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Literature for peptidase S01.228: hepatocyte growth factor activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, K Knockout, P Specificity, I Inhibitor, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Shamanaev,A., Litvak,M., Ivanov,I., Srivastava,P., Sun,M.F., Dickeson,S.K., Kumar,S., He,T.Z. and Gailani,D.<br>Factor XII Structure-Function Relationships<br>Semin Thromb Hemost (2024) 50, 937-952. PubMed  Europe PubMed DOI  V
    2. 2022
  2. Shamanaev,A., Ivanov,I., Sun,M.F., Litvak,M., Srivastava,P., Mohammed,B.M., Shaban,R., Maddur,A., Verhamme,I.M., McCarty,O.J.T., Law,R.H.P. and Gailani,D.<br>A Model for Surface-Dependent Factor XII Activation: The Roles of Factor XII Heavy Chain Domains<br>Blood Adv (2022) PubMed  Europe PubMed DOI
  3. Tokarski,M., Cierzniak,A. and Baczynska,D.<br>Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells<br>Int J Biochem Cell Biol (2022) 152, 106310-106310. PubMed  Europe PubMed DOI
    4. 2020
  4. Blay,V., Li,M.C., Ho,S.P., Stoller,M.L., Hsieh,H.P. and Houston,D.R.<br>Design of drug-like hepsin inhibitors against prostate cancer and kidney stones<br>Acta Pharm Sin B (2020) 10, 1309-1320. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Damalanka,V.C., Wildman,S.A. and Janetka,J.W.<br>Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin<br>MedChemComm (2019) 10, 1646-1655. PubMed  Europe PubMed DOI  PMC  EPMC  I
    6. 2018
  6. Fukushima,T., Uchiyama,S., Tanaka,H. and Kataoka,H.<br>Hepatocyte growth factor activator: a proteinase linking tissue injury with repair<br>Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI
    7. 2016
  7. Han,Z., Harris,P.K., Karmakar,P., Kim,T., Owusu,B.Y., Wildman,S.A., Klampfer,L. and Janetka,J.W.<br>alpha-Ketobenzothiazole serine protease inhibitors of aberrant HGF/c-MET and MSP/RON kinase pathway signaling in cancer<br>ChemMedChem (2016) 11, 585-599. PubMed  Europe PubMed DOI  I
  8. Venukadasula,P.K., Owusu,B.Y., Bansal,N., Ross,L.J., Hobrath,J.V., Bao,D., Truss,J.W., Stackhouse,M., Messick,T.E., Klampfer,L. and Galemmo RA Jr<br>Design and synthesis of nonpeptide inhibitors of hepatocyte growth factor activation<br>ACS Med Chem Lett (2016) 7, 177-181. PubMed  Europe PubMed DOI  PMC  EPMC  I
    9. 2015
  9. Franco,F.M., Jones,D.E., Harris,P.K., Han,Z., Wildman,S.A., Jarvis,C.M. and Janetka,J.W.<br>Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: evaluation of potency and selectivity derived from distinct binding pockets<br>Bioorg Med Chem (2015) 23, 2328-2343. PubMed  Europe PubMed DOI  I
  10. Slowinska,M., Bukowska,J., Hejmej,A., Bilinska,B., Kozlowski,K., Jankowski,J. and Ciereszko,A.<br>Hepatocyte growth factor activator is a potential target proteinase for Kazal-type inhibitor in turkey (Meleagris gallopavo) seminal plasma<br>Theriogenology (2015) 84, 425-436. PubMed  Europe PubMed DOI
    11. 2014
  11. Han,Z., Harris,P.K., Jones,D.E., Chugani,R., Kim,T., Agarwal,M., Shen,W., Wildman,S.A. and Janetka,J.W.<br>Inhibitors of HGFA, matriptase, and hepsin serine proteases: a nonkinase strategy to block cell signaling in cancer<br>ACS Med Chem Lett (2014) 5, 1219-1224. PubMed  Europe PubMed DOI  PMC  EPMC  I
    12. 2012
  12. Kataoka,H.<br>Hepatocyte growth factor activator<br>[ISSN:978-0-12-407742-3] (2012) 3, 3016-3020. DOI
    13. 2010
  13. Eigenbrot,C., Ganesan,R. and Kirchhofer,D.<br>Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1)<br>FEBS J (2010) 277, 2215-2222. PubMed  Europe PubMed DOI  S
  14. Ganesan,R., Eigenbrot,C. and Kirchhofer,D.<br>Structural and mechanistic insight into how antibodies inhibit serine proteases<br>Biochem J (2010) 430, 179-189. PubMed  Europe PubMed DOI
  15. Kataoka,H. and Kawaguchi,M.<br>Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo<br>FEBS J (2010) 277, 2230-2237. PubMed  Europe PubMed DOI
  16. Miyazawa,K.<br>Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor<br>FEBS J (2010) 277, 2208-2214. PubMed  Europe PubMed DOI
  17. Suzuki,K.<br>Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor<br>FEBS J (2010) 277, 2223-2229. PubMed  Europe PubMed DOI
    18. 2009
  18. Ganesan,R., Eigenbrot,C., Wu,Y., Liang,W.C., Shia,S., Lipari,M.T. and Kirchhofer,D.<br>Unraveling the allosteric mechanism of serine protease inhibition by an antibody<br>Structure (2009) 17, 1614-1624. PubMed  Europe PubMed DOI  S
  19. Kawaguchi,M., Orikawa,H., Baba,T., Fukushima,T. and Kataoka,H.<br>Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein<br>FEBS J (2009) 276, 3481-3490. PubMed  Europe PubMed DOI  P
    20. 2008
  20. Kitajima,Y., Ide,T., Ohtsuka,T. and Miyazaki,K.<br>Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer<br>Cancer Sci (2008) 99, 1341-1347. PubMed  Europe PubMed DOI
