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Literature for peptidase S01.275: DegS peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhou,C., Kong,Y., Zhang,N., Zhang,X., Qin,W., Zhang,L., Zhang,H., Yang,G. and Lu,F.
    Transcriptomic analysis of Bacillus licheniformis 2709 reveals the molecular mechanism of alkaline protease biosynthesis regulated by the DegS/DegU two-component system
    Int J Biol Macromol (2025) 306, 140868-140868. PubMed  Europe PubMed DOI
    2. 2024
  2. Zhao,J., Huang,X., Li,Q., Ren,F., Hu,H., Yuan,J., Wang,K., Hu,Y., Huang,J. and Min,X.
    DegS regulates the aerobic metabolism of Vibrio cholerae via the ArcA-isocitrate dehydrogenase pathway for growth and intestinal colonization
    Front Cell Infect Microbiol (2024) 14, 1482919-1482919. PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2023
  3. Gupta,A.K., Singh,K., Patidar,Y., Sharma,R., Sardesai,A.A., Reddy,G. and Gopal,B.
    Allosteric Determinants in High Temperature Requirement A Enzymes Are Conserved and Regulate the Population of Active Conformations
    ACS Chem Biol (2023) 18, 1487-1499. PubMed  Europe PubMed DOI
  4. Wang,K., Lu,H., Zou,M., Wang,G., Zhao,J., Huang,X., Ren,F., Hu,H., Huang,J. and Min,X.
    DegS protease regulates antioxidant capacity and adaptability to oxidative stress environment in Vibrio cholerae
    Front Cell Infect Microbiol (2023) 13, 1290508-1290508. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zou,M., Wang,K., Zhao,J., Lu,H., Yang,H., Huang,M., Wang,L., Wang,G., Huang,J. and Min,X.
    DegS protease regulates the motility, chemotaxis, and colonization of Vibrio cholerae
    Front Microbiol (2023) 14, 1159986-1159986. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2019
  6. Huang,J., Chen,Y., Chen,J., Liu,C., Zhang,T., Luo,S., Huang,M. and Min,X.
    Exploration of the effects of a degS mutant on the growth of Vibrio cholerae and the global regulatory function of degS by RNA sequencing
    PeerJ (2019) 7, e7959-e7959. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Kern,B., Leiser,O.P. and Misra,R.
    Suppressor mutations in degS overcome the acute temperature-sensitive phenotype of DeltadegP and DeltadegP Deltatol-pal mutants of Escherichia coli
    J Bacteriol (2019) 201, e00742-18-e00742-18. PubMed  Europe PubMed DOI
    8. 2018
  8. Bongard,J., Lorenz,M., Vetter,I.R., Stege,P., Porfetye,A.T., Schmitz,A.L., Kaschani,F., Wolf,A., Koch,U., Nussbaumer,P., Klebl,B., Kaiser,M. and Ehrmann,M.
    Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
    ACS Chem Biol (2018) 13, 1307-1312. PubMed  Europe PubMed DOI
    9. 2016
  9. Lu,C., Stock,G. and Knecht,V.
    Mechanisms for allosteric activation of protease DegS by ligand binding and oligomerization as revealed from molecular dynamics simulations
    Proteins (2016) 84, 1690-1705. PubMed  Europe PubMed DOI
    10. 2015
  10. de Regt,A.K., Baker,T.A. and Sauer,R.T.
    Steric clashes with bound OMP peptides activate the DegS stress-response protease
    Proc Natl Acad Sci U S A (2015) 112, 3326-3331. PubMed  Europe PubMed DOI
  11. de Regt,A.K., Kim,S., Sohn,J., Grant,R.A., Baker,T.A. and Sauer,R.T.
