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Literature for peptidase S10.001: carboxypeptidase Y

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, I Inhibitor, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Putman,J.I., Patel,A., Olds,M., Aziz,A., Asokan-Sheeja,H., Dong,H., Johnson-Winters,K.L. and Armstrong,D.W.
    Kinetic investigation on d-amino acid containing peptides and carboxypeptidase Y
    Arch Biochem Biophys (2025) 776, 110699-110699. PubMed  Europe PubMed DOI
    2. 2019
  2. Makino,M., Sahara,T., Morita,N. and Ueno,H.
    Carboxypeptidase Y activity and maintenance is modulated by a large helical structure
    FEBS Open Bio (2019) 9, 1337-1343. PubMed  Europe PubMed DOI
    3. 2018
  3. Beekman,C., Jiang,Z., Suzuki,B.M., Palmer,J.M., Lindner,D.L., O'Donoghue,A.J., Knudsen,G.M. and Bennett,R.J.
    Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of white-nose syndrome
    Biol Chem (2018) 399, 1375-1388. PubMed  Europe PubMed DOI
  4. Parzych,K.R., Ariosa,A., Mari,M. and Klionsky,D.J.
    A newly characterized vacuolar serine carboxypeptidase, Atg42/Ybr139w, is required for normal vacuole function and the terminal steps of autophagy in the yeast Saccharomyces cerevisiae
    Mol Biol Cell (2018) 29, 1089-1099. PubMed  Europe PubMed DOI  K
    5. 2017
  5. B S,G.K. and Surolia,A.
    N-Glycosylation analysis of yeast carboxypeptidase Y reveals the ultimate removal of phosphate from glycans at Asn368
    Int J Biol Macromol (2017) 98, 582-585. PubMed  Europe PubMed DOI
    6. 2016
  6. Duan,W., Zhang,Y. and Xu,G.
    Optimization and application of protein C-terminal labeling by carboxypeptidase Y
    Sheng Wu Gong Cheng Xue Bao (2016) 32, 135-148. PubMed  Europe PubMed
  7. Sepulveda-Gonzalez,M.E., Parra-Ortega,B., Betancourt-Cervantes,Y., Hernandez-Rodriguez,C., Xicohtencatl-Cortes,J. and Villa-Tanaca,L.
    Vacuolar proteases from Candida glabrata: acid aspartic protease PrA, neutral serine protease PrB and serine carboxypeptidase CpY. The nitrogen source influences their level of expression
    Rev Iberoam Micol (2016) 33, 26-33. PubMed  Europe PubMed DOI
  8. Tian,M., Zhang,N., Liu,X., Guo,L. and Yang,L.
    Sequential on-line C-terminal sequencing of peptides based on carboxypeptidase Y digestion and optically gated capillary electrophoresis with laser-induced fluorescence detection
    J Chromatogr A (2016) 1459, 152-159. PubMed  Europe PubMed DOI
    9. 2015
  9. Yu,X., Zhai,C., Zhong,X., Tang,W., Wang,X., Yang,H., Chen,W. and Ma,L.
    High-level expression and characterization of carboxypeptidase Y from Saccharomyces cerevisiae in Pichia pastoris GS115
    Biotechnol Lett (2015) 37, 161-167. PubMed  Europe PubMed DOI  E
    10. 2014
  10. Hecht,K.A., O'Donnell,A.F. and Brodsky,J.L.
    The proteolytic landscape of the yeast vacuole
    Cell Logist (2014) 4, e28023-e28023. PubMed  Europe PubMed DOI  PMC  EPMC  P
  11. Shin,S.Y., Bae,Y.H., Kim,S.K., Seong,Y.J., Choi,S.H., Kim,K.H., Park,Y.C. and Seo,J.H.
    Effects of signal sequences and folding accessory proteins on extracellular expression of carboxypeptidase Y in recombinant Saccharomyces cerevisiae
