Literature for peptidase S08.044: subtilisin NAT

(Topics flags: S Structure, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Guo,L., Chen,Y., He,Z., Wang,Z., Chen,Q., Chen,J., Oz,F., Xu,Z. and Zeng,M.
   Genomic and Transcriptomic Analysis of Mutant Bacillus subtilis with Enhanced Nattokinase Production via ARTP Mutagenesis
   Foods14, PubMed  Europe PubMed DOI
2024
2. Jain,A., Sondhi,N., Singh,K. and Kaur,J.
   Heterologous expression of nattokinase in E. coli: Biochemical characterization and functional analysis of fibrin binding residues
   Arch Biochem Biophys757, 110026-110026. PubMed  Europe PubMed DOI
3. Muric,M., Nikolic,M., Todorovic,A., Jakovljevic,V. and Vucicevic,K.
   Comparative Cardioprotective Effectiveness: NOACs vs. Nattokinase-Bridging Basic Research to Clinical Findings
   Biomolecules14, PubMed  Europe PubMed DOI  V
2023
4. Modi,A., Raval,I., Doshi,P., Joshi,M., Joshi,C. and Patel,A.K.
   Heterologous expression of recombinant nattokinase in Escherichia coli BL21(DE3) and media optimization for overproduction of nattokinase using RSM
   Protein Expr Purif203, 106198-106198. PubMed  Europe PubMed DOI
5. Suzuki,K., Nakamura,M., Sato,N., Futamura,K., Matsunaga,K. and Yagami,A.
   Nattokinase (Bac s 1), a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto
   Allergol Int72, 279-285. PubMed  Europe PubMed DOI
2021
6. Xiao,S., Hu,D., Gao,Y., Ai,Y., Luo,S., Chen,S., Wang,B., Zhou,L., Dong,Y. and Wang,Y.
   Safety assessment of subtilisin QK in rats
   BMC Pharmacol Toxicol22, 38-38. PubMed  Europe PubMed DOI
7. Yang,M., Wu,J., Huang,Q. and Jia,Y.
   Probing the Role of Catalytic Triad on the Cleavage between Intramolecular Chaperone and NK Mature Peptide
   J Agric Food Chem69, 2348-2353. PubMed  Europe PubMed DOI
2020
8. Song,X., Yang,Y., Liang,N., Yang,F., Chen,S., Zhou,L., Zhou,K. and Wang,Y.
   Quantitative pharmacokinetic evaluation of subtilisin QK-2 after a bolus IV injection in a rat model using a novel sandwich enzyme-linked immunosorbent assay
   J Pharm Biomed Anal186, 113264-113264. PubMed  Europe PubMed DOI
2019
9. Liu,Z., Zheng,W., Ge,C., Cui,W., Zhou,L. and Zhou,Z.
   High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters
   BMC Microbiol19, 89-89. PubMed  Europe PubMed DOI  E
10. Liu,Z., Zhao,H., Han,L., Cui,W., Zhou,L. and Zhou,Z.
    Improvement of the acid resistance, catalytic efficiency, and thermostability of nattokinase by multisite-directed mutagenesis
    Biotechnol Bioeng116, 1833-1843. PubMed  Europe PubMed DOI
11. Pan,X., Liang,P., Teng,L., Ren,Y., Peng,J., Liu,W. and Yang,Y.
    Study on molecular mechanisms of nattokinase in pharmacological action based on label-free liquid chromatography-tandem mass spectrometry
    Food Sci Nutr7, 3185-3193. PubMed  Europe PubMed DOI
12. Sharma,C., Salem,G.E.M., Sharma,N., Gautam,P. and Singh,R.
    Thrombolytic potential of novel thiol-dependent fibrinolytic protease from Bacillus cereus RSA1
    Biomolecules10, PubMed  Europe PubMed DOI
13. Wu,H., Wang,H., Xu,F., Chen,J., Duan,L. and Zhang,F.
    Acute toxicity and genotoxicity evaluations of Nattokinase, a promising agent for cardiovascular diseases prevention
    Regul Toxicol Pharmacol103, 205-209. PubMed  Europe PubMed DOI  U
2018
14. Cui,W., Suo,F., Cheng,J., Han,L., Hao,W., Guo,J. and Zhou,Z.
    Stepwise modifications of genetic parts reinforce the secretory production of nattokinase in Bacillus subtilis
    Microb Biotechnol11, 930-942. PubMed  Europe PubMed DOI
15. Mohammadi,F., Nezafat,N., Berenjian,A., Negahdaripour,M., Zamani,M., Ghoshoon,M.B., Morowvat,M.H., Hemmati,S. and Ghasemi,Y.
