Literature for peptidase S01.217: thrombin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Fredenburgh,J.C. and Weitz,J.I.
Exosite crosstalk in thrombin
J Thromb Haemost PubMed Europe PubMed DOI
Imberg,L., Siutkina,A.I., Erbacher,C., Schmidt,J., Broekmans,D.F., Ovsepyan,R.A., Daniliuc,C.G., Goncalves de Oliveira,E., Serafim,M.S.M., O'Donoghue,A.J., Pillaiyar,T., Panteleev,M.A., Poso,A., Kalinina,S.A., Bermudez,M., Nekipelov,K., Bendas,G., Karst,U. and Kalinin,D.V.
Pyrazinyl-Substituted Aminoazoles as Covalent Inhibitors of Thrombin: Synthesis, Structure, and Anticoagulant Properties
ACS Pharmacol Transl Sci8, 146-172. PubMed Europe PubMed DOI I
Lopez,M.J. and Yandrapalli,S.
Thrombin
PubMed Europe PubMed
Raucci,A., Sorrentino,G., Singh,S., Borbone,N., Oliviero,G., Piccialli,G., Terracciano,M. and Cinti,S.
Cost-effective, user-friendly detection and preconcentration of thrombin on a sustainable paper-based electrochemical platform
Anal Bioanal Chem PubMed Europe PubMed DOI
Ruiz,L., Jaramillo,S., Calvo,A., Torrente,M.A., Tassies,D., Reverter,J.C., Blasi,A. and Troconiz,I.
Dynamics of thrombin generation: Filling the gap between the system pharmacology theory and clinical practice in clinical pharmacology and therapeutics
Pharmacol Res Perspect13, e70014-e70014. PubMed Europe PubMed DOI

2024

Al-Horani,R.A.
Revisiting the effect of cholesteryl sulfate on clotting and fibrinolysis: Inhibition of human thrombin and other human blood proteases
Heliyon10, e28017-e28017. PubMed Europe PubMed DOI I
Aleksandrowicz,K., Hempel,D., Politynska,B., Wojtukiewicz,A.M., Honn,K.V., Tang,D.G. and Wojtukiewicz,M.Z.
The Complex Role of Thrombin in Cancer and Metastasis: Focus on Interactions with the Immune System
Semin Thromb Hemost50, 462-473. PubMed Europe PubMed DOI V
Ali,A.E. and Becker,R.C.
Factor XI: structure, function and therapeutic inhibition
J Thromb Thrombolysis57, 1315-1328. PubMed Europe PubMed DOI K V
Amani,M.H., Rahimnejad,M. and Ezoji,H.
Smartphone-assisted quantitative colorimetric identification of thrombin based on peroxidase mimetic features of fibrinogen-gold nanozymes
Mikrochim Acta191, 83-83. PubMed Europe PubMed DOI
Ardoino,N., Lunelli,L., Pucker,G., Vanzetti,L., Favaretto,R., Pasquardini,L., Pederzolli,C., Guardiani,C. and Potrich,C.
Optimization of Surface Functionalizations for Ring Resonator-Based Biosensors
Sensors (Basel)24, PubMed Europe PubMed DOI
Bar Barroeta,A., Albanese,P., Kadava,T., Jankevics,A., Marquart,J.A., Meijers,J.C.M. and Scheltema,R.A.
Thrombin activation of the factor XI dimer is a multistaged process for each subunit
J Thromb Haemost22, 1336-1346. PubMed Europe PubMed DOI
Biswas,I., Giri,H., Panicker,S.R. and Rezaie,A.R.
Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
Arterioscler Thromb Vasc Biol44, 603-616. PubMed Europe PubMed DOI
Cao,T., Li,S., Wang,X., Sun,Y. and Luo,C.
A novel target-triggered signal chemiluminescence kit for thrombin detection based on fusiform Au/MIL-53(Fe)
Talanta267, 125144-125144. PubMed Europe PubMed DOI
Chan,M.D., Yasamanova,A.N., Avakian,G.G., Nikonova,A.A. and Kamchatnov,P.R.
[The multidirectional effects of thrombin and the possibility of their control in neurology]
Zh Nevrol Psikhiatr Im S S Korsakova124, 42-48. PubMed Europe PubMed DOI V
Dai,Y., Kretz,C.A., Kim,P.Y. and Gross,P.L.
A specific fluorescence resonance energy quenching-based biosensor for measuring thrombin activity in whole blood
J Thromb Haemost PubMed Europe PubMed DOI
Di Cera,E.
A simple method to resolve rate constants when the binding mechanism obeys induced fit or conformational selection
J Biol Chem300, 107131-107131. PubMed Europe PubMed DOI
Gyldenholm,T., Hvas,A.M., Christensen,T.D. and Larsen,J.B.
Thrombin Generation Markers as Predictors of Cancer-Associated Venous Thromboembolism: A Systematic Review
Semin Thromb Hemost50, 384-401. PubMed Europe PubMed DOI V
Kim,G. and Yang,H.
Electrochemical biosensor using direct electron transfer and an antibody-aptamer hybrid sandwich for target detection in complex biological samples
Biosens Bioelectron253, 116184-116184. PubMed Europe PubMed DOI
Kumar,S., Summers,B., Basore,K., Pengo,V., Flaumenhaft,R. and Pozzi,N.
Cryo-EM structure and functional basis of prothrombin recognition by a Type-I anti-prothrombin antiphospholipid antibody
Blood143, 2005-2011. PubMed Europe PubMed DOI
Liu,Y. and Zhou,J.
Genetic Susceptibility of Thrombin Measurement Levels and the Risk of Colon Adenocarcinoma: A Mendelian Randomization Study
Br J Hosp Med (Lond)85, 1-13. PubMed Europe PubMed DOI
Manuvera,V.A., Kharlampieva,D.D., Bobrovsky,P.A., Grafskaia,E.N., Brovina,K.A. and Lazarev,V.N.
New anticoagulant protein from medicinal leech
Biochem Biophys Res Commun696, 149473-149473. PubMed Europe PubMed DOI
Overlinge,D., Ceglowska,M., Konkel,R. and Mazur-Marzec,H.
Aeruginosin 525 (AER525) from Cyanobacterium Aphanizomenon Sp. (KUCC C2): A New Serine Proteases Inhibitor
Mar Drugs22, PubMed Europe PubMed DOI I
Paul,S., Chatterjee,A., Das,K., Ray,A., Basu,A., Mukhopadhyay,S. and Sen,P.
Thrombin confers chemotherapeutic resistance by promoting transcriptional induction and post-translational stabilization of pro-survival MCL1 in TNBC
J Biol Chem108025-108025. PubMed Europe PubMed DOI
Risman,R.A., Belcher,H.A., Ramanujam,R.K., Weisel,J.W., Hudson,N.E. and Tutwiler,V.
Comprehensive Analysis of the Role of Fibrinogen and Thrombin in Clot Formation and Structure for Plasma and Purified Fibrinogen
Biomolecules14, PubMed Europe PubMed DOI
Stojanovski,B.M., Pelc,L.A. and Di Cera,E.
Thrombin has dual trypsin-like and chymotrypsin-like specificity
J Thromb Haemost22, 1009-1015. PubMed Europe PubMed DOI
Stojanovski,B.M., Mohammed,B.M. and Di Cera,E.
The Prothrombin-Prothrombinase Interaction
Subcell Biochem104, 409-423. PubMed Europe PubMed DOI V
Ustok,F.I., Adams,T.E. and Huntington,J.A.
Rapid and ordered cleavage of prothrombin by Hopsarin D in the absence of phospholipid membranes
J Thromb Haemost22, 3070-3083. PubMed Europe PubMed DOI
Vergnolle,N.
Thrombin stories in the gut
Biochimie226, 107-112. PubMed Europe PubMed DOI V
Wu,D., Prem,A., Xiao,J. and Salsbury,F.R.
Thrombin - A Molecular Dynamics Perspective
Mini Rev Med Chem24, 1112-1124. PubMed Europe PubMed DOI V
Zhang,J., Xu,D., Deng,Z., Tan,X., Guo,D., Qiao,Y., Li,Y., Hou,X., Wang,S. and Zhang,J.
Using tungsten oxide quantum-dot enhanced electrochemiluminescence to measure thrombin activity and screen its inhibitors
Talanta267, 125267-125267. PubMed Europe PubMed DOI