    Bioprocess Biosyst Eng (2014) 37, 1065-1071. PubMed  Europe PubMed DOI  E
    12. 2012
  12. Mortensen,U.H., Olesen,K. and Breddam,K.
    Carboxypeptidase C including carboxypeptidase Y
    [ISSN:978-0-12-407742-3] (2012) 3, 3408-3412. DOI
  13. Nagayama,M., Kuroda,K. and Ueda,M.
    Identification of interaction site of propeptide toward mature carboxypeptidase Y (mCPY) based on the similarity between propeptide and CPY Inhibitor (IC)
    Biosci Biotechnol Biochem (2012) 76, 153-156. PubMed  Europe PubMed DOI
    14. 2011
  14. Mukaiyama,H., Iwaki,T., Idiris,A. and Takegawa,K.
    Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe
    Appl Microbiol Biotechnol (2011) 90, 203-213. PubMed  Europe PubMed DOI
  15. Takahashi,S., Ono,H., Gotoh,T., Yoshizawa-Kumagaye,K. and Sugiyama,T.
    Novel internally quenched fluorogenic substrates for angiotensin I-converting enzyme and carboxypeptidase Y
    Biomed Res (2011) 32, 407-411. PubMed  Europe PubMed DOI  A
    16. 2009
  16. Maeda,H., Nagayama,M., Kuroda,K. and Ueda,M.
    Purification of inactive precursor of carboxypeptidase Y using selective cleavage method coupled with molecular display
    Biosci Biotechnol Biochem (2009) 73, 753-755. PubMed  Europe PubMed DOI  E
    17. 2006
  17. [YEAR:4-4-2006]Kato,M., Kuzuhara,Y., Maeda,H., Shiraga,S. and Ueda,M.
    Analysis of a processing system for proteases using yeast cell surface engineering: conversion of precursor of proteinase A to active proteinase A
    Appl Microbiol Biotechnol (4-4-2006) 72, 1229-1237. PubMed  Europe PubMed DOI
  18. Yoshida,T., Lepp,Z., Kadota,Y., Satoh,Y., Itoh,K. and Chuman,H.
    Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation
    J Chem Inf Model (2006) 46, 2093-2103. PubMed  Europe PubMed DOI  I
    19. 2004
  19. Mortensen,U.H., Olesen,K. and Breddam,K.
    Serine carboxypeptidase C including carboxypeptidase Y
    [ISSN:0-12-079610-4] (2004) 2, 1919-1923.  V
    20. 2003
  20. Kato,M., Sato,Y., Shirai,K., Hayashi,R., Balny,C. and Lange,R.
    The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure
    Eur J Biochem (2003) 270, 4587-4593. PubMed  Europe PubMed DOI
  21. Okumura,R., Koizumi,Y. and Sekiya,J.
    Synthesis of hydroxymethylglutathione from glutathione and L-serine catalyzed by carboxypeptidase Y
    Biosci Biotechnol Biochem (2003) 67, 434-437. PubMed  Europe PubMed DOI
  22. Takegawa,K., Tokudomi,S., Bhuiyan,M.S., Tabuchi,M., Fujita,Y., Iwaki,T., Utsumi,S. and Tanaka,N.
    Heterologous expression and characterization of Schizosaccharomyces pombe vacuolar carboxypeptidase Y in Saccharomyces cerevisiae
    Curr Genet (2003) 42, 252-259. PubMed  Europe PubMed DOI
    23. 2002
  23. Kinsho,T., Ueno,H., Hayashi,R., Hashizume,C. and Kimura,K.
    Sub-zero temperature inactivation of carboxypeptidase Y under high hydrostatic pressure
    Eur J Biochem (2002) 269, 4666-4674. PubMed  Europe PubMed DOI
  24. Mima,J., Jung,G., Onizuka,T., Ueno,H. and Hayashi,R.
    Amphipathic property of free thiol group contributes to an increase inthe catalytic efficiency of carboxypeptidase Y
    Eur J Biochem (2002) 269, 3220-3225. PubMed  Europe PubMed DOI
    25. 2001
  25. Hahm,M.S. and Chung,B.H.
    Refolding and purification of yeast carboxypeptidase Y expressed as inclusion bodies in Escherichia coli
    Protein Expr Purif (2001) 22, 101-107. PubMed  Europe PubMed DOI  E  I
  26. [YEAR:5-5-2001]Kanosue,Y., Hiraga,Y., Kojima,S. and Ohkata,K.