    A conserved activation cluster is required for allosteric communication in HtrA-family proteases
    Structure (2015) 23, 517-526. PubMed  Europe PubMed DOI
    12. 2014
  12. Hizukuri,Y., Oda,T., Tabata,S., Tamura-Kawakami,K., Oi,R., Sato,M., Takagi,J., Akiyama,Y. and Nogi,T.
    A structure-based model of substrate discrimination by a noncanonical PDZ tandem in the intramembrane-cleaving protease RseP
    Structure (2014) 22, 326-336. PubMed  Europe PubMed DOI
    13. 2013
  13. Barchinger,S.E. and Ades,S.E.
    Regulated proteolysis: control of the Escherichia coli sigma(E)-dependent cell envelope stress response
    Subcell Biochem (2013) 66, 129-160. PubMed  Europe PubMed DOI  V
  14. Mauldin,R.V. and Sauer,R.T.
    Allosteric regulation of DegS protease subunits through a shared energy landscape
    Nat Chem Biol (2013) 9, 90-96. PubMed  Europe PubMed DOI
    15. 2012
  15. Weber,N. and Kolmar,H.
    DegP protease
    [ISSN:978-0-12-407742-3] (2012) 3, 2567-2571. DOI
    16. 2011
  16. Roberts,D.P., Lohrke,S.M., McKenna,L., Lakshman,D.K., Kong,H. and Lydon,J.
    Mutation of a degS homologue in Enterobacter cloacae decreases colonization and biological control of damping-off on cucumber
    Phytopathology (2011) 101, 271-280. PubMed  Europe PubMed DOI  M
  17. Singh,N., Kuppili,R.R. and Bose,K.
    The structural basis of mode of activation and functional diversity: a case study with HtrA family of serine proteases
    Arch Biochem Biophys (2011) 516, 85-96. PubMed  Europe PubMed DOI  V  S
    18. 2010
  18. Hasenbein,S., Meltzer,M., Hauske,P., Kaiser,M., Huber,R., Clausen,T. and Ehrmann,M.
    Conversion of a regulatory into a degradative protease
    J Mol Biol (2010) 397, 957-966. PubMed  Europe PubMed DOI
  19. Sohn,J., Grant,R.A. and Sauer,R.T.
    Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution
    J Biol Chem (2010) 285, 34039-34047. PubMed  Europe PubMed DOI
    20. 2009
  20. Hauske,P., Mamant,N., Hasenbein,S., Nickel,S., Ottmann,C., Clausen,T., Ehrmann,M. and Kaiser,M.
    Peptidic small molecule activators of the stress sensor DegS
    Mol Biosyst (2009) 5, 980-985. PubMed  Europe PubMed DOI
  21. Meltzer,M., Hasenbein,S., Mamant,N., Merdanovic,M., Poepsel,S., Hauske,P., Kaiser,M., Huber,R., Krojer,T., Clausen,T. and Ehrmann,M.
    Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
    Res Microbiol (2009) 160, 660-666. PubMed  Europe PubMed DOI  V
  22. Muller,C., Bang,I.S., Velayudhan,J., Karlinsey,J., Papenfort,K., Vogel,J. and Fang,F.C.
    Acid stress activation of the sigma(E) stress response in Salmonella enterica serovar Typhimurium
    Mol Microbiol (2009) 71, 1228-1238. PubMed  Europe PubMed DOI
  23. Sohn,J. and Sauer,R.T.
    OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations
    Mol Cell (2009) 33, 64-74. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Sohn,J., Grant,R.A. and Sauer,R.T.
    OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism
    Structure (2009) 17, 1411-1421. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2008
  25. Ades,S.E.
    Regulation by destruction: design of the sigmaE envelope stress response
    Curr Opin Microbiol (2008) 11, 535-540. PubMed  Europe PubMed DOI
    26. 2007
  26. Cezairliyan,B.O. and Sauer,R.T.
    Inhibition of regulated proteolysis by RseB
    Proc Natl Acad Sci U S A (2007) 104, 3771-3776. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Chaba,R., Grigorova,I.L., Flynn,J.M., Baker,T.A. and Gross,C.A.
    Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction
    Genes Dev (2007) 21, 124-136. PubMed  Europe PubMed DOI  PMC  EPMC
  28. [YEAR:1-1-2007]Hasenbein,S., Merdanovic,M. and Ehrmann,M.
    Determinants of regulated proteolysis in signal transduction
    Genes Dev (1-1-2007) 21, 6-10. PubMed  Europe PubMed DOI
  29. Hasselblatt,H., Kurzbauer,R., Wilken,C., Krojer,T., Sawa,J., Kurt,J., Kirk,R., Hasenbein,S., Ehrmann,M. and Clausen,T.
    Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress
    Genes Dev (2007) 21, 2659-2670. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Sohn,J., Grant,R.A. and Sauer,R.T.
