Literature for peptidase S01.001: chymotrypsin A (cattle-type)
(Topics flags: S Structure, A Assay, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)
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Stefan,A. and Hochkoeppler,A.
The catalytic action of enzymes exposed to charged substrates outperforms the activity exerted on their neutral counterparts
Biochem Biophys Res Commun751, 151436-151436. PubMed Europe PubMed DOI -
Ansari,N.K., Khan,H.S. and Naeem,A.
Doxorubicin as a Drug Repurposing for Disruption of alpha-Chymotrypsinogen-A Aggregates
Protein J43, 842-857. PubMed Europe PubMed DOI -
Gajardo-Parra,N.F., Cea-Klapp,E., Chandra,A., Canales,R., Garrido,J.M., Held,C. and Guajardo,N.V.
Assessing the effect of deep eutectic solvents on alpha-chymotrypsin thermal stability and activity
ChemSusCheme202401414-e202401414. PubMed Europe PubMed DOI -
Gholizadeh,M., Shareghi,B. and Farhadian,S.
Revealing the interaction between alpha-chymotrypsin and eugenol: An integrated multi-spectral and dynamic simulation approach
Int J Biol Macromol277, 134504-134504. PubMed Europe PubMed DOI -
Patel,C.K. and Mukherjee,T.K.
Biomolecular Condensation of Trypsin Prevents Autolysis and Promotes Ca(2+)-Mediated Activation of Esterase Activity
Biomacromolecules25, 6082-6092. PubMed Europe PubMed DOI -
Shirazi,S.H., Rizvi,F., Sherwani,Z.A., Siddiqui,A.R., Ul-Haq,Z., Siddiqui,H., Choudhary,M.I. and Ahmad,M.S.
Synthesis of isoniazid derivatives and evaluation of their alpha-chymotrypsin inhibitory effect through in silico guided in vitro studies
Biochem Biophys Res Commun735, 150805-150805. PubMed Europe PubMed DOI I -
Sindhikara,D., Iskandar,S.E., Guan,L., Maini,R., Hipolito,C.J., Sun,C., Vasicek,L.A., Weinglass,A. and Saldanha,S.A.
Analysis and Prediction of Chymotrypsin Substrate Preferences through Large Data Acquisition with Target-Free mRNA Display
Chembiocheme202400760-e202400760. PubMed Europe PubMed DOI -
Yadav,B., Yadav,N. and Venkatesu,P.
Unravelling the stabilization mechanism of mono-, di- and tri-cholinium citrate-ethylene glycol DESs towards alpha-chymotrypsin for preservation and activation of the enzyme
Phys Chem Chem Phys26, 28025-28036. PubMed Europe PubMed DOI -
Ying,Y. and Li,H.
Native top-down mass spectrometry for monitoring the rapid chymotrypsin catalyzed hydrolysis reaction
Anal Chim Acta1285, 341971-341971. PubMed Europe PubMed DOI -
Solovyev,M., Kashinskaya,E. and Gisbert,E.
A meta-analysis for assessing the contributions of trypsin and chymotrypsin as the two major endoproteases in protein hydrolysis in fish intestine
Comp Biochem Physiol A Mol Integr Physiol278, 111372-111372. PubMed Europe PubMed DOI -
Vreeke,G.J.C., Vincken,J.P. and Wierenga,P.A.
The path of proteolysis by bovine chymotrypsin
Food Res Int165, 112485-112485. PubMed Europe PubMed DOI -
Balabushevich,N.G., Kovalenko,E.A., Filatova,L.Y., Kirzhanova,E.A., Mikhalchik,E.V., Volodkin,D. and Vikulina,A.S.
Hybrid Mucin-Vaterite Microspheres for Delivery of Proteolytic Enzyme Chymotrypsin
Macromol Biosci22, e2200005-e2200005. PubMed Europe PubMed DOI -
Biswas,P., Adhikari,A., Pal,U., Mondal,S., Mukherjee,D., Ghosh,R., Obaid,R.J., Moussa,Z., Choudhury,S.S., Ahmed,S.A., Das,R. and Pal,S.K.
A combined spectroscopic and molecular modeling Study on structure-function-dynamics under chemical modification: Alpha-chymotrypsin with formalin preservative
Front Chem10, 978668-978668. PubMed Europe PubMed DOI -
Gul,S. and Khan,A.M.
Molecular docking studies of isolated marine natural products against alpha-chymotrypsin
Nat Prod Res1-4. PubMed Europe PubMed DOI -
Lan,T., Tian,Q.Q., Li,M.H. and He,W.
Activatable endoplasmic reticulum-targeted NIR fluorescent probe with a large Stokes shift for detecting and imaging chymotrypsin
Analyst147, 4098-4104. PubMed Europe PubMed DOI -
Liu,K.
Method development and optimization for measuring chymotrypsin and chymotrypsin inhibitor activities
J Food Sci87, 2018-2033. PubMed Europe PubMed DOI -
Liu,S.Y., Zou,X., Gao,X. and Zhang,Y.Y.
De Novo Design of a Highly Selective Nonpeptide Fluorogenic Probe for Chymotrypsin Activity Sensing in a Living System
Anal Chem94, 17922-17929. PubMed Europe PubMed DOI -
Nemeth,B.Z., Demcsak,A., Micsonai,A., Kiss,B., Schlosser,G., Geisz,A., Hegyi,E., Sahin-Toth,M. and Pal,G.
Arg236 in human chymotrypsin B2 (CTRB2) is a key determinant of high enzyme activity, trypsinogen degradation capacity, and protection against pancreatitis
Biochim Biophys Acta Proteins Proteom1870, 140831-140831. PubMed Europe PubMed DOI -
Riley,M.B., Strandquist,E., Weitzel,C.S. and Driskell,J.D.
Structure and activity of native and thiolated alpha-chymotrypsin adsorbed onto gold nanoparticles
Colloids Surf B Biointerfaces220, 112867-112867. PubMed Europe PubMed DOI -
Song,Y., Gong,K., Yan,H., Hong,W., Wang,L., Wu,Y., Li,W., Li,W. and Cao,Z.
Correction: Sj7170, a unique dual-function peptide with a specific alpha-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom
J Biol Chem298, 102543-102543. PubMed Europe PubMed DOI -
Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
Biol Chem402, 861-867. PubMed Europe PubMed DOI -
Gault,S. and Cockell,C.S.
Perchlorate Salts Exert a Dominant, Deleterious Effect on the Structure, Stability, and Activity of alpha-Chymotrypsin
Astrobiology21, 405-412. PubMed Europe PubMed DOI -
Gault,S., Jaworek,M.W., Winter,R. and Cockell,C.S.
Perchlorate salts confer psychrophilic characteristics in alpha-chymotrypsin
Sci Rep11, 16523-16523. PubMed Europe PubMed DOI -
Lather,J. and George,J.
Improving Enzyme Catalytic Efficiency by Co-operative Vibrational Strong Coupling of Water
J Phys Chem Lett12, 379-384. PubMed Europe PubMed DOI -
Li,H., Wang,Y., He,X., Chen,J., Xu,F., Liu,Z. and Zhou,Y.