    Extracellular production of a potent and chemically resistant nattokinase in immobilized Escherichia coli using response surface methodology
    Curr Pharm Biotechnol19, 856-868. PubMed  Europe PubMed DOI
16. Wu,C., Gao,C., Lu,S., Xu,X., Wen,N., Zhang,S. and Liu,M.
    Construction of polylysine dendrimer nanocomposites carrying nattokinase and their application in thrombolysis
    J Biomed Mater Res A106, 440-449. PubMed  Europe PubMed DOI  U
2017
17. Cai,D., Zhu,C. and Chen,S.
    Microbial production of nattokinase: current progress, challenge and prospect
    World J Microbiol Biotechnol33, 84-84. PubMed  Europe PubMed DOI  E
18. Selvarajan,E.
    Nattokinase: an updated critical review on challenges and perspectives
    Cardiovasc Hematol Agents Med Chem PubMed  Europe PubMed DOI  V  U
2016
19. Lampe,B.J. and English,J.C.
    Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto
    Food Chem Toxicol88, 87-99. PubMed  Europe PubMed DOI
20. Mao,R., Zhou,K., Han,Z. and Wang,Y.
    Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles
    Microb Cell Fact15, 80-80. PubMed  Europe PubMed DOI  E
21. Wei,G., Tian,N., Siezen,R., Schuppan,D. and Helmerhorst,E.J.
    Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease
    Am J Physiol Gastrointest Liver Physiol311, G571-G580. PubMed  Europe PubMed DOI
2015
22. Hitosugi,M., Hamada,K. and Misaka,K.
    Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with lifestyle diseases
    Int J Gen Med8, 41-46. PubMed  Europe PubMed DOI  U
23. Wei,X., Zhou,Y., Chen,J., Cai,D., Wang,D., Qi,G. and Chen,S.
    Efficient expression of nattokinase in Bacillus licheniformis: host strain construction and signal peptide optimization
    J Ind Microbiol Biotechnol42, 287-295. PubMed  Europe PubMed DOI  E
24. Weng,M., Deng,X., Bao,W., Zhu,L., Wu,J., Cai,Y., Jia,Y., Zheng,Z. and Zou,G.
    Improving the activity of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation
    Biochem Biophys Res Commun465, 580-586. PubMed  Europe PubMed DOI
2014
25. Dabbagh,F., Negahdaripour,M., Berenjian,A., Behfar,A., Mohammadi,F., Zamani,M., Irajie,C. and Ghasemi,Y.
    Nattokinase: production and application
    Appl Microbiol Biotechnol98, 9199-9206. PubMed  Europe PubMed DOI
26. Jia,Y., Cao,X., Deng,Y., Bao,W., Tang,C., Ding,H., Zheng,Z. and Zou,G.
    Four residues of propeptide are essential for precursor folding of nattokinase
    Acta Biochim Biophys Sin (Shanghai)46, 957-964. PubMed  Europe PubMed DOI
27. Xu,J., Du,M., Yang,X., Chen,Q., Chen,H. and Lin,D.H.
    Thrombolytic effects in vivo of nattokinase in a carrageenan-induced rat model of thrombosis
    Acta Haematol132, 247-253. PubMed  Europe PubMed DOI  U
2013
28. Yanagisawa,Y., Chatake,T., Naito,S., Ohsugi,T., Yatagai,C., Sumi,H., Kawaguchi,A., Chiba-Kamosida,K., Ogawa,M., Adachi,T. and Morimoto,Y.
    X-ray structure determination and deuteration of nattokinase
    J Synchrotron Radiat20, 875-879. PubMed  Europe PubMed DOI  S
2012
29. Graycar,T.P., Bott,R.R., Power,S.D. and Estell,D.A.
    Subtilisins
    [ISSN:978-0-12-407742-3]3, 3148-3155. DOI
2011
30. Yongjun,C., Wei,B., Shujun,J., Meizhi,W., Yan,J., Yan,Y., Zhongliang,Z. and Goulin,Z.
    Directed evolution improves the fibrinolytic activity of nattokinase from Bacillus natto
