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Literature for peptidase S08.121: cytotoxin SubAB

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Askari Badouei,M., Jajarmi,M., Narimani,A., Zahraei Salehi,T., Ghanbarpour,R., Nemati,A., Morabito,S. and Koochakzadeh,A.
    Distribution and molecular analysis of Subtilase cytotoxin gene (subAB) variants in Shiga toxin-producing Escherichia coli (STEC) isolated from different sources in Iran
    Vet Ital (2024) 60 PubMed  Europe PubMed DOI
    2. 2022
  2. Hama,S., Nakahara,M., Watanabe-Takahashi,M., Shimizu,E., Tsutsuki,H., Yahiro,K. and Nishikawa,K.
    Development of a novel tetravalent peptide that absorbs subtilase cytotoxin by targeting the receptor-binding B-subunit
    Biochem Biophys Res Commun (2022) 629, 95-100. PubMed  Europe PubMed DOI
  3. Sessler,K., Schmidt,H. and Barth,H.
    Novel Aspects of the SubA Subunit of the Subtilase Cytotoxin
    Toxins (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Tsutsuki,H., Zhang,T., Yahiro,K., Ono,K., Fujiwara,Y., Iyoda,S., Wei,F.Y., Monde,K., Seto,K., Ohnishi,M., Oshiumi,H., Akaike,T. and Sawa,T.
    Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection
    iScience (2022) 25, 104050-104050. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Tsutsuki,H., Zhang,T., Harada,A., Rahman,A., Ono,K., Yahiro,K., Niidome,T. and Sawa,T.
    Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells
    Biochem Biophys Res Commun (2020) 525, 1068-1073. PubMed  Europe PubMed DOI
  6. Tsutsuki,H., Ogura,K., Moss,J. and Yahiro,K.
    Host response to the subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli
    Microbiol Immunol (2020) 64, 657-665. PubMed  Europe PubMed DOI  V
  7. Yahiro,K., Ogura,K., Goto,Y., Iyoda,S., Kobayashi,T., Takeuchi,H., Ohnishi,M. and Moss,J.
    Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival
    Sci Rep (2020) 10, 18943-18943. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2018
  8. Yahiro,K., Nagasawa,S., Ichimura,K., Takeuchi,H., Ogura,K., Tsutsuki,H., Shimizu,T., Iyoda,S., Ohnishi,M., Iwase,H., Moss,J. and Noda,M.
    Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues
    Cell Death Discov (2018) 4, 22-22. PubMed  Europe PubMed DOI  PMC  EPMC  I
    9. 2017
  9. Tasara,T., Fierz,L., Klumpp,J., Schmidt,H. and Stephan,R.
    Draft genome sequences of five shiga toxin-producing Escherichia coli isolates harboring the new and recently described subtilase cytotoxin allelic variant subAB2-3
    Genome Announc (2017) 5 PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2016
  10. Hauser,E., Bruederle,M., Reich,C., Bruckbauer,A., Funk,J. and Schmidt,H.
    Subtilase contributes to the cytotoxicity of a Shiga toxin-producing Escherichia coli strain encoding three different toxins
    Int J Food Microbiol (2016) 217, 156-161. PubMed  Europe PubMed DOI
  11. Orden,J.A., Dominguez-Bernal,G., de la Fuente,R. and Carrion,J.
    Subtilase cytotoxin-encoding subAB2 variants in verotoxin-producing Escherichia coli strains isolated from goats and sheep
    Res Vet Sci (2016) 105, 74-76. PubMed  Europe PubMed DOI
  12. Tsutsuki,H., Yahiro,K., Ogura,K., Ichimura,K., Iyoda,S., Ohnishi,M., Nagasawa,S., Seto,K., Moss,J. and Noda,M.
    Subtilase cytotoxin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli induces stress granule formation
    Cell Microbiol (2016) 18, 1024-1040. PubMed  Europe PubMed DOI
    13. 2015
  13. Funk,J., Biber,N., Schneider,M., Hauser,E., Enzenmuller,S., Fortsch,C., Barth,H. and Schmidt,H.
    Cytotoxic and apoptotic effects of recombinant subtilase cytotoxin variants of shiga toxin-producing Escherichia coli
    Infect Immun (2015) 83, 2338-2349. PubMed  Europe PubMed DOI  E
  14. Nuesch-Inderbinen,M.T., Funk,J., Cernela,N., Tasara,T., Klumpp,J., Schmidt,H. and Stephan,R.
    Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga toxin-producing Escherichia coli strains isolated from wild ruminants and sheep differs from that of cattle and pigs and is predominated by the new allelic variant subAB2-2
