Literature for peptidase S01.500: HtrA peptidase (Helicobacter-type)

(Topics flags: T Target, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Zarzecka,U., Pu,C., Posselt,G. and Wessler,S.
   The multifunctional role of the protease HtrA in Helicobacter pylori pathogenesis
   FEBS Lett (2025) PubMed  Europe PubMed DOI
2024
2. Linz,B., Sticht,H., Tegtmeyer,N. and Backert,S.
   Cancer-associated SNPs in bacteria: lessons from Helicobacter pylori
   Trends Microbiol (2024) 32, 847-857. PubMed  Europe PubMed DOI
3. Sharafutdinov,I., Tegtmeyer,N., Rohde,M., Olofsson,A., Rehman,Z.U., Arnqvist,A. and Backert,S.
   Campylobacter jejuni Surface-Bound Protease HtrA, but Not the Secreted Protease nor Protease in Shed Membrane Vesicles, Disrupts Epithelial Cell-to-Cell Junctions
   Cells (2024) 13 PubMed  Europe PubMed DOI  PMC  EPMC
2023
4. Cui,L., Shi,X., Li,H., Wang,S., Guo,L., Lan,Z., Dai,Y., Zhang,Q., Wu,Y. and Liu,W.
   Crystal structures and solution conformations of HtrA from Helicobacter pylori reveal pH-dependent oligomeric conversion and conformational rearrangements
   Int J Biol Macromol (2023) 243, 125274-125274. PubMed  Europe PubMed DOI
2022
5. Bernegger,S., Hutterer,E., Zarzecka,U., Schmidt,T.P., Huemer,M., Widlroither,I., Posselt,G., Skorko-Glonek,J. and Wessler,S.
   E-Cadherin Orthologues as Substrates for the Serine Protease High Temperature Requirement A (HtrA)
   Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
6. Sharafutdinov,I., Ekici,A., Vieth,M., Backert,S. and Linz,B.
   Early and late genome-wide gastric epithelial transcriptome response during infection with the human carcinogen Helicobacterpylori
   Cell Insight (2022) 1, 100032-100032. PubMed  Europe PubMed DOI  PMC  EPMC
7. Sharafutdinov,I., Tegtmeyer,N., Musken,M. and Backert,S.
   Campylobacter jejuni Serine Protease HtrA Induces Paracellular Transmigration of Microbiota across Polarized Intestinal Epithelial Cells
   Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
2021
8. Bernegger,S., Vidmar,R., Fonovic,M., Posselt,G., Turk,B. and Wessler,S.
   Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells
   Cell Commun Signal (2021) 19, 108-108. PubMed  Europe PubMed DOI  PMC  EPMC
2020
9. Bernegger,S., Brunner,C., Vizovisek,M., Fonovic,M., Cuciniello,G., Giordano,F., Stanojlovic,V., Jarzab,M., Simister,P., Feller,S.M., Obermeyer,G., Posselt,G., Turk,B., Cabrele,C., Schneider,G. and Wessler,S.
   A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding
   Sci Rep (2020) 10, 10563-10563. PubMed  Europe PubMed DOI  PMC  EPMC
2019
10. Harrer,A., Bucker,R., Boehm,M., Zarzecka,U., Tegtmeyer,N., Sticht,H., Schulzke,J.D. and Backert,S.
    Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
    Gut Pathog (2019) 11, 4-4. PubMed  Europe PubMed DOI  PMC  EPMC
11. Neddermann,M. and Backert,S.
    How many protein molecules are secreted by single Helicobacter pylori cells: quantification of serine protease HtrA
    Cell Microbiol (2019) , e13022-e13022. PubMed  Europe PubMed DOI
12. Zarzecka,U., Modrak-Wojcik,A., Figaj,D., Apanowicz,M., Lesner,A., Bzowska,A., Lipinska,B., Zawilak-Pawlik,A., Backert,S. and Skorko-Glonek,J.
    Properties of the HtrA protease from bacterium Helicobacter pylori whose activity is indispensable for growth under stress conditions
    Front Microbiol (2019) 10, 961-961. PubMed  Europe PubMed DOI  PMC  EPMC
13. Zawilak-Pawlik,A., Zarzecka,U., Zyla-Uklejewicz,D., Lach,J., Strapagiel,D., Tegtmeyer,N., Bohm,M., Backert,S. and Skorko-Glonek,J.
    Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations
    Sci Rep (2019) 9, 11794-11794. PubMed  Europe PubMed DOI  PMC  EPMC
14. Zhang,Z., Huang,Q., Tao,X., Song,G., Zheng,P., Li,H., Sun,H. and Xia,W.
    The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping
    J Biol Chem (2019) 294, 7990-8000. PubMed  Europe PubMed DOI
2018
15. Albrecht,N., Tegtmeyer,N., Sticht,H., Skorko-Glonek,J. and Backert,S.
    Amino-terminal processing of Helicobacter pylori serine protease HtrA: role in oligomerization and activity regulation
    Front Microbiol (2018) 9, 642-642. PubMed  Europe PubMed DOI  PMC  EPMC
16. Backert,S., Bernegger,S., Skorko-Glonek,J. and Wessler,S.
    Extracellular HtrA serine proteases: an emerging new strategy in bacterial pathogenesis
