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Literature for peptidase S01.079: transmembrane peptidase, serine 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: M Mutation, T Target, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Arora,R., Pifkova,L., Deutschmann,A.U. and Reisinger,E.
    Tmprss3 is expressed in several cell types of the inner ear including type II but hardly in type I spiral ganglion neurons
    Front Cell Neurosci (2025) 19, 1690227-1690227. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Rezaie,N., Ghazanfari,S.S., Mousavikia,S.M., Mansour Samaei,N., Oladnabi,M., Sarli,A. and Khosravi,T.
    A novel frameshift variant in the TMPRSS3 gene causes nonsyndromic hearing loss in a consanguineous family
    BMC Med Genomics (2024) 17, 283-283. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Wang,Y., Liang,Y., Huang,B., Cen,X., Huang,L. and Chen,K.
    [Late-onset hereditary hearing loss caused by TMPRSS3 compound heterozygous mutations]
    Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2024) 38, 679-686. PubMed  Europe PubMed DOI
  4. Zhang,X., Wu,J., Wang,M., Chen,L., Wang,P., Jiang,Q. and Yang,C.
    The role of gene mutations and immune responses in sensorineural hearing loss
    Int Immunopharmacol (2024) 143, 113515-113515. PubMed  Europe PubMed DOI  V
    5. 2022
  5. Chen,Y.S., Cabrera,E., Tucker,B.J., Shin,T.J., Moawad,J.V., Totten,D.J., Booth,K.T. and Nelson,R.F.
    TMPRSS3 expression is limited in spiral ganglion neurons: implication for successful cochlear implantation
    J Med Genet (2022) 59, 1219-1226. PubMed  Europe PubMed DOI  V
  6. Wen,J.Y., Fang,Y.Y., Chen,G., He,R.Q., Huang,H.Q., Wang,R.S., Zeng,D.T., Huang,W.J. and Qin,X.G.
    Upregulation of the transmembrane protease serine 3 mRNA level in radioresistant colorectal cancer tissues
    Biomark Med (2022) 16, 693-715. PubMed  Europe PubMed DOI
    7. 2019
  7. Zhang,Z.W., Pang,B., Chen,Y.C. and Peng,A.Q.
    TMPRSS3 regulates cell viability and apoptosis processes of HEI-OC1 cells via regulation on circ-Slc4a2, miR-182, and AKT cascade
    J Gene Med (2019) , e3118-e3118. PubMed  Europe PubMed DOI
    8. 2018
  8. Li,S.L., Chen,X., Wu,T., Zhang,X.W., Li,H., Zhang,Y. and Ji,Z.Z.
    Knockdown of TMPRSS3 inhibits gastric cancer cell proliferation, invasion and EMT via regulation of the ERK1/2 and PI3K/Akt pathways
    Biomed Pharmacother (2018) 107, 841-848. PubMed  Europe PubMed DOI  K  T
  9. Liu,W., Lowenheim,H., Santi,P.A., Glueckert,R., Schrott-Fischer,A. and Rask-Andersen,H.
    Expression of trans-membrane serine protease 3 (TMPRSS3) in the human organ of Corti
    Cell Tissue Res (2018) 372, 445-456. PubMed  Europe PubMed DOI
  10. Wang,J.Y., Jin,X. and Li,X.F.
    Knockdown of TMPRSS3, a transmembrane serine protease, inhibits proliferation, migration, and invasion in human nasopharyngeal carcinoma cells
    Oncol Res (2018) 26, 95-101. PubMed  Europe PubMed DOI
    11. 2017
  11. Gao,X., Huang,S.S., Yuan,Y.Y., Xu,J.C., Gu,P., Bai,D., Kang,D.Y., Han,M.Y., Wang,G.J., Zhang,M.G., Li,J. and Dai,P.
    Identification of TMPRSS3 as a significant contributor to autosomal recessive hearing loss in the Chinese population
    Neural Plast (2017) 2017, 3192090-3192090. PubMed  Europe PubMed DOI  PMC  EPMC  M
    12. 2016
  12. Battelino,S., Klancar,G., Kovac,J., Battelino,T. and Trebusak Podkrajsek,K.
    TMPRSS3 mutations in autosomal recessive nonsyndromic hearing loss
    Eur Arch Otorhinolaryngol (2016) 273, 1151-1154. PubMed  Europe PubMed DOI  M
  13. Zhang,D., Qiu,S., Wang,Q. and Zheng,J.
    TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis
    Oncol Rep (2016) 35, 81-88. PubMed  Europe PubMed DOI  T
    14. 2014
  14. Chung,J., Park,S.M., Chang,S.O., Chung,T., Lee,K.Y., Kim,A.R., Park,J.H., Kim,V., Park,W.Y., Oh,S.H., Kim,D., Park,W.J. and Choi,B.Y.