2023

Adams,R., Coleman,R. and Stanton,T.
Performance of Chromogenic Protein C (PC) Testing
Methods Mol Biol2663, 225-232. PubMed Europe PubMed DOI
Ali,G.K., Algethami,F.K. and Omer,K.M.
Gold single atom-based aptananozyme as an ultrasensitive and selective colorimetric probe for detection of thrombin and C-reactive protein
Mikrochim Acta191, 59-59. PubMed Europe PubMed DOI
Asena Ozbek,M., Ozgur,E., Bereli,N. and Denizli,A.
Molecular imprinted based microcryogels for thrombin purification
J Chromatogr B Analyt Technol Biomed Life Sci1228, 123848-123848. PubMed Europe PubMed DOI
Cimen,D., Bereli,N., Gunaydin,S. and Denizli,A.
Preparation of magnetic poly(ethylene glycol dimethacrylate-N-Methacryloyl-(L)-glutamic acid) particles for thrombin purification
J Chromatogr B Analyt Technol Biomed Life Sci1219, 123653-123653. PubMed Europe PubMed DOI
Dong,H., Liu,X., Gan,L., Fan,D., Sun,X., Zhang,Z. and Wu,P.
Nucleic acid aptamer-based biosensors and their application in thrombin analysis
Bioanalysis15, 513-532. PubMed Europe PubMed DOI V
Erickson,R., Huang,C., Allen,C., Ireland,J., Roth,G., Zou,Z., Lu,J., Lafont,B.A.P., Garza,N.L., Brumbaugh,B., Zhao,M., Suzuki,M., Olano,L., Brzostowski,J., Fischer,E.R., Twigg,H.L., III, Johnson,R.F. and Sun,P.D.
SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition
Nat Commun14, 6380-6380. PubMed Europe PubMed DOI
Fuhrmann,D.C., Becker,S. and Brune,B.
Mitochondrial ferritin expression in human macrophages is facilitated by thrombin-mediated cleavage under hypoxia
FEBS Lett597, 276-287. PubMed Europe PubMed DOI
Komives,E.A.
Dynamic allostery in thrombin-a review
Front Mol Biosci10, 1200465-1200465. PubMed Europe PubMed DOI
Li,X., Song,X., Mahmood,D.F.D., Sim,M.M.S., Bidarian,S.J. and Wood,J.P.
Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation
Thromb Res230, 84-93. PubMed Europe PubMed DOI
Matsui,S., Nakamura,O. and Tsutsui,S.
Unique properties of prothrombin in the bullhead shark Heterodontus japonicus: the first report of purification and characterization of a blood coagulation factor in Chondrichthyes
J Comp Physiol B193, 71-80. PubMed Europe PubMed DOI
Nagano,M., Kubota,K., Sakata,A., Nakamura,R., Yoshitomi,T., Wakui,K. and Yoshimoto,K.
A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice
Mol Ther Nucleic Acids33, 762-772. PubMed Europe PubMed DOI I
Parunov,L.A., Liang,Y., Lu,Q., Shibeko,A.M., Tucker,E.I., Lee,T.K., Ataullakhanov,F.I., Scott,D.E. and Ovanesov,M.V.
Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation
Blood Adv7, 2622-2631. PubMed Europe PubMed DOI
Riccardi,C., Perez de Carvasal,K., Platella,C., Meyer,A., Smietana,M., Morvan,F. and Montesarchio,D.
Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects
Bioorg Chem141, 106917-106917. PubMed Europe PubMed DOI
Wu,S., Wang,T., Li,J., Zhang,Z., Li,C., Xiao,S., He,J., Wang,X., Hu,Z., Wang,X., Zheng,S., Liang,X., Chen,G., Li,Y., Li,X., Zhan,Y., Zou,Q., Jiang,H., Zheng,Q., Ban,L., Liu,H. and Fang,Y.
First-in-human trial of SAR107375E, a novel small molecule anticoagulant with dual inhibition of factor Xa and factor IIa
Expert Opin Investig Drugs32, 1085-1094. PubMed Europe PubMed DOI I
Xu,J., Ye,W., Yang,T.T., Yan,T., Cai,H., Zhou,A. and Yang,Y.
DNA accelerates the protease inhibition of a bacterial serpin chloropin
Front Mol Biosci10, 1157186-1157186. PubMed Europe PubMed DOI
Zhang,Q.D., Duan,Q.Y., Tu,J. and Wu,F.G.
Thrombin and Thrombin-Incorporated Biomaterials for Disease Treatments
Adv Healthc Matere2302209-e2302209. PubMed Europe PubMed DOI V

2022

Al-Amer,O.M.
The role of thrombin in haemostasis
Blood Coagul Fibrinolysis33, 145-148. PubMed Europe PubMed DOI V
Bar Barroeta,A., Marquart,J.A. and Meijers,J.C.M.
A FRET-based assay for the quantitation of the thrombin-factor XI interaction
Thromb Res214, 23-28. PubMed Europe PubMed DOI
Dukhin,O.A., Kalinsaya,A.I., Shpektor,A.V. and Vasilieva,E.Y.
[The role of thrombin in the pathogenesis of atherosclerosis and its complications]
Kardiologiia62, 73-81. PubMed Europe PubMed DOI V
Eaton,M.P., Nadtochiy,S.M., Stefanos,T., LeMoine,D. and Anderson,B.J.
Delayed concentration effect models for dabigatran anticoagulation
Paediatr Anaesth32, 1113-1120. PubMed Europe PubMed DOI I
Eivazzadeh-Keihan,R., Saadatidizaji,Z., Maleki,A., de la Guardia,M., Mahdavi,M., Barzegar,S. and Ahadian,S.
Recent Progresses in Development of Biosensors for Thrombin Detection
Biosensors (Basel)12, PubMed Europe PubMed DOI V
Jiang,H., Zhang,Y., Wu,Y., Cheng,J., Feng,S., Wang,J., Wang,X. and Cheng,M.
Identification of Montelukast as flavivirus NS2B-NS3 protease inhibitor by inverse virtual screening and experimental validation
Biochem Biophys Res Commun606, 87-93. PubMed Europe PubMed DOI I
Laki,K.
The Polymerization of Proteins: the Action of Thrombin on Fibrinogen
Arch Biochem Biophys726, 109244-109244. PubMed Europe PubMed DOI
Modrzycka,S., Kolt,S., Polderdijk,S.G.I., Adams,T.E., Potoczek,S., Huntington,J.A., Kasperkiewicz,P. and Drag,M.
Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma
Chem Sci13, 6813-6829. PubMed Europe PubMed DOI
Olson,S.T.
Commentary on "The polymerization of proteins: The action of thrombin on fibrinogen"
Arch Biochem Biophys109176-109176. PubMed Europe PubMed DOI
Ruben,E.A., Summers,B., Rau,M.J., Fitzpatrick,J.A.J. and Di Cera,E.
Cryo-EM structure of the prothrombin-prothrombinase complex
Blood139, 3463-3473. PubMed Europe PubMed DOI
Wang,J., Sun,X., Li,N., Sheng,R. and Guo,R.
An overview of thrombin inhibitors in the perspective of structure-activity relationships
Curr Med Chem PubMed Europe PubMed DOI
Yang,P., Guo,X., Zhang,J., Chen,C., Gan,Y., Xie,W., Du,Y. and Wu,Z.
Picomolar thrombin detection by orchestration of triple signal amplification strategy with hierarchically porous Ti3C2Tx MXene electrode material-catalytic hairpin assembly reaction-metallic nanoprobes
Biosens Bioelectron208, 114228-114228. PubMed Europe PubMed DOI
Zabrodskaya,Y.A., Egorov,V.V., Sokolov,A.V., Shvetsov,A.V., Gorshkova,Y.E., Ivankov,O.I., Kostevich,V.A., Gorbunov,N.P., Ramsay,E.S., Fedorova,N.D., Bondarenko,A.B. and Vasilyev,V.B.
Caught red handed: modeling and confirmation of the myeloperoxidase ceruloplasmin alpha-thrombin complex
Biometals35, 1157-1168. PubMed Europe PubMed DOI
Zhang,X., Yang,Y., Wang,Y., Wu,J., Fang,Q., Wang,Y., Zhao,M. and Peng,S.
(1R,3S)-THCCA-Asn: To show the discovery of selective inhibitor of thrombin by successfully combining virtual screening and biological assay
Eur J Med Chem242, 114681-114681. PubMed Europe PubMed DOI