    FEMS Microbiol Lett325, 155-161. PubMed  Europe PubMed DOI
2010
31. Jia,Y., Liu,H., Bao,W., Weng,M., Chen,W., Cai,Y., Zheng,Z. and Zou,G.
    Functional analysis of propeptide as an intramolecular chaperone for in vivo folding of subtilisin nattokinase
    FEBS Lett584, 4789-4796. PubMed  Europe PubMed DOI
2009
32. Hsia,C.H., Shen,M.C., Lin,J.S., Wen,Y.K., Hwang,K.L., Cham,T.M. and Yang,N.C.
    Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects
    Nutr Res29, 190-196. PubMed  Europe PubMed DOI
33. Hsu,R.L., Lee,K.T., Wang,J.H., Lee,L.Y. and Chen,R.P.
    Amyloid-degrading ability of nattokinase from Bacillus subtilis Natto
    J Agric Food Chem57, 503-508. PubMed  Europe PubMed DOI  U
34. Ku,T.W., Tsai,R.L. and Pan,T.M.
    A simple and cost-saving approach to optimize the production of subtilisin NAT by submerged cultivation of Bacillus subtilis Natto
    J Agric Food Chem57, 292-296. PubMed  Europe PubMed DOI
35. Weng,M., Zheng,Z., Bao,W., Cai,Y., Yin,Y. and Zou,G.
    Enhancement of oxidative stability of the subtilisin nattokinase by site-directed mutagenesis expressed in Escherichia coli
    Biochim Biophys Acta1794, 1566-1572. PubMed  Europe PubMed DOI
36. Yan,F., Yan,J., Sun,W., Yao,L., Wang,J., Qi,Y. and Xu,H.
    Thrombolytic effect of subtilisin QK on carrageenan induced thrombosis model in mice
    J Thromb Thrombolysis28, 444-448. PubMed  Europe PubMed DOI
2007
37. Wu,S., Feng,C., Zhong,J. and Huan,L.
    Roles of S3 site residues of nattokinase on its activity and substrate specificity
    J Biochem142, 357-364. PubMed  Europe PubMed DOI
2006
38. Pais,E., Alexy,T., Holsworth,R.E., Jr. and Meiselman,H.J.
    Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity
    Clin Hemorheol Microcirc35, 139-142. PubMed  Europe PubMed
39. Upadhyay,V.K., Kelly,A.L. and McSweeney,P.L.H.
    Use of nattokinase, a subtilisin-like serine proteinase, to accelerate proteolysis in Cheddar cheese during ripening
    Lait86, 227-240. DOI
40. [YEAR:17-1-2006]Zheng,Z.L., Ye,M.Q., Zuo,Z.Y., Liu,Z.G., Tai,K.C. and Zou,G.L.
    Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation
    Biochem J395, 509-515. PubMed  Europe PubMed DOI
2005
41. [YEAR:15-6-2005]Chiang,C.J., Chen,H.C., Chao,Y.P. and Tzen,J.T.
    Efficient system of artificial oil bodies for functional expression and purification of recombinant nattokinase in Escherichia coli
    J Agric Food Chem53, 4799-4804. PubMed  Europe PubMed DOI  E
42. Ko,J., Yan,J., Zhu,L. and Qi,Y.
    Subtilisin QK, a fibrinolytic enzyme, inhibits the exogenous nitrite and hydrogen peroxide induced protein nitration, in vitro and in vivo
    J Biochem Mol Biol38, 577-583. PubMed  Europe PubMed
2004
43. Graycar,T.P., Ballinger,M.D. and Wells,J.A.
    Subtilisins
    [ISSN:0-12-079610-4]2, 1786-1792.  V
2001
44. [YEAR:6-7-2001]Urano,T., Ihara,H., Umemura,K., Suzuki,Y., Oike,M., Akita,S., Tsukamoto,Y., Suzuki,I. and Takada,A.
    The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis cleaves and inactivates plasminogen activator inhibitor type 1
    J Biol Chem276, 24690-24696. PubMed  Europe PubMed DOI
1992
45. Nakamura,T., Yamagata,Y. and Ichishima,E.
    Nucleotide sequence of the subtilisin NAT gene, aprN, of Bacillus subtilis (natto)
    Biosci Biotechnol Biochem56, 1869-1871. PubMed  Europe PubMed
1989
46. Kamata,H., Yamagata,Y., Nakamura,T., Nakajima,T., Oda,K., Murao,S. and Ichishima,E.
    Characterization of the complex between alpha2-macroglobulin and a serine proteinase from Bacillus natto
    Agric Biol Chem53, 2695-2702. DOI