A green deep eutectic solvent modified magnetic titanium dioxide nanoparticles for the solid-phase extraction of chymotrypsin
Talanta230, 122341-122341. PubMed Europe PubMed DOI -
Mahmoud,G.S., Hosny,G. and Sayed,S.A.
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats
Can J Physiol Pharmacol1-9. PubMed Europe PubMed DOI -
Piovarci,I., Hianik,T. and Ivanov,I.N.
Detection of Chymotrypsin by Optical and Acoustic Methods
Biosensors (Basel)11, PubMed Europe PubMed DOI -
Zou,X., Zhao,Y., Lai,C., Liang,Y. and Lin,W.
A non-peptide probe for detecting chymotrypsin activity based on protection-deprotection strategy in living systems
J Mater Chem B9, 8417-8423. PubMed Europe PubMed DOI -
Dau,T., Bartolomucci,G. and Rappsilber,J.
Proteomics Using Protease Alternatives to Trypsin Benefits from Sequential Digestion with Trypsin
Anal Chem92, 9523-9527. PubMed Europe PubMed DOI -
De Marco Verissimo,C., Jewhurst,H.L., Tikhonova,I.G., Urbanus,R.T., Maule,A.G., Dalton,J.P. and Cwiklinski,K.
Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases
PLoS Negl Trop Dis14, e0008510-e0008510. PubMed Europe PubMed DOI -
Di Giosia,M., Marforio,T.D., Cantelli,A., Valle,F., Zerbetto,F., Su,Q., Wang,H. and Calvaresi,M.
Inhibition of alpha-chymotrypsin by pristine single-wall carbon nanotubes: clogging up the active site
J Colloid Interface Sci571, 174-184. PubMed Europe PubMed DOI I -
Gault,S., Jaworek,M.W., Winter,R. and Cockell,C.S.
High pressures increase alpha-chymotrypsin enzyme activity under perchlorate stress
Commun Biol3, 550-550. PubMed Europe PubMed DOI -
Hasan,S., Isar,M. and Naeem,A.
Macromolecular crowding stabilises native structure of alpha-chymotrypsinogen-A against hexafluoropropanol-induced aggregates
Int J Biol Macromol PubMed Europe PubMed DOI -
Li,G., Wei,H., Bi,J., Ding,X., Li,L., Xu,S., Yang,G. and Ren,W.
Insights into dietary switch in cetaceans: evidence from molecular evolution of proteinases and lipases
J Mol Evol PubMed Europe PubMed DOI -
Mosztbacher,D., Demcsak,A. and Sahin-Toth,M.
Measuring digestive protease activation in the mouse pancreas
Pancreatology20, 288-292. PubMed Europe PubMed DOI A -
Ostermeier,L., Oliva,R. and Winter,R.
The multifaceted effects of DMSO and high hydrostatic pressure on the kinetic constants of hydrolysis reactions catalyzed by alpha-chymotrypsin
Phys Chem Chem Phys22, 16325-16333. PubMed Europe PubMed DOI -
Yang,F., Totsingan,F., Dolan,E., Khare,S.D. and Gross,R.A.
Protease-catalyzed l-aspartate oligomerization: substrate selectivity and computational modeling
ACS Omega5, 4403-4414. PubMed Europe PubMed DOI -
Ramesh,B., Abnouf,S., Mali,S., Moree,W.J., Patil,U., Bark,S.J. and Varadarajan,N.
Engineered chymotrypsiN for mass spectrometry-based detection of protein glycosylation
ACS Chem Biol14, 2616-2628. PubMed Europe PubMed DOI P -
Schumann,N.C., Bruning,J., Marshall,A.C. and Abell,A.D.
The role of N-terminal heterocycles in hydrogen bonding to alpha-chymotrypsin
Bioorg Med Chem Lett29, 396-399. PubMed Europe PubMed DOI I -
Shi,Y.J., Huang,C.H., Lee,Y.C., Wang,L.J., Chiou,J.T. and Chang,L.S.
Naja atra cardiotoxins enhance the protease activity of chymotrypsin
Int J Biol Macromol136, 512-520. PubMed Europe PubMed DOI -
Dusekova,E., Garajova,K., Yavaser,R., Varhac,R. and Sedlak,E.
Hofmeister effect on catalytic properties of chymotrypsin is substrate-dependent
Biophys Chem243, 8-16. PubMed Europe PubMed DOI -
Efremova,M.V., Veselov,M.M., Barulin,A.V., Gribanovsky,S.L., Le-Deygen,I.M., Uporov,I.V., Kudryashova,E.V., Sokolsky-Papkov,M., Majouga,A.G., Golovin,Y.I., Kabanov,A.V. and Klyachko,N.L.
In situ observation of chymotrypsin catalytic activity change actuated by nonheating low-frequency magnetic field
ACS Nano12, 3190-3199. PubMed Europe PubMed DOI -
Farhadian,S., Shareghi,B., Momeni,L., Abou-Zied,O.K., Sirotkin,V.A., Tachiya,M. and Saboury,A.A.
Insights into the molecular interaction between sucrose and alpha-chymotrypsin
Int J Biol Macromol114, 950-960. PubMed Europe PubMed DOI -
Luo,X., Zhu,W., Ding,L., Ye,X., Gao,H., Tai,X., Wu,Z., Qian,Y., Ruan,X., Li,J., Li,S. and Chen,Z.
Bldesin, the first functionally characterized pathogenic fungus defensin with Kv1.3 channel and chymotrypsin inhibitory activities
J Biochem Mol Toxicole22244-e22244. PubMed Europe PubMed DOI I -
Wang,J., Zheng,X., Wang,W., Guo,H., Liu,R. and Zong,W.
A study on the interaction between cadmium and alpha-chymotrypsin and the underlying mechanisms
J Biochem Mol Toxicole22248-e22248. PubMed Europe PubMed DOI -
Yang,L., Li,H., Wu,P., Mahal,A., Xue,J., Xu,L. and Wei,X.
Dinghupeptins A-D, chymotrypsin inhibitory cyclodepsipeptides produced by a soil-derived Streptomyces
J Nat Prod81, 1928-1936. PubMed Europe PubMed DOI I -
Andersson,C.D., Martinez,N., Zeller,D., Rondahl,S.H., Koza,M.M., Frick,B., Ekstrom,F., Peters,J. and Linusson,A.
Changes in dynamics of alpha-chymotrypsin due to covalent inhibitors investigated by elastic incoherent neutron scattering
Phys Chem Chem Phys19, 25369-25379. PubMed Europe PubMed DOI I -
Ghosh,C., Mondal,T. and Bhattacharyya,K.
Enzyme activity of alpha-chymotrypsin: deactivation by gold nano-cluster and reactivation by glutathione
J Colloid Interface Sci494, 74-81. PubMed Europe PubMed DOI I -
Li,S., Fu,Y., Ma,X. and Zhang,Y.
Label-free fluorometric detection of chymotrypsin activity using graphene oxide/nucleic-acid-stabilized silver nanoclusters hybrid materials
Biosens Bioelectron88, 210-216. PubMed Europe PubMed DOI A -
Marasini,B.P., Rahim,F., Perveen,S., Karim,A., Mohammed Khan,K., Atta-Ur-Rahman and Choudhary,M.I.
