Literature for peptidase homologue S01.993: testis-specific protein 50

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

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    2024
  1. Niu,C.X., Li,J.W., Li,X.L., Zhang,L.L., Lang,Y., Song,Z.B., Yu,C.L., Yang,X.G., Zhao,H.F., Sun,J.L., Zheng,L.H., Wang,X., Sun,Y., Han,X.H., Wang,G.N. and Bao,Y.L.
    PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality
    Zool Res45, 1037-1047. PubMed  Europe PubMed DOI  K
  2. 2021
  3. Scovell,J.M., Bournat,J.C., Szafran,A.T., Solis,M., Moore,J., Rivera,A., Chen,C.H., Zhang,J., Wilken,N., Seth,A. and Jorgez,C.J.
    PRSS50 is a testis protease responsible for proper sperm tail formation and function
    Development148, PubMed  Europe PubMed DOI
  4. 2018
  5. Cao,Q.H., Liu,F., Li,C.Z., Liu,N., Shu,M., Lin,Y., Ding,L. and Xue,L.
    Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer
    BMC Cancer18, 94-94. PubMed  Europe PubMed DOI
  6. 2016
  7. Mi,X.G., Song,Z.B., Sun,L.G., Bao,Y.L., Yu,C.L., Wu,Y. and Li,Y.X.
    Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation
    Int J Biochem Cell Biol73, 63-71. PubMed  Europe PubMed DOI
  8. 2015
  9. Song,Z.B., Ni,J.S., Wu,P., Bao,Y.L., Liu,T., Li,M., Fan,C., Zhang,W.J., Sun,L.G., Huang,Y.X. and Li,Y.X.
    Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression
    Cell Death Dis6, e1703-e1703. PubMed  Europe PubMed DOI
  10. Yang,C., Zhang,D.M., Song,Z.B., Hou,Y.Q., Bao,Y.L., Sun,L.G., Yu,C.L. and Li,Y.X.
    Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-alpha and IL-1beta, and activation of the NF-kappaB signaling pathway
    PLoS ONE10, e0145095-e0145095. PubMed  Europe PubMed DOI
  11. Yuan,J., Wu,C., Huang,M., Zhou,J., Ben,W. and Zhang,G.
    TSP50 depends on its threonine protease activity and its interactions with TNF-alpha-induced NF-kappaB for its role in human cervical tumorigenesis
    Cell Biochem Biophys71, 891-896. PubMed  Europe PubMed DOI
  12. 2014
  13. Liu,Y.L. and Sun,Y.N.
    Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-kappaB-mediated pathway
    Mol Biol Rep41, 7743-7747. PubMed  Europe PubMed DOI
  14. Mi,X.G., Song,Z.B., Wu,P., Zhang,Y.W., Sun,L.G., Bao,Y.L., Zhang,Y., Zheng,L.H., Sun,Y., Yu,C.L., Wu,Y., Wang,G.N. and Li,Y.X.
    Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression
    Toxicol Lett224, 349-355. PubMed  Europe PubMed DOI
  15. Song,Z.B., Liu,B., Li,Y.Y., Wu,P., Bao,Y.L., Huang,Y.X., Wu,Y., Sun,L.G., Yu,C.L., Sun,Y., Zheng,L.H. and Li,Y.X.
    The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation
    Cell Signal26, 2266-2275. PubMed  Europe PubMed DOI
  16. Zhang,X.
    Depression of testes-specific protease 50 (TSP50) inhibits cell proliferation and induces apoptosis in laryngocarcinoma
    Tumour Biol35, 10781-10788. PubMed  Europe PubMed DOI  K
  17. 2012
  18. Li,Y.Y., Bao,Y.L., Song,Z.B., Sun,L.G., Wu,P., Zhang,Y., Fan,C., Huang,Y.X., Wu,Y., Yu,C.L., Sun,Y., Zheng,L.H., Wang,G.N. and Li,Y.X.
    The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation
    PLoS ONE7, e35030-e35030. PubMed  Europe PubMed DOI
  19. 2011
  20. Song,Z.B., Bao,Y.L., Zhang,Y., Mi,X.G., Wu,P., Wu,Y., Yu,C.L., Sun,Y., Zheng,L.H., Huang,Y.X., Liu,B. and Li,Y.X.
    Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor kappaB (NF-kappaB) signalling pathway
    Biochem J436, 457-467. PubMed  Europe PubMed DOI
  21. 2010
  22. Wang,M., Bao,Y.L., Wu,Y., Yu,C.L., Meng,X.Y., Huang,Y.X., Sun,Y., Zheng,L.H. and Li,Y.X.
    Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway
    J Cell Biochem111, 75-81. PubMed  Europe PubMed DOI
  23. 2008
  24. Huang,Y., Wang,Y., Wang,M., Sun,B., Li,Y., Bao,Y., Tian,K. and Xu,H.
    Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells
    Biochem Biophys Res Commun374, 658-661. PubMed  Europe PubMed DOI
  25. Wang,M., Bao,Y.L., Wu,Y., Yu,C.L., Meng,X., Xu,H.P. and Li,Y.X.
    Identification and characterization of the human testes-specific protease 50 gene promoter
    DNA Cell Biol27, 307-314. PubMed  Europe PubMed DOI
  26. 2007
  27. [YEAR:1-2-2007]Xu,H., Shan,J., Jurukovski,V., Yuan,L., Li,J. and Tian,K.
    TSP50 encodes a testis-specific protease and is negatively regulated by p53
    Cancer Res67, 1239-1245. PubMed  Europe PubMed DOI
  28. 2006
  29. Wei,J., Liu,Y., Yang,S., Xu,J., Kong,H., Han,B., Bao,Y., Wu,Y., Yin,W., Li,W., Yan,G., Luo,G., Xu,H.P., Li,Y. and Yang,B.
    Screening of single-chain variable fragments against TSP50 from a phage display antibody library and their expression as soluble proteins
    J Biomol Screen11, 546-552. PubMed  Europe PubMed DOI
  30. 2004
  31. Xu,H.P., Yuan,L., Shan,J. and Feng,H.
    Localization and expression of TSP50 protein in human and rodent testes
    Urology64, 826-832. PubMed  Europe PubMed DOI
  32. 2002
  33. [YEAR:1-1-2002]Shan,J., Yuan,L., Xiao,Q., Chiorazzi,N., Budman,D., Teichberg,S. and Xu,H.P.
    TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells
    Cancer Res62, 290-294. PubMed  Europe PubMed
  34. 1999
  35. [YEAR:1-7-1999]Yuan,L., Shan,J., De Risi,D., Broome,J., Lovecchio,J., Gal,D., Vinciguerra,V. and Xu,H.P.
    Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer
    Cancer Res59, 3215-3221. PubMed  Europe PubMed