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Literature for peptidase S01.191: complement factor D

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, M Mutation, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Eskin Tanriverdi,M.D., Kaya Sezginer,E., Erol Koc,E.M. and Moraloglu Tekin,O.
    Evaluation of serum and peritoneal fluid mannose-binding lectin associated serine protease-3, adipsin, properdin, and complement factor-H levels in endometriosis patients
    Int J Gynaecol Obstet (2025) PubMed  Europe PubMed DOI
  2. Gadhachanda,V.R., Wiles,J.A., Podos,S.D., Boyer,D., Thanassi,J., Patel,D., Zhao,Y., Wang,L. and Huang,M.
    First-in-Class Clinically Investigated Oral Factor D Inhibitors for the Treatment of Complement-Mediated Diseases
    Pharm Res (2025) 42, 1119-1131. PubMed  Europe PubMed DOI
  3. Opoku Mensah,B., Anim,E., Ahenkorah Fondjo,L., Gyan,B. and Dapare,P.P.M.
    Diagnostic performance of urinary adipsin as a screening biomarker for pre-eclampsia
    Int J Gynaecol Obstet (2025) PubMed  Europe PubMed DOI
    4. 2023
  4. Dani,R., Oroszlan,G., Martinusz,R., Farkas,B., Dobos,B., Vadas,E., Zavodszky,P., Gal,P. and Dobo,J.
    Quantification of the zymogenicity and the substrate-induced activity enhancement of complement factor D
    Front Immunol (2023) 14, 1197023-1197023. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Feng,H., Yao,L., Zeng,Z., Jiang,L., Shang,Y., Wang,H., Li,L., Wang,Z., Wang,X., Yang,H., Zhao,Q., Ren,X., Zhang,T., Zhang,R., Guo,Y., Lu,Q., Hu,Q., Zhang,W., Ding,C., Shao,H., Cheng,G., Luo,Q. and Wen,G.
    Identification of Embryonic Chicken Proteases Activating Newcastle Disease Virus and Their Roles in the Pathogenicity of Virus Used as In Ovo Vaccine
    J Virol (2023) 97, e0032423-e0032423. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Gullipalli,D., Miwa,T., Golla,M., Sato,S., Angampalli,S. and Song,W.C.
    MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity
    J Immunol (2023) 210, 1543-1551. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Kawakami,E., Saiki,N., Yoneyama,Y., Moriya,C., Maezawa,M., Kawamura,S., Kinebuchi,A., Kono,T., Funata,M., Sakoda,A., Kondo,S., Ebihara,T., Matsumoto,H., Togami,Y., Ogura,H., Sugihara,F., Okuzaki,D., Kojima,T., Deguchi,S., Vallee,S., McQuade,S., Islam,R., Natarajan,M., Ishigaki,H., Nakayama,M., Nguyen,C.T., Kitagawa,Y., Wu,Y., Mori,K., Hishiki,T., Takasaki,T., Itoh,Y., Takayama,K., Nio,Y. and Takebe,T.
    Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
    Cell Stem Cell (2023) 30, 1315-1330. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Sekine,H., Machida,T. and Fujita,T.
    Factor D
    Immunol Rev (2023) 313, 15-24. PubMed  Europe PubMed DOI  V
    9. 2022
  9. Duan,Y., Zhang,X., Zhang,X., Lin,J., Shu,X., Man,W., Jiang,M., Zhang,Y., Wu,D., Zhao,Z. and Sun,D.
    Inhibition of macrophage-derived foam cells by Adipsin attenuates progression of atherosclerosis
    Biochim Biophys Acta Mol Basis Dis (2022) 1868, 166533-166533. PubMed  Europe PubMed DOI
  10. Gavriilaki,E., Papakonstantinou,A. and Agrios,K.A.
    Novel Insights into Factor D Inhibition
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  V
    11. 2021
  11. Barratt,J. and Weitz,I.
    Complement Factor D as a Strategic Target for Regulating the Alternative Complement Pathway
