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Literature for peptidase S08.121: cytotoxin SubAB

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Askari Badouei,M., Jajarmi,M., Narimani,A., Zahraei Salehi,T., Ghanbarpour,R., Nemati,A., Morabito,S. and Koochakzadeh,A.<br>Distribution and molecular analysis of Subtilase cytotoxin gene (subAB) variants in Shiga toxin-producing Escherichia coli (STEC) isolated from different sources in Iran<br>Vet Ital (2024) 60 PubMed  Europe PubMed DOI
    2. 2022
  2. Hama,S., Nakahara,M., Watanabe-Takahashi,M., Shimizu,E., Tsutsuki,H., Yahiro,K. and Nishikawa,K.<br>Development of a novel tetravalent peptide that absorbs subtilase cytotoxin by targeting the receptor-binding B-subunit<br>Biochem Biophys Res Commun (2022) 629, 95-100. PubMed  Europe PubMed DOI
  3. Sessler,K., Schmidt,H. and Barth,H.<br>Novel Aspects of the SubA Subunit of the Subtilase Cytotoxin<br>Toxins (Basel) (2022) 14 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Tsutsuki,H., Zhang,T., Yahiro,K., Ono,K., Fujiwara,Y., Iyoda,S., Wei,F.Y., Monde,K., Seto,K., Ohnishi,M., Oshiumi,H., Akaike,T. and Sawa,T.<br>Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection<br>iScience (2022) 25, 104050-104050. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2020
  5. Tsutsuki,H., Zhang,T., Harada,A., Rahman,A., Ono,K., Yahiro,K., Niidome,T. and Sawa,T.<br>Involvement of protein disulfide isomerase in subtilase cytotoxin-induced cell death in HeLa cells<br>Biochem Biophys Res Commun (2020) 525, 1068-1073. PubMed  Europe PubMed DOI
  6. Tsutsuki,H., Ogura,K., Moss,J. and Yahiro,K.<br>Host response to the subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli<br>Microbiol Immunol (2020) 64, 657-665. PubMed  Europe PubMed DOI  V
  7. Yahiro,K., Ogura,K., Goto,Y., Iyoda,S., Kobayashi,T., Takeuchi,H., Ohnishi,M. and Moss,J.<br>Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival<br>Sci Rep (2020) 10, 18943-18943. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2018
  8. Yahiro,K., Nagasawa,S., Ichimura,K., Takeuchi,H., Ogura,K., Tsutsuki,H., Shimizu,T., Iyoda,S., Ohnishi,M., Iwase,H., Moss,J. and Noda,M.<br>Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues<br>Cell Death Discov (2018) 4, 22-22. PubMed  Europe PubMed DOI  PMC  EPMC  I
    9. 2017
  9. Tasara,T., Fierz,L., Klumpp,J., Schmidt,H. and Stephan,R.<br>Draft genome sequences of five shiga toxin-producing Escherichia coli isolates harboring the new and recently described subtilase cytotoxin allelic variant subAB2-3<br>Genome Announc (2017) 5 PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2016
  10. Hauser,E., Bruederle,M., Reich,C., Bruckbauer,A., Funk,J. and Schmidt,H.<br>Subtilase contributes to the cytotoxicity of a Shiga toxin-producing Escherichia coli strain encoding three different toxins<br>Int J Food Microbiol (2016) 217, 156-161. PubMed  Europe PubMed DOI
  11. Orden,J.A., Dominguez-Bernal,G., de la Fuente,R. and Carrion,J.<br>Subtilase cytotoxin-encoding subAB2 variants in verotoxin-producing Escherichia coli strains isolated from goats and sheep<br>Res Vet Sci (2016) 105, 74-76. PubMed  Europe PubMed DOI
  12. Tsutsuki,H., Yahiro,K., Ogura,K., Ichimura,K., Iyoda,S., Ohnishi,M., Nagasawa,S., Seto,K., Moss,J. and Noda,M.<br>Subtilase cytotoxin produced by locus of enterocyte effacement-negative shiga-toxigenic Escherichia coli induces stress granule formation<br>Cell Microbiol (2016) 18, 1024-1040. PubMed  Europe PubMed DOI
    13. 2015