2021

Al Zamel,I., Palakkott,A. and Ayoub,M.A.
Synergistic activation of thrombin and angiotensin II receptors revealed by bioluminescence resonance energy transfer
FEBS Lett PubMed Europe PubMed DOI
Aliter,K.F. and Al-Horani,R.A.
Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19
Cardiovasc Drugs Ther35, 195-203. PubMed Europe PubMed DOI V I
Bhakta,V., Hamada,M., Nouanesengsy,A., Lapierre,J., Perruzza,D.L. and Sheffield,W.P.
Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis
Sci Rep11, 5565-5565. PubMed Europe PubMed DOI
Boro,M., Govatati,S., Kumar,R., Singh,N.K., Pichavaram,P., Traylor,J.G., Jr., Orr,A.W. and Rao,G.N.
Correction: Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis
Cell Death Differ PubMed Europe PubMed DOI
Campello,E., Bulato,C., Spiezia,L., Boscolo,A., Poletto,F., Cola,M., Gavasso,S., Simion,C., Radu,C.M., Cattelan,A., Tiberio,I., Vettor,R., Navalesi,P. and Simioni,P.
Thrombin generation in patients with COVID-19 with and without thromboprophylaxis
Clin Chem Lab Med PubMed Europe PubMed DOI
Crossen,J. and Diamond,S.L.
Thermal shift assay to probe melting of thrombin, fibrinogen, fibrin monomer, and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen
Biochim Biophys Acta Gen Subj1865, 129805-129805. PubMed Europe PubMed DOI I
Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
Int J Mol Sci22, PubMed Europe PubMed DOI
Hamada,M., Bhakta,V., Andres,S.N. and Sheffield,W.P.
Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant
Front Cardiovasc Med8, 647405-647405. PubMed Europe PubMed DOI
Huang,W., Hu,G.B., Liang,W.B., Wang,J.M., Lu,M.L., Yuan,R. and Xiao,D.R.
Ruthenium(II) Complex-Grafted Hollow Hierarchical Metal-Organic Frameworks with Superior Electrochemiluminescence Performance for Sensitive Assay of Thrombin
Anal Chem93, 6239-6245. PubMed Europe PubMed DOI
Kearney,K.J., Butler,J., Posada,O.M., Wilson,C., Heal,S., Ali,M., Hardy,L., Ahnstrom,J., Gailani,D., Foster,R., Hethershaw,E., Longstaff,C. and Philippou,H.
Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI
Proc Natl Acad Sci U S A118, PubMed Europe PubMed DOI
Koh,C.Y., Shih,N., Yip,C.Y.C., Li,A.W.L., Chen,W., Amran,F.S., Leong,E.J.E., Iyer,J.K., Croft,G., Mazlan,M.I.B., Chee,Y.L., Yap,E.S., Monroe,D.M., Hoffman,M., Becker,R.C., de Kleijn,D.P.V., Verma,V., Gupta,A., Chaudhary,V.K., Richards,A.M., Kini,R.M. and Chan,M.Y.
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
Nat Commun12, 6912-6912. PubMed Europe PubMed DOI
Kunnapuu,J., Bokharaie,H. and Jeltsch,M.
Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
Biology (Basel)10, PubMed Europe PubMed DOI
Larsen,J.B. and Hvas,A.M.
Thrombin: A Pivotal Player in Hemostasis and Beyond
Semin Thromb Hemost PubMed Europe PubMed DOI V
Lo,Y.C., Peng,C.T. and Chen,Y.T.
Case Report: Factor VII Deficiency Presented With Cephalohematoma After Birth
Front Pediatr9, 755121-755121. PubMed Europe PubMed DOI
Lu,Y., Biswas,I., Villoutreix,B.O. and Rezaie,A.R.
Role of Gly197 in the structure and function of protein C
Biochim Biophys Acta Gen Subj1865, 129892-129892. PubMed Europe PubMed DOI
Nakajima,Y., Minami,H. and Nogami,K.
Acidic Region Residues 1680-1684 in the A3 Domain of Factor VIII Contain a Thrombin-Interactive Site Responsible for Proteolytic Cleavage at Arg1689
Thromb Haemost PubMed Europe PubMed DOI
Peacock,R.B. and Komives,E.A.
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin
Biochemistry PubMed Europe PubMed DOI
Pelc,L.A., Koester,S.K., Kukla,C.R., Chen,Z. and Di Cera,E.
The active site region plays a critical role in Na(+) binding to thrombin
J Biol Chem298, 101458-101458. PubMed Europe PubMed DOI
Reda,S., Ruhl,H., Witkowski,J., Muller,J., Pavlova,A., Oldenburg,J. and Potzsch,B.
PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy
Front Cardiovasc Med8, 755281-755281. PubMed Europe PubMed DOI
Sriram,K. and Insel,P.A.
Inflammation and thrombosis in COVID-19 pathophysiology: Proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
Physiol Rev101, 545-567. PubMed Europe PubMed DOI
Troisi,R., Balasco,N., Autiero,I., Vitagliano,L. and Sica,F.
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands
Int J Mol Sci22, PubMed Europe PubMed DOI V
Wan,J., Vadaq,N., Konings,J., Jaeger,M., Kumar,V., de Laat,B., Joosten,L., Netea,M.G., van der Ven,A.J., DE Groot,P.G., de Mast,Q. and Roest,M.
Kallikrein augments the anticoagulant function of the protein C system in thrombin generation
J Thromb Haemost PubMed Europe PubMed DOI
Watanabe,Y., Oguri,R., Suzuki,R., Meng,Q., Ishikawa,Y., Tatsukawa,H., Hashimoto,H. and Hitomi,K.
Thrombin-deficient mutant of medaka, a model fish, displays serious retardation in blood coagulation
Biosci Biotechnol Biochem85, 824-833. PubMed Europe PubMed DOI
Wong,P.C. and Quan,M.L.
Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys
Res Pract Thromb Haemost5, e12524-e12524. PubMed Europe PubMed DOI I
Ye,F., Garton,H.J.L., Hua,Y., Keep,R.F. and Xi,G.
The Role of Thrombin in Brain Injury After Hemorrhagic and Ischemic Stroke
Transl Stroke Res12, 496-511. PubMed Europe PubMed DOI V
Zhou,M., Gao,D., Yang,Z., Zhou,C., Tan,Y., Wang,W. and Jiang,Y.
Streaming-enhanced, chip-based biosensor with acoustically active, biomarker-functionalized micropillars: A case study of thrombin detection
Talanta222, 121480-121480. PubMed Europe PubMed DOI

2020

Agarwal,V., Bhatia,V. and Gorsi,U.
Response to article on endoscopic ultrasound-guided thrombin injection, a management approach for visceral artery pseudoaneurysms
Endosc Int Open8, E967-E967. PubMed Europe PubMed DOI
Alvarez-Arce,A., Lee-Rivera,I., Lopez,E. and Lopez-Colome,A.M.
Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation
Cell Signal75, 109748-109748. PubMed Europe PubMed DOI
Bano,S., Fatima,S., Ahamad,S., Ansari,S., Gupta,D., Tabish,M., Rehman,S.U. and Jairajpuri,M.A.
Identification and characterization of a novel isoform of heparin cofactor II in human liver
IUBMB Life PubMed Europe PubMed DOI
Batteux,B., Bodeau,S., Gras-Champel,V., Liabeuf,S., Lanoix,J.P., Schmit,J.L., Andrejak,C., Zerbib,Y., Haye,G., Masmoudi,K., Lemaire-Hurtel,A.S. and Bennis,Y.
Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19
Br J Clin Pharmacol PubMed Europe PubMed DOI I
Belay,E.S., O'Donnell,J., Flamant,E., Hinton,Z., Klifto,C.S. and Anakwenze,O.
Intravenous tranexamic acid versus topical thrombin in shoulder arthroplasty
J Shoulder Elbow Surg PubMed Europe PubMed DOI I
Bhagwat,S.R., Hajela,K., Bhutada,S., Choudhary,K., Saxena,M., Sharma,S. and Kumar,A.
Identification of unexplored substrates of the serine protease, thrombin, using N-terminomics strategy
Int J Biol Macromol144, 449-459. PubMed Europe PubMed DOI P
Biscombe,C.J.C., Dower,S.K., Muir,I.L. and Harvie,D.J.E.
Modeling Thrombin Generation in Plasma under Diffusion and Flow
Biophys J119, 162-181. PubMed Europe PubMed DOI
Boban,A. and Hermans,C.
Safety of relaxing coagulation control by anti-TFPI in hemophilia patients: impact of tissue distribution of tissue factor
J Thromb Haemost PubMed Europe PubMed DOI
Boussofara,A., Laroussi,L., Baccouche,H., Bennour,E., Kasbaoui,S., Triki,H., Zied,E.H., Kammoun,I., Halima,A.B., Addad,F., Marrakchi,S., Romdhane,N.B. and Kachboura,S.
ImpaCt of aspirin regimen on THrombin generation in diabEtic patients with acute coronary syndrome: CARTHaGE-ACS trial
Eur J Clin Pharmacol PubMed Europe PubMed DOI
Brunet,J.G., Sharma,T., Tasneem,S., Liang,M., Wilson,M.D., Rivard,G.E. and Hayward,C.P.M.
Thrombin generation abnormalities in Quebec platelet disorder
Int J Lab Hematole13302-e13302. PubMed Europe PubMed DOI I
Cantrell,R. and Palumbo,J.S.
The thrombin-inflammation axis in cancer progression
Thromb Res191 Suppl 1, S117-S117. PubMed Europe PubMed DOI V
Chang,Y.H., Wu,J.C., Yu,H.M., Hsu,H.T., Wu,Y.T., Yu,A.L., Yu,C.T. and Wong,C.H.
Design and synthesis of glyco-peptides as anti-cancer agents targeting thrombin-protease activated receptor-1 interaction
Chem Commun (Camb)56, 5827-5830. PubMed Europe PubMed DOI
Chen,Y., Xiang,J., Liu,B., Chen,Z. and Zuo,X.
Gold nanoparticle-engineered electrochemical aptamer biosensor for ultrasensitive detection of thrombin
Anal Methods12, 3729-3733. PubMed Europe PubMed DOI
Cheng,S., Tu,M., Liu,H., An,Y., Du,M. and Zhu,B.
A novel heptapeptide derived from Crassostrea gigas shows anticoagulant activity by targeting for thrombin active domain
Food Chem334, 127507-127507. PubMed Europe PubMed DOI
Chistolini,A., Ruberto,F., Alessandri,F., Santoro,C., Barone,F., Cristina Puzzolo,M., Ceccarelli,G., De Luca,M.L., Mancone,M., Alvaro,D., Pulcinelli,F.M., Martelli,M., Foa,R. and Pugliese,F.
Effect of low or high doses of low-molecular-weight heparin on thrombin generation and other haemostasis parameters in critically ill patients with COVID-19
Br J Haematol PubMed Europe PubMed DOI
Daud,S.A., Kaur,B., McClure,G.R., Belley-Cote,E.P., Harlock,J., Crowther,M. and Whitlock,R.P.
Fibrin and Thrombin Sealants in Vascular and Cardiac Surgery: A Systematic Review and Meta-analysis
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2019

Acquasaliente,L., Pelc,L.A. and Di Cera,E.
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Lenz,M., Shimon,M.B., Benninger,F., Neufeld,M.Y., Shavit-Stein,E., Vlachos,A. and Maggio,N.
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus
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Using Ca-doped carbon dots as catalyst to amplify signal to determine ultratrace thrombin by free-label aptamer-SERS method
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A label-free electrochemical aptasensor based on magnetic biocomposites with Pb(2+)-dependent DNAzyme for the detection of thrombin
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2018