    Kinetic evidence for the hydrophobic atmosphere of the catalytic cavity in carboxypeptidase Y based on a linear relationship between Michaelis-Menten constant Km and hydrophobicity of the substrates
    Chem Lett (Jpn) (5-5-2001) 2001, 418-419.
  27. Nakase,H., Murata,S., Ueno,H. and Hayashi,R.
    Substrate recognition mechanism of carboxypeptidase Y
    Biosci Biotechnol Biochem (2001) 65, 2465-2471. PubMed  Europe PubMed DOI
  28. Ohsumi,K., Matsuda,Y., Nakajima,H. and Kitamoto,K.
    Cloning and characterization of the cpyA gene encoding intracellular carboxypeptidase from Aspergillus nidulans
    Biosci Biotechnol Biochem (2001) 65, 1175-1180. PubMed  Europe PubMed DOI
    29. 1999
  29. Hahm,M.S., Bae,J.H., Choi,E.S. and Chung,B.H.
    In vitro activation of yeast pro-carboxypeptidase Y expressed as inclusion bodies in Escherichia coli
    Biotechnol Lett (1999) 21, 881-885.  E
  30. Jung,G., Ueno,H. and Hayashi,R.
    Carboxypeptidase Y: Structural basis for protein sorting and catalytic triad
    J Biochem (1999) 126, 1-6. PubMed  Europe PubMed
  31. [YEAR:18-1-1999]Mock,W.L. and Xu,D.
    Catalytic activity of carboxypeptidase B and of carboxypeptidase Y with anisylazoformyl substrates
    Bioorg Med Chem Lett (18-1-1999) 9, 187-192. PubMed  Europe PubMed DOI
    32. 1998
  32. Jung,G., Ueno,H. and Hayashi,R.
    Proton-relay system of carboxypeptidase Y as a sole catalytic site: studies on mutagenic replacement of His 397
    J Biochem (1998) 124, 446-450. PubMed  Europe PubMed  I
  33. Shiba,Y., Fukui,F., Ichikawa,K., Serizawa,N. and Yoshikawa,H.
    Process development for high-level secretory production of carboxypeptidase Y by Saccharomyces cerevisiae
    Appl Microbiol Biotechnol (1998) 50, 34-41. PubMed  Europe PubMed DOI  E
    34. 1997
  34. Olesen,K. and Breddam,K.
    Substrates with charged P1 residues are efficiently hydrolyzed by serine carboxypeptidases when S3-P1 interactions are facilitated
    Biochemistry (1997) 36, 12235-12241. PubMed  Europe PubMed DOI
  35. Sorensen,S.B. and Breddam,K.
    The specificity of carboxypeptidase Y may be altered by changing the hydrophobicity of the S1' binding pocket
    Protein Sci (1997) 6, 2227-2232. PubMed  Europe PubMed DOI  PMC  EPMC
    36. 1996
  36. Elsliger,M.A., Pshezhetsky,A.V., Vinogradova,M.V., Svedas,V.K. and Potier,M.
    Comparative modeling of substrate binding in the S1' subsite of serine carboxypeptidases from yeast, wheat, and human
    Biochemistry (1996) 35, 14899-14909. PubMed  Europe PubMed DOI
  37. Ohi,H., Ohtani,W., Okazaki,N., Furuhata,N. and Ohmura,T.
    Cloning and characterization of the Pichia pastoris PRC1 gene encoding carboxypeptidase Y
    Yeast (1996) 12, 31-40. PubMed  Europe PubMed DOI
  38. Olesen,K., Meldal,M. and Breddam,K.
    Extended subsite characterization of carboxypeptidase Y using substrates based on intramolecularly quenched fluorescence
    Protein Pept Lett (1996) 3, 67-74.
