Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S03.001: togavirin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Geng,Q., Navaratnarajah,C.K. and Zhang,W.
    Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Chykunova,Y., Plewka,J., Wilk,P., Torzyk,K., Sienczyk,M., Dubin,G. and Pyrc,K.
    Autoinhibition of suicidal capsid protease from O'nyong'nyong virus
    Int J Biol Macromol (2024) 262, 130136-130136. PubMed  Europe PubMed DOI
    3. 2023
  3. Reitmayer,C.M., Levitt,E., Basu,S., Atkinson,B., Fragkoudis,R., Merits,A., Lumley,S., Larner,W., Diaz,A.V., Rooney,S., Thomas,C.J.E., von Wyschetzki,K., Rausalu,K. and Alphey,L.
    Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti
    Proc Natl Acad Sci U S A (2023) 120, e2303080120-e2303080120. PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2020
  4. Fatma,B., Kumar,R., Singh,V.A., Nehul,S., Sharma,R., Kesari,P., Kuhn,R.J. and Tomar,S.
    Alphavirus capsid protease inhibitors as potential antiviral agents for Chikungunya infection
    Antiviral Res (2020) , 104808-104808. PubMed  Europe PubMed DOI  A  I
    5. 2019
  5. Singh,P., Kumar,D., Vishvakarma,V.K., Yadav,P., Jayaraj,A. and Kumari,K.
    Computational approach to study the synthesis of noscapine and potential of stereoisomers against nsP3 protease of CHIKV
    Heliyon (2019) 5, e02795-e02795. PubMed  Europe PubMed DOI  PMC  EPMC  I
    6. 2018
  6. Sharma,R., Kesari,P., Kumar,P. and Tomar,S.
    Structure-function insights into chikungunya virus capsid protein: small molecules targeting capsid hydrophobic pocket
    Virology (2018) 515, 223-234. PubMed  Europe PubMed DOI  S
    7. 2017
  7. Yap,M.L., Klose,T., Urakami,A., Hasan,S.S., Akahata,W. and Rossmann,M.G.
    Structural studies of Chikungunya virus maturation
    Proc Natl Acad Sci U S A (2017) 114, 13703-13707. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2015
  8. Aggarwal,M., Sharma,R., Kumar,P., Parida,M. and Tomar,S.
    Kinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay
    Sci Rep (2015) 5, 14753-14753. PubMed  Europe PubMed DOI  A
    9. 2014
  9. Aggarwal,M., Dhindwal,S., Kumar,P., Kuhn,R.J. and Tomar,S.
    Trans-protease activity and structural insights into the active form of the alphavirus capsid protease
    J Virol (2014) 88, 12242-12253. PubMed  Europe PubMed DOI  A  S
    10. 2012
  10. Aggarwal,M., Tapas,S., Preeti, Siwach,A., Kumar,P., Kuhn,R.J. and Tomar,S.
    Crystal structure of aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts
    PLoS ONE (2012) 7, e51288-e51288. PubMed  Europe PubMed DOI  PMC  EPMC  S
  11. Ryan,M.D.
    Togavirin
    [ISSN:978-0-12-407742-3] (2012) 3, 3110-3112. DOI
  12. Shin,G., Yost,S.A., Miller,M.T., Elrod,E.J., Grakoui,A. and Marcotrigiano,J.
    Structural and functional insights into alphavirus polyprotein processing and pathogenesis
    Proc Natl Acad Sci U S A (2012) 109, 16534-16539. PubMed  Europe PubMed DOI
    13. 2011
  13. Aggarwal,M., Dhindwal,S., Pratap,S., Kuhn,R.J., Kumar,P. and Tomar,S.
    Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane
    Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 67, 1394-1398. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2010
  14. Thomas,S., Rai,J., John,L., Gunther,S., Drosten,C., Putzer,B.M. and Schaefer,S.
    Functional dissection of the alphavirus capsid protease: sequence requirements for activity
    Virol J (2010) 7, 327-327. PubMed  Europe PubMed DOI
    15. 2008
  15. Morillas,M., Eberl,H., Allain,F.H., Glockshuber,R. and Kuennemann,E.
    Novel enzymatic activity derived from the Semliki Forest virus capsid protein
    J Mol Biol (2008) 376, 721-735. PubMed  Europe PubMed DOI
    16. 2006
  16. Mukhopadhyay,S., Zhang,W., Gabler,S., Chipman,P.R., Strauss,E.G., Strauss,J.H., Baker,T.S., Kuhn,R.J. and Rossmann,M.G.
    Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses
    Structure (2006) 14, 63-73. PubMed  Europe PubMed DOI  PMC  EPMC  S
    17. 2004
  17. Ryan,M.D.
    Togavirin
    [ISSN:0-12-079610-4] (2004) 2, 1767-1769.  V
  18. [YEAR:16-4-2004]Sanchez,I.E., Morillas,M., Zobeley,E., Kiefhaber,T. and Glockshuber,R.
    Fast folding of the two-domain Semliki Forest virus capsid protein explains co-translational proteolytic activity
    J Mol Biol (16-4-2004) 338, 159-167. PubMed  Europe PubMed DOI
    19. 2002
  19. Tong,L.
    Viral proteases
    Chem Rev (2002) 102, 4609-4626. PubMed  Europe PubMed DOI  V
    20. 1999
  20. Ten Dam,E., Flint,M. and Ryan,M.D.
    Virus-encoded proteinases of the Togaviridae
    J Gen Virol (1999) 80, 1879-1888. PubMed  Europe PubMed
    21. 1998
  21. Skoging,U. and Liljestrom,P.
    Role of the C-terminal tryptophan residue for the structure-function of the alphavirus capsid protein
    J Mol Biol (1998) 279, 865-872. PubMed  Europe PubMed DOI
    22. 1996
  22. Choi,H.K., Lee,S., Zhang,Y.P., McKinney,B.R., Wengler,G., Rossmann,M.G. and Kuhn,R.J.
    Structural analysis of Sindbis virus capsid mutants involving assembly and catalysis
    J Mol Biol (1996) 262, 151-167. PubMed  Europe PubMed DOI
    23. 1995
  23. Rumenapf,T., Strauss,E.G. and Strauss,J.H.
    Aura virus is a New World representative of Sindbis-like viruses
    Virology (1995) 208, 621-633. PubMed  Europe PubMed DOI
    24. 1993
  24. Tong,L., Wengler,G. and Rossmann,M.G.
    Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures
    J Mol Biol (1993) 230, 228-247. PubMed  Europe PubMed DOI  S
    25. 1991
  25. Choi,H.K., Tong,L., Minor,W., Dumas,P., Boege,U., Rossmann,M.G. and Wengler,G.
    Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion
    Nature (1991) 354, 37-43. PubMed  Europe PubMed DOI  S
  26. Ringe,D. and Petsko,G.A.
    Viral proteases. Molecular metamorphosis
    Nature (1991) 354, 22-23. PubMed  Europe PubMed DOI  S
    27. 1990
  27. Hahn,C.S. and Strauss,J.H.
    Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease
    J Virol (1990) 64, 3069-3073. PubMed  Europe PubMed  PMC  EPMC
    28. 1988
  28. Krausslich,H.G. and Wimmer,E.
    Viral proteinases
    Annu Rev Biochem (1988) 57, 701-754. PubMed  Europe PubMed DOI
    29. 1987
  29. Melancon,P. and Garoff,H.
    Processing of the Semliki forest virus structural polyprotein: role of the capsid protease
    J Virol (1987) 61, 1301-1309. PubMed  Europe PubMed  PMC  EPMC
    30. 1981
  30. Rice,C.M. and Strauss,J.H.
    Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins
    Proc Natl Acad Sci U S A (1981) 78, 2062-2066. PubMed  Europe PubMed  PMC  EPMC
    31. 1978
  31. Aliperti,G. and Schlesinger,M.J.
    Evidence for an autoprotease activity of Sindbis virus capsid protein
    Virology (1978) 90, 366-369. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use