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Literature for peptidase S01.146: granzyme K

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, R Splicing, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Donado,C.A., Theisen,E., Zhang,F., Nathan,A., Fairfield,M.L., Rupani,K.V., Jones,D., Johannes,K.P., Raychaudhuri,S., Dwyer,D.F., Jonsson,A.H. and Brenner,M.B.<br>Granzyme K activates the entire complement cascade<br>Nature (2025) PubMed  Europe PubMed DOI
  2. Lyu,Q. and Li,L.<br>Granzyme K, Regulated by the N6-Methyladenosine Methyltransferase Wilms' tumor 1-associate protein, Enhances Myocardial Infarction Injury<br>DNA Cell Biol (2025) PubMed  Europe PubMed DOI  K
  3. Mastellos,D.C. and Lambris,J.D.<br>'Complement-ing' tissue inflammation via granzyme K?<br>Nat Immunol (2025) PubMed  Europe PubMed DOI
  4. Poppelaars,F. and Daha,M.R.<br>Granzyme K sets complement in motion<br>Kidney Int (2025) PubMed  Europe PubMed DOI
    5. 2024
  5. Aubert,A., Liu,A., Kao,M., Goeres,J., Richardson,K.C., Nierves,L., Jung,K., Nabai,L., Zhao,H., Orend,G., Krawetz,R., Lange,P.F., Younger,A., Chan,J. and Granville,D.J.<br>Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis<br>JCI Insight (2024) 9, e181935-e181935. PubMed  Europe PubMed DOI
  6. Donado,C.A., Jonsson,A.H., Theisen,E., Zhang,F., Nathan,A., Rupani,K.V., Jones,D., Raychaudhuri,S., Dwyer,D.F. and Brenner,M.B.<br>Granzyme K drives a newly-intentified pathway of complement activation<br>bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  7. Kim,H.Y. and Ha,H.<br>Distinct granzyme k expression in immune cells: a single-cell rna-seq meta-analysis<br>Genes Genomics (2024) 46, 1097-1106. PubMed  Europe PubMed DOI
    8. 2023
  8. Duquette,D., Harmon,C., Zaborowski,A., Michelet,X., O'Farrelly,C., Winter,D., Koay,H.F. and Lynch,L.<br>Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation<br>J Immunol (2023) 211, 633-647. PubMed  Europe PubMed DOI
    9. 2022
  9. Kaiserman,D., Zhao,P., Rowe,C.L., Leong,A., Barlow,N., Joeckel,L.T., Hitchen,C., Stewart,S.E., Hollenberg,M.D., Bunnett,N., Suhrbier,A. and Bird,P.I.<br>Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2<br>PLoS ONE (2022) 17, e0270584-e0270584. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Bouwman,A.C., van Daalen,K.R., Crnko,S., Ten Broeke,T. and Bovenschen,N.<br>Intracellular and Extracellular Roles of Granzyme K<br>Front Immunol (2021) 12, 677707-677707. PubMed  Europe PubMed DOI  PMC  EPMC  V
    11. 2019
  11. Turner,C.T., Zeglinski,M.R., Richardson,K.C., Zhao,H., Shen,Y., Papp,A., Bird,P.I. and Granville,D.J.<br>Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling<br>J Invest Dermatol (2019) 139, 930-939. PubMed  Europe PubMed DOI
    12. 2017
  12. Joeckel,L.T., Allison,C.C., Pellegrini,M., Bird,C.H. and Bird,P.I.<br>Granzyme K-deficient mice show no evidence of impaired antiviral immunity<br>Immunol Cell Biol (2017) 95, 676-683. PubMed  Europe PubMed DOI  K
    13. 2016
  13. Sharma,M., Merkulova,Y., Raithatha,S., Parkinson,L.G., Shen,Y., Cooper,D. and Granville,D.J.<br>Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1<br>FEBS J (2016) 283, 1734-1747. PubMed  Europe PubMed DOI
  14. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.<br>Granzymes A and K differentially potentiate LPS-induced cytokine response<br>Cell Death Discov (2016) 2, 16084-16084. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2014
  15. Ahmad,J., Bird,P.I. and Kaiserman,D.<br>Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature<br>Biol Chem (2014) 395, 1253-1262. PubMed  Europe PubMed DOI
