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Literature for peptidase S01.228: hepatocyte growth factor activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Shamanaev,A., Litvak,M., Ivanov,I., Srivastava,P., Sun,M.F., Dickeson,S.K., Kumar,S., He,T.Z. and Gailani,D.
    Factor XII Structure-Function Relationships
    Semin Thromb Hemost50, 937-952. PubMed  Europe PubMed DOI  V
    2. 2022
  2. Shamanaev,A., Ivanov,I., Sun,M.F., Litvak,M., Srivastava,P., Mohammed,B.M., Shaban,R., Maddur,A., Verhamme,I.M., McCarty,O.J.T., Law,R.H.P. and Gailani,D.
    A Model for Surface-Dependent Factor XII Activation: The Roles of Factor XII Heavy Chain Domains
    Blood Adv PubMed  Europe PubMed DOI
  3. Tokarski,M., Cierzniak,A. and Baczynska,D.
    Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells
    Int J Biochem Cell Biol152, 106310-106310. PubMed  Europe PubMed DOI
    4. 2020
  4. Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R.
    Design of drug-like hepsin inhibitors against prostate cancer and kidney stones
    Acta Pharm Sin B10, 1309-1320. PubMed  Europe PubMed DOI
    5. 2019
  5. Damalanka,V.C., Wildman,S.A. and Janetka,J.W.
    Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin
    MedChemComm10, 1646-1655. PubMed  Europe PubMed DOI  I
    6. 2018
  6. Fukushima,T., Uchiyama,S., Tanaka,H. and Kataoka,H.
    Hepatocyte growth factor activator: a proteinase linking tissue injury with repair
    Int J Mol Sci19, PubMed  Europe PubMed DOI
    7. 2016
  7. Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W.
    alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer
    ChemMedChem11, 585-599. PubMed  Europe PubMed DOI  I
  8. Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr
    Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation
    ACS Med Chem Lett7, 177-181. PubMed  Europe PubMed DOI  I
    9. 2015
  9. Franco,F.M., Jones,D.E., Harris,P.K., Han,Z., Wildman,S.A., Jarvis,C.M. and Janetka,J.W.
    Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: evaluation of potency and selectivity derived from distinct binding pockets
    Bioorg Med Chem23, 2328-2343. PubMed  Europe PubMed DOI  I
  10. Slowinska,M., Bukowska,J., Hejmej,A., Bilinska,B., Kozlowski,K., Jankowski,J. and Ciereszko,A.
    Hepatocyte growth factor activator is a potential target proteinase for Kazal-type inhibitor in turkey (Meleagris gallopavo) seminal plasma
    Theriogenology84, 425-436. PubMed  Europe PubMed DOI
    11. 2014
  11. Han,Z., Harris,P.K., Jones,D.E., Chugani,R., Kim,T., Agarwal,M., Shen,W., Wildman,S.A. and Janetka,J.W.
    Inhibitors of HGFA, matriptase, and hepsin serine proteases: a nonkinase strategy to block cell signaling in cancer
    ACS Med Chem Lett5, 1219-1224. PubMed  Europe PubMed DOI  I
    12. 2012
  12. Kataoka,H.
    Hepatocyte growth factor activator
    [ISSN:978-0-12-407742-3]3, 3016-3020. DOI
    13. 2010
  13. Eigenbrot,C., Ganesan,R. and Kirchhofer,D.
    Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)