    Int J Med Microbiol (2015) 305, 124-128. PubMed  Europe PubMed DOI
    15. 2014
  15. Nagasawa,S., Ogura,K., Tsutsuki,H., Saitoh,H., Moss,J., Iwase,H., Noda,M. and Yahiro,K.
    Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway
    Cell Microbiol (2014) 16, 1582-1601. PubMed  Europe PubMed DOI
  16. Wang,H., Rogers,T.J., Paton,J.C. and Paton,A.W.
    Differential effects of Escherichia coli subtilase cytotoxin and shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines
    Infect Immun (2014) 82, 3567-3579. PubMed  Europe PubMed DOI
  17. Yahiro,K., Tsutsuki,H., Ogura,K., Nagasawa,S., Moss,J. and Noda,M.
    DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy
    Infect Immun (2014) 82, 4899-4908. PubMed  Europe PubMed DOI
    18. 2013
  18. Gerhardt,E., Masso,M., Paton,A.W., Paton,J.C., Zotta,E. and Ibarra,C.
    Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21
    Infect Immun (2013) 81, 2931-2937. PubMed  Europe PubMed DOI
  19. Le Nours,J., Paton,A.W., Byres,E., Troy,S., Herdman,B.P., Johnson,M.D., Paton,J.C., Rossjohn,J. and Beddoe,T.
    Structural basis of subtilase cytotoxin SubAB assembly
    J Biol Chem (2013) 288, 27505-27516. PubMed  Europe PubMed DOI  S
  20. Michelacci,V., Tozzoli,R., Caprioli,A., Martinez,R., Scheutz,F., Grande,L., Sanchez,S. and Morabito,S.
    A new pathogenicity island carrying an allelic variant of the Subtilase cytotoxin is common among Shiga toxin producing Escherichia coli of human and ovine origin
    Clin Microbiol Infect (2013) 19, E149-E156. PubMed  Europe PubMed DOI
    21. 2012
  21. Ray,R., de Ridder,G.G., Eu,J.P., Paton,A.W., Paton,J.C. and Pizzo,S.V.
    The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling
    J Biol Chem (2012) 287, 32755-32769. PubMed  Europe PubMed DOI
  22. Tsutsuki,H., Yahiro,K., Suzuki,K., Suto,A., Ogura,K., Nagasawa,S., Ihara,H., Shimizu,T., Nakajima,H., Moss,J. and Noda,M.
    Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kappaB activation
    Infect Immun (2012) 80, 3939-3951. PubMed  Europe PubMed DOI
  23. Yahiro,K., Moss,J. and Noda,M.
    Subtilase cytotoxin (SubAB)
    [ISSN:978-0-12-407742-3] (2012) 3, 3155-3161. DOI
    24. 2011
  24. Furukawa,T., Yahiro,K., Tsuji,A.B., Terasaki,Y., Morinaga,N., Miyazaki,M., Fukuda,Y., Saga,T., Moss,J. and Noda,M.
    Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli
    Microb Pathog (2011) 50, 159-167. PubMed  Europe PubMed DOI
  25. Nakajima,S., Hiramatsu,N., Hayakawa,K., Saito,Y., Kato,H., Huang,T., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.
    Selective abrogation of BiP/GRP78 blunts activation of NF-kappaB through the ATF6 branch of the UPR: involvement of C/EBPbeta and mTOR-dependent dephosphorylation of Akt
    Mol Cell Biol (2011) 31, 1710-1718. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Wang,H., Paton,A.W., McColl,S.R. and Paton,J.C.
    In vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin
    Infect Immun (2011) 79, 1671-1679. PubMed  Europe PubMed DOI
  27. Yahiro,K., Satoh,M., Morinaga,N., Tsutsuki,H., Ogura,K., Nagasawa,S., Nomura,F., Moss,J. and Noda,M.
    Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells
    Infect Immun (2011) 79, 617-627. PubMed  Europe PubMed DOI
  28. Zhao,Y., Tian,T., Huang,T., Nakajima,S., Saito,Y., Takahashi,S., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.
    Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response
    Toxicol Sci (2011) 120, 79-86. PubMed  Europe PubMed DOI
    29. 2010
  29. Beddoe,T., Paton,A.W., Le Nours,J., Rossjohn,J. and Paton,J.C.
    Structure, biological functions and applications of the AB5 toxins
    Trends Biochem Sci (2010) 35, 411-418. PubMed  Europe PubMed DOI  V
  30. May,K.L., Paton,J.C. and Paton,A.W.
    Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak
    Infect Immun (2010) 78, 4691-4696. PubMed  Europe PubMed DOI
  31. Nakajima,S., Saito,Y., Takahashi,S., Hiramatsu,N., Kato,H., Johno,H., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.
    Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response
    Biochem Biophys Res Commun (2010) 397, 176-180. PubMed  Europe PubMed DOI
  32. Paton,A.W. and Paton,J.C.
    Escherichia coli subtilase cytotoxin
    Toxins (Basel) (2010) 2, 215-228. PubMed  Europe PubMed DOI  PMC  EPMC  P
  33. Tozzoli,R., Caprioli,A., Cappannella,S., Michelacci,V., Marziano,M.L. and Morabito,S.
    Production of the subtilase AB5 cytotoxin by Shiga toxin-negative Escherichia coli
    J Clin Microbiol (2010) 48, 178-183. PubMed  Europe PubMed DOI
  34. Wang,H., Paton,J.C., Thorpe,C.M., Bonder,C.S., Sun,W.Y. and Paton,A.W.
    Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli
    J Infect Dis (2010) 202, 1415-1423. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Yahiro,K., Morinaga,N., Moss,J. and Noda,M.
    Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling
    Microb Pathog (2010) 49, 153-163. PubMed  Europe PubMed DOI
    36. 2009
  36. Harama,D., Koyama,K., Mukai,M., Shimokawa,N., Miyata,M., Nakamura,Y., Ohnuma,Y., Ogawa,H., Matsuoka,S., Paton,A.W., Paton,J.C., Kitamura,M. and Nakao,A.
    A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response
    J Immunol (2009) 183, 1368-1374. PubMed  Europe PubMed DOI
  37. Hu,C.C., Dougan,S.K., Winter,S.V., Paton,A.W., Paton,J.C. and Ploegh,H.L.
    Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes
    J Exp Med (2009) 206, 2429-2440. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Kondo,Y., Tokuda,N., Fan,X., Yamashita,T., Honke,K., Takematsu,H., Togayachi,A., Ohta,M., Kotzusumi,Y., Narimatsu,H., Tajima,O. and Furukawa,K.
    Glycosphingolipids are not pivotal receptors for subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice
    Biochem Biophys Res Commun (2009) 378, 179-181. PubMed  Europe PubMed DOI
  39. Lofling,J.C., Paton,A.W., Varki,N.M., Paton,J.C. and Varki,A.
    A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome
    Kidney Int (2009) 76, 140-144. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Matsuura,G., Morinaga,N., Yahiro,K., Komine,R., Moss,J., Yoshida,H. and Noda,M.
    Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in Vero cells via mitochondrial membrane damage
    Infect Immun (2009) 77, 2919-2924. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Smith,R.D., Willett,R., Kudlyk,T., Pokrovskaya,I., Paton,A.W., Paton,J.C. and Lupashin,V.V.
    The COG complex, Rab6 and COPI define a novel golgi retrograde trafficking pathway that is exploited by SubAB toxin
    Traffic (2009) 10, 1502-1517. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Yamazaki,H., Hiramatsu,N., Hayakawa,K., Tagawa,Y., Okamura,M., Ogata,R., Huang,T., Nakajima,S., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.
    Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response
    J Immunol (2009) 183, 1480-1487. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2008
  43. Byres,E., Paton,A.W., Paton,J.C., Lofling,J.C., Smith,D.F., Wilce,M.C., Talbot,U.M., Chong,D.C., Yu,H., Huang,S., Chen,X., Varki,N.M., Varki,A., Rossjohn,J. and Beddoe,T.
    Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
    Nature (2008) 456, 648-652. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Chong,D.C., Paton,J.C., Thorpe,C.M. and Paton,A.W.
    Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP
    Cell Microbiol (2008) 10, 795-806. PubMed  Europe PubMed DOI
  45. Morinaga,N., Yahiro,K., Matsuura,G., Moss,J. and Noda,M.
    Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1
    Cell Microbiol (2008) 10, 921-929. PubMed  Europe PubMed DOI
  46. Wolfson,J.J., May,K.L., Thorpe,C.M., Jandhyala,D.M., Paton,J.C. and Paton,A.W.
    Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways
    Cell Microbiol (2008) 10, 1775-1786. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2007
  47. Morinaga,N., Yahiro,K., Matsuura,G., Watanabe,M., Nomura,F., Moss,J. and Noda,M.
    Two distinct cytotoxic activities of subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli
    Infect Immun (2007) 75, 488-496. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Wang,H., Paton,J.C. and Paton,A.W.
    Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB5 toxin that targets the endoplasmic reticulum
    J Infect Dis (2007) 196, 1093-1101. PubMed  Europe PubMed DOI
    49. 2006
  49. [YEAR:5-10-2006]Paton,A.W., Beddoe,T., Thorpe,C.M., Whisstock,J.C., Wilce,M.C., Rossjohn,J., Talbot,U.M. and Paton,J.C.
    AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
    Nature (5-10-2006) 443, 548-552. PubMed  Europe PubMed DOI  P
  50. Yahiro,K., Morinaga,N., Satoh,M., Matsuura,G., Tomonaga,T., Nomura,F., Moss,J. and Noda,M.
    Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin
    Mol Microbiol (2006) 62, 480-490. PubMed  Europe PubMed DOI
    51. 2005
  51. Talbot,U.M., Paton,J.C. and Paton,A.W.
    Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli
    Infect Immun (2005) 73, 4432-4436. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2004
  52. [YEAR:5-7-2004]Paton,A.W., Srimanote,P., Talbot,U.M., Wang,H. and Paton,J.C.
    A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli
    J Exp Med (5-7-2004) 200, 35-46. PubMed  Europe PubMed DOI  PMC  EPMC
    53. 2002
  53. Sandvig,K. and van Deurs,B.
    Membrane traffic exploited by protein toxins
    Annu Rev Cell Dev Biol (2002) 18, 1-24. PubMed  Europe PubMed DOI
    54. 2000
  54. Fan,E., Merritt,E.A., Verlinde,C.L. and Hol,W.G.
    AB(5) toxins: structures and inhibitor design
    Curr Opin Struct Biol (2000) 10, 680-686. PubMed  Europe PubMed DOI  V

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