  16. Hirata,Y., Inagaki,H., Shimizu,T. and Kawada,T.<br>Substrate specificity of human granzyme 3: analyses of the P3- P2-P1 triplet using fluorescence resonance energy transfer substrate libraries<br>BioScience Trends (2014) 8, 126-131. PubMed  Europe PubMed DOI  A  P
  17. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.<br>Holistic view on the extended substrate specificities of orthologous granzymes<br>J Proteome Res (2014) 13, 1785-1793. PubMed  Europe PubMed DOI  P
  18. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.<br>Substrate specificities of the granzyme tryptases A and K<br>J Proteome Res (2014) 13, 6067-6077. PubMed  Europe PubMed DOI  P
  19. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.<br>Human granzymes: related but far apart<br>Med Hypotheses (2014) 83, 688-693. PubMed  Europe PubMed DOI  V
    20. 2012
  20. Bovenschen,N.<br>Granzyme K<br>[ISSN:978-0-12-407742-3] (2012) 3, 2725-2728. DOI
  21. Zhong,C., Li,C., Wang,X., Toyoda,T., Gao,G. and Fan,Z.<br>Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells<br>Cell Death Differ (2012) 19, 882-890. PubMed  Europe PubMed DOI
    22. 2011
  22. Cooper,D.M., Pechkovsky,D.V., Hackett,T.L., Knight,D.A. and Granville,D.J.<br>Granzyme K activates protease-activated receptor-1<br>PLoS ONE (2011) 6, e21484-e21484. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Joeckel,L.T., Wallich,R., Martin,P., Sanchez-Martinez,D., Weber,F.C., Martin,S.F., Borner,C., Pardo,J., Froelich,C. and Simon,M.M.<br>Mouse granzyme K has pro-inflammatory potential<br>Cell Death Differ (2011) 18, 1112-1119. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2010
  24. Bovenschen,N. and Kummer,J.A.<br>Orphan granzymes find a home<br>Immunol Rev (2010) 235, 117-127. PubMed  Europe PubMed DOI  V
  25. Guo,Y., Chen,J., Shi,L. and Fan,Z.<br>Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells<br>J Immunol (2010) 185, 5348-5359. PubMed  Europe PubMed DOI  P
    26. 2009
  26. Bovenschen,N., Quadir,R., van den Berg,A.L., Brenkman,A.B., Vandenberghe,I., Devreese,B., Joore,J. and Kummer,J.A.<br>Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A<br>J Biol Chem (2009) 284, 3504-3512. PubMed  Europe PubMed DOI  P
  27. Froelich,C.J., Pardo,J. and Simon,M.M.<br>Granule-associated serine proteases: granzymes might not just be killer proteases<br>Trends Immunol (2009) 30, 117-123. PubMed  Europe PubMed DOI  V
  28. Hua,G., Wang,S., Zhong,C., Xue,P. and Fan,Z.<br>Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis<br>J Immunol (2009) 182, 2152-2159. PubMed  Europe PubMed DOI
    29. 2008
  29. Chowdhury,D. and Lieberman,J.<br>Death by a thousand cuts: granzyme pathways of programmed cell death<br>Annu Rev Immunol (2008) 26, 389-420. PubMed  Europe PubMed DOI  V
  30. Jenkins,M.R., Trapani,J.A., Doherty,P.C. and Turner,S.J.<br>Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice<br>Viral Immunol (2008) 21, 341-346. PubMed  Europe PubMed DOI
    31. 2007
  31. Rucevic,M., Fast,L.D., Jay,G.D., Trespalcios,F.M., Sucov,A., Siryaporn,E. and Lim,Y.P.<br>Altered levels and molecular forms of granzyme k in plasma from septic patients<br>Shock (2007) 27, 488-493. PubMed  Europe PubMed DOI
  32. Zhao,T., Zhang,H., Guo,Y., Zhang,Q., Hua,G., Lu,H., Hou,Q., Liu,H. and Fan,Z.<br>Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells<br>Cell Death Differ (2007) 14, 489-499. PubMed  Europe PubMed DOI
