Literature for peptidase S01.285: HtrA4 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature

(Topics flags: T Target, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Lin,Y., Liu,Z., Yang,J., Li,X., Hu,Y., Gao,L., Li,X., Bi,Y. and Wang,Y.<br>Placental Pathology and HTRA4-Mediated Autophagic Flux Disruption in Selective Fetal Growth Restriction Types I and III: A Morphological and Transcriptomic Study<br>FASEB J (2026) 40, e71471-e71471. PubMed  Europe PubMed DOI
  2. 2025
  3. Kong,H., Ma,X., Wang,F., Su,Y., Chang,Y. and Xin,H.<br>Htra4 promotes vascular endothelial cell injury and is associated with the early-onset of preeclampsia<br>Sci Rep (2025) 15, 11752-11752. PubMed  Europe PubMed DOI  PMC  EPMC
  4. 2024
  5. Donohoe,M.E., Morey,R., Li,Y., Pizzo,D., Kallol,S., Cho,H.Y., Soncin,F. and Parast,M.M.<br>Identification of HTRA4 as a Transcriptional Target of p63 in Trophoblast<br>Am J Pathol (2024) 194, 1162-1170. PubMed  Europe PubMed DOI  K
  6. Rosochowicz,M.A., Kulcenty,K. and Suchorska,W.M.<br>Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review<br>Mol Diagn Ther (2024) 28, 347-377. PubMed  Europe PubMed DOI  V
  7. 2021
  8. Fantone,S., Giannubilo,S.R., Marzioni,D. and Tossetta,G.<br>HTRA family proteins in pregnancy outcome<br>Tissue Cell (2021) 72, 101549-101549. PubMed  Europe PubMed DOI
  9. 2019
  10. Kummari,R., Dutta,S., Chaganti,L.K. and Bose,K.<br>Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway<br>Biochem J (2019) 476, 1445-1463. PubMed  Europe PubMed DOI
  11. Tseng,E., Yee Teoh,S.S., Wang,Y. and Nie,G.<br>Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin<br>Placenta (2019) 76, 51-53. PubMed  Europe PubMed DOI
  12. Wenta,T., Jarzab,M., Rychlowski,M., Borysiak,M., Latala,A., Zurawa-Janicka,D., Filipek,A. and Lipinska,B.<br>Cellular substrates and pro-apoptotic function of the human HtrA4 protease<br>J Proteomics (2019) 209, 103505-103505. PubMed  Europe PubMed DOI
  13. Wenta,T., Rychlowski,M., Jarzab,M. and Lipinska,B.<br>HtrA4 Protease promotes chemotherapeutic-dependent cancer cell death<br>Cells (2019) 8 PubMed  Europe PubMed DOI
  14. 2018
  15. Sun,M.L., Sun,L.M. and Wang,Y.Q.<br>Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes<br>J Mol Recognit (2018) 31, e2698-e2698. PubMed  Europe PubMed DOI  I
  16. 2017
  17. Zurawa-Janicka,D., Wenta,T., Jarzab,M., Skorko-Glonek,J., Glaza,P., Gieldon,A., Ciarkowski,J. and Lipinska,B.<br>Structural insights into the activation mechanisms of human HtrA serine proteases<br>Arch Biochem Biophys (2017) 621, 6-23. PubMed  Europe PubMed DOI  V
  18. 2014
  19. Chen,Y.Y., Chuang,P.Y., Chen,C.P., Chiu,Y.H., Lo,H.F., Cheong,M.L., Huang,J.Y., Kuo,P.L. and Chen,H.<br>Functional antagonism between high temperature requirement protein A (HtrA) family members regulates trophoblast invasion<br>J Biol Chem (2014) 289, 22958-22968. PubMed  Europe PubMed DOI
  20. 2012
  21. Chien,J. and Shridhar,V.<br>HtrA1 peptidase<br>[ISSN:978-0-12-407742-3] (2012) 3, 2577-2584. DOI
  22. 2011
  23. Clausen,T., Kaiser,M., Huber,R. and Ehrmann,M.<br>HTRA proteases: regulated proteolysis in protein quality control<br>Nat Rev Mol Cell Biol (2011) 12, 152-162. PubMed  Europe PubMed DOI  V
  24. 2009
  25. Chien,J., Campioni,M., Shridhar,V. and Baldi,A.<br>HtrA serine proteases as potential therapeutic targets in cancer<br>Curr Cancer Drug Targets (2009) 9, 451-468. PubMed  Europe PubMed DOI  T
  26. 2004
  27. Dingwall,C. and Holbrook,J.D.<br>Human HtrA proteases<br>[ISSN:0-12-079610-4] (2004) 2, 1476-1480.  V