  13. Funk,J., Biber,N., Schneider,M., Hauser,E., Enzenmuller,S., Fortsch,C., Barth,H. and Schmidt,H.<br>Cytotoxic and apoptotic effects of recombinant subtilase cytotoxin variants of shiga toxin-producing Escherichia coli<br>Infect Immun (2015) 83, 2338-2349. PubMed  Europe PubMed DOI  E
  14. Nuesch-Inderbinen,M.T., Funk,J., Cernela,N., Tasara,T., Klumpp,J., Schmidt,H. and Stephan,R.<br>Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga toxin-producing Escherichia coli strains isolated from wild ruminants and sheep differs from that of cattle and pigs and is predominated by the new allelic variant subAB2-2<br>Int J Med Microbiol (2015) 305, 124-128. PubMed  Europe PubMed DOI
    15. 2014
  15. Nagasawa,S., Ogura,K., Tsutsuki,H., Saitoh,H., Moss,J., Iwase,H., Noda,M. and Yahiro,K.<br>Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway<br>Cell Microbiol (2014) 16, 1582-1601. PubMed  Europe PubMed DOI
  16. Wang,H., Rogers,T.J., Paton,J.C. and Paton,A.W.<br>Differential effects of Escherichia coli subtilase cytotoxin and shiga toxin 2 on chemokine and proinflammatory cytokine expression in human macrophage, colonic epithelial, and brain microvascular endothelial cell lines<br>Infect Immun (2014) 82, 3567-3579. PubMed  Europe PubMed DOI
  17. Yahiro,K., Tsutsuki,H., Ogura,K., Nagasawa,S., Moss,J. and Noda,M.<br>DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy<br>Infect Immun (2014) 82, 4899-4908. PubMed  Europe PubMed DOI
    18. 2013
  18. Gerhardt,E., Masso,M., Paton,A.W., Paton,J.C., Zotta,E. and Ibarra,C.<br>Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21<br>Infect Immun (2013) 81, 2931-2937. PubMed  Europe PubMed DOI
  19. Le Nours,J., Paton,A.W., Byres,E., Troy,S., Herdman,B.P., Johnson,M.D., Paton,J.C., Rossjohn,J. and Beddoe,T.<br>Structural basis of subtilase cytotoxin SubAB assembly<br>J Biol Chem (2013) 288, 27505-27516. PubMed  Europe PubMed DOI  S
  20. Michelacci,V., Tozzoli,R., Caprioli,A., Martinez,R., Scheutz,F., Grande,L., Sanchez,S. and Morabito,S.<br>A new pathogenicity island carrying an allelic variant of the Subtilase cytotoxin is common among Shiga toxin producing Escherichia coli of human and ovine origin<br>Clin Microbiol Infect (2013) 19, E149-E156. PubMed  Europe PubMed DOI
    21. 2012
  21. Ray,R., de Ridder,G.G., Eu,J.P., Paton,A.W., Paton,J.C. and Pizzo,S.V.<br>The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling<br>J Biol Chem (2012) 287, 32755-32769. PubMed  Europe PubMed DOI
  22. Tsutsuki,H., Yahiro,K., Suzuki,K., Suto,A., Ogura,K., Nagasawa,S., Ihara,H., Shimizu,T., Nakajima,H., Moss,J. and Noda,M.<br>Subtilase cytotoxin enhances Escherichia coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-kappaB activation<br>Infect Immun (2012) 80, 3939-3951. PubMed  Europe PubMed DOI
  23. Yahiro,K., Moss,J. and Noda,M.<br>Subtilase cytotoxin (SubAB)<br>[ISSN:978-0-12-407742-3] (2012) 3, 3155-3161. DOI
    24. 2011
  24. Furukawa,T., Yahiro,K., Tsuji,A.B., Terasaki,Y., Morinaga,N., Miyazaki,M., Fukuda,Y., Saga,T., Moss,J. and Noda,M.<br>Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli<br>Microb Pathog (2011) 50, 159-167. PubMed  Europe PubMed DOI
  25. Nakajima,S., Hiramatsu,N., Hayakawa,K., Saito,Y., Kato,H., Huang,T., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.<br>Selective abrogation of BiP/GRP78 blunts activation of NF-kappaB through the ATF6 branch of the UPR: involvement of C/EBPbeta and mTOR-dependent dephosphorylation of Akt<br>Mol Cell Biol (2011) 31, 1710-1718. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Wang,H., Paton,A.W., McColl,S.R. and Paton,J.C.<br>In vivo leukocyte changes induced by Escherichia coli subtilase cytotoxin<br>Infect Immun (2011) 79, 1671-1679. PubMed  Europe PubMed DOI
