J Med Chem PubMed  Europe PubMed DOI  I
    8. 2024
  8. Bonjorno,A.F., Pavan,A.R., Fernandes,G.F.S., Scarim,C.B., Castagnolo,D. and Dos Santos,J.L.
    BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery
    Front Chem12, 1358539-1358539. PubMed  Europe PubMed DOI
  9. Ghanbarpour,A., Sauer,R.T. and Davis,J.H.
    A proteolytic AAA+ machine poised to unfold protein substrates
    Nat Commun15, 9681-9681. PubMed  Europe PubMed DOI
  10. Ishikawa,F., Homma,M., Tanabe,G. and Uchihashi,T.
    [Protein degradation in bacteria: focus on the ClpP protease]
    Nihon Saikingaku Zasshi79, 1-13. PubMed  Europe PubMed DOI
  11. Ishikawa,F., Uchida,C. and Tanabe,G.
    Proteolytic Regulation in the Biosynthesis of Natural Product Via a ClpP Protease System
    ACS Chem Biol19, 1794-1802. PubMed  Europe PubMed DOI
  12. Ishikawa,F., Homma,M., Tanabe,G. and Uchihashi,T.
    Protein degradation by a component of the chaperonin-linked protease ClpP
    Genes Cells29, 695-709-709. PubMed  Europe PubMed DOI  V
  13. Kumari,S., Ali,A. and Kumar,M.
    Nucleotide-induced ClpC oligomerization and its non-preferential association with ClpP isoforms of pathogenic Leptospira
    Int J Biol Macromol266, 131371-131371. PubMed  Europe PubMed DOI
  14. Lin,F., Mabanglo,M.F., Zhou,J.L., Binepal,G., Barghash,M.M., Wong,K.S., Gray-Owen,S.D., Batey,R.A. and Houry,W.A.
    Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases
    J Med Chem67, 15131-15147. PubMed  Europe PubMed DOI
  15. Shih,T.T., Sauer,R.T. and Baker,T.A.
    How the double-ring ClpAP protease motor grips the substrate to unfold and degrade stable proteins
    J Biol Chem107861-107861. PubMed  Europe PubMed DOI
  16. Sieber,S.A., Gronauer,T.F., Eck,L.K. and Ludwig,C.
    A Photocrosslinking Probe to Capture the Substrates of Caseinolytic Protease P
    Angew Chem Int Ed Engle202409220-e202409220. PubMed  Europe PubMed DOI
  17. Wan,T., Cao,Y., Lai,Y., Pan,Z., Li,Y. and Zhuo,L.
    Functional investigation of the two ClpPs and three ClpXs in Myxococcus xanthus DK1622
    mSpheree0036324-e0036324. PubMed  Europe PubMed DOI
    18. 2023
  18. Azadmanesh,J., Seleem,M.A., Struble,L., Wood,N.A., Fisher,D.J., Lovelace,J.J., Artigues,A., Fenton,A.W., Borgstahl,G.E.O., Ouellette,S.P. and Conda-Sheridan,M.
    The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis
    J Biol Chem299, 102762-102762. PubMed  Europe PubMed DOI
  19. Brugger,C., Schwartz,J., Novick,S., Tong,S., Hoskins,J.R., Majdalani,N., Kim,R., Filipovski,M., Wickner,S., Gottesman,S., Griffin,P.R. and Deaconescu,A.M.