  21. Mukai,S., Fukushima,T., Naka,D., Tanaka,H., Osada,Y. and Kataoka,H.<br>Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases<br>FEBS J (2008) 275, 1003-1017. PubMed  Europe PubMed DOI
    22. 2007
  22. Hayashi,T., Nishioka,J., Nakagawa,N., Kamada,H., Gabazza,E.C., Kobayashi,T., Hattori,A. and Suzuki,K.<br>Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator<br>J Thromb Haemost (2007) 5, 1477-1485. PubMed  Europe PubMed DOI
  23. Wu,Y., Eigenbrot,C., Liang,W.C., Stawicki,S., Shia,S., Fan,B., Ganesan,R., Lipari,M.T. and Kirchhofer,D.<br>Structural insight into distinct mechanisms of protease inhibition by antibodies<br>Proc Natl Acad Sci U S A (2007) 104, 19784-19789. PubMed  Europe PubMed DOI  PMC  EPMC  S
    24. 2005
  24. [YEAR:11-3-2005]Shia,S., Stamos,J., Kirchhofer,D., Fan,B., Wu,J., Corpuz,R.T., Santell,L., Lazarus,R.A. and Eigenbrot,C.<br>Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B<br>J Mol Biol (11-3-2005) 346, 1335-1349. PubMed  Europe PubMed DOI  S
  25. [YEAR:1-9-2005]Tjin,E.P., Bende,R.J., Derksen,P.W., van Huijstee,A.P., Kataoka,H., Spaargaren,M. and Pals,S.T.<br>Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator<br>J Immunol (1-9-2005) 175, 2807-2813. PubMed  Europe PubMed
    26. 2004
  26. Itoh,H., Naganuma,S., Takeda,N., Miyata,S., Uchinokura,S., Fukushima,T., Uchiyama,S., Tanaka,H., Nagaike,K., Shimomura,T., Miyazawa,K., Yamada,G., Kitamura,N., Koono,M. and Kataoka,H.<br>Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice<br>Gastroenterology (2004) 127, 1423-1435. PubMed  Europe PubMed DOI  K
  27. Kitamura,N.<br>Hepatocyte growth factor activator<br>[ISSN:0-12-079610-4] (2004) 2, 1712-1713.  V
  28. Tjin,E.P., Derksen,P.W., Kataoka,H., Spaargaren,M. and Pals,S.T.<br>Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator<br>Blood (2004) 104, 2172-2175. PubMed  Europe PubMed DOI
    29. 2003
  29. Kataoka,H., Miyata,S., Uchinokura,S. and Itoh,H.<br>Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor<br>Cancer Metastasis Rev (2003) 22, 223-236. PubMed  Europe PubMed DOI
    30. 2002
  30. Kaibori,M., Inoue,T., Oda,M., Naka,D., Kawaguchi,T., Kitamura,N., Miyazawa,K., Kwon,A.H., Kamiyama,Y. and Okumura,T.<br>Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF<br>Biochem Biophys Res Commun (2002) 290, 475-481. PubMed  Europe PubMed DOI  U
    31. 2001
  31. van Adelsberg,J., Sehgal,S., Kukes,A., Brady,C., Barasch,J., Yang,J. and Huan,Y.<br>Activation of hepatocyte growth factor (HGF) by endogenous HGF activator is required for metanephric kidney morphogenesis in vitro<br>J Biol Chem (2001) 276, 15099-15106. PubMed  Europe PubMed DOI
    32. 1999
  32. Shimomura,T., Denda,K., Kawaguchi,T., Matsumoto,K., Miyazawa,K. and Kitamura,N.<br>Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form<br>J Biochem (1999) 126, 821-828. PubMed  Europe PubMed
    33. 1998
  33. [YEAR:1-12-1998]Miyazawa,K., Wang,Y., Minoshima,S., Shimizu,N. and Kitamura,N.<br>Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene - phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator<br>Eur J Biochem (1-12-1998) 258, 355-361. PubMed  Europe PubMed DOI
    34. 1996
  34. Choi-Miura,N.H., Tobe,T., Sumiya,J., Nakano,Y., Sano,Y., Mazda,T. and Tomita,M.<br>Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: It has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator<br>J Biochem (1996) 119, 1157-1165. PubMed  Europe PubMed
  35. [YEAR:16-2-1996]Miyazawa,K., Shimomura,T. and Kitamura,N.<br>Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator<br>J Biol Chem (16-2-1996) 271, 3615-3618. PubMed  Europe PubMed DOI
    36. 1995
  36. [YEAR:1-4-1995]Shimomura,T., Miyazawa,K., Komiyama,Y., Hiraoka,H., Naka,D., Morimoto,Y. and Kitamura,N.<br>Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator<br>Eur J Biochem (1-4-1995) 229, 257-261. PubMed  Europe PubMed DOI
    37. 1993
  37. [YEAR:15-5-1993]Miyazawa,K., Shimomura,T., Kitamura,A., Kondo,J., Morimoto,Y. and Kitamura,N.<br>Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII<br>J Biol Chem (15-5-1993) 268, 10024-10028. PubMed  Europe PubMed
  38. [YEAR:25-10-1993]Shimomura,T., Kondo,J., Ochiai,M., Naka,D., Miyazawa,K., Morimoto,Y. and Kitamura,N.<br>Activation of the zymogen of hepatocyte growth factor activator by thrombin<br>J Biol Chem (25-10-1993) 268, 22927-22932. PubMed  Europe PubMed
    39. 1992
  39. Shimomura,T., Ochiai,M., Kondo,J. and Morimoto,Y.<br>A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture<br>Cytotechnology (1992) 8, 219-229. PubMed  Europe PubMed DOI

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