Synthesis, structure-activity relationships studies of benzoxazinone derivatives as alpha-chymotrypsin inhibitors
Bioorg Chem70, 210-221. PubMed Europe PubMed DOI I -
Patra,A., Samanta,N., Das,D.K. and Mitra,R.K.
Enhanced catalytic activity of alpha-chymotrypsin in cationic surfactant solutions: the component specificity revisited
J Phys Chem B121, 1457-1465. PubMed Europe PubMed DOI -
Sirotkin,V.A. and Kuchierskaya,A.A.
Preferential solvation/hydration of alpha-chymotrypsin in water-acetonitrile mixtures
J Phys Chem B121, 4422-4430. PubMed Europe PubMed DOI -
Stewart,J.J.
An investigation into the applicability of the semiempirical method PM7 for modeling the catalytic mechanism in the enzyme chymotrypsin
J Mol Model23, 154-154. PubMed Europe PubMed DOI -
Stratton,A., Ericksen,M., Harris,T.V., Symmonds,N. and Silverstein,T.P.
Mercury(II) binds to both of chymotrypsin's histidines, causing inhibition followed by irreversible denaturation/aggregation
Protein Sci26, 292-305. PubMed Europe PubMed DOI I -
Wu,L., Yang,S.H., Xiong,H., Yang,J.Q., Guo,J., Yang,W.C. and Yang,G.F.
Nonpeptide-based small-molecule probe for fluorogenic and chromogenic detection of chymotrypsin
Anal Chem89, 3687-3693. PubMed Europe PubMed DOI A -
Zhang,S.-G., Xie,Z.-B., Liu,L.-S., Liang,M. and Le,Z.-G.
Synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by alpha-chymotrypsin
Chin Chem Lett28, 101-104. DOI -
Bagchi,D., Ghosh,A., Singh,P., Dutta,S., Polley,N., Althagafi,I.I., Jassas,R.S., Ahmed,S.A. and Pal,S.K.
Allosteric inhibitory molecular recognition of a photochromic dye by a digestive enzyme: dihydroindolizine makes alpha-chymotrypsin photo-responsive
Sci Rep6, 34399-34399. PubMed Europe PubMed DOI -
Garringer,M. and Qasim,M.A.
Effect of osmolytes and guanidinium chloride on the enzymatic properties of bovine alpha-chymotrypsin
Protein Pept Lett23, 504-507. PubMed Europe PubMed -
Giansanti,P., Tsiatsiani,L., Low,T.Y. and Heck,A.J.
Six alternative proteases for mass spectrometry-based proteomics beyond trypsin
Nat Protoc11, 993-1006. PubMed Europe PubMed DOI -
Kanamori,Y., Iwasaki,A., Sumimoto,S. and Suenaga,K.
Urumamide, a novel chymotrypsin inhibitor with a beta-amino acid from a marine cyanobacterium Okeania sp
Tetrahedron Lett57, 4213-4216. DOI I -
Liang,M., Xie,Z., Ai,F. and Le,Z.
Synthesis of quinoline derivatives catalyzed by alpha-chymotrypsin
Chin J Org Chem36, 2704-2708. DOI -
Ono,S., Nakai,T., Kuroda,H., Miyatake,R., Horino,Y., Abe,H., Umezaki,M. and Oyama,H.
Site-selective chemical modification of chymotrypsin using peptidyl derivatives bearing optically active diphenyl 1-amino-2-phenylethylphosphonate: stereochemical effect of the diphenyl phosphonate moiety
Biopolymers106, 521-530. PubMed Europe PubMed DOI I -
Schuabb,V., Winter,R. and Czeslik,C.
Improved activity of alpha-chymotrypsin on silica particles - a high-pressure stopped-flow study
Biophys Chem218, 1-6. PubMed Europe PubMed DOI -
Siddiqui,H., Farooq,R., Marasini,B.P., Malik,R., Syed,N., Moin,S.T., Atta-Ur-Rahman and Choudhary,M.I.
Synthesis and in vitro alpha-chymotrypsin inhibitory activity of 6-chlorobenzimidazole derivatives
Bioorg Med Chem24, 3387-3395. PubMed Europe PubMed DOI I -
Uritsky,N., Shokhen,M. and Albeck,A.
Stepwise versus concerted mechanisms in general-base catalysis by serine proteases
Angew Chem Int Ed Engl55, 1680-1684. PubMed Europe PubMed DOI -
Zhang,X., Bruning,J.B., George,J.H. and Abell,A.D.
A mechanistic study on the inhibition of alpha-chymotrypsin by a macrocyclic peptidomimetic aldehyde
Org Biomol Chem14, 6970-6978. PubMed Europe PubMed DOI I -
Kurinomaru,T., Kameda,T. and Shiraki,K.
Effects of multivalency and hydrophobicity of polyamines on enzyme hyperactivation of alpha-chymotrypsin
J Mol Catal B Enzym115, 135-139. DOI -
Li,L.-P., Cai,X., Xiang,Y., Zhang,Y., Song,J., Yang,D.-C., Guan,Z. and He,Y.-H.
The alpha-chymotrypsin-catalyzed Povarov reaction: one-pot synthesis of tetrahydroquinoline derivatives
Green Chem17, 3148-3156. DOI -
Luong,T.Q. and Winter,R.
Combined pressure and cosolvent effects on enzyme activity - a high-pressure stopped-flow kinetic study on alpha-chymotrypsin
Phys Chem Chem Phys17, 23273-23278. PubMed Europe PubMed DOI -
Romero,C.M., Abella,J.S., Velazquez,A. and Sancho,J.
Thermal denaturation of alpha-chymotrypsinogen A in presence of polyols at pH 2.0 and pH 3.0
J Therm Anal Calor120, 489-499. DOI -
Shibao,P.Y., Anjolette,F.A., Lopes,N.P. and Arantes,E.C.
First serine protease inhibitor isolated from Rhinella schneideri poison
J Venom Anim Toxins Incl Trop Dis21, 30-30. PubMed Europe PubMed DOI I -
Sun,D., Jiang,G., Xie,Z. and Le,Z.
alpha-chymotrypsin-catalyzed synthesis of bis(indolyl)alkanes in water
Chin J Chem33, 409-412. DOI -
Uccello-Barretta,G., Balzano,F., Aiello,F., Vanni,L., Mori,M., Menta,S., Calcaterra,A. and Botta,B.
Hydrolytic inhibition of alpha-chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach
Org Biomol Chem13, 916-924. PubMed Europe PubMed DOI I -
Zhang,L., Xiao,X., Yuan,Y., Guo,Y., Li,M. and Pu,X.
Probing immobilization mechanism of alpha-chymotrypsin onto carbon nanotube in organic media by molecular dynamics simulation
Sci Rep5, 9297-9297. PubMed Europe PubMed DOI -
Zhang,X., Heng,S. and Abell,A.D.
Photoregulation of alpha-chymotrypsin activity by spiropyran-based inhibitors in solution and attached to an optical fiber
Chemistry21, 10703-10713. PubMed Europe PubMed DOI I -
Chen,Q., Zhang,J., Zhao,K., Li,W., Miao,Q., Sun,Y., Zhao,X., Wei,T. and Yang,F.
Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin
Protein Cell5, 643-647. PubMed Europe PubMed DOI -
Cleary,J.A., Doherty,W., Evans,P. and Malthouse,J.P.
Hemiacetal stabilization in a chymotrypsin inhibitor complex and the reactivity of the hydroxyl group of the catalytic serine residue of chymotrypsin
Biochim Biophys Acta1844, 1119-1127. PubMed Europe PubMed DOI I -
Gupta,B.S., Taha,M. and Lee,M.-J.
Superactivity of alpha-chymotrypsin with biological buffers, TRIS, TES, TAPS, and TAPSO in aqueous solutions
RSC Adv4, 51111-51116. DOI -
Khan,Z.A., Afzal,N., Hussain,Z., Naqvi,S.A.R., Bari,A., Shahzad,S.A., Yar,M., Mahmood,N., Bukhari,S.A., Mansha,A., Zahoor,A.F., Khan,A.R. and Ahmad,M.
Synthesis of 2-aryl-4H-3,1-benzoxazin-4-ones: a class of alpha-chymotrypsin inhibitors
Asian J Chem26, 4561-4565. DOI I -
Latif,M.A., Tejo,B.A., Abedikargiban,R., Abdul Rahman,M.B. and Micaelo,N.M.
Modeling stability and flexibility of alpha-chymotrypsin in room temperature ionic liquids
J Biomol Struct Dyn32, 1263-1273. PubMed Europe PubMed DOI -
Murata,H., Cummings,C.S., Koepsel,R.R. and Russell,A.J.
Rational tailoring of substrate and inhibitor affinity via ATRP polymer-based protein engineering
Biomacromolecules15, 2817-2823. PubMed Europe PubMed DOI -
Perveen,S., Mustafa,S., Latif,M., Iqbal,L., Usmani,T.H., Khan,K.M. and Voelter,W.
Unsymmetrical 1,3-disubstituted urea derivatives as alpha-chymotrypsin inhibitors
Med Chem Res23, 3585-3592. DOI I -
Xie,Z.B., Sun,D.Z., Jiang,G.F. and Le,Z.G.
Facile synthesis of bis(indolyl)methanes catalyzed by alpha-chymotrypsin
Molecules19, 19665-19677. PubMed Europe PubMed DOI -
Karna,N., Debowski,D., Gitlin,A., Legowska,A. and Rolka,K.
Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1
FEBS J280, 6213-6222. PubMed Europe PubMed DOI -
Moyano,F., Setien,E., Silber,J.J. and Correa,N.M.
Enzymatic hydrolysis of N-benzoyl-L-tyrosine p-nitroanilide by alpha-chymotrypsin in DMSO-water/AOT/n-heptane reverse micelles. A unique interfacial effect on the enzymatic activity
Langmuir29, 8245-8254. PubMed Europe PubMed DOI -
Terentyeva,T.G., Hofkens,J., Komatsuzaki,T., Blank,K. and Li,C.B.
Time-resolved single molecule fluorescence spectroscopy of an alpha-chymotrypsin catalyzed reaction
J Phys Chem B117, 1252-1260. PubMed Europe PubMed DOI -
Vorob'ev,M.M.
Quantification of two-step proteolysis model with consecutive demasking and hydrolysis of peptide bonds using casein hydrolysis by chymotrypsin
Biochem Eng J74, 60-68. -
Yamashita,S., Sakabe,M., Ishizawa,T., Hasegawa,K., Urano,Y. and Kokudo,N.
Visualization of the leakage of pancreatic juice using a chymotrypsin-activated fluorescent probe
Br J Surg100, 1220-1228. PubMed Europe PubMed DOI A -
Graf,L., Szilagyi,L. and Venekei,I.
Chymotrypsin
[ISSN:978-0-12-407742-3]3, 2626-2633. DOI -
Haerteis,S., Krappitz,M., Diakov,A., Krappitz,A., Rauh,R. and Korbmacher,C.
Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the gamma subunit of the human epithelial sodium channel
J Gen Physiol140, 375-389. PubMed Europe PubMed DOI P -
Hu,S.H., Kuo,C.H., Chang,C.M., Liu,Y.C., Chiang,W.D. and Shieh,C.J.
Solvent selection and optimization of alpha-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Tyr-NH2 using mixture design and response surface methodology
Biotechnol Prog28, 1443-1449. PubMed Europe PubMed DOI -
Liuni,P., Jeganathan,A. and Wilson,D.J.
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsin
Angew Chem Int Ed Engl51, 9666-9669. PubMed Europe PubMed DOI -
Petrillo,T., O'Donohoe,C.A., Howe,N. and Malthouse,J.P.
Importance of tetrahedral intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin and subtilisin
Biochemistry51, 6164-6170. PubMed Europe PubMed DOI I -
Simon,L.M., Laczko,I., Demcsak,A., Toth,D., Kotorman,M. and Fulop,L.
The formation of amyloid-like fibrils of alpha-chymotrypsin in different aqueous organic solvents
Protein Pept Lett19, 544-550. PubMed Europe PubMed DOI -
Singh,S. and Sieburth,S.M.
Serine protease inhibition by a silanediol peptidomimetic
Org Lett14, 4422-4425. PubMed Europe PubMed DOI I -
Zhu,L., Yang,W., Meng,Y.Y., Xiao,X., Guo,Y., Pu,X. and Li,M.
Effects of organic solvent and crystal water on gamma-chymotrypsin in acetonitrile media: observations from molecular dynamics simulation and DFT calculation
J Phys Chem B116, 3292-3304. PubMed Europe PubMed DOI -
Abuin,E., Lissi,E., Ahumada,M. and Calderon,C.
Effect of human serum albumin on the kinetics of N-glutaryl-L-phenylalanine p-nitroanilide hydrolysis catalyzed by alpha-chymotrypsin
Protein J30, 143-147. PubMed Europe PubMed DOI -
Brandt,N.N., Mankova,A.A. and Chikishev,A.Y.
IR spectroscopy of structural changes of alpha-chymotrypsin related to the changes of function in organic solvents
Moscow Univ Phys Bull66, 282-285. DOI -
Lauzon,C.B., van Zijl,P. and Stivers,J.T.
Using the water signal to detect invisible exchanging protons in the catalytic triad of a serine protease
J Biomol NMR50, 299-314. PubMed Europe PubMed DOI -
Lazar,L.M., Fisher,S.Z., Moulin,A.G., Kovalevsky,A., Novak,W.R., Langan,P., Petsko,G.A. and Ringe,D.
Time-of-flight neutron diffraction study of bovine gamma-chymotrypsin at the Protein Crystallography Station
Acta Crystallogr Sect F Struct Biol Cryst Commun67, 587-590. PubMed Europe PubMed DOI S -
Pastor,I., Vilaseca,E., Madurga,S., Garces,J.L., Cascante,M. and Mas,F.
Effect of crowding by dextrans on the hydrolysis of N-succinyl-l-phenyl-Ala-p-nitroanilide catalyzed by alpha-chymotrypsin
J Phys Chem B115, 1115-1121. PubMed Europe PubMed DOI -
Ruark,C.D., Hack,C.E., Robinson,P.J. and Gearhart,J.M.