    Structure of phosphorylated-like RssB, the adaptor delivering sigma(s) to the ClpXP proteolytic machinery, reveals an interface switch for activation
    J Biol Chem299, 105440-105440. PubMed  Europe PubMed DOI
  20. Dayananda,A., Dennison,T.S.H., Fonseka,H.Y.Y., Avestan,M.S., Wang,Q., Tehver,R. and Stan,G.
    Allosteric communication in the gating mechanism for controlled protein degradation by the bacterial ClpP peptidase
    J Chem Phys158, 125101-125101. PubMed  Europe PubMed DOI
  21. Ghanbarpour,A., Cohen,S.E., Fei,X., Kinman,L.F., Bell,T.A., Zhang,J.J., Baker,T.A., Davis,J.H. and Sauer,R.T.
    A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation
    Nat Commun14, 7281-7281. PubMed  Europe PubMed DOI
  22. Jin,M., Zhu,S., Tang,Y., Kong,X., Wang,X., Li,Y., Jiang,S., Wei,L., Hu,C., Wang,B. and Song,W.
    Ayanin, a natural flavonoid inhibitor of Caseinolytic protease, is a promising therapeutic agent to combat methicillin-resistant Staphylococcus aureus infections
    Biochem Pharmacol217, 115814-115814. PubMed  Europe PubMed DOI  I
  23. Petkov,R., Camp,A.H., Isaacson,R.L. and Torpey,J.H.
    Targeting bacterial degradation machinery as an antibacterial strategy
    Biochem J480, 1719-1731. PubMed  Europe PubMed DOI  V
  24. Schmitz,K.R., Handy,E.L., Compton,C.L., Gupta,S., Bishai,W.R., Sauer,R.T. and Sello,J.K.
    Acyldepsipeptide antibiotics and a bioactive fragment thereof differentially perturb Mycobacterium tuberculosis ClpXP1P2 activity in vitro
    ACS Chem Biol18, 724-733. PubMed  Europe PubMed DOI
  25. Song,H., Choi,E. and Lee,E.J.
    Membrane-Bound Protease FtsH Protects PhoP from the Proteolysis by Cytoplasmic ClpAP Protease in Salmonella Typhimurium
    J Microbiol Biotechnol33, 1130-1140. PubMed  Europe PubMed DOI
  26. Xu,L., Henriksen,C., Mebus,V., Guerillot,R., Petersen,A., Jacques,N., Jiang,J.H., Derks,R.J.E., Sanchez-Lopez,E., Giera,M., Leeten,K., Stinear,T.P., Oury,C., Howden,B.P., Peleg,A.Y. and Frees,D.
    A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
    Antimicrob Agents Chemother67, e0032823-e0032823. PubMed  Europe PubMed DOI
  27. Xu,X., Zhang,L., Yang,T., Qiu,Z., Bai,L. and Luo,Y.
    Targeting caseinolytic protease P and its AAA1 chaperone for tuberculosis treatment
    Drug Discov Today28, 103508-103508. PubMed  Europe PubMed DOI  V
    28. 2022
  28. Burslem,G.M.
    BacPROTACs to basics: Targeted protein degradation in bacteria
    Cell185, 2203-2205. PubMed  Europe PubMed DOI
  29. Fatima,N.I., Fazili,K.M. and Bhat,N.H.
    Proteolysis dependent cell cycle regulation in Caulobacter crescentus
    Cell Div17, 3-3. PubMed  Europe PubMed DOI
  30. Gurung,V. and Biswas,I.
    ClpX/P-Dependent Degradation of Novel Substrates in Streptococcus mutans
    J Bacteriol204, e0059421-e0059421. PubMed  Europe PubMed DOI
  31. Kim,L., Lee,B.G., Kim,M., Kim,M.K., Kwon,D.H., Kim,H., Brotz-Oesterhelt,H., Roh,S.H. and Song,H.K.
    Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis
    EMBO J41, e109755-e109755. PubMed  Europe PubMed DOI
  32. Mabanglo,M.F. and Houry,W.A.
    Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules
    J Biol Chem298, 101781-101781. PubMed  Europe PubMed DOI  V
  33. Mahmoud,S.A., Aldikacti,B. and Chien,P.
    ATP hydrolysis tunes specificity of a AAA+ protease
    Cell Rep40, 111405-111405. PubMed  Europe PubMed DOI
  34. Morreale,F.E., Kleine,S., Leodolter,J., Junker,S., Hoi,D.M., Ovchinnikov,S., Okun,A., Kley,J., Kurzbauer,R., Junk,L., Guha,S., Podlesainski,D., Kazmaier,U., Boehmelt,G., Weinstabl,H., Rumpel,K., Schmiedel,V.M., Hartl,M., Haselbach,D., Meinhart,A., Kaiser,M. and Clausen,T.
