Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S08.019: lactocepin I

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout, P Specificity, I Inhibitor, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zawawi,N.F., Mubarik,N.R. and Ambarsari,L.
    Partial Purification, Characterisation and Gene Detection of Protease by Lacticaseibacillus paracasei IN17 from Inasua
    Trop Life Sci Res (2025) 36, 159-177. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Christensen,L.F., Hoie,M.H., Bang-Berthelsen,C.H., Marcatili,P. and Hansen,E.B.
    Comparative Structure Analysis of the Multi-Domain, Cell Envelope Proteases of Lactic Acid Bacteria
    Microorganisms (2023) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2020
  3. Hansen,E.B. and Marcatili,P.
    Modeled Structure of the Cell Envelope Proteinase of Lactococcus lactis
    Front Bioeng Biotechnol (2020) 8, 613986-613986. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2017
  4. Okondo,M.C., Johnson,D.C., Sridharan,R., Go,E.B., Chui,A.J., Wang,M.S., Poplawski,S.E., Wu,W., Liu,Y., Lai,J.H., Sanford,D.G., Arciprete,M.O., Golub,T.R., Bachovchin,W.W. and Bachovchin,D.A.
    DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis
    Nat Chem Biol (2017) 13, 46-53. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Guo,T., Ouyang,X., Xin,Y., Wang,Y., Zhang,S. and Kong,J.
    Characterization of a new cell envelope proteinase PrtP from Lactobacillus rhamnosus CGMCC11055
    J Agric Food Chem (2016) 64, 6985-6992. PubMed  Europe PubMed DOI  P
  6. Vukotic,G., Strahinic,I., Begovic,J., Lukic,J., Kojic,M. and Fira,D.
    Survey on proteolytic activity and diversity of proteinase genes in mesophilic lactobacilli
    Microbiology (2016) 85, 33-41. DOI
    7. 2015
  7. Borsting,M.W., Qvist,K.B., Brockmann,E., Vindelov,J., Pedersen,T.L., Vogensen,F.K. and Ardo,Y.
    Classification of Lactococcus lactis cell envelope proteinase based on gene sequencing, peptides formed after hydrolysis of milk, and computer modeling
    J Dairy Sci (2015) 98, 68-77. PubMed  Europe PubMed DOI
  8. Vukotic,G., Mirkovic,N., Jovcic,B., Miljkovic,M., Strahinic,I., Fira,D., Radulovic,Z. and Kojic,M.
    Proteinase PrtP impairs lactococcin LcnB activity in Lactococcus lactis BGMN1-501: new insights into bacteriocin regulation
    Front Microbiol (2015) 6, 92-92. PubMed  Europe PubMed DOI  PMC  EPMC  K
    9. 2013
  9. Griffiths,M.W. and Tellez,A.M.
    Lactobacillus helveticus: the proteolytic system
    Front Microbiol (2013) 4, 30-30. PubMed  Europe PubMed DOI  PMC  EPMC  V
  10. Hormannsperger,G., von Schillde,M.A. and Haller,D.
    Lactocepin as a protective microbial structure in the context of IBD
    Gut Microbes (2013) 4, 152-157. PubMed  Europe PubMed DOI
    11. 2012
  11. Broadbent,J.R. and Steele,J.L.
    Lactocepin: the cell envelope-associated endopeptidase of lactococci
    [ISSN:978-0-12-407742-3] (2012) 3, 3188-3195. DOI
  12. van Huynegem,K. and Steidler,L.
    Clinical development of lactocepin: a novel bacterial biologic?
    Expert Rev Clin Immunol (2012) 8, 597-599. PubMed  Europe PubMed DOI
  13. von Schillde,M.A., Hormannsperger,G., Weiher,M., Alpert,C.A., Hahne,H., Bauerl,C., van Huynegem,K., Steidler,L., Hrncir,T., Perez-Martinez,G., Kuster,B. and Haller,D.