Quantitative structure-activity relationships for organophosphates binding to trypsin and chymotrypsin
J Toxicol Environ Health A74, 1-23. PubMed Europe PubMed DOI I -
Terentyeva,T.G., Van Rossom,W., Van der Auweraer,M., Blank,K. and Hofkens,J.
Morpholinecarbonyl-rhodamine 110 based substrates for the determination of protease activity with accurate kinetic parameters
Bioconjug Chem22, 1932-1938. PubMed Europe PubMed DOI A -
Verma,P.K., Rakshit,S., Mitra,R.K. and Pal,S.K.
Role of hydration on the functionality of a proteolytic enzyme alpha-chymotrypsin under crowded environment
Biochimie93, 1424-1433. PubMed Europe PubMed DOI -
Attri,P., Venkatesu,P. and Lee,M.J.
Influence of osmolytes and denaturants on the structure and enzyme activity of alpha-chymotrypsin
J Phys Chem B114, 1471-1478. PubMed Europe PubMed DOI -
Legowska,A., Debowski,D., Lesner,A., Wysocka,M. and Rolka,K.
Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach
Mol Divers14, 51-58. PubMed Europe PubMed DOI I -
Qasim,M.A., Song,J., Markley,J.L. and Laskowski,M., Jr.
Cleavage of peptide bonds bearing ionizable amino acids at P(1) by serine proteases with hydrophobic S(1) pocket
Biochem Biophys Res Commun400, 507-510. PubMed Europe PubMed DOI P -
Chen,A.Y., Jani,A.S., Zheng,L., Burke,P.J. and Brody,J.P.
Microfabricated arrays of cylindrical wells facilitate single-molecule enzymology of alpha-chymotrypsin
Biotechnol Prog25, 929-937. PubMed Europe PubMed DOI A -
Lesner,A., Wysocka,M., Solek,M., Legowska,A. and Rolka,K.
Low-molecular-weight aldehyde inhibitors of cathepsin G
Protein Pept Lett16, 408-410. PubMed Europe PubMed DOI I -
Mino,G. and Contreras,R.
On the role of short and strong hydrogen bonds on the mechanism of action of a model chymotrypsine active site
J Phys Chem A113, 5769-5772. PubMed Europe PubMed DOI -
Novak,W.R., Moulin,A.G., Blakeley,M.P., Schlichting,I., Petsko,G.A. and Ringe,D.
A preliminary neutron diffraction study of gamma-chymotrypsin
Acta Crystallograph Sect F Struct Biol Cryst Commun65, 317-320. PubMed Europe PubMed DOI S -
Pietrusewicz,E., Sienczyk,M. and Oleksyszyn,J.
Novel diphenyl esters of peptidyl alpha-aminoalkylphosphonates as inhibitors of chymotrypsin and subtilisin
J Enzyme Inhib Med Chem24, 1229-1236. PubMed Europe PubMed DOI I -
Banerjee,D. and Pal,S.K.
Conformational Dynamics at the Active Site of alpha-Chymotrypsin and Enzymatic Activity
Langmuir24, 8163-8168. PubMed Europe PubMed DOI -
Khan,K.M., Mughal,U.R., Lodhi,M.A. and Choudhary,M.I.
Synthesis and chymotrypsin inhibitory activity of substituted oxazolones
Lett Drug Des Discov5, 52-56. DOI I -
Linington,R.G., Edwards,D.J., Shuman,C.F., McPhail,K.L., Matainaho,T. and Gerwick,W.H.
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp
J Nat Prod71, 22-27. PubMed Europe PubMed DOI I -
Pearson,D., Alexander,N. and Abell,A.D.
Improved photocontrol of alpha-chymotrypsin activity: peptidomimetic trifluoromethylketone photoswitch enzyme inhibitors
Chemistry14, 7358-7365. PubMed Europe PubMed DOI I -
Shokhen,M., Khazanov,N. and Albeck,A.
Screening of the active site from water by the incoming ligand triggers catalysis and inhibition in serine proteases
Proteins70, 1578-1587. PubMed Europe PubMed DOI -
Wysocka,M., Lesner,A., Legowska,A., Jaskiewicz,A., Miecznikowska,H. and Rolka,K.
Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1)
Protein Pept Lett15, 260-264. PubMed Europe PubMed DOI -
Baumann,H.I., Keller,S., Wolter,F.E., Nicholson,G.J., Jung,G., Sussmuth,R.D. and Juttner,F.
Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens
J Nat Prod70, 1611-1615. PubMed Europe PubMed DOI I -
Bruylants,G., Redfield,C. and Bartik,K.
Developments in the characterisation of the catalytic triad of alpha-chymotrypsin: effect of the protonation state of Asp102 on the 1H NMR signals of His57
Chembiochem8, 51-54. PubMed Europe PubMed DOI -
Moulin,A., Bell,J.H., Pratt,R.F. and Ringe,D.
Inhibition of chymotrypsin by a complex of ortho-vanadate and benzohydroxamic acid: structure of the inert complex and its mechanistic interpretation
Biochemistry46, 5982-5990. PubMed Europe PubMed DOI I -
Spink,E., Hewage,C. and Malthouse,J.P.
Determination of the structure of tetrahedral transition state analogues bound at the active site of chymotrypsin using 18O and 2H isotope shifts in the 13C NMR spectra of glyoxal inhibitors
Biochemistry46, 12868-12874. PubMed Europe PubMed DOI S I -
Spink,E., Cosgrove,S., Rogers,L., Hewage,C. and Malthouse,J.P.
13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes
J Biol Chem282, 7852-7861. PubMed Europe PubMed DOI I -
Wysocka,M., Kwiatkowska,B., Rzadkiewicz,M., Lesner,A. and Rolka,K.
Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods
Comb Chem High Throughput Screen10, 171-180. PubMed Europe PubMed DOI A -
[YEAR:15-12-2006]Hudaky,P. and Perczel,A.
A self-stabilized model of the chymotrypsin catalytic pocket. The energy profile of the overall catalytic cycle
Proteins62, 749-759. PubMed Europe PubMed DOI -
Shibli,A., Smoum,R., Goldberg,I., Rubinstein,A. and Srebnik,M.
alpha-Amino boronates as cyanoborane complexes: crystal structure and inhibition properties for the serine proteases: alpha-chymotrypsin and trypsin
Appl Organomet Chem20, 459-462. DOI S I -
Sola,R.J. and Griebenow,K.
Influence of modulated structural dynamics on the kinetics of alpha-chymotrypsin catalysis. Insights through chemical glycosylation, molecular dynamics and domain motion analysis
FEBS J273, 5303-5319. PubMed Europe PubMed DOI -
[YEAR:15-3-2005]Abuin,E., Lissi,E. and Duarte,R.
Kinetics of N-glutaryl-L-phenylalanine p-nitroanilide hydrolysis catalyzed by alpha-chymotrypsin in aqueous solutions of dodecyltrimethylammonium bromide
J Colloid Interface Sci283, 539-543. PubMed Europe PubMed DOI -
[YEAR:7-1-2005]Segev,O., Columbus,I., Ashani,Y. and Cohen,Y.
Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions
J Org Chem70, 309-314. PubMed Europe PubMed DOI I -
Singh,N., Jabeen,T., Sharma,S., Roy,I., Gupta,M.N., Bilgrami,S., Somvanshi,R.K., Dey,S., Perbandt,M., Betzel,C., Srinivasan,A. and Singh,T.P.
Detection of native peptides as potent inhibitors of enzymes. Crystal structure of the complex formed between treated bovine alpha-chymotrypsin and an autocatalytically produced fragment, IIe-Val-Asn-Gly-Glu-Glu-Ala-Val-Pro-Gly-Ser-Trp-Pro-Trp, at 2.2 angstroms resolution
FEBS J272, 562-572. PubMed Europe PubMed DOI S I -
[YEAR:3-12-2004]Czapinska,H., Helland,R., Smalas,A.O. and Otlewski,J.
Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants
J Mol Biol344, 1005-1020. PubMed Europe PubMed DOI S -
Graf,L., Szilagyi,L. and Venekei,I.
Chymotrypsin
[ISSN:0-12-079610-4]2, 1495-1501. V -
[YEAR:27-1-2004]Hengge,A.C. and Stein,R.L.
Role of protein conformational mobility in enzyme catalysis: acylation of alpha-chymotrypsin by specific peptide substrates
Biochemistry43, 742-747. PubMed Europe PubMed DOI -
[YEAR:2-11-2004]Radisky,E.S., Kwan,G., Karen Lu,C.J. and Koshland,D.E., Jr.
Binding, proteolytic, and crystallographic analyses of mutations at the protease-inhibitor interface of the subtilisin BPN'/chymotrypsin inhibitor 2 complex
Biochemistry43, 13648-13656. PubMed Europe PubMed DOI S -
[YEAR:3-5-2004]Roy,I. and Gupta,M.N.
Preparation of highly active alpha-chymotrypsin for catalysis in organic media
Bioorg Med Chem Lett14, 2191-2193. PubMed Europe PubMed DOI -
Verheyden,G., Matrai,J., Volckaert,G. and Engelborghs,Y.
A fluorescence stopped-flow kinetic study of the conformational activation of alpha-chymotrypsin and several mutants
Protein Sci13, 2533-2540. PubMed Europe PubMed DOI -
[YEAR:25-3-2003]Case,A. and Stein,R.L.
Mechanistic origins of the substrate selectivity of serine proteases
Biochemistry42, 3335-3348. PubMed Europe PubMed DOI -
[YEAR:31-10-2003]Helland,R., Czapinska,H., Leiros,I., Olufsen,M., Otlewski,J. and Smalas,A.O.
Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin
J Mol Biol333, 845-861. PubMed Europe PubMed DOI -
[YEAR:1-3-2002]Djurdjevic-Pahl,A., Hewage,C. and Malthouse,J.P.
13C-NMR study of the inhibition of delta-chymotrypsin by a tripeptide-glyoxal inhibitor
Biochem J362, 339-347. PubMed Europe PubMed DOI I -
[YEAR:8-4-2002]Wouters,J., Huygens,M., Pochet,L., Pirotte,B., Durant,F. and Masereel,B.
Structural approach of the mechanism of inhibition of alpha-chymotrypsin by coumarins
Bioorg Med Chem Lett12, 1109-1112. PubMed Europe PubMed DOI I -
[YEAR:9-7-2001]Aoyama,Y., Uenaka,M., Konoike,T., Hayasaki-Kajiwara,Y., Naya,N. and Nakajima,M.
Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones
Bioorg Med Chem Lett11, 1691-1694. PubMed Europe PubMed DOI I -
Bodi,A., Kaslik,G., Venekei,I. and Graf,L.
Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin
Eur J Biochem268, 6238-6246. PubMed Europe PubMed DOI -
[YEAR:30-11-2001]Ghani,U., Ng,K.K.S., Atta,u.R., Choudhary,M.I., Ullah,N. and James,M.N.G.
Crystal structure of gamma-chymotrypsin in complex with 7-hydroxycoumarin
J Mol Biol314, 519-525. PubMed Europe PubMed DOI S I -
[YEAR:27-2-2001]Neidhart,D., Wei,Y., Cassidy,C., Lin,J., Cleland,W.W. and Frey,P.A.
Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin
Biochemistry40, 2439-2447. PubMed Europe PubMed DOI -
Spreti,N., Di Profio,P., Marte,L., Bufali,S., Brinchi,L. and Savelli,G.
Activation and stabilization of alpha-chymotrypsin by cationic additives
Eur J Biochem268, 6491-6497. PubMed Europe PubMed DOI -
Kitson,T.M. and Freeman,G.H.
3,4-Dihydro-3,4,6-trimethyl-2H,8H-pyrano-[3,2g]-1,3-benzoxazin-2,8-dione, a potential fluorogenic reporter group reagent for esterases-synthesis and interaction with chymotrypsin
Bioorg Chem28, 273-282. PubMed Europe PubMed DOI I -
Mac Sweeney,A., Birrane,G., Walsh,M.A., O'Connell,T., Malthouse,J.P. and Higgins,T.M.
Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
Acta Crystallogr D Biol Crystallogr56, 280-286. PubMed Europe PubMed DOI S I -
Pochet,L., Doucet,C., Dive,G., Wouters,J., Masereel,B., Reboud-Ravaux,M. and Pirotte,B.
Coumarinic derivatives as mechanism-based inhibitors of alpha-chymotrypsin and human leukocyte elastase
Bioorg Med Chem8, 1489-1501. PubMed Europe PubMed DOI I -
[YEAR:19-5-1999]Bao,D.H., Huskey,W.P., Kettner,C.A. and Jordan,F.
Hydrogen bonding to active-site histidine in peptidyl boronic acid inhibitor complexes of chymotrypsin and subtilisin: proton magnetic resonance assignments and H D fractionation
J Am Chem Soc121, 4684-4689. DOI I -
Bianco,A., Kaiser,D. and Jung,G.
N-Hydroxy peptides as substrates for alpha-chymotrypsin
J Pept Res54, 544-548. PubMed Europe PubMed DOI A -
Hudaky,P., Kaslik,G., Venekei,I. and Graf,L.
The differential specificity of chymotrypsin A and B is determined by amino acid 226
Eur J Biochem259, 528-533. PubMed Europe PubMed DOI -
[YEAR:10-12-1999]Janes,L.E., Cimpoia,A. and Kazlauskas,R.J.
Protease-mediated separation of cis and trans diastereomers of 2(R,S)-benzyloxymethyl-4(S)-carboxylic acid 1,3-dioxolane methyl ester: Intermediates for the synthesis of dioxolane nucleosides
J Org Chem64, 9019-9029. -
Kashima,A., Inoue,Y., Sugio,S., Maeda,I., Nose,T. and Shimohigashi,Y.
X-ray crystal structure of a dipeptide-chymotrypsin complex in an inhibitory interaction
Eur J Biochem255, 12-23. PubMed Europe PubMed S I -
[YEAR:25-8-1998]Lin,J., Cassidy,C.S. and Frey,P.A.
Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin
Biochemistry37, 11940-11948. PubMed Europe PubMed DOI -
[YEAR:15-3-1998]Rafiq,A. and Bailey,G.