    Allosteric activation of DegS, a stress sensor PDZ protease
    Cell (2007) 131, 572-583. PubMed  Europe PubMed DOI
  31. Yan,J., Ko,J. and Qi,Y.
    Abridged region from Escherichia coli periplasmic stress sensor DegS acts as plasminogen activator in vitro
    J Microbiol Biotechnol (2007) 17, 594-599. PubMed  Europe PubMed
  32. Yan,N. and Shi,Y.
    Allosteric activation of a bacterial stress sensor
    Cell (2007) 131, 441-443. PubMed  Europe PubMed DOI
    33. 2006
  33. [YEAR:29-8-2006]Mo,E., Peters,S.E., Willers,C., Maskell,D.J. and Charles,I.G.
    Single, double and triple mutants of Salmonella enterica serovar Typhimurium degP (htrA), degQ (hhoA) and degS (hhoB) have diverse phenotypes on exposure to elevated temperature and their growth in vivo is attenuated to different extents
    Microb Pathog (29-8-2006) 41, 174-182. PubMed  Europe PubMed DOI
    34. 2005
  34. Huesgen,P.F., Schuhmann,H. and Adamska,I.
    The family of Deg proteases in cyanobacteria and chloroplasts of higher plants
    Physiol Plant (2005) 123, 413-420.
    35. 2004
  35. [YEAR:1-11-2004]Grigorova,I.L., Chaba,R., Zhong,H.J., Alba,B.M., Rhodius,V., Herman,C. and Gross,C.A.
    Fine-tuning of the Escherichia coli sigmaE envelope stress response relies on multiple mechanisms to inhibit signal-independent proteolysis of the transmembrane anti-sigma factor, RseA
    Genes Dev (1-11-2004) 18, 2686-2697. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Grininger,M., Ravelli,R.B., Heider,U. and Zeth,K.
    Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm
    Acta Crystallogr D Biol Crystallogr (2004) 60, 1429-1431. PubMed  Europe PubMed DOI  S
  37. Kolmar,H.
    DegP or protease Do
    [ISSN:0-12-079610-4] (2004) 2, 1472-1476.  V
  38. [YEAR:14-5-2004]Wilken,C., Kitzing,K., Kurzbauer,R., Ehrmann,M. and Clausen,T.
    Crystal structure of the DegS stress sensor: how a PDZ domain recognizes misfolded protein and activates a protease
    Cell (14-5-2004) 117, 483-494. PubMed  Europe PubMed DOI  S
  39. [YEAR:2-7-2004]Zeth,K.
    Structural analysis of DegS, a stress sensor of the bacterial periplasm
    FEBS Lett (2-7-2004) 569, 351-358. PubMed  Europe PubMed DOI
    40. 2003
  40. [YEAR:4-4-2003]Walsh,N.P., Alba,B.M., Bose,B., Gross,C.A. and Sauer,R.T.
    OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain
    Cell (4-4-2003) 113, 61-71. PubMed  Europe PubMed DOI
    41. 2002
  41. [YEAR:15-8-2002]Alba,B.M., Leeds,J.A., Onufryk,C., Lu,C.Z. and Gross,C.A.
    DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response
    Genes Dev (15-8-2002) 16, 2156-2168. PubMed  Europe PubMed DOI  PMC  EPMC
  42. [YEAR:29-10-2002]Silva,P., Choi,Y.J., Hassan,H.A. and Nixon,P.J.
    Involvement of the HtrA family of proteases in the protection of the cyanobacterium Synechocystis PCC 6803 from light stress and in the repair of photosystem II
    Philos Trans R Soc Lond B Biol Sci (29-10-2002) 357, 1461-1467. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2001
  43. Alba,B.M., Zhong,H.J., Pelayo,J.C. and Gross,C.A.
    degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma (E) activity
    Mol Microbiol (2001) 40, 1323-1333. PubMed  Europe PubMed DOI
    44. 1996
  44. Bass,S., Gu,Q.M. and Christen,A.
    Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated RlpA
    J Bacteriol (1996) 178, 1154-1161. PubMed  Europe PubMed
  45. Waller,P.R. and Sauer,R.T.
    Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease
    J Bacteriol (1996) 178, 1146-1153. PubMed  Europe PubMed  PMC  EPMC

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