  27. Yahiro,K., Satoh,M., Morinaga,N., Tsutsuki,H., Ogura,K., Nagasawa,S., Nomura,F., Moss,J. and Noda,M.<br>Identification of subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells<br>Infect Immun (2011) 79, 617-627. PubMed  Europe PubMed DOI
  28. Zhao,Y., Tian,T., Huang,T., Nakajima,S., Saito,Y., Takahashi,S., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.<br>Subtilase cytotoxin activates MAP kinases through PERK and IRE1 branches of the unfolded protein response<br>Toxicol Sci (2011) 120, 79-86. PubMed  Europe PubMed DOI
    29. 2010
  29. Beddoe,T., Paton,A.W., Le Nours,J., Rossjohn,J. and Paton,J.C.<br>Structure, biological functions and applications of the AB5 toxins<br>Trends Biochem Sci (2010) 35, 411-418. PubMed  Europe PubMed DOI  V
  30. May,K.L., Paton,J.C. and Paton,A.W.<br>Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak<br>Infect Immun (2010) 78, 4691-4696. PubMed  Europe PubMed DOI
  31. Nakajima,S., Saito,Y., Takahashi,S., Hiramatsu,N., Kato,H., Johno,H., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.<br>Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response<br>Biochem Biophys Res Commun (2010) 397, 176-180. PubMed  Europe PubMed DOI
  32. Paton,A.W. and Paton,J.C.<br>Escherichia coli subtilase cytotoxin<br>Toxins (Basel) (2010) 2, 215-228. PubMed  Europe PubMed DOI  PMC  EPMC  P
  33. Tozzoli,R., Caprioli,A., Cappannella,S., Michelacci,V., Marziano,M.L. and Morabito,S.<br>Production of the subtilase AB5 cytotoxin by Shiga toxin-negative Escherichia coli<br>J Clin Microbiol (2010) 48, 178-183. PubMed  Europe PubMed DOI
  34. Wang,H., Paton,J.C., Thorpe,C.M., Bonder,C.S., Sun,W.Y. and Paton,A.W.<br>Tissue factor-dependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli<br>J Infect Dis (2010) 202, 1415-1423. PubMed  Europe PubMed DOI  PMC  EPMC
  35. Yahiro,K., Morinaga,N., Moss,J. and Noda,M.<br>Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling<br>Microb Pathog (2010) 49, 153-163. PubMed  Europe PubMed DOI
    36. 2009
  36. Harama,D., Koyama,K., Mukai,M., Shimokawa,N., Miyata,M., Nakamura,Y., Ohnuma,Y., Ogawa,H., Matsuoka,S., Paton,A.W., Paton,J.C., Kitamura,M. and Nakao,A.<br>A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response<br>J Immunol (2009) 183, 1368-1374. PubMed  Europe PubMed DOI
  37. Hu,C.C., Dougan,S.K., Winter,S.V., Paton,A.W., Paton,J.C. and Ploegh,H.L.<br>Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes<br>J Exp Med (2009) 206, 2429-2440. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Kondo,Y., Tokuda,N., Fan,X., Yamashita,T., Honke,K., Takematsu,H., Togayachi,A., Ohta,M., Kotzusumi,Y., Narimatsu,H., Tajima,O. and Furukawa,K.<br>Glycosphingolipids are not pivotal receptors for subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice<br>Biochem Biophys Res Commun (2009) 378, 179-181. PubMed  Europe PubMed DOI
  39. Lofling,J.C., Paton,A.W., Varki,N.M., Paton,J.C. and Varki,A.<br>A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome<br>Kidney Int (2009) 76, 140-144. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Matsuura,G., Morinaga,N., Yahiro,K., Komine,R., Moss,J., Yoshida,H. and Noda,M.<br>Novel subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli induces apoptosis in Vero cells via mitochondrial membrane damage<br>Infect Immun (2009) 77, 2919-2924. PubMed  Europe PubMed DOI  PMC  EPMC