    Lactocepin secreted by lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines
    Cell Host Microbe (2012) 11, 387-396. PubMed  Europe PubMed DOI  U
    14. 2011
  14. Lozo,J., Strahinic,I., Dalgalarrondo,M., Chobert,J.M., Haertle,T. and Topisirovic,L.
    Comparative analysis of beta-casein proteolysis by PrtP proteinase from Lactobacillus paracasei subsp. paracasei BGHN14, PrtR proteinase from Lactobacillus rhamnosus BGT10 and PrtH proteinase from Lactobacillus helveticus BGRA43
    Int Dairy J (2011) 21, 863-868. DOI  P
    15. 2009
  15. Nikolic,M., Tolinacki,M., Fira,D., Golic,N. and Topisirovic,L.
    Variation in specificity of the PrtP extracellular proteinases in Lactococcus lactis and Lactobacillus paracasei subsp. paracasei
    Folia Microbiol (Praha) (2009) 54, 188-194. PubMed  Europe PubMed DOI
    16. 2007
  16. Habimana,O., Le Goff,C., Juillard,V., Bellon-Fontaine,M.N., Buist,G., Kulakauskas,S. and Briandet,R.
    Positive role of cell wall anchored proteinase PrtP in adhesion of lactococci
    BMC Microbiol (2007) 7, 36-36. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2006
  17. Broadbent,J.R., Rodriguez,B.T., Joseph,P., Smith,E.A. and Steele,J.L.
    Conversion of Lactococcus lactis cell envelope proteinase specificity by partial allele exchange
    J Appl Microbiol (2006) 100, 1307-1317. PubMed  Europe PubMed DOI
    18. 2004
  18. Reid,J.R. and Coolbear,T.
    Lactocepin: the cell envelope-associated endopeptidase of lactococci
    [ISSN:0-12-079610-4] (2004) 2, 1803-1808.  V
    19. 2001
  19. Christensson,C., Pillidge,C.J., Ward,L.J.H. and O'Toole,P.W.
    Nucleotide sequence and characterization of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris HP
    J Appl Microbiol (2001) 91, 334-343. PubMed  Europe PubMed DOI
    20. 2000
  20. Bruinenberg,P.G., de Vos,W.M. and Siezen,R.J.
    Deletion of various carboxy-terminal domains of Lactococcus lactis SK11 proteinase: Effects on activity, specificity, and stability of the truncated enzyme
    Appl Environ Microbiol (2000) 66, 2859-2865. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Flambard,B. and Juillard,V.
    The autoproteolysis of Lactococcus lactis lactocepin III affects its specificity towards beta-casein
    Appl Environ Microbiol (2000) 66, 5134-5140. PubMed  Europe PubMed DOI  PMC  EPMC
    22. 1999
  22. Exterkate,F.A. and Alting,A.C.
    Role of calcium in activity and stability of the Lactococcus lactis cell envelope proteinase
    Appl Environ Microbiol (1999) 65, 1390-1396. PubMed  Europe PubMed  PMC  EPMC
  23. Reid,J.R. and Coolbear,T.
    Specificity of Lactococcus lactis subsp. cremoris SK11 proteinase, lactocepin III, in low-water-activity, high-salt- concentration humectant systems and its stability compared with that of lactocepin I
    Appl Environ Microbiol (1999) 65, 2947-2953. PubMed  Europe PubMed  PMC  EPMC
  24. Siezen,R.J.
    Multi-domain, cell-envelope proteinases of lactic acid bacteria
    Antonie Van Leeuwenhoek (1999) 76, 139-155. PubMed  Europe PubMed DOI
    25. 1998
  25. Kunji,E.R., Fang,G., Jeronimus-Stratingh,C.M., Bruins,A.P., Poolman,B. and Konings,W.N.
    Reconstruction of the proteolytic pathway for use of beta-casein by Lactococcus lactis
    Mol Microbiol (1998) 27, 1107-1118. PubMed  Europe PubMed DOI
  26. Reid,J.R. and Coolbear,T.
    Altered specificity of lactococcal proteinase P(I) (lactocepin I) in humectant systems reflecting the water activity and salt content of cheddar cheese