    Cell Microbiol (2018) , e12845-e12845. PubMed  Europe PubMed DOI
17. Boehm,M., Simson,D., Escher,U., Schmidt,A.M., Bereswill,S., Tegtmeyer,N., Backert,S. and Heimesaat,M.M.
    Function of serine protease HtrA in the lifecycle of the foodborne pathogen Campylobacter jejuni
    Eur J Microbiol Immunol (Bp) (2018) 8, 70-77. PubMed  Europe PubMed DOI  PMC  EPMC  T
18. Rai,N., Muthukumaran,R. and Amutha,R.
    Identification of inhibitor against H. pylori HtrA protease using structure-based virtual screening and molecular dynamics simulations approaches
    Microb Pathog (2018) 118, 365-377. PubMed  Europe PubMed DOI  T  I
2017
19. Harrer,A., Boehm,M., Backert,S. and Tegtmeyer,N.
    Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
    Gut Pathog (2017) 9, 40-40. PubMed  Europe PubMed DOI  PMC  EPMC
20. Noto,J.M. and Peek RM Jr
    Helicobacter pylori makes a molecular incision to gain epithelial entry
    Cell Host Microbe (2017) 22, 434-436. PubMed  Europe PubMed DOI
2016
21. Abfalter,C.M., Schubert,M., Gotz,C., Schmidt,T.P., Posselt,G. and Wessler,S.
    HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens
    Cell Commun Signal (2016) 14, 30-30. PubMed  Europe PubMed DOI  PMC  EPMC
22. Schmidt,T.P., Perna,A.M., Fugmann,T., Bohm,M., Jan Hiss, Haller,S., Gotz,C., Tegtmeyer,N., Hoy,B., Rau,T.T., Neri,D., Backert,S., Schneider,G. and Wessler,S.
    Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA
    Sci Rep (2016) 6, 23264-23264. PubMed  Europe PubMed DOI  PMC  EPMC  P
23. Tegtmeyer,N., Moodley,Y., Yamaoka,Y., Pernitzsch,S.R., Schmidt,V., Traverso,F.R., Schmidt,T.P., Rad,R., Yeoh,K.G., Bow,H., Torres,J., Gerhard,M., Schneider,G., Wessler,S. and Backert,S.
    Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA
    Mol Microbiol (2016) 99, 925-944. PubMed  Europe PubMed DOI  I
2015
24. Perna,A.M., Rodrigues,T., Schmidt,T.P., Bohm,M., Stutz,K., Reker,D., Pfeiffer,B., Altmann,K.H., Backert,S., Wessler,S. and Schneider,G.
    Fragment-based de novo design reveals a small-molecule inhibitor of Helicobacter pylori HtrA
    Angew Chem Int Ed Engl (2015) 54, 10244-10248. PubMed  Europe PubMed DOI  I
2014
25. Perna,A.M., Reisen,F., Schmidt,T.P., Geppert,T., Pillong,M., Weisel,M., Hoy,B., Simister,P.C., Feller,S.M., Wessler,S. and Schneider,G.
    Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site
    Chem Sci (2014) 5, 3583-3590. PubMed  Europe PubMed DOI
2013
26. Boehm,M., Haenel,I., Hoy,B., Brondsted,L., Smith,T.G., Hoover,T., Wessler,S. and Tegtmeyer,N.
    Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum
    Eur J Microbiol Immunol (Bp) (2013) 3, 163-173. PubMed  Europe PubMed DOI  PMC  EPMC
27. Hoy,B., Brandstetter,H. and Wessler,S.
    The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions
    J Basic Microbiol (2013) 53, 402-409. PubMed  Europe PubMed DOI
2012
28. Hoy,B., Geppert,T., Boehm,M., Reisen,F., Plattner,P., Gadermaier,G., Sewald,N., Ferreira,F., Briza,P., Schneider,G., Backert,S. and Wessler,S.
    Distinct roles of secreted HtrA proteases from Gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin
    J Biol Chem (2012) 287, 10115-10120. PubMed  Europe PubMed DOI
2011
29. Baek,K.T., Vegge,C.S. and Brondsted,L.
    HtrA chaperone activity contributes to host cell binding in Campylobacter jejuni
    Gut Pathog (2011) 3, 13-13. PubMed  Europe PubMed DOI
30. Lower,M., Geppert,T., Schneider,P., Hoy,B., Wessler,S. and Schneider,G.
    Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia
    PLoS ONE (2011) 6, e17986-e17986. PubMed  Europe PubMed DOI  PMC  EPMC  I
2008
31. Lower,M., Weydig,C., Metzler,D., Reuter,A., Starzinski-Powitz,A., Wessler,S. and Schneider,G.
    Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA
    PLoS ONE (2008) 3, e3510-e3510. PubMed  Europe PubMed DOI  PMC  EPMC
2005
32. Rigoulay,C., Entenza,J.M., Halpern,D., Widmer,E., Moreillon,P., Poquet,I. and Gruss,A.
    Comparative analysis of the roles of HtrA-like surface proteases in two virulent Staphylococcus aureus strains
    Infect Immun (2005) 73, 563-572. PubMed  Europe PubMed DOI  PMC  EPMC
2004
33. [YEAR:15-8-2004]Rigoulay,C., Poquet,I., Madsen,S.M. and Gruss,A.
    Expression of the Staphylococcus aureus surface proteins HtrA1 and HtrA2 in Lactococcus lactis
    FEMS Microbiol Lett (15-8-2004) 237, 279-288. PubMed  Europe PubMed DOI
34. Salama,N.R., Shepherd,B. and Falkow,S.
    Global transposon mutagenesis and essential gene analysis of Helicobacter pylori
    J Bacteriol (2004) 186, 7926-7935. PubMed  Europe PubMed DOI  PMC  EPMC