  41. Smith,R.D., Willett,R., Kudlyk,T., Pokrovskaya,I., Paton,A.W., Paton,J.C. and Lupashin,V.V.<br>The COG complex, Rab6 and COPI define a novel golgi retrograde trafficking pathway that is exploited by SubAB toxin<br>Traffic (2009) 10, 1502-1517. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Yamazaki,H., Hiramatsu,N., Hayakawa,K., Tagawa,Y., Okamura,M., Ogata,R., Huang,T., Nakajima,S., Yao,J., Paton,A.W., Paton,J.C. and Kitamura,M.<br>Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response<br>J Immunol (2009) 183, 1480-1487. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2008
  43. Byres,E., Paton,A.W., Paton,J.C., Lofling,J.C., Smith,D.F., Wilce,M.C., Talbot,U.M., Chong,D.C., Yu,H., Huang,S., Chen,X., Varki,N.M., Varki,A., Rossjohn,J. and Beddoe,T.<br>Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin<br>Nature (2008) 456, 648-652. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Chong,D.C., Paton,J.C., Thorpe,C.M. and Paton,A.W.<br>Clathrin-dependent trafficking of subtilase cytotoxin, a novel AB5 toxin that targets the endoplasmic reticulum chaperone BiP<br>Cell Microbiol (2008) 10, 795-806. PubMed  Europe PubMed DOI
  45. Morinaga,N., Yahiro,K., Matsuura,G., Moss,J. and Noda,M.<br>Subtilase cytotoxin, produced by Shiga-toxigenic Escherichia coli, transiently inhibits protein synthesis of Vero cells via degradation of BiP and induces cell cycle arrest at G1 by downregulation of cyclin D1<br>Cell Microbiol (2008) 10, 921-929. PubMed  Europe PubMed DOI
  46. Wolfson,J.J., May,K.L., Thorpe,C.M., Jandhyala,D.M., Paton,J.C. and Paton,A.W.<br>Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways<br>Cell Microbiol (2008) 10, 1775-1786. PubMed  Europe PubMed DOI  PMC  EPMC
    47. 2007
  47. Morinaga,N., Yahiro,K., Matsuura,G., Watanabe,M., Nomura,F., Moss,J. and Noda,M.<br>Two distinct cytotoxic activities of subtilase cytotoxin produced by Shiga-toxigenic Escherichia coli<br>Infect Immun (2007) 75, 488-496. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Wang,H., Paton,J.C. and Paton,A.W.<br>Pathologic changes in mice induced by subtilase cytotoxin, a potent new Escherichia coli AB5 toxin that targets the endoplasmic reticulum<br>J Infect Dis (2007) 196, 1093-1101. PubMed  Europe PubMed DOI
    49. 2006
  49. [YEAR:5-10-2006]Paton,A.W., Beddoe,T., Thorpe,C.M., Whisstock,J.C., Wilce,M.C., Rossjohn,J., Talbot,U.M. and Paton,J.C.<br>AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP<br>Nature (5-10-2006) 443, 548-552. PubMed  Europe PubMed DOI  P
  50. Yahiro,K., Morinaga,N., Satoh,M., Matsuura,G., Tomonaga,T., Nomura,F., Moss,J. and Noda,M.<br>Identification and characterization of receptors for vacuolating activity of subtilase cytotoxin<br>Mol Microbiol (2006) 62, 480-490. PubMed  Europe PubMed DOI
    51. 2005
  51. Talbot,U.M., Paton,J.C. and Paton,A.W.<br>Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli<br>Infect Immun (2005) 73, 4432-4436. PubMed  Europe PubMed DOI  PMC  EPMC
    52. 2004
  52. [YEAR:5-7-2004]Paton,A.W., Srimanote,P., Talbot,U.M., Wang,H. and Paton,J.C.<br>A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli<br>J Exp Med (5-7-2004) 200, 35-46. PubMed  Europe PubMed DOI  PMC  EPMC
    53. 2002
  53. Sandvig,K. and van Deurs,B.<br>Membrane traffic exploited by protein toxins<br>Annu Rev Cell Dev Biol (2002) 18, 1-24. PubMed  Europe PubMed DOI
    54. 2000
  54. Fan,E., Merritt,E.A., Verlinde,C.L. and Hol,W.G.<br>AB(5) toxins: structures and inhibitor design<br>Curr Opin Struct Biol (2000) 10, 680-686. PubMed  Europe PubMed DOI  V

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