    Appl Environ Microbiol (1998) 64, 588-593. PubMed  Europe PubMed  PMC  EPMC
    27. 1995
  27. Juillard,V., Laan,H., Kunji,E.R., Jeronimus-Stratingh,C.M., Bruins,A.P. and Konings,W.N.
    The extracellular PI-type proteinase of Lactococcus lactis hydrolyzes beta-casein into more than one hundred different oligopeptides
    J Bacteriol (1995) 177, 3472-3478. PubMed  Europe PubMed  PMC  EPMC
  28. Reid,J.R., Coolbear,T., Moore,C.H., Harding,D.R. and Pritchard,G.G.
    Involvement of enzyme-substrate charge interactions in the caseinolytic specificity of lactococcal cell envelope-associated proteinases
    Appl Environ Microbiol (1995) 61, 3934-3939. PubMed  Europe PubMed  PMC  EPMC
    29. 1994
  29. Bruinenberg,P.G., Doesburg,P., Alting,A.C., Exterkate,F.A., de Vos,W.M. and Siezen,R.J.
    Evidence for a large dispensable segment in the subtilisin-like catalytic domain of the Lactococcus lactis cell-envelope proteinase
    Protein Eng (1994) 7, 991-996. PubMed  Europe PubMed
  30. Reid,J.R., Coolbear,T., Pillidge,C.J. and Pritchard,G.G.
    Specificity of hydrolysis of bovine kappa-casein by cell envelope-associated proteinases from Lactococcus lactis strains
    Appl Environ Microbiol (1994) 60, 801-806. PubMed  Europe PubMed  PMC  EPMC
  31. Visser,S., Slangen,C.J., Robben,A.J., van Dongen,W.D., Heerma,W. and Haverkamp,J.
    Action of a cell-envelope proteinase (CEPIII-type) from Lactococcus lactis subsp. cremoris AM1 on bovine kappa-casein
    Appl Microbiol Biotechnol (1994) 41, 644-651. PubMed  Europe PubMed DOI
    32. 1993
  32. Exterkate,F.A., Alting,A.C. and Bruinenberg,P.G.
    Diversity of cell envelope proteinase specificity among strains of Lactococcus lactis and its relationship to charge characteristics of the substrate-binding region
    Appl Environ Microbiol (1993) 59, 3640-3647. PubMed  Europe PubMed  PMC  EPMC
  33. Exterkate,F.A. and Alting,A.C.
    The conversion of the alpha(s1)-casein-(1-23)-fragment by the free and bound form of the cell-envelope proteinase of Lactococcus lactis subsp. cremoris under conditions prevailing in cheese
    Syst Appl Microbiol (1993) 16, 1-8.  P
  34. Siezen,R.J., Bruinenberg,P.G., Vos,P., van Alen-Boerrigter,I., Nijhuis,M., Alting,A.C., Exterkate,F.A. and de Vos,W.M.
    Engineering of the substrate-binding region of the subtilisin-like, cell-envelope proteinase of Lactococcus lactis
    Protein Eng (1993) 6, 927-937. PubMed  Europe PubMed
  35. Tan,P.S., Poolman,B. and Konings,W.N.
    Proteolytic enzymes of Lactococcus lactis
    J Dairy Res (1993) 60, 269-286. PubMed  Europe PubMed
    36. 1992
  36. Coolbear,T., Reid,J.R. and Pritchard,G.G.
    Stability and specificity of the cell wall-associated proteinase from Lactococcus lactis subsp. cremoris H2 released by treatment with lysozyme in the presence of calcium ions
    Appl Environ Microbiol (1992) 58, 3263-3270. PubMed  Europe PubMed  PMC  EPMC
  37. Law,J., Vos,P., Hayes,F., Daly,C., de Vos,W.M. and Fitzgerald,G.
    Cloning and partial sequencing of the proteinase gene complex from Lactococcus lactis subsp. lactis UC317
    J Gen Microbiol (1992) 138, 709-718. PubMed  Europe PubMed
  38. Monnet,V., Ley,J.P. and Gonzalez,S.
    Substrate specificity of the cell envelope-located proteinase of Lactococcus lactis subsp. lactis NCDO 763