A more sensitive Hummel assay for chymotrypsin
Anal Biochem257, 233-234. PubMed Europe PubMed DOI A -
Stoll,V.S., Eger,B.T., Hynes,R.C., Martichonok,V., Jones,J.B. and Pai,E.F.
Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes
Biochemistry37, 451-462. PubMed Europe PubMed DOI S I -
Capasso,C., Rizzi,M., Menegatti,E., Ascenzi,P. and Bolognesi,M.
Crystal structure of the bovine alpha-chymotrypsin:Kunitz inhibitor complex. An example of multiple protein:protein recognition sites
J Mol Recognit10, 26-35. PubMed Europe PubMed DOI S -
[YEAR:14-11-1997]Galunsky,B., Ignatova,S. and Kasche,V.
Temperature effects on S1- and S'1-enantioselectivity of alpha-chymotrypsin
Biochim Biophys Acta1343, 130-138. PubMed Europe PubMed DOI -
[YEAR:26-11-1997]Ito,K., Igarashi,K., Muramatsu,M., Harada,T., Hayashi,Y., Katada,J. and Uno,I.
Potent inactivator of alpha-chymotrypsin: 2,2-dimethyl-3-(N-4-cyanobenzoyl)amino-5-phenyl pentanoic anhydride
Biochem Biophys Res Commun240, 850-855. PubMed Europe PubMed DOI -
Kurth,T., Ullmann,D., Jakubke,H.D. and Hedstrom,L.
Converting trypsin to chymotrypsin: Structural determinants of S1' specificity
Biochemistry36, 10098-10104. PubMed Europe PubMed DOI -
Takahashi,K.
Restriction of the specificities of trypsin and alpha-chymotrypsin at a high alkaline pH value
Protein Pept Lett4, 33-38. -
Varallyay,E., Lengyel,Z., Graf,L. and Szilagyi,L.
The role of disulfide bond C191-C220 in trypsin and chymotrypsin
Biochem Biophys Res Commun230, 592-596. PubMed Europe PubMed DOI -
Kitson,T.M.
Comparison of resorufin acetate and p-nitrophenyl acetate as substrates for chymotrypsin
Bioorg Chem24, 331-339. A -
Rodgers,K.J., Melrose,J. and Ghosh,P.
Biotin-labeled potato chymotrypsin inhibitor-1: a useful probe for the detection and quantitation of chymotrypsin-like serine proteinases on Western blots and its application in the detection of a serine proteinase synthesised by articular chondrocytes
Anal Biochem227, 129-134. PubMed Europe PubMed DOI A -
[YEAR:26-7-1994]Hedstrom,L., Farr-Jones,S., Kettner,C.A. and Rutter,W.J.
Converting trypsin to chymotrypsin: ground-state binding does not determine substrate specificity
Biochemistry33, 8764-8769. PubMed Europe PubMed DOI I -
[YEAR:26-7-1994]Hedstrom,L., Perona,J.J. and Rutter,W.J.
Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant
Biochemistry33, 8757-8763. PubMed Europe PubMed DOI -
[YEAR:22-11-1994]Kreutter,K., Steinmetz,A.C., Liang,T.C., Prorok,M., Abeles,R.H. and Ringe,D.
Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones
Biochemistry33, 13792-13800. PubMed Europe PubMed DOI S I -
[YEAR:16-8-1994]Prorok,M., Albeck,A., Foxman,B.M. and Abeles,R.H.
Chloroketone hydrolysis by chymotrypsin and N-methylhistidyl-57-chymotrypsin: implications for the mechanism of chymotrypsin inactivation by chloroketones
Biochemistry33, 9784-9790. PubMed Europe PubMed I -
[YEAR:12-4-1994]Schellenberger,V., Turck,C.W. and Rutter,W.J.
Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni
Biochemistry33, 4251-4257. PubMed Europe PubMed -
[YEAR:14-6-1994]Yennawar,N.H., Yennawar,H.P. and Farber,G.K.
X-ray crystal structure of gamma-chymotrypsin in hexane
Biochemistry33, 7326-7336. PubMed Europe PubMed S -
Norin,M., Hult,K., Mattson,A. and Norin,T.
Molecular modelling of chymotrypsin-substrate interactions: Calculation of enantioselectivity
Biocatal Biotransform7, 131-147. DOI P -
[YEAR:5-5-1992]Frigerio,F., Coda,A., Pugliese,L., Lionetti,C., Menegatti,E., Amiconi,G., Schnebli,H.P., Ascenzi,P. and Bolognesi,M.
Crystal and molecular structure of the bovine alpha-chymotrypsin-eglin c complex at 2.0 A resolution
J Mol Biol225, 107-123. PubMed Europe PubMed DOI S -
[YEAR:6-3-1992]Hedstrom,L., Szilagyi,L. and Rutter,W.J.
Converting trypsin to chymotrypsin: the role of surface loops
Science255, 1249-1253. PubMed Europe PubMed -
Harel,M., Su,C.T., Frolow,F., Silman,I. and Sussman,J.L.
Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products
Biochemistry30, 5217-5225. PubMed Europe PubMed -
Siezen,R.J., de Vos,W.M., Leunissen,J.A. and Dijkstra,B.W.
Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases
Protein Eng4, 719-737. PubMed Europe PubMed -
Bolognesi,M., Pugliese,L., Gatti,G., Frigerio,F., Coda,A., Antolini,L., Schnebli,H.P., Menegatti,E., Amiconi,G. and Ascenzi,P.
X-ray crystal structure of the bovine alpha-chymotrypsin/eglin c complex at 2.6 A resolution
J Mol Recognit3, 163-168. PubMed Europe PubMed DOI S -
Okada,Y., Tsuboi,S., Tsuda,Y., Nagamatsu,Y. and Yamamoto,J.
Synthesis of a trihexacontapeptide corresponding to the sequence 8-70 of eglin c and studies on the relationship between the structure and the inhibitory activity against human leukocyte elastase, cathepsin G and alpha-chymotrypsin
FEBS Lett272, 113-116. PubMed Europe PubMed DOI -
Schmitt,S., Goetschel,J.D., Rommelt,E.M. and Adler,C.
One-step purification of trypsin and alpha-chymotrypsin by affinity chromatography on Eupergit-aprotinin, a novel carrier for purification of serine proteases
J Chromatogr510, 239-242. PubMed Europe PubMed DOI -
[YEAR:20-5-1987]Fujinaga,M., Sielecki,A.R., Read,R.J., Ardelt,W., Laskowski,M., Jr. and James,M.N.
Crystal and molecular structures of the complex of alpha-chymotrypsin with its inhibitor turkey ovomucoid third domain at 1.8 A resolution
J Mol Biol195, 397-418. PubMed Europe PubMed S -
Stein,R.L. and Strimpler,A.M.
P1 residue determines the operation of the catalytic triad of serine proteases during hydrolyses of acyl-enzymes
J Am Chem Soc109, 4387-4390. -
Tulinsky,A. and Blevins,R.A.
Structure of a tetrahedral transition state complex of alpha-chymotrypsin dimer at 1.8-A resolution
J Biol Chem262, 7737-7743. PubMed Europe PubMed S I -
[YEAR:25-3-1986]Daniels,S.B. and Katzenellenbogen,J.A.
