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Literature for peptidase S01.146: granzyme K

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, R Splicing, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Donado,C.A., Theisen,E., Zhang,F., Nathan,A., Fairfield,M.L., Rupani,K.V., Jones,D., Johannes,K.P., Raychaudhuri,S., Dwyer,D.F., Jonsson,A.H. and Brenner,M.B.
    Granzyme K activates the entire complement cascade
    Nature PubMed  Europe PubMed DOI
    2. 2024
  2. Aubert,A., Liu,A., Kao,M., Goeres,J., Richardson,K.C., Nierves,L., Jung,K., Nabai,L., Zhao,H., Orend,G., Krawetz,R., Lange,P.F., Younger,A., Chan,J. and Granville,D.J.
    Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis
    JCI Insight9, e181935-e181935. PubMed  Europe PubMed DOI
  3. Donado,C.A., Jonsson,A.H., Theisen,E., Zhang,F., Nathan,A., Rupani,K.V., Jones,D., Raychaudhuri,S., Dwyer,D.F. and Brenner,M.B.
    Granzyme K drives a newly-intentified pathway of complement activation
    bioRxiv PubMed  Europe PubMed DOI
  4. Kim,H.Y. and Ha,H.
    Distinct granzyme k expression in immune cells: a single-cell rna-seq meta-analysis
    Genes Genomics46, 1097-1106. PubMed  Europe PubMed DOI
    5. 2023
  5. Duquette,D., Harmon,C., Zaborowski,A., Michelet,X., O'Farrelly,C., Winter,D., Koay,H.F. and Lynch,L.
    Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation
    J Immunol211, 633-647. PubMed  Europe PubMed DOI
    6. 2022
  6. Kaiserman,D., Zhao,P., Rowe,C.L., Leong,A., Barlow,N., Joeckel,L.T., Hitchen,C., Stewart,S.E., Hollenberg,M.D., Bunnett,N., Suhrbier,A. and Bird,P.I.
    Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2
    PLoS ONE17, e0270584-e0270584. PubMed  Europe PubMed DOI
    7. 2021
  7. Bouwman,A.C., van Daalen,K.R., Crnko,S., Ten Broeke,T. and Bovenschen,N.
    Intracellular and Extracellular Roles of Granzyme K
    Front Immunol12, 677707-677707. PubMed  Europe PubMed DOI  V
    8. 2019
  8. Turner,C.T., Zeglinski,M.R., Richardson,K.C., Zhao,H., Shen,Y., Papp,A., Bird,P.I. and Granville,D.J.
    Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling
    J Invest Dermatol139, 930-939. PubMed  Europe PubMed DOI
    9. 2017
  9. Joeckel,L.T., Allison,C.C., Pellegrini,M., Bird,C.H. and Bird,P.I.
    Granzyme K-deficient mice show no evidence of impaired antiviral immunity
    Immunol Cell Biol95, 676-683. PubMed  Europe PubMed DOI  K
    10. 2016
  10. Sharma,M., Merkulova,Y., Raithatha,S., Parkinson,L.G., Shen,Y., Cooper,D. and Granville,D.J.
    Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1
    FEBS J283, 1734-1747. PubMed  Europe PubMed DOI
  11. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.
    Granzymes A and K differentially potentiate LPS-induced cytokine response
    Cell Death Discov2, 16084-16084. PubMed  Europe PubMed DOI
    12. 2014
  12. Ahmad,J., Bird,P.I. and Kaiserman,D.
    Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
    Biol Chem395, 1253-1262. PubMed  Europe PubMed DOI
  13. Hirata,Y., Inagaki,H., Shimizu,T. and Kawada,T.
    Substrate specificity of human granzyme 3: analyses of the P3- P2-P1 triplet using fluorescence resonance energy transfer substrate libraries
    BioScience Trends8, 126-131. PubMed  Europe PubMed DOI  A  P
  14. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.
    Substrate specificities of the granzyme tryptases A and K
    J Proteome Res13, 6067-6077. PubMed  Europe PubMed DOI  P
  15. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res13, 1785-1793. PubMed  Europe PubMed DOI  P
  16. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.
    Human granzymes: related but far apart
    Med Hypotheses83, 688-693. PubMed  Europe PubMed DOI  V
    17. 2012
  17. Bovenschen,N.
    Granzyme K
    [ISSN:978-0-12-407742-3]3, 2725-2728. DOI
  18. Zhong,C., Li,C., Wang,X., Toyoda,T., Gao,G. and Fan,Z.
    Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells
    Cell Death Differ19, 882-890. PubMed  Europe PubMed DOI
    19. 2011
  19. Cooper,D.M., Pechkovsky,D.V., Hackett,T.L., Knight,D.A. and Granville,D.J.
    Granzyme K activates protease-activated receptor-1
    PLoS ONE6, e21484-e21484. PubMed  Europe PubMed DOI
  20. Joeckel,L.T., Wallich,R., Martin,P., Sanchez-Martinez,D., Weber,F.C., Martin,S.F., Borner,C., Pardo,J., Froelich,C. and Simon,M.M.