    BacPROTACs mediate targeted protein degradation in bacteria
    Cell185, 2338-2353. PubMed  Europe PubMed DOI
  35. Wei,B., Zhang,T., Wang,P., Pan,Y., Li,J., Chen,W., Zhang,M., Ji,Q., Wu,W., Lan,L., Gan,J. and Yang,C.G.
    Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP
    Nat Commun13, 6909-6909. PubMed  Europe PubMed DOI
    36. 2021
  36. Bishop,C.E., Shadid,T.M., Lavey,N.P., Kempher,M.L., Ballard,J.D. and Duerfeldt,A.S.
    Identification of ClpP Dual Isoform Disruption as an Anti-sporulation Strategy for Clostridioides difficile
    J BacteriolJB0041121-JB0041121. PubMed  Europe PubMed DOI
  37. Feng,Y., Nouri,K. and Schimmer,A.D.
    Mitochondrial ATP-Dependent Proteases-Biological Function and Potential Anti-Cancer Targets
    Cancers (Basel)13, PubMed  Europe PubMed DOI
  38. Kang,Z.H., Liu,Y.T., Gou,Y., Deng,Q.R., Hu,Z.Y. and Li,G.R.
    Progress and prospect of single-molecular ClpX ATPase researching system-a mini-review
    Gene774, 145420-145420. PubMed  Europe PubMed DOI
  39. Rizzolo,K., Yu,A.Y.H., Ologbenla,A., Kim,S.R., Zhu,H., Ishimori,K., Thibault,G., Leung,E., Zhang,Y.W., Teng,M., Haniszewski,M., Miah,N., Phanse,S., Minic,Z., Lee,S., Caballero,J.D., Babu,M., Tsai,F.T.F., Saio,T. and Houry,W.A.
    Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
    Nat Commun12, 281-281. PubMed  Europe PubMed DOI
  40. Rizzolo,K., Yu,A.Y.H., Ologbenla,A., Kim,S.R., Zhu,H., Ishimori,K., Thibault,G., Leung,E., Zhang,Y.W., Teng,M., Haniszewski,M., Miah,N., Phanse,S., Minic,Z., Lee,S., Caballero,J.D., Babu,M., Tsai,F.T.F., Saio,T. and Houry,W.A.
    Author Correction: Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex
    Nat Commun12, 2753-2753. PubMed  Europe PubMed DOI
  41. Yeom,J. and Groisman,E.A.
    Low cytoplasmic magnesium increases the specificity of the Lon and ClpAP proteases
    J Bacteriol203, e0014321-e0014321. PubMed  Europe PubMed DOI
  42. Zou,L., Evans,C.R., Do,V.D., Losefsky,Q.P., Ngo,D.Q. and McGillivray,S.M.
    Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne
    Front Microbiol12, 719548-719548. PubMed  Europe PubMed DOI
    43. 2020
  43. Binepal,G., Mabanglo,M.F., Goodreid,J.D., Leung,E., Barghash,M.M., Wong,K.S., Lin,F., Cossette,M., Bansagi,J., Song,B., Balasco Serrao,V.H., Pai,E.F., Batey,R.A., Gray-Owen,S.D. and Houry,W.A.