    FEBS J277, 2215-2222. PubMed  Europe PubMed DOI  S
  14. Ganesan,R., Eigenbrot,C. and Kirchhofer,D.
    Structural and mechanistic insight into how antibodies inhibit serine proteases
    Biochem J430, 179-189. PubMed  Europe PubMed DOI
  15. Kataoka,H. and Kawaguchi,M.
    Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo
    FEBS J277, 2230-2237. PubMed  Europe PubMed DOI
  16. Miyazawa,K.
    Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor
    FEBS J277, 2208-2214. PubMed  Europe PubMed DOI
  17. Suzuki,K.
    Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor
    FEBS J277, 2223-2229. PubMed  Europe PubMed DOI
    18. 2009
  18. Ganesan,R., Eigenbrot,C., Wu,Y., Liang,W.C., Shia,S., Lipari,M.T. and Kirchhofer,D.
    Unraveling the allosteric mechanism of serine protease inhibition by an antibody
    Structure17, 1614-1624. PubMed  Europe PubMed DOI  S
  19. Kawaguchi,M., Orikawa,H., Baba,T., Fukushima,T. and Kataoka,H.
    Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein
    FEBS J276, 3481-3490. PubMed  Europe PubMed DOI  P
    20. 2008
  20. Kitajima,Y., Ide,T., Ohtsuka,T. and Miyazaki,K.
    Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer
    Cancer Sci99, 1341-1347. PubMed  Europe PubMed DOI
  21. Mukai,S., Fukushima,T., Naka,D., Tanaka,H., Osada,Y. and Kataoka,H.
    Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases
    FEBS J275, 1003-1017. PubMed  Europe PubMed DOI
    22. 2007
  22. Hayashi,T., Nishioka,J., Nakagawa,N., Kamada,H., Gabazza,E.C., Kobayashi,T., Hattori,A. and Suzuki,K.
    Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator
    J Thromb Haemost5, 1477-1485. PubMed  Europe PubMed DOI
  23. Wu,Y., Eigenbrot,C., Liang,W.C., Stawicki,S., Shia,S., Fan,B., Ganesan,R., Lipari,M.T. and Kirchhofer,D.
    Structural insight into distinct mechanisms of protease inhibition by antibodies
    Proc Natl Acad Sci U S A104, 19784-19789. PubMed  Europe PubMed DOI  S
    24. 2005
  24. [YEAR:11-3-2005]Shia,S., Stamos,J., Kirchhofer,D., Fan,B., Wu,J., Corpuz,R.T., Santell,L., Lazarus,R.A. and Eigenbrot,C.
    Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
    J Mol Biol346, 1335-1349. PubMed  Europe PubMed DOI  S
  25. [YEAR:1-9-2005]Tjin,E.P., Bende,R.J., Derksen,P.W., van Huijstee,A.P., Kataoka,H., Spaargaren,M. and Pals,S.T.
    Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator
    J Immunol175, 2807-2813. PubMed  Europe PubMed
    26. 2004
  26. Itoh,H., Naganuma,S., Takeda,N., Miyata,S., Uchinokura,S., Fukushima,T., Uchiyama,S., Tanaka,H., Nagaike,K., Shimomura,T., Miyazawa,K., Yamada,G., Kitamura,N., Koono,M. and Kataoka,H.
    Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice
    Gastroenterology127, 1423-1435. PubMed  Europe PubMed DOI  K
  27. Kitamura,N.
    Hepatocyte growth factor activator
    [ISSN:0-12-079610-4]2, 1712-1713.  V
  28. Tjin,E.P., Derksen,P.W., Kataoka,H., Spaargaren,M. and Pals,S.T.
    Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
    Blood104, 2172-2175. PubMed  Europe PubMed DOI
    29. 2003
  29. Kataoka,H., Miyata,S., Uchinokura,S. and Itoh,H.
    Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor
    Cancer Metastasis Rev22, 223-236. PubMed  Europe PubMed DOI
    30. 2002
  30. Kaibori,M., Inoue,T., Oda,M., Naka,D., Kawaguchi,T., Kitamura,N., Miyazawa,K., Kwon,A.H., Kamiyama,Y. and Okumura,T.
    Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF
    Biochem Biophys Res Commun290, 475-481. PubMed  Europe PubMed DOI  U
    31. 2001
  31. van Adelsberg,J., Sehgal,S., Kukes,A., Brady,C., Barasch,J., Yang,J. and Huan,Y.
    Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro
    J Biol Chem276, 15099-15106. PubMed  Europe PubMed DOI
    32. 1999
  32. Shimomura,T., Denda,K., Kawaguchi,T., Matsumoto,K., Miyazawa,K. and Kitamura,N.
    Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form
    J Biochem126, 821-828. PubMed  Europe PubMed
    33. 1998
  33. [YEAR:1-12-1998]Miyazawa,K., Wang,Y., Minoshima,S., Shimizu,N. and Kitamura,N.
    Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene - phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator
    Eur J Biochem258, 355-361. PubMed  Europe PubMed DOI
    34. 1996
  34. Choi-Miura,N.H., Tobe,T., Sumiya,J., Nakano,Y., Sano,Y., Mazda,T. and Tomita,M.
    Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: It has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator
    J Biochem119, 1157-1165. PubMed  Europe PubMed
  35. [YEAR:16-2-1996]Miyazawa,K., Shimomura,T. and Kitamura,N.
    Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator
    J Biol Chem271, 3615-3618. PubMed  Europe PubMed DOI
    36. 1995
  36. [YEAR:1-4-1995]Shimomura,T., Miyazawa,K., Komiyama,Y., Hiraoka,H., Naka,D., Morimoto,Y. and Kitamura,N.
    Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator
    Eur J Biochem229, 257-261. PubMed  Europe PubMed DOI
    37. 1993
  37. [YEAR:15-5-1993]Miyazawa,K., Shimomura,T., Kitamura,A., Kondo,J., Morimoto,Y. and Kitamura,N.
    Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
    J Biol Chem268, 10024-10028. PubMed  Europe PubMed
  38. [YEAR:25-10-1993]Shimomura,T., Kondo,J., Ochiai,M., Naka,D., Miyazawa,K., Morimoto,Y. and Kitamura,N.
    Activation of the zymogen of hepatocyte growth factor activator by thrombin
    J Biol Chem268, 22927-22932. PubMed  Europe PubMed
    39. 1992
  39. Shimomura,T., Ochiai,M., Kondo,J. and Morimoto,Y.
    A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture
    Cytotechnology8, 219-229. PubMed  Europe PubMed DOI

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