Abdel Aziz,M.H. and Desai,U.R.
Novel heparin mimetics reveal cooperativity between exosite 2 and sodium-binding site of thrombin
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Afosah,D.K., Verespy S 3rd, Al-Horani,R.A., Boothello,R.S., Karuturi,R. and Desai,U.R.
A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin
Bioorg Med Chem Lett28, 1101-1105. PubMed Europe PubMed DOI I
Awachat,R., Wagh,A.A., Aher,M., Fernandes,M. and Kumar,V.A.
Favorable 2'-substitution in the loop region of a thrombin-binding DNA aptamer
Bioorg Med Chem Lett28, 1765-1768. PubMed Europe PubMed DOI I
Cheng,W., Pan,J., Yang,J., Zheng,Z., Lu,F., Chen,Y. and Gao,W.
A photoelectrochemical aptasensor for thrombin based on the use of carbon quantum dot-sensitized TiO2 and visible-light photoelectrochemical activity
Mikrochim Acta185, 263-263. PubMed Europe PubMed DOI A
Chinnaraj,M., Planer,W. and Pozzi,N.
Structure of coagulation factor II: molecular mechanism of thrombin generation and development of next-generation anticoagulants
Front Med (Lausanne)5, 281-281. PubMed Europe PubMed DOI S
Chinnaraj,M., Chen,Z., Pelc,L.A., Grese,Z., Bystranowska,D., Di Cera,E. and Pozzi,N.
Structure of prothrombin in the closed form reveals new details on the mechanism of activation
Sci Rep8, 2945-2945. PubMed Europe PubMed DOI S
Dolot,R., Lam,C.H., Sierant,M., Zhao,Q., Liu,F.W., Nawrot,B., Egli,M. and Yang,X.
Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity
Nucleic Acids Res46, 4819-4830. PubMed Europe PubMed DOI S I
Duan,W., Wang,X., Wang,H. and Li,F.
Fluorescent and colorimetric dual-mode aptasensor for thrombin detection based on target-induced conjunction of split aptamer fragments
Talanta180, 76-80. PubMed Europe PubMed DOI A
Kanade,G.D., Pingale,K.D. and Karpe,Y.A.
Activities of thrombin and factor Xa are essential for replication of hepatitis E virus and are possibly implicated in the ORF1 polyprotein processing
J Virol92, e01853-17-e01853-17. PubMed Europe PubMed DOI
Khonsari,Y.N. and Sun,S.
Electrochemiluminescent aptasensor for thrombin using nitrogen-doped graphene quantum dots
Mikrochim Acta185, 430-430. PubMed Europe PubMed DOI A
Kintigh,J., Monagle,P. and Ignjatovic,V.
A review of commercially available thrombin generation assays
Res Pract Thromb Haemost2, 42-48. PubMed Europe PubMed DOI A
Li,J., Jiao,Y., Liu,Q. and Chen,Z.
The aptamer-thrombin-aptamer sandwich complex-bridged gold nanoparticle oligomers for high-precision profiling of thrombin by dark field microscopy
Anal Chim Acta1028, 66-76. PubMed Europe PubMed DOI A
Li,J., Zhou,W., Yuan,R. and Xiang,Y.
Aptamer proximity recognition-dependent strand translocation for enzyme-free and amplified fluorescent detection of thrombin via catalytic hairpin assembly
Anal Chim Acta1038, 126-131. PubMed Europe PubMed DOI A
Liu,Y., Jiang,X., Cao,W., Sun,J. and Gao,F.
Detection of thrombin based on fluorescence energy transfer between semiconducting polymer dots and BHQ-labelled aptamers
Sensors (Basel)18, PubMed Europe PubMed DOI A
Peacock,R.B., Davis,J.R., Markwick,P.R.L. and Komives,E.A.
Dynamic consequences of mutation of tryptophan 215 in thrombin
Biochemistry57, 2694-2703. PubMed Europe PubMed DOI
Perez-Escalante,E., Gonzalez-Olivares,L.G., Cruz-Guerrero,A.E., Galan-Vidal,C.A., Paez-Hernandez,M.E. and Alvarez-Romero,G.A.
Size exclusion chromatography (SEC-HPLC) as an alternative to study thrombin inhibition
J Chromatogr B Analyt Technol Biomed Life Sci1074-1075, 34-38. PubMed Europe PubMed DOI A
Sivaraja,M., Pozzi,N., Rienzo,M., Lin,K., Shiau,T.P., Clemens,D.M., Igoudin,L., Zalicki,P., Chang,S.S., Estiarte,M.A., Short,K.M., Williams,D.C., Datta,A., Di Cera,E. and Kita,D.B.
Reversible covalent direct thrombin inhibitors
PLoS ONE13, e0201377-e0201377. PubMed Europe PubMed DOI I
Song,H.P., Jang,J.Y., Bae,S.H., Choi,S.B., Yu,B.J. and Kim,M.I.
Convenient colorimetric detection of thrombin via aptamer-mediated inhibition and restoration of the oxidase activity of nanoceria
J Nanosci Nanotechnol18, 6570-6574. PubMed Europe PubMed DOI A I
Troisi,R., Napolitano,V., Spiridonova,V., Russo Krauss,I. and Sica,F.
Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Nucleic Acids Res46, 12177-12185. PubMed Europe PubMed DOI I
Urbanova,V., Jayaramulu,K., Schneemann,A., Kment,S., Fischer,R.A. and Zboril,R.
Hierarchical porous fluorinated graphene oxide@metal-organic gel composite: label-free electrochemical aptasensor for selective detection of thrombin
ACS Appl Mater Interfaces10, 41089-41097. PubMed Europe PubMed DOI A
Wang,H., Li,S., Wang,J., Chen,S., Sun,X.L. and Wu,Q.
N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding
elife7, PubMed Europe PubMed DOI
Wang,Y.H., Xia,H., Huang,K.J., Wu,X., Ma,Y.Y., Deng,R., Lu,Y.F. and Han,Z.W.
Ultrasensitive determination of thrombin by using an electrode modified with WSe2 and gold nanoparticles, aptamer-thrombin-aptamer sandwiching, redox cycling, and signal enhancement by alkaline phosphatase
Mikrochim Acta185, 502-502. PubMed Europe PubMed DOI A
Wen,D., He,M., Ma,K., Cui,Y., Kong,J., Yang,H. and Liu,Q.
Highly sensitive fluorometric determination of thrombin by on-chip signal amplification initiated by terminal deoxynucleotidyl transferase
Mikrochim Acta185, 380-380. PubMed Europe PubMed DOI A I
Xiong,Y., Liang,M., Cheng,Y., Zou,J. and Li,Y.
An "off-on" phosphorescent aptasensor for the detection of thrombin based on PRET
Analyst144, 161-171. PubMed Europe PubMed DOI L
Xu,Q., Wang,G., Zhang,M., Xu,G., Lin,J. and Luo,X.
Aptamer based label free thrombin assay based on the use of silver nanoparticles incorporated into self-polymerized dopamine
Mikrochim Acta185, 253-253. PubMed Europe PubMed DOI A
Zhang,Y., Xia,J., Zhang,F., Wang,Z. and Liu,Q.
A dual-channel homogeneous aptasensor combining colorimetric with electrochemical strategy for thrombin
Biosens Bioelectron120, 15-21. PubMed Europe PubMed DOI A
Zhao,J., Zhu,L., Zhou,W., Yin,L., Wang,Y., Fan,Y., Chen,Y. and Liu,H.
In silico prediction of inhibitory constant of thrombin inhibitors using machine learning
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2017