    A novel mutation of TMPRSS3 related to milder auditory phenotype in Korean postlingual deafness: a possible future implication for a personalized auditory rehabilitation
    J Mol Med (Berl) (2014) 92, 651-663. PubMed  Europe PubMed DOI  M
  15. Li,Y., Peng,A., Ge,S., Wang,Q. and Liu,J.
    miR-204 suppresses cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3
    Hear Res (2014) 314, 60-64. PubMed  Europe PubMed DOI
    16. 2013
  16. Molina,L., Fasquelle,L., Nouvian,R., Salvetat,N., Scott,H.S., Guipponi,M., Molina,F., Puel,J.L. and Delprat,B.
    Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression
    Hum Mol Genet (2013) 22, 1289-1299. PubMed  Europe PubMed DOI
    17. 2012
  17. Lee,K., Khan,S., Islam,A., Ansar,M., Andrade,P.B., Kim,S., Santos-Cortez,R.L., Ahmad,W. and Leal,S.M.
    Novel TMPRSS3 variants in Pakistani families with autosomal recessive non-syndromic hearing impairment
    Clin Genet (2012) 82, 56-63. PubMed  Europe PubMed DOI  M
    18. 2011
  18. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci (2011) 99, 1-50. PubMed  Europe PubMed DOI  V
  19. Fasquelle,L., Scott,H.S., Lenoir,M., Wang,J., Rebillard,G., Gaboyard,S., Venteo,S., Francois,F., Mausset-Bonnefont,A.L., Antonarakis,S.E., Neidhart,E., Chabbert,C., Puel,J.L., Guipponi,M. and Delprat,B.
    Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing
    J Biol Chem (2011) 286, 17383-17397. PubMed  Europe PubMed DOI  K
    20. 2008
  20. Guipponi,M., Toh,M.Y., Tan,J., Park,D., Hanson,K., Ballana,E., Kwong,D., Cannon,P.Z., Wu,Q., Gout,A., Delorenzi,M., Speed,T.P., Smith,R.J., Dahl,H.H., Petersen,M., Teasdale,R.D., Estivill,X., Park,W.J. and Scott,H.S.
    An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss
    Hum Mutat (2008) 29, 130-141. PubMed  Europe PubMed DOI
  21. Guipponi,M., Antonarakis,S.E. and Scott,H.S.
    TMPRSS3, a type II transmembrane serine protease mutated in non-syndromic autosomal recessive deafness
    Front Biosci (2008) 13, 1557-1567. PubMed  Europe PubMed DOI  V
    22. 2007
  22. Elbracht,M., Senderek,J., Eggermann,T., Thurmer,C., Park,J., Westhofen,M. and Zerres,K.
    Autosomal recessive postlingual hearing loss (DFNB8): compound heterozygosity for two novel TMPRSS3 mutations in German siblings
    J Med Genet (2007) 44, e81-e81. PubMed  Europe PubMed DOI  M
    23. 2005
  23. [YEAR:14-7-2005]Wattenhofer,M., Sahin-Calapoglu,N., Andreasen,D., Kalay,E., Caylan,R., Braillard,B., Fowler-Jaeger,N., Reymond,A., Rossier,B.C., Karaguzel,A. and Antonarakis,S.E.
    A novel TMPRSS3 missense mutation in a DFNB8/10 family prevents proteolytic activation of the protein
    Hum Genet (14-7-2005) 117, 528-535. PubMed  Europe PubMed DOI  M
    24. 2004
  24. [YEAR:24-9-2004]Ahmed,Z.M., Li,X.C., Powell,S.D., Riazuddin,S., Young,T.L., Ramzan,K., Ahmad,Z., Luscombe,S., Dhillon,K., MacLaren,L., Ploplis,B., Shotland,L.I., Ives,E., Riazuddin,S., Friedman,T.B., Morell,R.J. and Wilcox,E.R.
