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Literature for peptidase S01.146: granzyme K

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, R Splicing, P Specificity, K Knockout, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Donado,C.A., Theisen,E., Zhang,F., Nathan,A., Fairfield,M.L., Rupani,K.V., Jones,D., Johannes,K.P., Raychaudhuri,S., Dwyer,D.F., Jonsson,A.H. and Brenner,M.B.
    Granzyme K activates the entire complement cascade
    Nature (2025) PubMed  Europe PubMed DOI
  2. Lyu,Q. and Li,L.
    Granzyme K, Regulated by the N6-Methyladenosine Methyltransferase Wilms' tumor 1-associate protein, Enhances Myocardial Infarction Injury
    DNA Cell Biol (2025) PubMed  Europe PubMed DOI  K
  3. Mastellos,D.C. and Lambris,J.D.
    'Complement-ing' tissue inflammation via granzyme K?
    Nat Immunol (2025) PubMed  Europe PubMed DOI
  4. Poppelaars,F. and Daha,M.R.
    Granzyme K sets complement in motion
    Kidney Int (2025) PubMed  Europe PubMed DOI
    5. 2024
  5. Aubert,A., Liu,A., Kao,M., Goeres,J., Richardson,K.C., Nierves,L., Jung,K., Nabai,L., Zhao,H., Orend,G., Krawetz,R., Lange,P.F., Younger,A., Chan,J. and Granville,D.J.
    Granzyme B cleaves Tenascin-C to release its C-terminal domain in rheumatoid arthritis
    JCI Insight (2024) 9, e181935-e181935. PubMed  Europe PubMed DOI
  6. Donado,C.A., Jonsson,A.H., Theisen,E., Zhang,F., Nathan,A., Rupani,K.V., Jones,D., Raychaudhuri,S., Dwyer,D.F. and Brenner,M.B.
    Granzyme K drives a newly-intentified pathway of complement activation
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  7. Kim,H.Y. and Ha,H.
    Distinct granzyme k expression in immune cells: a single-cell rna-seq meta-analysis
    Genes Genomics (2024) 46, 1097-1106. PubMed  Europe PubMed DOI
    8. 2023
  8. Duquette,D., Harmon,C., Zaborowski,A., Michelet,X., O'Farrelly,C., Winter,D., Koay,H.F. and Lynch,L.
    Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation
    J Immunol (2023) 211, 633-647. PubMed  Europe PubMed DOI
    9. 2022
  9. Kaiserman,D., Zhao,P., Rowe,C.L., Leong,A., Barlow,N., Joeckel,L.T., Hitchen,C., Stewart,S.E., Hollenberg,M.D., Bunnett,N., Suhrbier,A. and Bird,P.I.
    Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2
    PLoS ONE (2022) 17, e0270584-e0270584. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Bouwman,A.C., van Daalen,K.R., Crnko,S., Ten Broeke,T. and Bovenschen,N.
    Intracellular and Extracellular Roles of Granzyme K
    Front Immunol (2021) 12, 677707-677707. PubMed  Europe PubMed DOI  PMC  EPMC  V
    11. 2019
  11. Turner,C.T., Zeglinski,M.R., Richardson,K.C., Zhao,H., Shen,Y., Papp,A., Bird,P.I. and Granville,D.J.
    Granzyme K expressed by classically activated macrophages contributes to inflammation and impaired remodeling
    J Invest Dermatol (2019) 139, 930-939. PubMed  Europe PubMed DOI
    12. 2017
  12. Joeckel,L.T., Allison,C.C., Pellegrini,M., Bird,C.H. and Bird,P.I.
    Granzyme K-deficient mice show no evidence of impaired antiviral immunity
    Immunol Cell Biol (2017) 95, 676-683. PubMed  Europe PubMed DOI  K
    13. 2016
  13. Sharma,M., Merkulova,Y., Raithatha,S., Parkinson,L.G., Shen,Y., Cooper,D. and Granville,D.J.
    Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1
    FEBS J (2016) 283, 1734-1747. PubMed  Europe PubMed DOI
  14. Wensink,A.C., Kok,H.M., Meeldijk,J., Fermie,J., Froelich,C.J., Hack,C.E. and Bovenschen,N.
    Granzymes A and K differentially potentiate LPS-induced cytokine response
    Cell Death Discov (2016) 2, 16084-16084. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2014
  15. Ahmad,J., Bird,P.I. and Kaiserman,D.
    Analysis of the evolution of granule associated serine proteases of immune defence (GASPIDs) suggests a revised nomenclature