Andrianova,M.S., Grudtsov,V.P., Komarova,N.V., Kuznetsov,E.V. and Kuznetsov,A.E.
ISFET-based Aptasensor for thrombin detection using horseradish peroxidase
Procedia Eng174, 1084-1092. DOI A
Chen,D., Shi,J., Liu,J., Zhang,X., Deng,X., Yang,Y., Cui,S., Zhu,Q., Gong,G. and Xu,Y.
Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors
Bioorg Med Chem25, 458-470. PubMed Europe PubMed DOI I
Chen,S., Liu,P., Su,K., Li,X., Qin,Z., Xu,W., Chen,J., Li,C. and Qiu,J.
Electrochemical aptasensor for thrombin using co-catalysis of hemin/G-quadruplex DNAzyme and octahedral Cu2O-Au nanocomposites for signal amplification
Biosens Bioelectron99, 338-345. PubMed Europe PubMed DOI A
Deng,Y., Yue,X., Hu,H. and Zhou,X.
A new analytical experimental setup combining quartz crystal microbalance with surface enhancement Raman spectroscopy and its application in determination of thrombin
Microchem J132, 385-390. DOI A
Du,C., Hu,Y., Zhang,Q., Guo,Z., Ge,G., Wang,S., Zhai,C. and Zhu,M.
Competition-derived FRET-switching cationic conjugated polymer-Ir(III) complex probe for thrombin detection
Biosens Bioelectron100, 132-138. PubMed Europe PubMed DOI A
Dunster,J.L. and King,J.R.
Mathematical modelling of thrombin generation: asymptotic analysis and pathway characterization
IMA J Appl Math82, 60-96. DOI A
Esposito,V., Russo,A., Amato,T., Vellecco,V., Bucci,M., Mayol,L., Russo,G., Virgilio,A. and Galeone,A.
The "Janus face" of the thrombin binding aptamer: investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications
Bioorg Chem76, 202-209. PubMed Europe PubMed DOI I
Gdalya,H., Nachliel,E., Gutman,M., Einav,Y. and Tsfadia,Y.
The translocation of Na+ ion inside human thrombin accounts for the activation of the enzyme
Isr J Chem57, 413-423. DOI
Handley,L.D., Fuglestad,B., Stearns,K., Tonelli,M., Fenwick,R.B., Markwick,P.R. and Komives,E.A.
NMR reveals a dynamic allosteric pathway in thrombin
Sci Rep7, 39575-39575. PubMed Europe PubMed DOI S I
Hou,Y., Liu,J., Hong,M., Li,X., Ma,Y., Yue,Q. and Li,C.Z.
A reusable aptasensor of thrombin based on DNA machine employing resonance light scattering technique
Biosens Bioelectron92, 259-265. PubMed Europe PubMed DOI A
Hughes,Q.W., Le,B.T., Gilmore,G., Baker,R.I. and Veedu,R.N.
Construction of a bivalent thrombin binding aptamer and its antidote with improved properties
Molecules22, PubMed Europe PubMed DOI I
Iyer,J.K., Koh,C.Y., Kazimirova,M., Roller,L., Jobichen,C., Swaminathan,K., Mizuguchi,J., Iwanaga,S., Nuttall,P.A., Chan,M.Y. and Kini,R.M.
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum
FASEB J31, 2981-2995. PubMed Europe PubMed DOI S
Lee,W., Lee,S., Choi,J., Park,J.H., Kim,K.M., Jee,J.G. and Bae,J.S.
Antithrombotic properties of JJ1, a potent and novel thrombin inhibitor
Sci Rep7, 14862-14862. PubMed Europe PubMed DOI I
Lin,K.C., Jagannath,B., Muthukumar,S. and Prasad,S.
Sub-picomolar label-free detection of thrombin using electrochemical impedance spectroscopy of aptamer-functionalized MoS2
Analyst142, 2770-2780. PubMed Europe PubMed DOI A
Lin,Y., Li,J., Wang,Y., Sun,Y., Ding,C., Sun,W. and Luo,C.
A chemiluminescence biosensor for the detection of thrombin based on the aptamer composites
Spectrochim Acta A Mol Biomol Spectrosc192, 153-158. PubMed Europe PubMed DOI A
Liu,M., Li,J. and Li,B.
A colorimetric aptamer biosensor based on cationic polythiophene derivative as peroxidase mimetics for the ultrasensitive detection of thrombin
Talanta175, 224-228. PubMed Europe PubMed DOI A
Megia-Fernandez,A., Mills,B., Michels,C., Chankeshwara,S.V., Dhaliwal,K. and Bradley,M.
Highly selective and rapidly activatable fluorogenic thrombin sensors and application in human lung tissue
Org Biomol Chem15, 4344-4350. PubMed Europe PubMed DOI L
Niu,Y., Chu,M., Xu,P., Meng,S., Zhou,Q., Zhao,W., Zhao,B. and Shen,J.
An aptasensor based on heparin-mimicking hyperbranched polyester with anti-biofouling interface for sensitive thrombin detection
Biosens Bioelectron101, 174-180. PubMed Europe PubMed DOI A
Pica,A., Russo Krauss,I., Parente,V., Tateishi-Karimata,H., Nagatoishi,S., Tsumoto,K., Sugimoto,N. and Sica,F.
Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers
Nucleic Acids Res45, 461-469. PubMed Europe PubMed DOI I
Riccardi,C., Russo Krauss,I., Musumeci,D., Morvan,F., Meyer,A., Vasseur,J.J., Paduano,L. and Montesarchio,D.
Fluorescent thrombin binding aptamer-tagged nanoparticles for an efficient and reversible control of thrombin activity
ACS Appl Mater Interfaces9, 35574-35587. PubMed Europe PubMed DOI I
Roloff,A., Carlini,A.S., Callmann,C.E. and Gianneschi,N.C.
Micellar thrombin-binding aptamers: reversible nanoscale anticoagulants
J Am Chem Soc139, 16442-16445. PubMed Europe PubMed DOI I
Shen,G., Zhang,H., Yang,C., Yang,Q. and Tang,Y.
Thrombin ultrasensitive detection based on chiral supramolecular assembly signal-amplified strategy induced by thrombin-binding aptamer
Anal Chem89, 548-551. PubMed Europe PubMed DOI A
Sun,Y., Wang,Y., Li,J., Ding,C., Lin,Y., Sun,W. and Luo,C.
An ultrasensitive chemiluminescence aptasensor for thrombin detection based on iron porphyrin catalyzing luminescence desorbed from chitosan modified magnetic oxide graphene composite
Talanta174, 809-818. PubMed Europe PubMed DOI A
Thompson,R.E., Liu,X., Ripoll-Rozada,J., Alonso-Garcia,N., Parker,B.L., Pereira,P.J.B. and Payne,R.J.
Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors
Nat Chem9, 909-917. PubMed Europe PubMed DOI S
Wang,W., Xu,D.-D., Pang,D.-W. and Tang,H.-W.
Fluorescent sensing of thrombin using a magnetic nano-platform with aptamer-target-aptamer sandwich and fluorescent silica nanoprobe
J Lumin187, 9-13. DOI A
Wang,X., Sun,D., Tong,Y., Zhong,Y. and Chen,Z.
A voltammetric aptamer-based thrombin biosensor exploiting signal amplification via synergetic catalysis by DNAzyme and enzyme decorated AuPd nanoparticles on a poly(o-phenylenediamine) support
Mikrochim Acta184, 1791-1799. DOI A
Wen,C.Y., Bi,J.H., Wu,L.L. and Zeng,J.B.
Aptamer-functionalized magnetic and fluorescent nanospheres for one-step sensitive detection of thrombin
Mikrochim Acta185, 77-77. PubMed Europe PubMed DOI A
Wu,Y., Zou,L., Lei,S., Yu,Q. and Ye,B.
Highly sensitive electrochemical thrombin aptasensor based on peptide-enhanced electrocatalysis of hemin/G-quadruplex and nanocomposite as nanocarrier
Biosens Bioelectron97, 317-324. PubMed Europe PubMed DOI A
Xu,Y., Tan,S., Liang,Q. and Ding,M.
One-step facile synthesis of aptamer-modified graphene oxide for highly specific enrichment of human alpha-thrombin in plasma
Sensors (Basel)17, PubMed Europe PubMed DOI
Yang,X., Lv,J., Yang,Z., Yuan,R. and Chai,Y.
A sensitive electrochemical aptasensor for thrombin detection based on electroactive Co-based metal-organic frameworks with target-triggering NESA strategy
Anal Chem89, 11636-11640. PubMed Europe PubMed DOI A
Yang,Y., Yang,Z., Lv,J., Yuan,R. and Chai,Y.
Thrombin aptasensor enabled by Pt nanoparticles-functionalized Co-based metal organic frameworks assisted electrochemical signal amplification
Talanta169, 44-49. PubMed Europe PubMed DOI A
Zhang,Q., Zhang,D., Xu,G., Xu,Y., Lu,Y., Li,S. and Liu,Q.
Spectroscopic detection of thrombin with peptides self-assembled on gold nanoparticles hybridized graphene oxide
Sens Actuators, B Chem242, 443-449. DOI A
Zhao,B., Zhang,Y., Huang,Y., Yu,J., Li,Y., Wang,Q., Ma,Y., Song,H.Y., Yu,M. and Mo,W.
A novel hirudin derivative inhibiting thrombin without bleeding for subcutaneous injection
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2016