    Front Immunol (2021) 12, 712572-712572. PubMed  Europe PubMed DOI  PMC  EPMC  V
    12. 2020
  12. Schafer,N., Wolf,H.N., Enzbrenner,A., Schikora,J., Reichenthaler,M., Enzmann,V. and Pauly,D.
    Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells
    Antioxidants (Basel) (2020) 9 PubMed  Europe PubMed DOI
  13. Tarabeih,N., Kalinkovich,A., Shalata,A. and Livshits,G.
    Circulating Levels of Visceral Adipose Tissue-Derived Serine Protease Inhibitor (Vaspin) Appear as a Marker of Musculoskeletal Pain Disability
    Diagnostics (Basel) (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
    14. 2019
  14. Ding,M., Fan,J., Wang,W., Wang,H. and Liu,H.
    Molecular characterization, expression and antimicrobial activity of complement factor D in Megalobrama amblycephala
    Fish Shellfish Immunol (2019) 89, 43-51. PubMed  Europe PubMed DOI
  15. Karki,R.G., Powers,J., Mainolfi,N., Anderson,K., Belanger,D.B., Liu,D., Ji,N., Jendza,K., Gelin,C.F., Mac Sweeney,A., Solovay,C., Delgado,O., Crowley,M., Liao,S.M., Argikar,U.A., Flohr,S., La Bonte,L.R., Lorthiois,E.L., Vulpetti,A., Brown,A., Long,D., Prentiss,M., Gradoux,N., de Erkenez,A., Cumin,F., Adams,C., Jaffee,B. and Mogi,M.
    Design, synthesis, and preclinical characterization of selective factor D inhibitors targeting the alternative complement pathway
    J Med Chem (2019) 62, 4656-4668. PubMed  Europe PubMed DOI  I
    16. 2018
  16. Sng,C.C.T., O'Byrne,S., Prigozhin,D.M., Bauer,M.R., Harvey,J.C., Ruhle,M., Challis,B.G., Lear,S., Roberts,L.D., Workman,S., Janowitz,T., Magiera,L., Doffinger,R., Buckland,M.S., Jodrell,D.J., Semple,R.K., Wilson,T.J., Modis,Y. and Thaventhiran,J.E.D.
    A type III complement factor D deficiency: structural insights for inhibition of the alternative pathway
    J Allergy Clin Immunol (2018) 142, 311-314. PubMed  Europe PubMed DOI  M
  17. Vulpetti,A., Ostermann,N., Randl,S., Yoon,T., Mac Sweeney,A., Cumin,F., Lorthiois,E., Rudisser,S., Erbel,P. and Maibaum,J.
    Discovery and design of first benzylamine-based ligands binding to an unlocked conformation of the complement factor D
    ACS Med Chem Lett (2018) 9, 490-495. PubMed  Europe PubMed DOI  PMC  EPMC  I
    18. 2017
  18. Lorthiois,E., Anderson,K., Vulpetti,A., Rogel,O., Cumin,F., Ostermann,N., Steinbacher,S., Mac Sweeney,A., Delgado,O., Liao,S.M., Randl,S., Rudisser,S., Dussauge,S., Fettis,K., Kieffer,L., de Erkenez,A., Yang,L., Hartwieg,C., Argikar,U.A., La Bonte,L.R., Newton,R., Kansara,V., Flohr,S., Hommel,U., Jaffee,B. and Maibaum,J.
    Discovery of highly potent and selective small-molecule reversible factor D inhibitors demonstrating alternative complement pathway inhibition in vivo
    J Med Chem (2017) 60, 5717-5735. PubMed  Europe PubMed DOI  I
  19. Peng,B., Zhang,L., Yan,J., Qi,H., Zhang,W., Fan,L., Hu,Y., Lin,L., Li,X., Hu,R., Xie,L., Zhang,J., Wu,Y., Li,L. and Zhou,R.
    Assessment of the diagnostic value of a urinary adipsin rapid strip test for pre-eclampsia: a prospective multicenter study
    J Obstet Gynaecol Res (2017) 43, 30-33. PubMed  Europe PubMed DOI
  20. Pihl,R., Jensen,L., Hansen,A.G., Thogersen,I.B., Andres,S., Dagnaes-Hansen,F., Oexle,K., Enghild,J.J. and Thiel,S.
    Analysis of factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale patients highlights the role of MASP-3 as a maturase in the alternative pathway of complement
    J Immunol (2017) PubMed  Europe PubMed DOI
  21. Vulpetti,A., Randl,S., Rudisser,S., Ostermann,N., Erbel,P., Mac Sweeney,A., Zoller,T., Salem,B., Gerhartz,B., Cumin,F., Hommel,U., Dalvit,C., Lorthiois,E. and Maibaum,J.