  39. Stennicke,H.R., Mortensen,U.H. and Breddam,K.
    Studies on the hydrolytic properties of (serine) carboxypeptidase Y
    Biochemistry (1996) 35, 7131-7141. PubMed  Europe PubMed DOI
  40. Stennicke,H.R., Henriksen,D.B. and Breddam,K.
    Evaluation of the significance of charge and length of side chain on the P'1-S'1 interactions in (serine) carboxypeptidase Y
    Protein Pept Lett (1996) 3, 75-80.  P
    41. 1995
  41. Olesen,K. and Breddam,K.
    Increase of the P1 Lys/Leu substrate preference of carboxypeptidase Y by rational design based on known primary and tertiary structures of serine carboxypeptidases
    Biochemistry (1995) 34, 15689-15699. PubMed  Europe PubMed
  42. Sorensen,S.B., Raaschou-Nielsen,M., Mortensen,U.H., Remington,S.J. and Breddam,K.
    Site-directed mutagenesis on (serine) carboxypeptidase Y from yeast. The significance of Thr60 and Met398 in hydrolysis and aminolysis reactions
    J Am Chem Soc (1995) 117, 5944-5950.
    43. 1994
  43. [YEAR:15-2-1994]Christensen,U.
    Effects of pH on carboxypeptidase-Y-catalyzed hydrolysis and aminolysis reactions
    Eur J Biochem (15-2-1994) 220, 149-153. PubMed  Europe PubMed
  44. Endrizzi,J.A., Breddam,K. and Remington,S.J.
    2.8-A structure of yeast serine carboxypeptidase
    Biochemistry (1994) 33, 11106-11120. PubMed  Europe PubMed  S  I
  45. Mortensen,U.H., Remington,S.J. and Breddam,K.
    Site-directed mutagenesis on (serine) carboxypeptidase Y. A hydrogen bond network stabilizes the transition state by interaction with the C-terminal carboxylate group of the substrate
    Biochemistry (1994) 33, 508-517. PubMed  Europe PubMed
  46. [YEAR:3-6-1994]Mortensen,U.H., Raaschou-Nielsen,M. and Breddam,K.
    Recognition of C-terminal amide groups by (serine) carboxypeptidase Y investigated by site-directed mutagenesis
    J Biol Chem (3-6-1994) 269, 15528-15532. PubMed  Europe PubMed
  47. Mortensen,U.H. and Breddam,K.
    A conserved glutamic acid bridge in serine carboxypeptidases, belonging to the alpha/beta hydrolase fold, acts as a pH-dependent protein-stabilizing element
    Protein Sci (1994) 3, 838-842. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Mortensen,U.H., Stennicke,H.R., Raaschou-Nielsen,M. and Breddam,K.
    Mechanistic study on carboxypeptidase Y-catalyzed transacylation reactions. Mutationally altered enzymes for peptide synthesis
    J Am Chem Soc (1994) 116, 34-41.
  49. Olesen,K., Mortensen,U.H., Aasmul-Olsen,S., Kielland-Brandt,M.C., Remington,S.J. and Breddam,K.
    The activity of carboxypeptidase Y toward substrates with basic P1 amino acid residues is drastically increased by mutational replacement of leucine 178
    Biochemistry (1994) 33, 11121-11126. PubMed  Europe PubMed DOI
  50. Remington,S.J. and Breddam,K.
    Carboxypeptidases C and D
    Methods Enzymol (1994) 244, 231-248. PubMed  Europe PubMed DOI  V
  51. Stennicke,H.R., Mortensen,U.H., Christensen,U., Remington,S.J. and Breddam,K.
    Effects of introduced aspartic and glutamic acid residues on the P'1 substrate specificity, pH dependence and stability of carboxypeptidase Y
    Protein Eng (1994) 7, 911-916. PubMed  Europe PubMed
  52. [YEAR:21-4-1994]Washio,K. and Ishikawa,K.