    Development of Antibiotics That Dysregulate the Neisserial ClpP Protease
    ACS Infect Dis6, 3224-3236. PubMed  Europe PubMed DOI
  44. Eyermann,B., Meixner,M., Brotz-Oesterhelt,H., Antes,I. and Sieber,S.A.
    Acyldepsipeptide probes facilitate specific detection of caseinolytic protease P independent of its oligomeric and activity state
    Chembiochem21, 235-240. PubMed  Europe PubMed DOI
  45. Fei,X., Bell,T.A., Jenni,S., Stinson,B.M., Baker,T.A., Harrison,S.C. and Sauer,R.T.
    Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate
    elife9, PubMed  Europe PubMed DOI  S
  46. Fei,X., Bell,T.A., Barkow,S.R., Baker,T.A. and Sauer,R.T.
    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates
    elife9, PubMed  Europe PubMed DOI
  47. Ju,Y., He,L., Zhou,Y., Yang,T., Sun,K., Song,R., Yang,Y., Li,C., Sang,Z., Bao,R. and Luo,Y.
    Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo
    J Med Chem63, 3104-3119. PubMed  Europe PubMed DOI  I
  48. Kim,S., Zuromski,K.L., Bell,T.A., Sauer,R.T. and Baker,T.A.
    ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
    elife9, PubMed  Europe PubMed DOI
  49. Kotamarthi,H.C., Sauer,R.T. and Baker,T.A.
    The non-dominant AAA+ ring in the ClpAP protease functions as an anti-stalling motor to accelerate protein unfolding and translocation
    Cell Rep30, 2644-2654. PubMed  Europe PubMed DOI
  50. LaBreck,C.J., Trebino,C.E., Ferreira,C.N., Morrison,J.J., DiBiasio,E.C., Conti,J. and Camberg,J.L.
    Degradation of MinD oscillator complexes by Escherichia coli ClpXP
    J Biol Chem PubMed  Europe PubMed DOI
  51. Lakshmanan,A., Jin,Z., Nety,S.P., Sawyer,D.P., Lee-Gosselin,A., Malounda,D., Swift,M.B., Maresca,D. and Shapiro,M.G.
    Acoustic biosensors for ultrasound imaging of enzyme activity
    Nat Chem Biol PubMed  Europe PubMed DOI
  52. Li,Y., Corro,J.H., Palmer,C.D. and Ojha,A.K.
    Progression from remodeling to hibernation of ribosomes in zinc-starved mycobacteria
    Proc Natl Acad Sci U S A117, 19528-19537. PubMed  Europe PubMed DOI
  53. Lopez,K.E., Rizo,A.N., Tse,E., Lin,J., Scull,N.W., Thwin,A.C., Lucius,A.L., Shorter,J. and Southworth,D.R.
    Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis
    Nat Struct Mol Biol27, 406-416. PubMed  Europe PubMed DOI  S
  54. Malik,I.T., Pereira,R., Vielberg,M.T., Mayer,C., Straetener,J., Thomy,D., Famulla,K., Castro,H., Sass,P., Groll,M. and Brotz-Oesterhelt,H.
    Functional characterisation of ClpP mutations conferring resistance to acyldepsipeptide antibiotics in Firmicutes
    Chembiochem PubMed  Europe PubMed DOI
  55. Mellergaard,M., Hogh,R.I., Lund,A., Aldana,B.I., Guerillot,R., Moller,S.H., Hayes,A.S., Panagiotopoulou,N., Frimand,Z., Jepsen,S.D., Hansen,C.H.F., Andresen,L., Larsen,A.R., Peleg,A.Y., Stinear,T.P., Howden,B.P., Waagepetersen,H.S., Frees,D. and Skov,S.
    Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes
    J Biol Chem PubMed  Europe PubMed DOI
  56. Micevski,D., Zeth,K., Mulhern,T.D., Schuenemann,V.J., Zammit,J.E., Truscott,K.N. and Dougan,D.A.
    Insight into the RssB-mediated recognition and delivery of sigma(s) to the AAA+ protease, ClpXP