    Structure-based library design and fragment screening for the identification of reversible complement factor D protease inhibitors
    J Med Chem (2017) 60, 1946-1958. PubMed  Europe PubMed DOI  I
    22. 2016
  22. Banda,N.K., Acharya,S., Scheinman,R.I., Mehta,G., Coulombe,M., Takahashi,M., Sekine,H., Thiel,S., Fujita,T. and Holers,V.M.
    Mannan-binding lectin-associated serine protease 1/3 cleavage of pro-factor D into factor D in vivo and attenuation of collagen antibody-induced arthritis through their targeted inhibition by RNA interference-mediated gene silencing
    J Immunol (2016) 197, 3680-3694. PubMed  Europe PubMed DOI
  23. Godahewa,G.I., Perera,N.C., Bathige,S.D., Nam,B.H., Noh,J.K. and Lee,J.
    Complement factor D homolog involved in the alternative complement pathway of rock bream (Oplegnathus fasciatus): molecular and functional characterization and immune responsive mRNA expression analysis
    Fish Shellfish Immunol (2016) 55, 423-433. PubMed  Europe PubMed DOI
  24. Maibaum,J., Liao,S.M., Vulpetti,A., Ostermann,N., Randl,S., Rudisser,S., Lorthiois,E., Erbel,P., Kinzel,B., Kolb,F.A., Barbieri,S., Wagner,J., Durand,C., Fettis,K., Dussauge,S., Hughes,N., Delgado,O., Hommel,U., Gould,T., Mac Sweeney,A., Gerhartz,B., Cumin,F., Flohr,S., Schubart,A., Jaffee,B., Harrison,R., Risitano,A.M., Eder,J. and Anderson,K.
    Small-molecule factor D inhibitors targeting the alternative complement pathway
    Nat Chem Biol (2016) 12, 1105-1110. PubMed  Europe PubMed DOI  I
  25. Song,N.J., Kim,S., Jang,B.H., Chang,S.H., Yun,U.J., Park,K.M., Waki,H., Li,D.Y., Tontonoz,P. and Park,K.W.
    Small molecule-induced complement factor D (adipsin) promotes lipid accumulation and adipocyte differentiation
    PLoS ONE (2016) 11, e0162228-e0162228. PubMed  Europe PubMed DOI
  26. Yang,C.Y., Phillips,J.G., Stuckey,J.A., Bai,L., Sun,H., Delproposto,J., Brown,W.C. and Chinnaswamy,K.
    Buried hydrogen bond interactions contribute to the high potency of complement factor D inhibitors
    ACS Med Chem Lett (2016) 7, 1092-1096. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    27. 2014
  27. Forneris,F., Burnley,B.T. and Gros,P.
    Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D
    Acta Crystallogr D Biol Crystallogr (2014) 70, 733-743. PubMed  Europe PubMed DOI  PMC  EPMC  S
  28. Lo,J.C., Ljubicic,S., Leibiger,B., Kern,M., Leibiger,I.B., Moede,T., Kelly,M.E., Chatterjee Bhowmick,D., Murano,I., Cohen,P., Banks,A.S., Khandekar,M.J., Dietrich,A., Flier,J.S., Cinti,S., Bluher,M., Danial,N.N., Berggren,P.O. and Spiegelman,B.M.
    Adipsin is an adipokine that improves beta cell function in diabetes
    Cell (2014) 158, 41-53. PubMed  Europe PubMed DOI
    29. 2012
  29. Forneris,F. and Gros,P.
    Complement factor D
    [ISSN:978-0-12-407742-3] (2012) 3, 2841-2848. DOI
    30. 2010
  30. Forneris,F., Ricklin,D., Wu,J., Tzekou,A., Wallace,R.S., Lambris,J.D. and Gros,P.
    Structures of C3b in complex with factors B and D give insight into complement convertase formation
    Science (2010) 330, 1816-1820. PubMed  Europe PubMed DOI
    31. 2009
  31. Kong,H.J., Hong,G.E., Nam,B.H., Kim,Y.O., Kim,W.J., Lee,S.J., Lee,N.S., Do,J.W., Cho,H.K., Cheong,J., Lee,C.H. and Kim,K.K.