    Cloning and sequencing of the gene for type I carboxypeptidase in rice
    Biochim Biophys Acta (21-4-1994) 1199, 311-314. PubMed  Europe PubMed DOI
    53. 1993
  53. Olesen,K. and Kielland-Brandt,M.C.
    Altering substrate preference of carboxypeptidase Y by a novel strategy of mutagenesis eliminating wild type background
    Protein Eng (1993) 6, 409-415. PubMed  Europe PubMed
    54. 1987
  54. Blachly-Dyson,E. and Stevens,T.H.
    Yeast carboxypeptidase Y can be translocated and glycosylated without its amino-terminal signal sequence
    J Cell Biol (1987) 104, 1183-1191. PubMed  Europe PubMed  PMC  EPMC
  55. Valls,L.A., Hunter,C.P., Rothman,J.H. and Stevens,T.H.
    Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide
    Cell (1987) 48, 887-897. PubMed  Europe PubMed
  56. Winther,J.R. and Breddam,K.
    The free sulfhydryl group (Cys341) of carboxypeptidase Y: functional effects of mutational substitutions
    Carlsberg Res Commun (1987) 52, 263-273. DOI
    57. 1986
  57. Bech,L.M., Nielsen,J., Winther,J.R., Kielland-Brandt,M.C. and Breddam,K.
    Mutational replacement of methionine by arginine in the S1' substrate binding site of yeast carboxypeptidase
    Carlsberg Res Commun (1986) 51, 459-465. DOI
  58. Breddam,K.
    Serine carboxypeptidases. A review
    Carlsberg Res Commun (1986) 51, 83-128. DOI
    59. 1985
  59. [YEAR:15-11-1985]Kunugi,S., Fukuda,M. and Hayashi,R.
    Action of serine carboxypeptidases on endopeptidase substrates, peptide-4-methyl-coumaryl-7-amides
    Eur J Biochem (15-11-1985) 153, 37-40. PubMed  Europe PubMed  A
    60. 1981
  60. Hemmings,B.A., Zubenko,G.S., Hasilik,A. and Jones,E.W.
    Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae
    Proc Natl Acad Sci U S A (1981) 78, 435-439. PubMed  Europe PubMed  PMC  EPMC
    61. 1980
  61. [YEAR:9-9-1980]Fischer,E.P. and Holzer,H.
    Interaction of proteinases and their inhibitors from yeast. Activation of carboxypeptidase Y
    Biochim Biophys Acta (9-9-1980) 615, 187-198. PubMed  Europe PubMed
    62. 1979
  62. Bai,Y. and Hayashi,R.
    Properties of the single sulfhydryl group of carboxypeptidase Y. Effects of alkyl and aromatic mercurials on activities toward various synthetic substrates
    J Biol Chem (1979) 254, 8473-8479. PubMed  Europe PubMed
    63. 1978
  63. [YEAR:17-4-1978]Hasilik,A. and Tanner,W.
    Biosynthesis of the vacuolar yeast glycoprotein carboxypeptidase Y. Conversion of precursor into the enzyme
    Eur J Biochem (17-4-1978) 85, 599-608. PubMed  Europe PubMed
    64. 1977
  64. Hayashi,R.
    Carboxypeptidase Y in sequence determination of peptides
    Methods Enzymol (1977) 47, 84-93. PubMed  Europe PubMed DOI  V
    65. 1976
  65. [YEAR:18-10-1976]Hasilik,A. and Tanner,W.