Adams,T.E. and Huntington,J.A.
Structural transitions during prothrombin activation: on the importance of fragment 2
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Ahour,F. and Ahsani,M.K.
An electrochemical label-free and sensitive thrombin aptasensor based on graphene oxide modified pencil graphite electrode
Biosens Bioelectron86, 764-769. PubMed Europe PubMed DOI A
Arian,D., Harenberg,J. and Kramer,R.
A chromogenic and fluorogenic peptide substrate for the highly sensitive detection of proteases in biological matrices
J Med Chem59, 7576-7583. PubMed Europe PubMed DOI A
Bradford,H.N. and Krishnaswamy,S.
The fragment 1 region of prothrombin facilitates the favored binding of fragment 12 to zymogen and enforces zymogen-like character in the proteinase
J Biol Chem291, 11114-11123. PubMed Europe PubMed DOI
Bushi,D., Gera,O., Kostenich,G., Shavit-Stein,E., Weiss,R., Chapman,J. and Tanne,D.
A novel histochemical method for the visualization of thrombin activity in the nervous system
Neuroscience320, 93-104. PubMed Europe PubMed DOI L
Chen,H.-F., Dong,M.-H., Ren,Y.-J. and Wang,F.
Design, synthesis, biological evaluation and molecular docking studies of dabigatran analogs as potential thrombin inhibitors
J Iran Chem Soc13, 347-357. DOI I
Chen,L., Bao,Y., Denstedt,J. and Zhang,J.
Nanostructured bioluminescent sensor for rapidly detecting thrombin
Biosens Bioelectron77, 83-89. PubMed Europe PubMed DOI A
Chen,Z., Tan,L., Hu,L., Zhang,Y., Wang,S. and Lv,F.
Real colorimetric thrombin aptasensor by masking surfaces of catalytically active gold nanoparticles
ACS Appl Mater Interfaces8, 102-108. PubMed Europe PubMed DOI A
Choi,K.M., Jeong,J.M., Bae,J.S., Cho,D.H., Jung,S.H., Hwang,J.Y., Baeck,G.W. and Park,C.I.
Coagulation factor II from rock bream (Oplegnathus fasciatus): first report on the molecular biological function and expression analysis in the teleost
Fish Shellfish Immunol48, 145-153. PubMed Europe PubMed DOI
Deng,N., Jiang,B., Chen,Y., Liang,Z., Zhang,L., Liang,Y., Yang,K. and Zhang,Y.
Aptamer-conjugated gold functionalized graphene oxide nanocomposites for human alpha-thrombin specific recognition
J Chromatogr A1427, 16-21. PubMed Europe PubMed DOI A
Dong,M.H., Chen,H.F., Ren,Y.J. and Shao,F.M.
Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors
Bioorg Med Chem24, 73-84. PubMed Europe PubMed DOI I
Fan,D., Guo,C., Ma,H., Zhao,D., Li,Y., Wu,D. and Wei,Q.
Facile fabrication of an aptasensor for thrombin based on graphitic carbon nitride/TiO2 with high visible-light photoelectrochemical activity
Biosens Bioelectron75, 116-122. PubMed Europe PubMed DOI A I
Feng,J., Zhuo,C., Ma,X., Li,S. and Zhang,Y.
A peptide with a cysteine terminus: probe for label-free fluorescent detection of thrombin activity
Analyst141, 4481-4487. PubMed Europe PubMed DOI A
Gulpen,A.J., Ten Cate-Hoek,A.J. and ten Cate,H.
Upstream versus downstream thrombin inhibition
Expert Rev Cardiovasc Ther14, 1273-1282. PubMed Europe PubMed DOI I
Guo,L., Hao,L. and Zhao,Q.
An aptamer assay using rolling circle amplification coupled with thrombin catalysis for protein detection
Anal Bioanal Chem408, 4715-4722. PubMed Europe PubMed DOI A
Gurwitz,D.
The Alzheimer's disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII: comment
J Thromb Haemost14, 1488-1489. PubMed Europe PubMed DOI
Hao,L. and Zhao,Q.
Microplate based assay for thrombin detection using an RNA aptamer as affinity ligand and cleavage of a chromogenic or a fluorogenic peptide substrate
Mikrochim Acta183, 1891-1898. DOI A
Jin,X., Liu,X., Zhu,X., Li,H., Li,W., Huang,Y. and Yao,S.
A label-free fluorescence assay for thrombin activity analysis based on fluorescent protein and gold nanoparticles
Anal Methods8, 3691-3697. DOI A
Jung,Y.K., Kim,K.N., Baik,J.M. and Kim,B.-S.
Self-powered triboelectric aptasensor for label-free highly specific thrombin detection
Nano Energy30, 77-83. DOI A
Klei,L.R., Hu,D., Panek,R., Alfano,D.N., Bridwell,R.E., Bailey,K.M., Oravecz-Wilson,K.I., Concel,V.J., Hess,E.M., Van Beek,M., Delekta,P.C., Gu,S., Watkins,S.C., Ting,A.T., Gough,P.J., Foley,K.P., Bertin,J., McAllister-Lucas,L.M. and Lucas,P.C.
MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage
Cell Rep17, 221-232. PubMed Europe PubMed DOI
Kuang,L., Cao,S.P., Zhang,L., Li,Q.H., Liu,Z.C., Liang,R.P. and Qiu,J.D.
A novel nanosensor composed of aptamer bio-dots and gold nanoparticles for determination of thrombin with multiple signals
Biosens Bioelectron85, 798-806. PubMed Europe PubMed DOI A
Kurisaki,I., Takayanagi,M. and Nagaoka,M.
Bound Na(+) is a negative effecter for thrombin-substrate stereospecific complex formation
J Phys Chem B120, 4540-4547. PubMed Europe PubMed DOI
Mehta,A.Y., Mohammed,B.M., Martin,E.J., Brophy,D.F., Gailani,D. and Desai,U.R.
Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibalpha-binding and heparin-binding site of thrombin
J Thromb Haemost14, 828-838. PubMed Europe PubMed DOI
Muller,J., Becher,T., Mayer,G. and Potzsch,B.
Aptamer-based enzyme capture assay for measurement of plasma thrombin levels
Methods Mol Biol1380, 179-189. PubMed Europe PubMed DOI A I
Palekar,R.U., Jallouk,A.P., Myerson,J.W., Pan,H. and Wickline,S.A.
Inhibition of thrombin With PPACK-nanoparticles restores disrupted endothelial barriers and attenuates thrombotic risk in experimental atherosclerosis
Arterioscler Thromb Vasc Biol36, 446-455. PubMed Europe PubMed DOI I
Petrey,A.C. and de la Motte,C.A.
Thrombin cleavage of inter-alpha-inhibitor heavy chain 1 regulates leukocyte binding to an inflammatory hyaluronan matrix
J Biol Chem291, 24324-24334. PubMed Europe PubMed DOI
Pozzi,N., Zerbetto,M., Acquasaliente,L., Tescari,S., Frezzato,D., Polimeno,A., Gohara,D.W., Di Cera,E. and De Filippis,V.
Loop electrostatics asymmetry modulates the preexisting conformational equilibrium in thrombin
Biochemistry55, 3984-3994. PubMed Europe PubMed DOI
Pozzi,N., Bystranowska,D., Zuo,X. and Di Cera,E.
Structural architecture of prothrombin in solution revealed by single molecule spectroscopy
J Biol Chem291, 18107-18116. PubMed Europe PubMed DOI S
Pozzi,N., Chen,Z. and Di Cera,E.
How the linker connecting the two kringles influences activation and conformational plasticity of prothrombin
J Biol Chem291, 6071-6082. PubMed Europe PubMed DOI
Pozzi,N. and Di Cera,E.
Dual effect of histone H4 on prothrombin activation
J Thromb Haemost14, 1814-1818. PubMed Europe PubMed DOI
Ren,W., Ren,Y., Dong,M. and Gao,Y.
Design, synthesis, and thrombin inhibitory activity evaluation of some novel benzimidazole derivatives
Helv Chim Acta99, 325-332. DOI I
Robertson,A.L., Headey,S.J., Ng,N.M., Wijeyewickrema,L.C., Scanlon,M.J., Pike,R.N. and Bottomley,S.P.
Protein unfolding is essential for cleavage within the alpha-helix of a model protein substrate by the serine protease, thrombin
Biochimie122, 227-234. PubMed Europe PubMed DOI
Ruhmann,E.H., Rupp,M., Betz,M., Heine,A. and Klebe,G.
Boosting affinity by correct ligand preorganization for the S2 pocket of thrombin: a study by isothermal titration calorimetry, molecular dynamics, and high-resolution crystal structures
ChemMedChem11, 309-319. PubMed Europe PubMed DOI I
Sui,N., Wang,L., Xie,F., Liu,F., Xiao,H., Liu,M. and Yu,W.W.
Ultrasensitive aptamer-based thrombin assay based on metal enhanced fluorescence resonance energy transfer
Mikrochim Acta183, 1563-1570. DOI A I
Takayama,K., Taguchi,A., Yakushiji,F. and Hayashi,Y.
Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U
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Trapaidze,A., Herault,J.P., Herbert,J.M., Bancaud,A. and Gue,A.M.
Investigation of the selectivity of thrombin-binding aptamers for thrombin titration in murine plasma
Biosens Bioelectron78, 58-66. PubMed Europe PubMed DOI A I
van der Plas,M.J., Bhongir,R.K., Kjellstrom,S., Siller,H., Kasetty,G., Morgelin,M. and Schmidtchen,A.
Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
Nat Commun7, 11567-11567. PubMed Europe PubMed DOI
Verespy Iii,S., Mehta,A.Y., Afosah,D., Al-Horani,R.A. and Desai,U.R.
Allosteric partial inhibition of monomeric proteases. sulfated coumarins induce regulation, not just inhibition, of thrombin
Sci Rep6, 24043-24043. PubMed Europe PubMed DOI I
Wang,C., Lim,C.Y., Choi,E., Park,Y. and Park,J.
Highly sensitive user friendly thrombin detection using emission light guidance from quantum dots-aptamer beacons in 3-dimensional photonic crystal
Sens Actuators, B Chem223, 372-378. DOI A
Wang,F. and Ren,Y.-J.
Design, synthesis, biological evaluation and molecular docking of novel substituted 1-ethyl-1H-benzimidazole fluorinated derivatives as thrombin inhibitors
J Iran Chem Soc13, 1155-1166. DOI I
Wang,J., Jiang,X. and Han,H.
Turn-on near-infrared electrochemiluminescence sensing of thrombin based on resonance energy transfer between CdTe/CdS core/shell quantum dots and gold nanorods
Biosens Bioelectron82, 26-31. PubMed Europe PubMed DOI A
Wang,X., Lu,Z., Tan,L. and Jie,G.
Highly intense fluorescence of novel carbon nanocrystals combined with a DNAzyme-assisted autocatalytic multiple amplification strategy for sensitive detection of thrombin
Analyst141, 2865-2869. PubMed Europe PubMed DOI A
Xu,T., Lew-Tabor,A. and Rodriguez-Valle,M.
Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the yeast Pichia pastoris
Ticks Tick Borne Dis7, 180-187. PubMed Europe PubMed DOI
Yeh,C.H., Stafford,A.R., Leslie,B.A., Fredenburgh,J.C. and Weitz,J.I.
Dabigatran and argatroban diametrically modulate thrombin exosite function
PLoS ONE11, e0157471-e0157471. PubMed Europe PubMed DOI I
Zamolodchikov,D. and Strickland,S.
The Alzheimer's disease peptide beta-amyloid promotes thrombin generation through activation of coagulation factor XII: reply
J Thromb Haemost14, 1489- PubMed Europe PubMed DOI

2015

Alexander,E.T., Minton,A.R., Hayes,C.S., Goss,A., van Ryn,J. and Gilmour,S.K.
Thrombin inhibition and cyclophosphamide synergistically block tumor progression and metastasis
Cancer Biol Ther16, 1802-1811. PubMed Europe PubMed DOI I
Aoyama,H., Ijuin,R., Kato,J.Y., Urushiyama,S., Tetsuhashi,M., Hashimoto,Y. and Yokomatsu,T.
Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate
Bioorg Med Chem Lett25, 3676-3680. PubMed Europe PubMed DOI I
Ben Shimon,M., Lenz,M., Ikenberg,B., Becker,D., Shavit Stein,E., Chapman,J., Tanne,D., Pick,C.G., Blatt,I., Neufeld,M., Vlachos,A. and Maggio,N.
Thrombin regulation of synaptic transmission and plasticity: implications for health and disease
Front Cell Neurosci9, 151- PubMed Europe PubMed DOI
Cao,J.-T., Zhang,J.-J., Gong,Y., Ruan,X.-J., Liu,Y.-M., Chen,Y.-H. and Ren,S.-W.
A competitive photoelectrochemical aptasensor for thrombin detection based on the use of TiO2 electrode and glucose oxidase label
J Electroanal Chem759, 46-50. DOI A
Chahal,G., Thorpe,M. and Hellman,L.
The importance of exosite interactions for substrate cleavage by human thrombin
PLoS ONE10, e0129511-e0129511. PubMed Europe PubMed DOI
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Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors
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Allsop,T., Nagel,D., Neal,R., Davies,E.M., Mou,C., Bond,P., Rehman,S., Kalli,K., Webb,D.J., Calverhouse,P., Mascini,M. and Bennion,I.
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Label-free colorimetric detection of picomolar thrombin in blood plasma using a gold nanoparticle-based assay
Biosens Bioelectron25, 1922-1927. PubMed Europe PubMed DOI A
Chen,Z., Pelc,L.A. and Di Cera,E.
Crystal structure of prethrombin-1
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Clark,J.A., Humphries,J.E., Crean,S. and Reynolds,M.W.
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de Amorim,H.L., Netz,P.A. and Guimaraes,J.A.
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Hosokawa,K., Matsuda,H., Ohnishi,T., Gonda,M. and Koide,T.
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Kamath,P., Huntington,J.A. and Krishnaswamy,S.
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NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation
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Li,W., Johnson,D.J., Adams,T.E., Pozzi,N., De Filippis,V. and Huntington,J.A.
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Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif
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Peng,C.Y., Pan,S.L., Pai,H.C., Tsai,A.C., Guh,J.H., Chang,Y.L., Kuo,S.C., Lee,F.Y. and Teng,C.M.
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Pozmogova,G.E., Zaitseva,M.A., Smirnov,I.P., Shvachko,A.G., Murina,M.A. and Sergeenko,V.I.
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Yin,X., Wright,J., Wall,T. and Grammas,P.
Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer's Disease
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2009