    An immune responsive complement factor D/adipsin and kallikrein-like serine protease (PoDAK) from the olive flounder Paralichthys olivaceus
    Fish Shellfish Immunol (2009) 27, 486-492. PubMed  Europe PubMed DOI
    32. 2007
  32. Abrera-Abeleda,M.A., Xu,Y., Pickering,M.C., Smith,R.J. and Sethi,S.
    Mesangial immune complex glomerulonephritis due to complement factor D deficiency
    Kidney Int (2007) 71, 1142-1147. PubMed  Europe PubMed DOI  K
    33. 2006
  33. Sprong,T., Roos,D., Weemaes,C., Neeleman,C., Geesing,C.L., Mollnes,T.E. and van Deuren,M.
    Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
    Blood (2006) 107, 4865-4870. PubMed  Europe PubMed DOI  M
    34. 2004
  34. Volanakis,J.E.
    Complement factor D
    [ISSN:0-12-079610-4] (2004) 2, 1615-1617.  V
    35. 2001
  35. Biesma,D.H., Hannema,A.J., van Velzen-Blad,H., Mulder,L., van Zwieten,R., Kluijt,I. and Roos,D.
    A family with complement factor D deficiency
    J Clin Invest (2001) 108, 233-240. PubMed  Europe PubMed DOI  PMC  EPMC  M
  36. Fung,M., Loubser,P.G., Undar,A., Mueller,M., Sun,C., Sun,W.N., Vaughn,W.K. and Fraser,C.D., Jr.
    Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits
    J Thorac Cardiovasc Surg (2001) 122, 113-122. PubMed  Europe PubMed DOI
  37. Miner,J.L., Hahn,K.J., Spurlock,M.E. and Staten,N.R.
    Expression and complement D activity of porcine adipsin
    Protein Expr Purif (2001) 23, 14-21. PubMed  Europe PubMed DOI
  38. [YEAR:4-12-2001]Xu,Y., Ma,M., Ippolito,G.C., Schroeder,H.W., Jr., Carroll,M.C. and Volanakis,J.E.
    Complement activation in factor D-deficient mice
    Proc Natl Acad Sci U S A (4-12-2001) 98, 14577-14582. PubMed  Europe PubMed DOI  PMC  EPMC  K
    39. 2000
  39. Poorafshar,M., Aveskogh,M., Munday,B. and Hellman,L.
    Identification and structural analysis of four serine proteases in a monotreme, the platypus, Ornithorhynchus anatinus
    Immunogenetics (2000) 52, 19-28. PubMed  Europe PubMed DOI
  40. Sim,R.B. and Laich,A.
    Serine proteases of the complement system
    Biochem Soc Trans (2000) 28, 545-550. PubMed  Europe PubMed
    41. 1999
  41. [YEAR:15-2-1999]Jing,H., Macon,K.J., Moore,D., DeLucas,L.J., Volanakis,J.E. and Narayana,S.V.
    Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D
    EMBO J (15-2-1999) 18, 804-814. PubMed  Europe PubMed DOI  PMC  EPMC  S
  42. Tanhehco,E.J., Kilgore,K.S., Liff,D.A., Murphy,K.L., Fung,M.S., Sun,W.N., Sun,C. and Lucchesi,B.R.
    The anti-factor D antibody, MAb 166-32, inhibits the alternative pathway of the human complement system
    Transplant Proc (1999) 31, 2168-2171. PubMed  Europe PubMed DOI
  43. [YEAR:2-3-1999]Taylor,F.R., Bixler,S.A., Budman,J.I., Wen,D., Karpusas,M., Ryan,S.T., Jaworski,G.J., Safari-Fard,A., Pollard,S. and Whitty,A.
    Induced fit activation mechanism of the exceptionally specific serine protease, complement factor D
    Biochemistry (2-3-1999) 38, 2849-2859. PubMed  Europe PubMed DOI
  44. [YEAR:1-12-1999]Wong,E.T., Jenne,D.E., Zimmer,M., Porter,S.D. and Gilks,C.B.
    Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation
    Blood (1-12-1999) 94, 3730-3736. PubMed  Europe PubMed
    45. 1998
  45. Arlaud,G.J., Volanakis,J.E., Thielens,N.M., Narayana,S.V., Rossi,V. and Xu,Y.
    The atypical serine proteases of the complement system
    Adv Immunol (1998) 69, 249-307. PubMed  Europe PubMed
  46. Cole,L.B., Kilpatrick,J.M., Chu,N. and Babu,Y.S.
    Structure of 3,4-dichloroisocoumarin-inhibited factor D
    Acta Crystallogr D Biol Crystallogr (1998) 54, 711-717. PubMed  Europe PubMed DOI  S  I
  47. [YEAR:9-10-1998]Jing,H., Babu,Y.S., Moore,D., Kilpatrick,J.M., Liu,X.Y., Volanakis,J.E. and Narayana,S.V.
    Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity
    J Mol Biol (9-10-1998) 282, 1061-1081. PubMed  Europe PubMed DOI  S  I
    48. 1997
  48. Cole,L.B., Chu,N., Kilpatrick,J.M., Volanakis,J.E., Narayana,S.V. and Babu,Y.S.
    Structure of diisopropyl fluorophosphate-inhibited factor D
    Acta Crystallogr D Biol Crystallogr (1997) 53, 143-150. PubMed  Europe PubMed DOI  S
    49. 1996
  49. Volanakis,J.E. and Narayana,S.V.
    Complement factor D, a novel serine protease
    Protein Sci (1996) 5, 553-564. PubMed  Europe PubMed DOI  PMC  EPMC
    50. 1995
  50. Kim,S., Narayana,S.V. and Volanakis,J.E.
    Catalytic role of a surface loop of the complement serine protease factor D
    J Immunol (1995) 154, 6073-6079. PubMed  Europe PubMed
  51. Kim,S., Narayana,S.V. and Volanakis,J.E.
    Crystal structure of a complement factor D mutant expressing enhanced catalytic activity
    J Biol Chem (1995) 270, 24399-24405. PubMed  Europe PubMed DOI  S
    52. 1994
  52. Carson,M., Bugg,C.E., DeLucas,L.J. and Narayana,S.V.
    Comparison of homology models with the experimental structure of a novel serine protease
    Acta Crystallogr D Biol Crystallogr (1994) 50, 889-899. PubMed  Europe PubMed DOI  S
  53. Inagi,R., Miyata,T., Oda,O., Maeda,K. and Inoue,K.
    Evaluation of the proteolytic activity of factor D accumulated as an active serine protease in patients with chronic renal failure
    Nephron (1994) 66, 285-290. PubMed  Europe PubMed  I
  54. [YEAR:6-12-1994]Kim,S., Narayana,S.V. and Volanakis,J.E.
    Mutational analysis of the substrate binding site of human complement factor D
    Biochemistry (6-12-1994) 33, 14393-14399. PubMed  Europe PubMed DOI
  55. [YEAR:14-1-1994]Narayana,S.V., Carson,M., El-Kabbani,O., Kilpatrick,J.M., Moore,D., Chen,X., Bugg,C.E., Volanakis,J.E. and DeLucas,L.J.
    Structure of human factor D. A complement system protein at 2.0 A resolution
    J Mol Biol (14-1-1994) 235, 695-708. PubMed  Europe PubMed DOI  S
  56. Sniderman,A.D. and Cianflone,K.
    The adipsin-ASP pathway and regulation of adipocyte function
    Ann Med (1994) 26, 388-393. PubMed  Europe PubMed
  57. [YEAR:1-4-1994]Yamauchi,Y., Stevens,J.W., Macon,K.J. and Volanakis,J.E.
    Recombinant and native zymogen forms of human complement factor D
    J Immunol (1-4-1994) 152, 3645-3653. PubMed  Europe PubMed
  58. Zhu,L., Wigle,D., Hinek,A., Kobayashi,J., Ye,C., Zuker,M., Dodo,H., Keeley,F.W. and Rabinovitch,M.
    The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin
    J Clin Invest (1994) 94, 1163-1171. PubMed  Europe PubMed DOI  PMC  EPMC
    59. 1993
  59. Pascual,M., Catana,E., White,T., Spiegelman,B.M. and Schifferli,J.A.
    Inhibition of complement alternative pathway in mice with Fab antibody to recombinant adipsin/factor D
    Eur J Immunol (1993) 23, 1389-1392. PubMed  Europe PubMed DOI
  60. Perkins,S.J., Smith,K.F., Kilpatrick,J.M., Volanakis,J.E. and Sim,R.B.
    Modelling of the serine-proteinase fold by X-ray and neutron scattering and sedimentation analyses: Occurrence of the fold in factor D of the complement system