    Biosynthesis of carboxypeptidase Y in yeast. Evidence for a precursor form of the glycoprotein
    Biochem Biophys Res Commun (18-10-1976) 72, 1430-1436. PubMed  Europe PubMed
  66. Hayashi,R.
    Carboxypeptidase Y
    Methods Enzymol (1976) 45, 568-587. PubMed  Europe PubMed DOI  V
  67. Johansen,J.T., Breddam,K. and Ottesen,M.
    Isolation of carboxypeptidase Y by affinity chromatography
    Carlsberg Res Commun (1976) 41, 1-14. DOI
    68. 1975
  68. Lenney,J.F.
    Three yeast proteins that specifically inhibit yeast proteases A, B, and C
    J Bacteriol (1975) 122, 1265-1273. PubMed  Europe PubMed  PMC  EPMC  I
    69. 1974
  69. Kuhn,R.W., Walsh,K.A. and Neurath,H.
    Isolation and partial characterization of an acid carboxypeptidase from yeast
    Biochemistry (1974) 13, 3871-3877. PubMed  Europe PubMed
    70. 1973
  70. [YEAR:10-4-1973]Hayashi,R., Moore,S. and Stein,W.H.
    Carboxypeptidase from yeast. Large scale preparation and the application to COOH-terminal analysis of peptides and proteins
    J Biol Chem (10-4-1973) 248, 2296-2302. PubMed  Europe PubMed
  71. [YEAR:25-12-1973]Hayashi,R., Moore,S. and Stein,W.H.
    Serine at the active center of yeast carboxypeptidase
    J Biol Chem (25-12-1973) 248, 8366-8369. PubMed  Europe PubMed
    72. 1972
  72. Hayashi,R., Hata,T. and Minami,Y.
    Yeast pro-proteinase C. 3. Activation by protein denaturants
    Agric Biol Chem (1972) 36, 621-629.
  73. Hayashi,R. and Hata,T.
    Yeast pro-proteinase C. 4. Activation by yeast proteinase A and activation mechanism
    Agric Biol Chem (1972) 36, 630-638.
  74. Hayashi,R. and Hata,T.
    Action of yeast proteinase C on synthetic peptides and poly-alpha, L-amino acids
    Biochim Biophys Acta (1972) 263, 673-679. PubMed  Europe PubMed
  75. Shaw,D.C. and Wells,J.R.
    Radiochemical determination of a unique sequence around the reactive serine residue of a di-isopropyl phosphorofluoridate- sensitive plant carboxypeptidase and a yeast peptidase
    Biochem J (1972) 128, 229-235. PubMed  Europe PubMed  PMC  EPMC
    76. 1969
  76. Hayashi,R., Oka,Y. and Hata,T.
    Yeast pro-proteinase C: Part II. Isolation and some physicochemical properties
    Agric Biol Chem (1969) 33, 196-206. DOI
    77. 1968
  77. Hayashi,R., Oka,Y., Doi,E. and Hata,T.
    Activation of intracellular proteinases of yeast. Part II. Activation and some properties of pro-proteinase C
    Agric Biol Chem (1968) 32, 367-373. DOI
  78. Hayashi,R., Oka,Y., Doi,E. and Hata,T.
    Activation of intracellular proteinases of yeast. Part I. Occurrences of inactive precursors of proteinases B and C and their activation
    Agric Biol Chem (1968) 32, 359-366. DOI
    79. 1967
  79. Doi,E., Hayashi,R. and Hata,T.
    Purification of yeast proteinases: part II. Purification and some properties of yeast proteinase C
    Agric Biol Chem (1967) 31, 160-169. DOI
  80. Hata,T., Hayashi,R. and Doi,E.
    Purification of yeast proteinases. I. Fractionation and some properties of the proteinases
    Agric Biol Chem (1967) 31, 150-159. DOI
  81. Hata,T., Hayashi,R. and Doi,E.
    Purification of yeast proteinases. Part III. Isolation and physicochemical properties of yeast proteinase A and C
    Agric Biol Chem (1967) 31, 357-367. DOI

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