    Biol Chem (2014) 395, 1253-1262. PubMed  Europe PubMed DOI
  16. Hirata,Y., Inagaki,H., Shimizu,T. and Kawada,T.
    Substrate specificity of human granzyme 3: analyses of the P3- P2-P1 triplet using fluorescence resonance energy transfer substrate libraries
    BioScience Trends (2014) 8, 126-131. PubMed  Europe PubMed DOI  A  P
  17. Plasman,K., Maurer-Stroh,S., Gevaert,K. and Van Damme,P.
    Holistic view on the extended substrate specificities of orthologous granzymes
    J Proteome Res (2014) 13, 1785-1793. PubMed  Europe PubMed DOI  P
  18. Plasman,K., Demol,H., Bird,P.I., Gevaert,K. and Van Damme,P.
    Substrate specificities of the granzyme tryptases A and K
    J Proteome Res (2014) 13, 6067-6077. PubMed  Europe PubMed DOI  P
  19. Vahedi,F., Fraleigh,N., Vlasschaert,C., McElhaney,J. and Hanifi-Moghaddam,P.
    Human granzymes: related but far apart
    Med Hypotheses (2014) 83, 688-693. PubMed  Europe PubMed DOI  V
    20. 2012
  20. Bovenschen,N.
    Granzyme K
    [ISSN:978-0-12-407742-3] (2012) 3, 2725-2728. DOI
  21. Zhong,C., Li,C., Wang,X., Toyoda,T., Gao,G. and Fan,Z.
    Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells
    Cell Death Differ (2012) 19, 882-890. PubMed  Europe PubMed DOI
    22. 2011
  22. Cooper,D.M., Pechkovsky,D.V., Hackett,T.L., Knight,D.A. and Granville,D.J.
    Granzyme K activates protease-activated receptor-1
    PLoS ONE (2011) 6, e21484-e21484. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Joeckel,L.T., Wallich,R., Martin,P., Sanchez-Martinez,D., Weber,F.C., Martin,S.F., Borner,C., Pardo,J., Froelich,C. and Simon,M.M.
    Mouse granzyme K has pro-inflammatory potential
    Cell Death Differ (2011) 18, 1112-1119. PubMed  Europe PubMed DOI  PMC  EPMC
    24. 2010
  24. Bovenschen,N. and Kummer,J.A.
    Orphan granzymes find a home
    Immunol Rev (2010) 235, 117-127. PubMed  Europe PubMed DOI  V
  25. Guo,Y., Chen,J., Shi,L. and Fan,Z.
    Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells
    J Immunol (2010) 185, 5348-5359. PubMed  Europe PubMed DOI  P
    26. 2009
  26. Bovenschen,N., Quadir,R., van den Berg,A.L., Brenkman,A.B., Vandenberghe,I., Devreese,B., Joore,J. and Kummer,J.A.
    Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A
    J Biol Chem (2009) 284, 3504-3512. PubMed  Europe PubMed DOI  P
  27. Froelich,C.J., Pardo,J. and Simon,M.M.
    Granule-associated serine proteases: granzymes might not just be killer proteases
    Trends Immunol (2009) 30, 117-123. PubMed  Europe PubMed DOI  V
  28. Hua,G., Wang,S., Zhong,C., Xue,P. and Fan,Z.
    Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis
    J Immunol (2009) 182, 2152-2159. PubMed  Europe PubMed DOI
    29. 2008
  29. Chowdhury,D. and Lieberman,J.
    Death by a thousand cuts: granzyme pathways of programmed cell death
    Annu Rev Immunol (2008) 26, 389-420. PubMed  Europe PubMed DOI  V
  30. Jenkins,M.R., Trapani,J.A., Doherty,P.C. and Turner,S.J.
    Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice
    Viral Immunol (2008) 21, 341-346. PubMed  Europe PubMed DOI
    31. 2007
  31. Rucevic,M., Fast,L.D., Jay,G.D., Trespalcios,F.M., Sucov,A., Siryaporn,E. and Lim,Y.P.
    Altered levels and molecular forms of granzyme k in plasma from septic patients
    Shock (2007) 27, 488-493. PubMed  Europe PubMed DOI
  32. Zhao,T., Zhang,H., Guo,Y., Zhang,Q., Hua,G., Lu,H., Hou,Q., Liu,H. and Fan,Z.
    Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells
    Cell Death Differ (2007) 14, 489-499. PubMed  Europe PubMed DOI
  33. Zhao,T., Zhang,H., Guo,Y. and Fan,Z.
    Granzyme K directly processes Bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
    J Biol Chem (2007) 282, 12104-12111. PubMed  Europe PubMed DOI
    34. 2006
  34. [YEAR:19-12-2006]Hirata,Y., Inagaki,H., Shimizu,T., Li,Q., Nagahara,N., Minami,M. and Kawada,T.