    Int J Biochem (1992) 24, 707-718. PubMed  Europe PubMed DOI
    39. 1991
  39. Kojic,M., Fira,D., Banina,A. and Topisirovic,L.
    Characterization of the cell wall-bound proteinase of Lactobacillus casei HN14
    Appl Environ Microbiol (1991) 57, 1753-1757. PubMed  Europe PubMed  PMC  EPMC
  40. Laan,H. and Konings,W.N.
    Autoproteolysis of the extracellular serine proteinase of Lactococcus lactis subsp. cremoris Wg2
    Appl Environ Microbiol (1991) 57, 2586-2590. PubMed  Europe PubMed  PMC  EPMC
    41. 1989
  41. Laan,H. and Konings,W.N.
    Mechanism of proteinase release from Lactococcus lactis subsp. cremoris Wg2
    Appl Environ Microbiol (1989) 55, 3101-3106. PubMed  Europe PubMed  PMC  EPMC
    42. 1988
  42. Kok,J., Hill,D., Haandrikman,A.J., de Reuver,M.J., Laan,H. and Venema,G.
    Deletion analysis of the proteinase gene of Streptococcus cremoris Wg2
    Appl Environ Microbiol (1988) 54, 239-244. PubMed  Europe PubMed  PMC  EPMC  K
  43. Laan,H., Smid,E.J., De Leij,L., Schwander,E. and Konings,W.N.
    Monoclonal antibodies to the cell-wall-associated proteinase of Lactococcus lactis subsp. cremoris Wg2
    Appl Environ Microbiol (1988) 54, 2250-2256. PubMed  Europe PubMed  PMC  EPMC
  44. Visser,S., Slangen,C.J., Exterkate,F.A. and de Veer,G.J.C.M.
    Action of a cell wall proteinase (PI) from Streptococcus cremoris HP on bovine beta-casein
    Appl Microbiol Biotechnol (1988) 29, 61-66. DOI
    45. 1987
  45. Exterkate,F.A. and deVeer,G.J.C.M.
    Complexity of the native cell wall proteinase of Lactococcus lactis subsp. cremoris HP and purification of the enzyme
    Syst Appl Microbiol (1987) 9, 183-191.
  46. Monnet,V., Lebars,D., Neviani,E. and Gripon,J.C.
    Partial characterization and comparison of cell wall proteinases from 5 strains of Streptococcus lactis
    Le Lait (1987) 67, 51-61.
    47. 1986
  47. Monnet,V., Le Bars,D. and Gripon,J.C.
    Specificity of a cell wall proteinase from Streptococcus lactis NCDO763 towards bovine beta-casein
    FEMS Microbiol Lett (1986) 36, 127-131.
  48. Visser,S., Exterkate,F.A., Slangen,C.J. and de Veer,G.J.
    Comparative study of action of cell wall proteinases from various strains of Streptococcus cremoris on bovine alpha(s1)-, beta-, and kappa-casein
    Appl Environ Microbiol (1986) 52, 1162-1166. PubMed  Europe PubMed  PMC  EPMC
    49. 1985
  49. Geis,A., Bockelmann,W. and Teuber,M.
    Simultaneous extraction and purification of a cell wall-associated peptidase and beta-casein specific protease from Streptococcus cremoris AC1
    Appl Microbiol Biotechnol (1985) 23, 79-84.
    50. 1984
  50. Hugenholtz,J., Exterkate,F. and Konings,W.N.
    The proteolytic systems of Streptococcus cremoris: an immunological analysis
    Appl Environ Microbiol (1984) 48, 1105-1110. PubMed  Europe PubMed  PMC  EPMC
    51. 1979
  51. Exterkate,F.A.
    Accumulation of proteinase in the cell wall of Streptococcus cremoris strain AM1 and regulation of its production
    Arch Microbiol (1979) 120, 247-254. DOI
    52. 1976
  52. Efstathiou,J.D. and McKay,L.L.
    Plasmids in Streptococcus lactis: evidence that lactose metabolism and proteinase activity are plasmid linked
    Appl Environ Microbiol (1976) 32, 38-44. PubMed  Europe PubMed  PMC  EPMC
    53. 1975
  53. McKay,L.L. and Baldwin,K.A.
    Plasmid distribution and evidence for a proteinase plasmid in Streptococcus lactis C2-1
    Appl Microbiol (1975) 29, 546-548. PubMed  Europe PubMed  PMC  EPMC
    54. 1971
  54. Westhoff,D.C., Cowman,R.A. and Speck,M.L.
    Isolation and partial characterization of a particulate proteinase from a slow acid producing mutant of Streptococcus lactis
    J Dairy Sci (1971) 54, 1253-1258. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use