Adams,T.E., Li,W. and Huntington,J.A.
Molecular basis of thrombomodulin activation of slow thrombin
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Stabilization of the E* form turns thrombin into an anticoagulant
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Baum,B., Muley,L., Heine,A., Smolinski,M., Hangauer,D. and Klebe,G.
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Baum,B., Mohamed,M., Zayed,M., Gerlach,C., Heine,A., Hangauer,D. and Klebe,G.
More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the S1 pocket of thrombin
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Gandhi,P.S., Page,M.J., Chen,Z., Bush-Pelc,L. and Di Cera,E.
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Greenhalgh,D.G., Gamelli,R.L., Collins,J., Sood,R., Mozingo,D.W., Gray,T.E. and Alexander,W.A.
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Hanessian,S., Therrien,E., Zhang,J., Otterlo,W., Xue,Y., Gustafsson,D., Nilsson,I. and Fjellstrom,O.
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Huntington,J.A.
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Kroh,H.K., Panizzi,P. and Bock,P.E.
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Ng,N.M., Quinsey,N.S., Matthews,A.Y., Kaiserman,D., Wijeyewickrema,L.C., Bird,P.I., Thompson,P.E. and Pike,R.N.
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Petrera,N.S., Stafford,A.R., Leslie,B.A., Kretz,C.A., Fredenburgh,J.C. and Weitz,J.I.
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2008

Aizawa,P., Winge,S. and Karlsson,G.
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Bonifacio,L., Church,F.C. and Jarstfer,M.B.
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Cho,H., Baker,B.R., Wachsmann-Hogiu,S., Pagba,C.V., Laurence,T.A., Lane,S.M., Lee,L.P. and Tok,J.B.
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Crean,S.M., Michels,S.L. and Reynolds,M.W.
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De Smedt,E., Al Dieri,R., Spronk,H.M., Hamulyak,K., ten Cate,H. and Hemker,H.C.
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Friedrich,R., Riester,D., Gottig,P., Thurk,M., Schwienhorst,A. and Bode,W.
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Gandhi,P.S., Chen,Z., Mathews,F.S. and Di Cera,E.
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Girolami,A., Santarossa,L., Scarparo,P., Candeo,N. and Girolami,B.
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Hanessian,S., Simard,D., Bayrakdarian,M., Therrien,E., Nilsson,I. and Fjellstrom,O.
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Ilas,J., Jakopin,Z., Borstnar,T., Stegnar,M. and Kikelj,D.
3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function
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Isaacs,R.C., Solinsky,M.G., Cutrona,K.J., Newton,C.L., Naylor-Olsen,A.M., McMasters,D.R., Krueger,J.A., Lewis,S.D., Lucas,B.J., Kuo,L.C., Yan,Y., Lynch,J.J. and Lyle,E.A.
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles
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Kreutter,K.D., Lu,T., Lee,L., Giardino,E.C., Patel,S., Huang,H., Xu,G., FitzGerald,M., Haertlein,B.J., Mohan,V., Crysler,C., Eisennagel,S., Dasgupta,M., McMillan,M., Spurlino,J.C., Huebert,N.D., Maryanoff,B.E., Tomczuk,B.E., Damiano,B.P. and Player,M.R.
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Li,W., Adams,T.E., Nangalia,J., Esmon,C.T. and Huntington,J.A.
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Long,S.B., Long,M.B., White,R.R. and Sullenger,B.A.
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Myles,T. and Leung,L.L.
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2007

Ansell,J.
Factor Xa or thrombin: is factor Xa a better target?
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Bah,A., Chen,Z., Bush-Pelc,L.A., Mathews,F.S. and Di Cera,E.
Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4
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Blomberg,D., Fex,T., Xue,Y., Brickmann,K. and Kihlberg,J.
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Bush-Pelc,L.A., Marino,F., Chen,Z., Pineda,A.O., Mathews,F.S. and Di Cera,E.
Important role of the Cys-191 Cys-220 disulfide bond in thrombin function and allostery
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Chen,Y., Tan,W., Lu,X., Lu,Y., Qin,S., Li,S., Zeng,Y., Bu,H., Li,Y. and Cheng,J.
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Czodrowski,P., Sotriffer,C.A. and Klebe,G.
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Di Cera,E., Page,M.J., Bah,A., Bush-Pelc,L.A. and Garvey,L.C.
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Fortenberry,Y.M., Whinna,H.C., Cooper,S.T., Myles,T., Leung,L.L. and Church,F.C.
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Frederick,R., Robert,S., Charlier,C., Wouters,J., Masereel,B. and Pochet,L.
Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative
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Gerlach,C., Smolinski,M., Steuber,H., Sotriffer,C.A., Heine,A., Hangauer,D.G. and Klebe,G.
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Gianni,S., Ivarsson,Y., Bah,A., Bush-Pelc,L.A. and Di Cera,E.
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Hanessian,S., Ersmark,K., Wang,X., Del Valle,J.R., Blomberg,N., Xue,Y. and Fjellstrom,O.
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Henry,B.L., Monien,B.H., Bock,P.E. and Desai,U.R.
A novel allosteric pathway of thrombin inhibition: exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids
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Marino,F., Chen,Z.W., Ergenekan,C.E., Bush-Pelc,L.A., Mathews,F.S. and Di Cera,E.
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Motley,E.D., Eguchi,K., Patterson,M.M., Palmer,P.D., Suzuki,H. and Eguchi,S.
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Segers,K., Dahlback,B., Bock,P.E., Tans,G., Rosing,J. and Nicolaes,G.A.
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2006

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Kainmuller,E.K. and Bannwarth,W.
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Michaux,C., Salvagnini,C., Norberg,B., Marchand-Brynaert,J. and Wouters,J.
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Serruys,P.W., Vranckx,P. and Allikmets,K.
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Akhavan,S., Miteva,M.A., Villoutreix,B.O., Venisse,L., Peyvandi,F., Mannucci,P.M., Guillin,M.C. and Bezeaud,A.
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Bobofchak,K.M., Pineda,A.O., Mathews,F.S. and Di Cera,E.
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Christersson,C., Oldgren,J., Bylock,A., Wallentin,L. and Siegbahn,A.
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In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design
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Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization
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Eriksson,B.I., Dahl,O.E., Buller,H.R., Hettiarachchi,R., Rosencher,N., Bravo,M.L., Ahnfelt,L., Piovella,F., Stangier,J., Kalebo,P. and Reilly,P.
A new oral direct thrombin inhibitor, dabigatran etexilate, compared with enoxaparin for prevention of thromboembolic events following total hip or knee replacement: the BISTRO II randomized trial
J Thromb Haemost3, 103-111. PubMed Europe PubMed DOI I
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P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
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Papaconstantinou,M.E., Carrell,C.J., Pineda,A.O., Bobofchak,K.M., Mathews,F.S., Flordellis,C.S., Maragoudakis,M.E., Tsopanoglou,N.E. and Di Cera,E.
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Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models
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Petrassi,H.M., Williams,J.A., Li,J., Tumanut,C., Ek,J., Nakai,T., Masick,B., Backes,B.J. and Harris,J.L.
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Deletion of the 60-loop provides new insights into the substrate and inhibitor specificity of thrombin
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9-hydroxyazafluorenes and their use in thrombin inhibitors
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Whitton,C., Sands,D., Lee,T., Chang,A. and Longstaff,C.
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Full and partial deuterium solvent isotope effect studies of alpha-thrombin-catalyzed reactions of natural substrates
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[YEAR:1-4-2004]Altenburger,J.M., Lassalle,G.Y., Matrougui,M., Galtier,D., Jetha,J.C., Bocskei,Z., Berry,C.N., Lunven,C., Lorrain,J., Herault,J.P., Schaeffer,P., O'Connor,S.E. and Herbert,J.M.
SSR182289A, a selective and potent orally active thrombin inhibitor
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Baerga-Ortiz,A., Bergqvist,S., Mandell,J.G. and Komives,E.A.
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Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study
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Bostrom,S.L., Hansson,G.F., Sarich,T.C. and Wolzt,M.
The inhibitory effect of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma
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The direct thrombin inhibitor melagatran/ximelagatran
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Chi,L., Peng,Y.W., Gibson,G., Hicks,G., Mertz,T.E., Rapundalo,S., Janiczek,N., Edmunds,J.J. and Leadley,R.
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Crowther,M.A. and Weitz,J.I.
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Day,K., Krishnegowda,N. and Jagadeeswaran,P.
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The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity
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Duplantier,J.G., Dubuisson,L., Senant,N., Freyburger,G., Laurendeau,I., Herbert,J.M., Desmouliere,A. and Rosenbaum,J.
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Molecular mapping of the thrombin-heparin cofactor II complex
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Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy
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Hanessian,S., Tremblay,M. and Petersen,J.F.
The N-acyloxyiminium ion aza-Prins route to octahydroindoles: total synthesis and structural confirmation of the antithrombotic marine natural product oscillarin
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A critical role for thrombin in vertebrate lens regeneration
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Probing thrombin's ability to accommodate a V34F substitution within the factor XIII activation peptide segment (28-41)
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Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties
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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis
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Lubetsky,A., Hoffman,R., Zimlichman,R., Eldor,A., Zvi,J., Kostenko,V. and Brenner,B.
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A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury
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Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors
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2003