    Biomolecules10, PubMed  Europe PubMed DOI
  57. Saunders,R.A., Stinson,B.M., Baker,T.A. and Sauer,R.T.
    Multistep substrate binding and engagement by the AAA+ ClpXP protease
    Proc Natl Acad Sci U S A117, 28005-28013. PubMed  Europe PubMed DOI
  58. Schelin,J., Cohn,M.T., Frisk,B. and Frees,D.
    A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec
    Toxins (Basel)12, PubMed  Europe PubMed DOI
  59. Sen,A., Zhou,Y. and Imlay,J.A.
    During oxidative stress the Clp proteins of Escherichia coli ensure that iron pools remain sufficient to reactivate oxidized metalloenzymes
    J Bacteriol202, e00235-20-e00235-20. PubMed  Europe PubMed DOI
  60. Sha,Z., Chilakala,S., Crabill,G., Cheng,I., Xu,Y., Fishovitz,J. and Lee,I.
    A proteolytic site-directed affinity label to inhibit the human ATP-dependent protease caseinolytic complex XP
    Chembiochem21, 2049-2059. PubMed  Europe PubMed DOI  I
  61. Silber,N., Pan,S., Schakermann,S., Mayer,C., Brotz-Oesterhelt,H. and Sass,P.
    Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
    MBio11, PubMed  Europe PubMed DOI
  62. Tremblay,C.Y., Vass,R.H., Vachet,R.W. and Chien,P.
    The Cleavage Profile of Protein Substrates by ClpXP Reveals Deliberate Starts and Pauses
    Biochemistry59, 4294-4301. PubMed  Europe PubMed DOI
  63. Tsai,F.T. and Hill,C.P.
    Same structure, different mechanisms?
    elife9, PubMed  Europe PubMed DOI  S
  64. Zheng,D., Xu,Y., Yuan,G., Wu,X. and Li,Q.
    Bacterial ClpP Protease Is a Potential Target for Methyl Gallate
    Front Microbiol11, 598692-598692. PubMed  Europe PubMed DOI
    65. 2019
  65. Felix,J., Weinhaupl,K., Chipot,C., Dehez,F., Hessel,A., Gauto,D.F., Morlot,C., Abian,O., Gutsche,I., Velazquez-Campoy,A., Schanda,P. and Fraga,H.
    Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
    Sci Adv5, eaaw3818-eaaw3818. PubMed  Europe PubMed DOI  I
  66. Fetzer,C., Korotkov,V.S. and Sieber,S.A.
    Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains
    Org Biomol Chem17, 7124-7127. PubMed  Europe PubMed DOI  I
  67. Fux,A., Korotkov,V.S., Schneider,M., Antes,I. and Sieber,S.A.
    Chemical cross-linking enables drafting ClpXP proximity maps and taking snapshots of in situ interaction networks
    Cell Chem Biol26, 48-59. PubMed  Europe PubMed DOI
  68. Gatsogiannis,C., Balogh,D., Merino,F., Sieber,S.A. and Raunser,S.
    Cryo-EM structure of the ClpXP protein degradation machinery
    Nat Struct Mol Biol26, 946-954. PubMed  Europe PubMed DOI  S
  69. Griffith,E.C., Zhao,Y., Singh,A.P., Conlon,B.P., Tangallapally,R., Shadrick,W.R., Liu,J., Wallace,M.J., Yang,L., Elmore,J.M., Li,Y., Zheng,Z., Miller,D.J., Cheramie,M.N., Lee,R.B., LaFleur,M.D., Lewis,K. and Lee,R.E.