    Mouse granzyme K has pro-inflammatory potential
    Cell Death Differ18, 1112-1119. PubMed  Europe PubMed DOI
    21. 2010
  21. Bovenschen,N. and Kummer,J.A.
    Orphan granzymes find a home
    Immunol Rev235, 117-127. PubMed  Europe PubMed DOI  V
  22. Guo,Y., Chen,J., Shi,L. and Fan,Z.
    Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells
    J Immunol185, 5348-5359. PubMed  Europe PubMed DOI  P
    23. 2009
  23. Bovenschen,N., Quadir,R., van den Berg,A.L., Brenkman,A.B., Vandenberghe,I., Devreese,B., Joore,J. and Kummer,J.A.
    Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A
    J Biol Chem284, 3504-3512. PubMed  Europe PubMed DOI  P
  24. Froelich,C.J., Pardo,J. and Simon,M.M.
    Granule-associated serine proteases: granzymes might not just be killer proteases
    Trends Immunol30, 117-123. PubMed  Europe PubMed DOI  V
  25. Hua,G., Wang,S., Zhong,C., Xue,P. and Fan,Z.
    Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis
    J Immunol182, 2152-2159. PubMed  Europe PubMed DOI
    26. 2008
  26. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol26, 389-420. PubMed  Europe PubMed DOI  V
  27. Jenkins,M.R., Trapani,J.A., Doherty,P.C. and Turner,S.J.
    Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice
    Viral Immunol21, 341-346. PubMed  Europe PubMed DOI
    28. 2007
  28. Rucevic,M., Fast,L.D., Jay,G.D., Trespalcios,F.M., Sucov,A., Siryaporn,E. and Lim,Y.P.
    Altered levels and molecular forms of granzyme k in plasma from septic patients
    Shock27, 488-493. PubMed  Europe PubMed DOI
  29. Zhao,T., Zhang,H., Guo,Y. and Fan,Z.
    Granzyme K directly processes Bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
    J Biol Chem282, 12104-12111. PubMed  Europe PubMed DOI
  30. Zhao,T., Zhang,H., Guo,Y., Zhang,Q., Hua,G., Lu,H., Hou,Q., Liu,H. and Fan,Z.
    Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells
    Cell Death Differ14, 489-499. PubMed  Europe PubMed DOI
    31. 2006
  31. [YEAR:19-12-2006]Hirata,Y., Inagaki,H., Shimizu,T., Li,Q., Nagahara,N., Minami,M. and Kawada,T.
    Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity
    Arch Biochem Biophys446, 35-43. PubMed  Europe PubMed DOI  E
    32. 2005
  32. Bade,B., Lohrmann,J., ten Brinke,A., Wolbink,A.M., Wolbink,G.J., ten Berge,I.J., Virchow,J.C., Jr., Luttmann,W. and Hack,C.E.
    Detection of soluble human granzyme K in vitro and in vivo
    Eur J Immunol35, 2940-2948. PubMed  Europe PubMed DOI
    33. 2004
  33. Babe,L.M. and Schmidt,B.F.
    Granzyme K
    [ISSN:0-12-079610-4]2, 1552-1554.  V
    34. 2003
  34. Grossman,W.J., Revell,P.A., Lu,Z.H., Johnson,H., Bredemeyer,A.J. and Ley,T.J.
    The orphan granzymes of humans and mice
    Curr Opin Immunol15, 544-552. PubMed  Europe PubMed DOI  V
  35. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun308, 726-735. PubMed  Europe PubMed DOI
    36. 2002
  36. [YEAR:27-12-2002]Hink-Schauer,C., Estebanez-Perpina,E., Wilharm,E., Fuentes-Prior,P., Klinkert,W., Bode,W. and Jenne,D.E.
    The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features
    J Biol Chem277, 50923-50933. PubMed  Europe PubMed DOI  S
    37. 1999
  37. [YEAR:5-7-1999]Suemoto,T., Taniguchi,M., Shiosaka,S. and Yoshida,S.
    cDNA cloning and expression of a novel serine protease in the mouse brain
    Brain Res Mol Brain Res70, 273-281. PubMed  Europe PubMed DOI  R
  38. [YEAR:1-10-1999]Wilharm,E., Tschopp,J. and Jenne,D.E.
    Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice
    FEBS Lett459, 139-142. PubMed  Europe PubMed DOI
  39. [YEAR:17-9-1999]Wilharm,E., Parry,M.A., Friebel,R., Tschesche,H., Matschiner,G., Sommerhoff,C.P. and Jenne,D.E.
    Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma
    J Biol Chem274, 27331-27337. PubMed  Europe PubMed DOI
    40. 1998
  40. Babe,L.M., Yoast,S., Dreyer,M. and Schmidt,B.F.
    Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro
    Biotechnol Appl Biochem27, 117-124. PubMed  Europe PubMed
    41. 1997
  41. Brinkmann,T., Schafers,J., Gurtler,L., Kido,H., Niwa,Y., Katunuma,N. and Tschesche,H.
    Inhibition of tryptase TL2 from human T4+ lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant aprotinin and bikunin homologues
    J Protein Chem16, 651-660. PubMed  Europe PubMed DOI
    42. 1996
  42. Sayers,T.J., Lloyd,A.R., McVicar,D.W., O'Connor,M.D., Kelly,J.M., Carter,C.R., Wiltrout,T.A., Wiltrout,R.H. and Smyth,M.J.
    Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3
    J Leukoc Biol59, 763-768. PubMed  Europe PubMed  E
  43. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.
    Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    J Leukoc Biol60, 555-562. PubMed  Europe PubMed  V
    44. 1995
  44. Przetak,M.M., Yoast,S. and Schmidt,B.F.
    Cloning of cDNA for human granzyme 3
    FEBS Lett364, 268-271. PubMed  Europe PubMed DOI
    45. 1994
  45. [YEAR:1-3-1994]Sayers,T.J., Wiltrout,T.A., Smyth,M.J., Ottaway,K.S., Pilaro,A.M., Sowder,R., Henderson,L.E., Sprenger,H. and Lloyd,A.R.
    Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia
    J Immunol152, 2289-2297. PubMed  Europe PubMed

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