    Expression of enzymatically active human granzyme 3 in Escherichia coli for analysis of its substrate specificity
    Arch Biochem Biophys (19-12-2006) 446, 35-43. PubMed  Europe PubMed DOI  E
    35. 2005
  35. Bade,B., Lohrmann,J., ten Brinke,A., Wolbink,A.M., Wolbink,G.J., ten Berge,I.J., Virchow,J.C., Jr., Luttmann,W. and Hack,C.E.
    Detection of soluble human granzyme K in vitro and in vivo
    Eur J Immunol (2005) 35, 2940-2948. PubMed  Europe PubMed DOI
    36. 2004
  36. Babe,L.M. and Schmidt,B.F.
    Granzyme K
    [ISSN:0-12-079610-4] (2004) 2, 1552-1554.  V
    37. 2003
  37. Grossman,W.J., Revell,P.A., Lu,Z.H., Johnson,H., Bredemeyer,A.J. and Ley,T.J.
    The orphan granzymes of humans and mice
    Curr Opin Immunol (2003) 15, 544-552. PubMed  Europe PubMed DOI  V
  38. [YEAR:5-9-2003]Sattar,R., Ali,S.A. and Abbasi,A.
    Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling
    Biochem Biophys Res Commun (5-9-2003) 308, 726-735. PubMed  Europe PubMed DOI
    39. 2002
  39. [YEAR:27-12-2002]Hink-Schauer,C., Estebanez-Perpina,E., Wilharm,E., Fuentes-Prior,P., Klinkert,W., Bode,W. and Jenne,D.E.
    The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features
    J Biol Chem (27-12-2002) 277, 50923-50933. PubMed  Europe PubMed DOI  S
    40. 1999
  40. [YEAR:5-7-1999]Suemoto,T., Taniguchi,M., Shiosaka,S. and Yoshida,S.
    cDNA cloning and expression of a novel serine protease in the mouse brain
    Brain Res Mol Brain Res (5-7-1999) 70, 273-281. PubMed  Europe PubMed DOI  R
  41. [YEAR:17-9-1999]Wilharm,E., Parry,M.A., Friebel,R., Tschesche,H., Matschiner,G., Sommerhoff,C.P. and Jenne,D.E.
    Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma
    J Biol Chem (17-9-1999) 274, 27331-27337. PubMed  Europe PubMed DOI
  42. [YEAR:1-10-1999]Wilharm,E., Tschopp,J. and Jenne,D.E.
    Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice
    FEBS Lett (1-10-1999) 459, 139-142. PubMed  Europe PubMed DOI
    43. 1998
  43. Babe,L.M., Yoast,S., Dreyer,M. and Schmidt,B.F.
    Heterologous expression of human granzyme K in Bacillus subtilis and characterization of its hydrolytic activity in vitro
    Biotechnol Appl Biochem (1998) 27, 117-124. PubMed  Europe PubMed
    44. 1997
  44. Brinkmann,T., Schafers,J., Gurtler,L., Kido,H., Niwa,Y., Katunuma,N. and Tschesche,H.
    Inhibition of tryptase TL2 from human T4+ lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant aprotinin and bikunin homologues
    J Protein Chem (1997) 16, 651-660. PubMed  Europe PubMed DOI
    45. 1996
  45. Sayers,T.J., Lloyd,A.R., McVicar,D.W., O'Connor,M.D., Kelly,J.M., Carter,C.R., Wiltrout,T.A., Wiltrout,R.H. and Smyth,M.J.
    Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3
    J Leukoc Biol (1996) 59, 763-768. PubMed  Europe PubMed  E
  46. Smyth,M.J., O'Connor,M.D. and Trapani,J.A.
    Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    J Leukoc Biol (1996) 60, 555-562. PubMed  Europe PubMed  V
    47. 1995
  47. Przetak,M.M., Yoast,S. and Schmidt,B.F.
    Cloning of cDNA for human granzyme 3
    FEBS Lett (1995) 364, 268-271. PubMed  Europe PubMed DOI
    48. 1994
  48. [YEAR:1-3-1994]Sayers,T.J., Wiltrout,T.A., Smyth,M.J., Ottaway,K.S., Pilaro,A.M., Sowder,R., Henderson,L.E., Sprenger,H. and Lloyd,A.R.
    Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia
    J Immunol (1-3-1994) 152, 2289-2297. PubMed  Europe PubMed

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