    Biochem J (1993) 295, 87-99. PubMed  Europe PubMed  PMC  EPMC  S
  61. Volanakis,J.E., Barnum,S.R. and Kilpatrick,J.M.
    Purification and properties of human factor D
    Methods Enzymol (1993) 223, 82-97. PubMed  Europe PubMed DOI  V
    62. 1992
  62. Choy,L.N., Rosen,B.S. and Spiegelman,B.M.
    Adipsin and an endogenous pathway of complement from adipose cells
    J Biol Chem (1992) 267, 12736-12741. PubMed  Europe PubMed
  63. Kam,C.M., Oglesby,T.J., Pangburn,M.K., Volanakis,J.E. and Powers,J.C.
    Substituted isocoumarins as inhibitors of complement serine proteases
    J Immunol (1992) 149, 163-168. PubMed  Europe PubMed  I
  64. White,R.T., Damm,D., Hancock,N., Rosen,B.S., Lowell,B.B., Usher,P., Flier,J.S. and Spiegelman,B.M.
    Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
    J Biol Chem (1992) 267, 9210-9213. PubMed  Europe PubMed
    65. 1991
  65. Baker,B.C., Campbell,C.J., Grinham,C.J. and Turcatti,G.
    Purification and partial characterization of rat factor D
    Biochem J (1991) 279, 775-779. PubMed  Europe PubMed  PMC  EPMC
  66. [YEAR:25-4-1991]Catana,E. and Schifferli,J.A.
    Purification of human complement factor D from the peritoneal fluid of patients on chronic ambulatory peritoneal dialysis
    J Immunol Methods (25-4-1991) 138, 265-271. PubMed  Europe PubMed DOI
    67. 1990
  67. Miyata,T., Oda,O., Inagi,R., Sugiyama,S., Miyama,A., Maeda,K., Nakashima,I. and Yamanaka,N.
    Molecular and functional identification and purification of complement component factor D from urine of patients with chronic renal failure
    Mol Immunol (1990) 27, 637-644. PubMed  Europe PubMed DOI
    68. 1989
  68. Rosen,B.S., Cook,K.S., Yaglom,J., Groves,D.L., Volanakis,J.E., Damm,D., White,T. and Spiegelman,B.M.
    Adipsin and complement factor D activity: an immune-related defect in obesity
    Science (1989) 244, 1483-1487. PubMed  Europe PubMed
  69. Vasquez,J.R., Evnin,L.B., Higaki,J.N. and Craik,C.S.
    An expression system for trypsin
    J Cell Biochem (1989) 39, 265-276. PubMed  Europe PubMed DOI  E
    70. 1988
  70. Muller-Eberhard,H.J.
    Molecular organization and function of the complement system
    Annu Rev Biochem (1988) 57, 321-347. PubMed  Europe PubMed DOI
  71. Pascual,M., Steiger,G., Estreicher,J., Macon,K., Volanakis,J.E. and Schifferli,J.A.
    Metabolism of complement factor D in renal failure
    Kidney Int (1988) 34, 529-536. PubMed  Europe PubMed
    72. 1987
  72. Cook,K.S., Min,H.Y., Johnson,D., Chaplinsky,R.J., Flier,J.S., Hunt,C.R. and Spiegelman,B.M.
    Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve
    Science (1987) 237, 402-405. PubMed  Europe PubMed
  73. Flier,J.S., Cook,K.S., Usher,P. and Spiegelman,B.M.
    Severely impaired adipsin expression in genetic and acquired obesity
    Science (1987) 237, 405-408. PubMed  Europe PubMed
  74. [YEAR:15-3-1987]Kam,C.M., McRae,B.J., Harper,J.W., Niemann,M.A., Volanakis,J.E. and Powers,J.C.
    Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates
    J Biol Chem (15-3-1987) 262, 3444-3451. PubMed  Europe PubMed
    75. 1986
  75. Min,H.Y. and Spiegelman,B.M.
    Adipsin, the adipocyte serine protease: gene structure and control of expression by tumor necrosis factor
    Nucleic Acids Res (1986) 14, 8879-8892. PubMed  Europe PubMed  PMC  EPMC
  76. Sanders,P.W., Volanakis,J.E., Rostand,S.G. and Galla,J.H.
    Human complement protein D catabolism by the rat kidney
    J Clin Invest (1986) 77, 1299-1304. PubMed  Europe PubMed DOI  PMC  EPMC
    77. 1985
  77. Cook,K.S., Groves,D.L., Min,H.Y. and Spiegelman,B.M.
    A developmentally regulated mRNA from 3T3 adipocytes encodes a novel serine protease homologue
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