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Literature for peptidase homologue S01.993: testis-specific protein 50

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Li,X., Chen,Y., Gao,Z., Liu,X., Song,Z., Gao,F., Wang,S., Yu,C., Sun,L., Huang,Y., Zheng,L., Wang,G., Sun,Y., Li,J., Yang,X. and Bao,Y.
    TSP50 in Neural Stem Cells Regulates Aging-Related Cognitive Decline and Neuroinflammation by Altering the Gut Microbiota
    Aging Cell (2025) , e70188-e70188. PubMed  Europe PubMed DOI
    2. 2024
  2. Niu,C.X., Li,J.W., Li,X.L., Zhang,L.L., Lang,Y., Song,Z.B., Yu,C.L., Yang,X.G., Zhao,H.F., Sun,J.L., Zheng,L.H., Wang,X., Sun,Y., Han,X.H., Wang,G.N. and Bao,Y.L.
    PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality
    Zool Res (2024) 45, 1037-1047. PubMed  Europe PubMed DOI  K
    3. 2021
  3. Scovell,J.M., Bournat,J.C., Szafran,A.T., Solis,M., Moore,J., Rivera,A., Chen,C.H., Zhang,J., Wilken,N., Seth,A. and Jorgez,C.J.
    PRSS50 is a testis protease responsible for proper sperm tail formation and function
    Development (2021) 148 PubMed  Europe PubMed DOI  PMC  EPMC
    4. 2018
  4. Cao,Q.H., Liu,F., Li,C.Z., Liu,N., Shu,M., Lin,Y., Ding,L. and Xue,L.
    Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer
    BMC Cancer (2018) 18, 94-94. PubMed  Europe PubMed DOI
    5. 2016
  5. Mi,X.G., Song,Z.B., Sun,L.G., Bao,Y.L., Yu,C.L., Wu,Y. and Li,Y.X.
    Cardamonin inhibited cell viability and tumorigenesis partially through blockade of testes-specific protease 50-mediated nuclear factor-kappaB signaling pathway activation
    Int J Biochem Cell Biol (2016) 73, 63-71. PubMed  Europe PubMed DOI
    6. 2015
  6. Song,Z.B., Ni,J.S., Wu,P., Bao,Y.L., Liu,T., Li,M., Fan,C., Zhang,W.J., Sun,L.G., Huang,Y.X. and Li,Y.X.
    Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression
    Cell Death Dis (2015) 6, e1703-e1703. PubMed  Europe PubMed DOI
  7. Yang,C., Zhang,D.M., Song,Z.B., Hou,Y.Q., Bao,Y.L., Sun,L.G., Yu,C.L. and Li,Y.X.
    Protumoral TSP50 regulates macrophage activities and polarization via production of TNF-alpha and IL-1beta, and activation of the NF-kappaB signaling pathway
    PLoS ONE (2015) 10, e0145095-e0145095. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yuan,J., Wu,C., Huang,M., Zhou,J., Ben,W. and Zhang,G.
    TSP50 depends on its threonine protease activity and its interactions with TNF-alpha-induced NF-kappaB for its role in human cervical tumorigenesis
    Cell Biochem Biophys (2015) 71, 891-896. PubMed  Europe PubMed DOI
    9. 2014
  9. Liu,Y.L. and Sun,Y.N.
    Down-regulation of testes-specific protease 50 induces apoptosis in human laryngocarcinoma HEp2 cells in a NF-kappaB-mediated pathway
    Mol Biol Rep (2014) 41, 7743-7747. PubMed  Europe PubMed DOI
  10. Mi,X.G., Song,Z.B., Wu,P., Zhang,Y.W., Sun,L.G., Bao,Y.L., Zhang,Y., Zheng,L.H., Sun,Y., Yu,C.L., Wu,Y., Wang,G.N. and Li,Y.X.
    Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression
    Toxicol Lett (2014) 224, 349-355. PubMed  Europe PubMed DOI
  11. Song,Z.B., Liu,B., Li,Y.Y., Wu,P., Bao,Y.L., Huang,Y.X., Wu,Y., Sun,L.G., Yu,C.L., Sun,Y., Zheng,L.H. and Li,Y.X.
    The catalytic triad of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation
    Cell Signal (2014) 26, 2266-2275. PubMed  Europe PubMed DOI
  12. Zhang,X.
    Depression of testes-specific protease 50 (TSP50) inhibits cell proliferation and induces apoptosis in laryngocarcinoma
    Tumour Biol (2014) 35, 10781-10788. PubMed  Europe PubMed DOI  K
    13. 2012
  13. Li,Y.Y., Bao,Y.L., Song,Z.B., Sun,L.G., Wu,P., Zhang,Y., Fan,C., Huang,Y.X., Wu,Y., Yu,C.L., Sun,Y., Zheng,L.H., Wang,G.N. and Li,Y.X.
    The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation
    PLoS ONE (2012) 7, e35030-e35030. PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2011
  14. Song,Z.B., Bao,Y.L., Zhang,Y., Mi,X.G., Wu,P., Wu,Y., Yu,C.L., Sun,Y., Zheng,L.H., Huang,Y.X., Liu,B. and Li,Y.X.
    Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor kappaB (NF-kappaB) signalling pathway
    Biochem J (2011) 436, 457-467. PubMed  Europe PubMed DOI
    15. 2010
  15. Wang,M., Bao,Y.L., Wu,Y., Yu,C.L., Meng,X.Y., Huang,Y.X., Sun,Y., Zheng,L.H. and Li,Y.X.
    Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway
    J Cell Biochem (2010) 111, 75-81. PubMed  Europe PubMed DOI
    16. 2008
  16. Huang,Y., Wang,Y., Wang,M., Sun,B., Li,Y., Bao,Y., Tian,K. and Xu,H.
    Differential methylation of TSP50 and mTSP50 genes in different types of human tissues and mouse spermatic cells
    Biochem Biophys Res Commun (2008) 374, 658-661. PubMed  Europe PubMed DOI
  17. Wang,M., Bao,Y.L., Wu,Y., Yu,C.L., Meng,X., Xu,H.P. and Li,Y.X.
    Identification and characterization of the human testes-specific protease 50 gene promoter
    DNA Cell Biol (2008) 27, 307-314. PubMed  Europe PubMed DOI
    18. 2007
  18. [YEAR:1-2-2007]Xu,H., Shan,J., Jurukovski,V., Yuan,L., Li,J. and Tian,K.
    TSP50 encodes a testis-specific protease and is negatively regulated by p53
    Cancer Res (1-2-2007) 67, 1239-1245. PubMed  Europe PubMed DOI
    19. 2006
  19. Wei,J., Liu,Y., Yang,S., Xu,J., Kong,H., Han,B., Bao,Y., Wu,Y., Yin,W., Li,W., Yan,G., Luo,G., Xu,H.P., Li,Y. and Yang,B.
    Screening of single-chain variable fragments against TSP50 from a phage display antibody library and their expression as soluble proteins
    J Biomol Screen (2006) 11, 546-552. PubMed  Europe PubMed DOI
    20. 2004
  20. Xu,H.P., Yuan,L., Shan,J. and Feng,H.
    Localization and expression of TSP50 protein in human and rodent testes
    Urology (2004) 64, 826-832. PubMed  Europe PubMed DOI
    21. 2002
  21. [YEAR:1-1-2002]Shan,J., Yuan,L., Xiao,Q., Chiorazzi,N., Budman,D., Teichberg,S. and Xu,H.P.
    TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells
    Cancer Res (1-1-2002) 62, 290-294. PubMed  Europe PubMed
    22. 1999
  22. [YEAR:1-7-1999]Yuan,L., Shan,J., De Risi,D., Broome,J., Lovecchio,J., Gal,D., Vinciguerra,V. and Xu,H.P.
    Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer
    Cancer Res (1-7-1999) 59, 3215-3221. PubMed  Europe PubMed

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