Abrahams,J.P. and Thomassen,E.A.
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Effects of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, and dalteparin on the endogenous thrombin potential in venous blood from healthy male subjects
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Celikel,R., McClintock,R.A., Roberts,J.R., Mendolicchio,G.L., Ware,J., Varughese,K.I. and Ruggeri,Z.M.
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha
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Clement,B. and Lopian,K.
Characterization of in vitro biotransformation of new, orally active, direct thrombin inhibitor ximelagatran, an amidoxime and ester prodrug
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De Cristofaro,R. and De Candia,E.
Thrombin domains: structure, function and interaction with platelet receptors
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Dekker,R.J., Pannekoek,H. and Horrevoets,A.J.
A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin
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Eriksson,U.G., Bredberg,U., Gislen,K., Johansson,L.C., Frison,L., Ahnoff,M. and Gustafsson,D.
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Hasan,A.A., Warnock,M., Nieman,M., Srikanth,S., Mahdi,F., Krishnan,R., Tulinsky,A. and Schmaier,A.H.
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Hua,Y., Keep,R.F., Schallert,T., Hoff,J.T. and Xi,G.
A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model
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The molecular basis of thrombin allostery revealed by a 1.8 a structure of the "slow" form
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Kang,K.W., Choi,S.Y., Cho,M.K., Lee,C.H. and Kim,S.G.
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Lee,K., Park,C.W., Jung,W.H., Park,H.D., Lee,S.H., Chung,K.H., Park,S.K., Kwon,O.H., Kang,M., Park,D.H., Lee,S.K., Kim,E.E., Yoon,S.K. and Kim,A.
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide
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Cloning, purification and biochemical characterization of dipetarudin, a new chimeric thrombin inhibitor
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Mann,K.G.
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A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions
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Thrombin signaling in the brain: the role of protease-activated receptors
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Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively
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[YEAR:22-1-2002]Banerjee,M., Majumder,R., Weinreb,G., Wang,J. and Lentz,B.R.
Role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor X(a) to appropriate peptide bonds in prothrombin
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Berry,C.N., Lassalle,G., Lunven,C., Altenburger,J.M., Guilbert,F., Lale,A., Herault,J.P., Lecoffre,C., Pfersdorff,C., Herbert,J.M. and O'Connor,S.E.
SSR182289A, a novel, orally active thrombin inhibitor: in vitro profile and ex vivo anticoagulant activity
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Bianchini,E.P., Louvain,V.B., Marque,P.E., Juliano,M.A., Juliano,L. and le Bonniec,B.F.
Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates
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Campos,I.T., Amino,R., Sampaio,C.A., Auerswald,E.A., Friedrich,T., Lemaire,H.G., Schenkman,S. and Tanaka,A.S.
Infestin, a thrombin inhibitor presents in Triatoma infestans midgut, a Chagas' disease vector: gene cloning, expression and characterization of the inhibitor
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Design of selective thrombin inhibitors based on the (R)-Phe-Pro-Arg sequence
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Molecular design and structure-activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
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[YEAR:7-1-2002]Das,J., Kimball,S.D., Reid,J.A., Wang,T.C., Lau,W.F., Roberts,D.G., Seiler,S.M., Schumacher,W.A. and Ogletree,M.L.
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues
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[YEAR:19-11-2002]De Filippis,V., Colombo,G., Russo,I., Spadari,B. and Fontana,A.
Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation
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The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage
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Pharmacokinetics of an emerging new class of anticoagulant/antithrombotic drugs. A review of small-molecule thrombin inhibitors
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Purification of salmon thrombin and its potential as an alternative to mammalian thrombins in fibrin sealants
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Three-dimensional modeling of thrombin-fibrinogen interaction
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Sekine,O., Sugo,T., Ebisawa,K., Umeyama,H., Iwahana,H., Ruiz-Saez,A., de Bosch,N. and Matsudai,M.
Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perija leads to the loss of thrombin proteolytic activity
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Thrombin hydrolysis of V29F and V34L mutants of factor XIII (28-41) reveals roles of the P(9) and P(4) positions in factor XIII activation
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Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies
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Role of procoagulant lipids in human prothrombin activation. 1. Prothrombin activation by factor X(a) in the absence of factor Va and in the absence and presence of membranes
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2001

Ceelie,H., Bertina,R.M., Vlieg,A.V., Rosendaal,F.R. and Vos,H.L.
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Gehring,N.H., Frede,U., Neu-Yilik,G., Hundsdoerfer,P., Vetter,B., Hentze,M.W. and Kulozik,A.E.
Increased efficiency of mRNA 3' end formation: a new genetic mechanism contributing to hereditary thrombophilia
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Gilchrist,A., Solomon,N., Erickson,D., Sikand,A., Bauer,K.A., Kruskall,M.S. and Kocher,O.
Automated detection of the G20210A prothrombin mutation using the LCx microparticle enzyme immunoassay
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A novel purification method for histidine-tagged proteins containing a thrombin cleavage site
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Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates
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Activation of human prothrombin by arginine-specific cysteine proteinases (gingipains R) from Porphyromonas gingivalis
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Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species
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Levesque,S., St-Denis,Y., Bachand,B., Preville,P., Leblond,L., Winocour,P.D., Edmunds,J.J., Rubin,J.R. and Siddiqui,M.A.
Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues
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Marty,I., Peclat,V., Kirdaite,G., Salvi,R., So,A. and Busso,N.
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1999

Braat,E.A., Levi,M., Bos,R., Haverkate,F., Lassen,M.R., de Maat,M.P. and Rijken,D.C.
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Katz,B.A. and Luong,C.
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The crystal structure of alpha-thrombin-hirunorm IV complex reveals a novel specificity site recognition mode
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1998

Bone,R., Lu,T., Illig,C.R., Soll,R.M. and Spurlino,J.C.
Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes
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Conti,E., Rivetti,C., Wonacott,A. and Brick,P.
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Thrombin specificity: Further evidence for the importance of the beta-insertion loop and Trp96. Implications of the hydrophobic interaction between Trp96 and Pro60B Pro60C for the activity of thrombin
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Finkle,C.D., St Pierre,A., Leblond,L., Deschenes,I., DiMaio,J. and Winocour,P.D.
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis - comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban
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Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies
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Zheng,B., Clarke,J.B., Busby,W.H., Duan,C. and Clemmons,D.R.
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1997

Bode,W., Brandstetter,H., Mather,T. and Stubbs,M.T.
Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C
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Chirgadze,N.Y., Sall,D.J., Klimkowski,V.J., Clawson,D.K., Briggs,S.L., Hermann,R., Smith,G.F., Gifford-Moore,D.S. and Wery,J.P.
The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor
Protein Sci6, 1412-1417. PubMed Europe PubMed DOI S I
De Simone,G., Balliano,G., Milla,P., Gallina,C., Giordano,C., Tarricone,C., Rizzi,M., Bolognesi,M. and Ascenzi,P.
Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: A kinetic, thermodynamic and x-ray crystallographic study
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Kato,T., Oda,A., Inagaki,Y., Ohashi,H., Matsumoto,A., Ozaki,K., Miyakawa,Y., Watarai,H., Fuju,K., Kokubo,A., Kadoya,T., Ikeda,Y. and Miyazaki,H.
Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin
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Mutations within the reactive-site region of human pancreatic secretory trypsin inhibitor confer alpha-thrombin and factor Xa inhibitory activities
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Malkowski,M.G., Martin,P.D., Guzik,J.C. and Edwards,B.F.
The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: Movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding
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Malkowski,M.G., Martin,P.D., Lord,S.T. and Edwards,B.F.
Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16
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1996

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Nardini,M., Pesce,A., Rizzi,M., Casale,E., Ferraccioli,R., Balliano,G., Milla,P., Ascenzi,P. and Bolognesi,M.
Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study
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1995

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Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution
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1994

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1993

Carson,S.D. and Brozna,J.P.
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1992

Bode,W., Turk,D. and Karshikov,A.
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Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics
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The interaction of thrombin with fibrinogen. A structural basis for its specificity
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1991

[YEAR:15-8-1991]le Bonniec,B.F. and Esmon,C.T.
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1990

[YEAR:5-10-1990]Bode,W., Turk,D. and Sturzebecher,J.
Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-piperidine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin. X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin
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Grutter,M.G., Priestle,J.P., Rahuel,J., Grossenbacher,H., Bode,W., Hofsteenge,J. and Stone,S.R.
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1989

Bode,W., Mayr,I., Baumann,U., Huber,R., Stone,S.R. and Hofsteenge,J.
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment
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1988

[YEAR:22-3-1988]Hofsteenge,J., Braun,P.J. and Stone,S.R.
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1987

Brower,M.S., Walz,D.A., Garry,K.E. and Fenton,J.W.
Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity
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Identification of regions of alpha-thrombin involved in its interaction with hirudin
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1986

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1985

Kisiel,W., Smith,K.J. and McMullen,B.A.
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1984

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Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-l-arginyl)]-2-piperidinecarboxylic acid
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Effects of enzymatic deglycosylation on the biological activities of human thrombin and antithrombin
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1983

[YEAR:26-4-1983]Degen,S.J., MacGillivray,R.T. and Davie,E.W.
Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin
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1981

Fenton,J.W.
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Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates
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Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
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1980

Jackson,C.M. and Nemerson,Y.
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1979

Davie,E.W., Fujikawa,K., Kurachi,K. and Kisiel,W.
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1978

Kirchhof,B.R., Vermeer,C. and Hemker,H.C.
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1977

Fenton,J.W., Fasco,M.J., Stackrow,A.B., Aronson,D.L., Young,A.M. and Finlayson,J.S.
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1976

Geratz,J.D., Cheng,M.C. and Tidwell,R.R.
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1975

Geratz,J.D., Mar,E.C., Loeffler,L.J. and Fox,L.B.
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1974

Takagi,T. and Doolittle,R.F.
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1973

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1972

Schmer,G.
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Baughman,D.J.
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1969

Chase,T., Jr. and Shaw,E.
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1965

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1959

Hummel,B.C.
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1958

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1954

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1952

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1951

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1941

Astrup,T. and Darling,S.
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Collingwood,B.J. and MacMahon,M.T.
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