    Ureadepsipeptides as ClpP Activators
    ACS Infect Dis5, 1915-1925. PubMed  Europe PubMed DOI
  70. Lakemeyer,M., Bertosin,E., Moller,F., Balogh,D., Strasser,R., Dietz,H. and Sieber,S.A.
    Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer-hexamer assembly
    Angew Chem Int Ed Engl58, 7127-7132. PubMed  Europe PubMed DOI  I
  71. Lavey,N.P., Shadid,T., Ballard,J.D. and Duerfeldt,A.S.
    Clostridium difficile ClpP homologues are capable of uncoupled activity and exhibit different levels of susceptibility to acyldepsipeptide modulation
    ACS Infect Dis5, 79-89. PubMed  Europe PubMed DOI
  72. Mabanglo,M.F., Leung,E., Vahidi,S., Seraphim,T.V., Eger,B.T., Bryson,S., Bhandari,V., Zhou,J.L., Mao,Y.Q., Rizzolo,K., Barghash,M.M., Goodreid,J.D., Phanse,S., Babu,M., Barbosa,L.R.S., Ramos,C.H.I., Batey,R.A., Kay,L.E., Pai,E.F. and Houry,W.A.
    ClpP protease activation results from the reorganization of the electrostatic interaction networks at the entrance pores
    Commun Biol2, 410-410. PubMed  Europe PubMed DOI
  73. Montandon,C., Dougan,D.A. and van Wijk,K.J.
    N-Degron specificity of chloroplast ClpS1 in plants
    FEBS Lett593, 962-970. PubMed  Europe PubMed DOI  P
  74. Moreno-Cinos,C., Sassetti,E., Salado,I.G., Witt,G., Benramdane,S., Reinhardt,L., Cruz,C.D., Joossens,J., Van der Veken,P., Brotz-Oesterhelt,H., Tammela,P., Winterhalter,M., Gribbon,P., Windshugel,B. and Augustyns,K.
    alpha-Amino diphenyl phosphonates as novel inhibitors of Escherichia coli ClpP protease
    J Med Chem62, 774-797. PubMed  Europe PubMed DOI  I
  75. Moreno-Cinos,C., Goossens,K., Salado,I.G., Van der Veken,P., De Winter,H. and Augustyns,K.
    ClpP Protease, a promising antimicrobial target
    Int J Mol Sci20, PubMed  Europe PubMed DOI
  76. Mroue,N., Arya,A., Brown Gandt,A., Russell,C., Han,A., Gavrish,E. and LaFleur,M.
    Pharmacodynamics of ClpP activating antibiotic combinations against Gram-positive pathogens
    Antimicrob Agents Chemother64, e01554-19-e01554-19. PubMed  Europe PubMed DOI
  77. Pan,S., Malik,I.T., Thomy,D., Henrichfreise,B. and Sass,P.
    The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci
    Sci Rep9, 14129-14129. PubMed  Europe PubMed DOI
  78. Sivertsson,E.M., Jackson,S.E. and Itzhaki,L.S.
    The AAA+ protease ClpXP can easily degrade a 31 and a 52-knotted protein
    Sci Rep9, 2421-2421. PubMed  Europe PubMed DOI
  79. Tan,J., Grouleff,J.J., Jitkova,Y., Diaz,D.B., Griffith,E.C., Shao,W., Bogdanchikova,A.F., Poda,G., Schimmer,A.D., Lee,R.E. and Yudin,A.K.
    De novo design of boron-based peptidomimetics as potent inhibitors of human ClpP in the presence of human ClpX
    J Med Chem62, 6377-6390. PubMed  Europe PubMed DOI  I
  80. Wang,H. and Bowman,G.R.
    SpbR overproduction reveals the importance of proteolytic degradation for cell pole development and chromosome segregation in Caulobacter crescentus
    Mol Microbiol111, 1700-1714. PubMed  Europe PubMed DOI
    81. 2018
  81. Abeywansha,T., Chai,Q., Zhang,X., Wang,Z. and Wei,Y.
    Accessibility from the cytoplasm is critical for ssrA tag-mediated degradation of integral membrane proteins by ClpXP protease
    Biochemistry57, 5602-5608. PubMed  Europe PubMed DOI
  82. Dubiel,A., Wegrzyn,K., Kupinski,A.P. and Konieczny,I.
    ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
    Sci Rep8, 15287-15287. PubMed  Europe PubMed DOI
  83. Eom,G.E. and Kim,S.
    Identification of nucleophilic probes for protease-mediated transpeptidation
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