    Characterization of a new full length TMPRSS3 isoform and identification of mutant alleles responsible for nonsyndromic recessive deafness in Newfoundland and Pakistan
    BMC Med Genet (24-9-2004) 5, 24-24. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Sawasaki,T., Shigemasa,K., Gu,L., Beard,J.B. and O'Brien,T.J.
    The transmembrane protease serine (TMPRSS3/TADG-12) D variant: a potential candidate for diagnosis and therapeutic intervention in ovarian cancer
    Tumour Biol (2004) 25, 141-148. PubMed  Europe PubMed DOI
    26. 2003
  26. Lee,Y.J., Park,D., Kim,S.Y. and Park,W.J.
    Pathogenic mutations but not polymorphisms in congenital and childhood onset autosomal recessive deafness disrupt the proteolytic activity of TMPRSS3
    J Med Genet (2003) 40, 629-631. PubMed  Europe PubMed  PMC  EPMC  M
  27. Szabo,R., Wu,Q., Dickson,R.B., Netzel-Arnett,S., Antalis,T.M. and Bugge,T.H.
    Type II transmembrane serine proteases
    Thromb Haemost (2003) 90, 185-193. PubMed  Europe PubMed DOI  V
    28. 2002
  28. [YEAR:1-11-2002]Guipponi,M., Vuagniaux,G., Wattenhofer,M., Shibuya,K., Vazquez,M., Dougherty,L., Scamuffa,N., Guida,E., Okui,M., Rossier,C., Hancock,M., Buchet,K., Reymond,A., Hummler,E., Marzella,P.L., Kudoh,J., Shimizu,N., Scott,H.S., Antonarakis,S.E. and Rossier,B.C.
    The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro
    Hum Mol Genet (1-11-2002) 11, 2829-2836. PubMed  Europe PubMed
    29. 2001
  29. Ben-Yosef,T., Wattenhofer,M., Riazuddin,S., Ahmed,Z.M., Scott,H.S., Kudoh,J., Shibuya,K., Antonarakis,S.E., Bonne-Tamir,B., Radhakrishna,U., Naz,S., Ahmed,Z., Riazuddin,S., Pandya,A., Nance,W.E., Wilcox,E.R., Friedman,T.B. and Morell,R.J.
    Novel mutations of TMPRSS3 in four DFNB8/B10 families segregating congenital autosomal recessive deafness
    J Med Genet (2001) 38, 396-400. PubMed  Europe PubMed  PMC  EPMC
  30. Masmoudi,S., Antonarakis,S.E., Schwede,T., Ghorbel,A.M., Gratri,M., Pappasavas,M.P., Drira,M., Elgaied-Boulila,A., Wattenhofer,M., Rossier,C., Scott,H.S., Ayadi,H. and Guipponi,M.
    Novel missense mutations of TMPRSS3 in two consanguineous Tunisian families with non-syndromic autosomal recessive deafness
    Hum Mutat (2001) 18, 101-108. PubMed  Europe PubMed DOI
  31. Scott,H.S., Kudoh,J., Wattenhofer,M., Shibuya,K., Berry,A., Chrast,R., Guipponi,M., Wang,J., Kawasaki,K., Asakawa,S., Minoshima,S., Younus,F., Mehdi,S.Q., Radhakrishna,U., Papasavvas,M.P., Gehrig,C., Rossier,C., Korostishevsky,M., Gal,A., Shimizu,N., Bonne-Tamir,B. and Antonarakis,S.E.
    Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness
    Nat Genet (2001) 27, 59-63. PubMed  Europe PubMed DOI
    32. 2000
  32. [YEAR:15-11-2000]Underwood,L.J., Shigemasa,K., Tanimoto,H., Beard,J.B., Schneider,E.N., Wang,Y., Parmley,T.H. and O'Brien,T.J.
    Ovarian tumor cells express a novel multi-domain cell surface serine protease
    Biochim Biophys Acta (15-11-2000) 1502, 337-350. PubMed  Europe PubMed DOI

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