  33. Zhao,T., Zhang,H., Guo,Y. and Fan,Z.<br>Granzyme K directly processes Bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death<br>J Biol Chem (2007) 282, 12104-12111. PubMed  Europe PubMed DOI
    34. 2006
  34. [YEAR:19-12-2006]Hirata,Y., Inagaki,H., Shimizu,T., Li,Q., Nagahara,N., Minami,M. and Kawada,T.<br>Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity<br>Arch Biochem Biophys (19-12-2006) 446, 35-43. PubMed  Europe PubMed DOI  E
    35. 2005
  35. Bade,B., Lohrmann,J., ten Brinke,A., Wolbink,A.M., Wolbink,G.J., ten Berge,I.J., Virchow,J.C., Jr., Luttmann,W. and Hack,C.E.<br>Detection of soluble human granzyme K in vitro and in vivo<br>Eur J Immunol (2005) 35, 2940-2948. PubMed  Europe PubMed DOI
    36. 2004
  36. Babe,L.M. and Schmidt,B.F.<br>Granzyme K<br>[ISSN:0-12-079610-4] (2004) 2, 1552-1554.  V
    37. 2003
  37. Grossman,W.J., Revell,P.A., Lu,Z.H., Johnson,H., Bredemeyer,A.J. and Ley,T.J.<br>The orphan granzymes of humans and mice<br>Curr Opin Immunol (2003) 15, 544-552. PubMed  Europe PubMed DOI  V
  38. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.<br>Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling<br>Biochem Biophys Res Commun (5-9-2003) 308, 726-735. PubMed  Europe PubMed DOI
    39. 2002
  39. [YEAR:27-12-2002]Hink-Schauer,C., Estebanez-Perpina,E., Wilharm,E., Fuentes-Prior,P., Klinkert,W., Bode,W. and Jenne,D.E.<br>The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features<br>J Biol Chem (27-12-2002) 277, 50923-50933. PubMed  Europe PubMed DOI  S
    40. 1999
  40. [YEAR:5-7-1999]Suemoto,T., Taniguchi,M., Shiosaka,S. and Yoshida,S.<br>cDNA cloning and expression of a novel serine protease in the mouse brain<br>Brain Res Mol Brain Res (5-7-1999) 70, 273-281. PubMed  Europe PubMed DOI  R
  41. [YEAR:17-9-1999]Wilharm,E., Parry,M.A., Friebel,R., Tschesche,H., Matschiner,G., Sommerhoff,C.P. and Jenne,D.E.<br>Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma<br>J Biol Chem (17-9-1999) 274, 27331-27337. PubMed  Europe PubMed DOI
  42. [YEAR:1-10-1999]Wilharm,E., Tschopp,J. and Jenne,D.E.<br>Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice<br>FEBS Lett (1-10-1999) 459, 139-142. PubMed  Europe PubMed DOI
    43. 1998
  43. Babe,L.M., Yoast,S., Dreyer,M. and Schmidt,B.F.<br>Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro<br>Biotechnol Appl Biochem (1998) 27, 117-124. PubMed  Europe PubMed
    44. 1997
  44. Brinkmann,T., Schafers,J., Gurtler,L., Kido,H., Niwa,Y., Katunuma,N. and Tschesche,H.<br>Inhibition of tryptase TL2 from human T4+ lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant aprotinin and bikunin homologues<br>J Protein Chem (1997) 16, 651-660. PubMed  Europe PubMed DOI
    45. 1996
  45. Sayers,T.J., Lloyd,A.R., McVicar,D.W., O'Connor,M.D., Kelly,J.M., Carter,C.R., Wiltrout,T.A., Wiltrout,R.H. and Smyth,M.J.<br>Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3<br>J Leukoc Biol (1996) 59, 763-768. PubMed  Europe PubMed  E
  46. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.<br>Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies<br>J Leukoc Biol (1996) 60, 555-562. PubMed  Europe PubMed  V
    47. 1995
  47. Przetak,M.M., Yoast,S. and Schmidt,B.F.<br>Cloning of cDNA for human granzyme 3<br>FEBS Lett (1995) 364, 268-271. PubMed  Europe PubMed DOI
    48. 1994
  48. [YEAR:1-3-1994]Sayers,T.J., Wiltrout,T.A., Smyth,M.J., Ottaway,K.S., Pilaro,A.M., Sowder,R., Henderson,L.E., Sprenger,H. and Lloyd,A.R.<br>Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia<br>J Immunol (1-3-1994) 152, 2289-2297. PubMed  Europe PubMed

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