Halo enol lactones: studies on the mechanism of inactivation of alpha-chymotrypsin
Biochemistry25, 1436-1444. PubMed Europe PubMed I -
Groutas,W.C., Giri,P.K., Crowley,J.P., Castrisos,J.C. and Brubaker,M.J.
The Lossen rearrangement in biological systems. Inactivation of leukocyte elastase and alpha-chymotrypsin by (dl)-3-benzyl-N- (methanesulfonyloxy) succinimide
Biochem Biophys Res Commun141, 741-748. PubMed Europe PubMed I -
Blevins,R.A. and Tulinsky,A.
The refinement and the structure of the dimer of alpha-chymotrypsin at 1.67-A resolution
J Biol Chem260, 4264-4275. PubMed Europe PubMed S -
Church,F.C., Noyes,C.M. and Griffith,M.J.
Inhibition of chymotrypsin by heparin cofactor II
Proc Natl Acad Sci U S A82, 6431-6434. PubMed Europe PubMed -
[YEAR:9-4-1985]Hemmi,K., Harper,J.W. and Powers,J.C.
Inhibition of human leukocyte elastase, cathepsin G, chymotrypsin A alpha, and porcine pancreatic elastase with substituted isobenzofuranones and benzopyrandiones
Biochemistry24, 1841-1848. PubMed Europe PubMed I -
[YEAR:1-1-1985]Ringe,D., Seaton,B.A., Gelb,M.H. and Abeles,R.H.
Inactivation of chymotrypsin by 5-benzyl-6-chloro-2-pyrone: 13C NMR and X-ray diffraction analyses of the inactivator-enzyme complex
Biochemistry24, 64-68. PubMed Europe PubMed S I -
Tsukada,H. and Blow,D.M.
Structure of alpha-chymotrypsin refined at 1.68 A resolution
J Mol Biol184, 703-711. PubMed Europe PubMed S -
[YEAR:5-10-1985]Wang,D., Bode,W. and Huber,R.
Bovine chymotrypsinogen A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 A resolution
J Mol Biol185, 595-624. PubMed Europe PubMed S -
[YEAR:23-11-1984]Fischer,G., Bang,H., Berger,E. and Schellenberger,A.
Conformational specificity of chymotrypsin toward proline-containing substrates
Biochim Biophys Acta791, 87-97. PubMed Europe PubMed DOI -
[YEAR:18-12-1984]Gelb,M.H. and Abeles,R.H.
Mechanism of inactivation of chymotrypsin by 3-benzyl-6-chloro-2-pyrone
Biochemistry23, 6596-6604. PubMed Europe PubMed I -
[YEAR:10-4-1984]Hedstrom,L., Moorman,A.R., Dobbs,J. and Abeles,R.H.
Suicide inactivation of chymotrypsin by benzoxazinones
Biochemistry23, 1753-1759. PubMed Europe PubMed I -
Lambros,S.A., Richards,W.G. and Marchington,A.F.
Theoretical calculations on enzyme-substrate interactions: the binding of n-alkylboronic acids to alpha-chymotrypsin A
Theochem109, 61-71. I -
[YEAR:1-6-1984]Lijnen,H.R., Uytterhoeven,M. and Collen,D.
Inhibition of trypsin-like serine proteinases by tripeptide arginyl and lysyl chloromethylketones
Thromb Res34, 431-437. PubMed Europe PubMed I -
[YEAR:25-12-1983]Daniels,S.B., Cooney,E., Sofia,M.J., Chakravarty,P.K. and Katzenellenbogen,J.A.
Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin
J Biol Chem258, 15046-15053. PubMed Europe PubMed I -
Harper,J.W., Hemmi,K. and Powers,J.C.
New mechanism-based serine protease inhibitors: inhibition of human leukocyte elastase, porcine pancreatic elastase, human leukocyte cathepsin G, and chymotrypsin by 3-chloroisocoumarin and 3,3-dichlorophthatide
J Am Chem Soc105, 6518-6520. I -
Oksenoit,E.S., Petrova,E.N., Filippova,I.Y., Lavrenova,G.I., Tarasova,N.I. and Stepanov,V.M.
A chromogenic substrate of alpha-chymotrypsin - the p-nitroanilide of L-pyroglutamyl-L-phenylalanine
Chem Nat Compd19, 126- DOI A -
Shah,D.O. and Gorenstein,D.G.
Fluorine nuclear magnetic resonance spectroscopy of "transition state analogue" complexes of the D and L enantiomers of N-acetyl-p-fluorophenylalaninal and alpha-chymotrypsin
Biochemistry22, 6096-6101. -
Wipff,G., Dearing,A., Weiner,P.K., Blaney,J.M. and Kollman,P.A.
Molecular mechanics studies of enzyme-substrate interactions: the interaction of L- and D-N-acetyltryptophanamide with alpha-chymotrypsin
J Am Chem Soc105, 997-1005. -
Lobermann,H., Lottspeich,F., Bode,W. and Huber,R.
Interaction of human alpha1-proteinase inhibitor with chymotrypsinogen A and crystallization of a proteolytically modified alpha1-proteinase inhibitor
Hoppe Seylers Z Physiol Chem363, 1377-1388. PubMed Europe PubMed -
[YEAR:10-5-1982]Yoshimura,T., Barker,L.N. and Powers,J.C.
Specificity and reactivity of human leukocyte elastase, porcine pancreatic elastase, human granulocyte cathepsin G, and bovine pancreatic chymotrypsin with arylsulfonyl fluorides. Discovery of a new series of potent and specific irreversible elastase inhibitors
J Biol Chem257, 5077-5084. PubMed Europe PubMed I -
Hamilton,S.E. and Zerner,B.
Solvent effects on the deacylation of acyl-chymotrypsins: a critical comment on the charge-relay hypothesis
J Am Chem Soc103, 1827-1831. -
Shibata,M., Kieber-Emmons,T., Dutta,S. and Rein,R.
A comparative analysis of the stability of the chymotrypsin charge triad
Int J Quantum Chem20, 409-417. DOI -
Brodrick,J.W., Glaser,C.B., Largman,C., Geokas,M.C., Graceffo,M., Fassett,M. and Maeda,H.
Interaction of chymotrypsinogens with alpha1-protease inhibitor
Biochemistry19, 4865-4870. PubMed Europe PubMed -
DelMar,E.G., Largman,C., Brodrick,J.W. and Geokas,M.C.
A sensitive new substrate for chymotrypsin
Anal Biochem99, 316-320. PubMed Europe PubMed -
[YEAR:28-8-1979]Watanabe,H., Green,G.D. and Shaw,E.
A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones
Biochem Biophys Res Commun89, 1354-1360. PubMed Europe PubMed I -
Bloom,J.W. and Hunter,M.J.
Interactions of alpha1-antitrypsin with trypsin and chymotrypsin
J Biol Chem253, 547-559. PubMed Europe PubMed -
Lively,M.O. and Powers,J.C.
Specificity and reactivity of human granulocyte elastase and cathepsin G, porcine pancreatic elastase, bovine chymotrypsin and trypsin toward inhibition with sulfonyl fluorides
Biochim Biophys Acta525, 171-179. PubMed Europe PubMed I -
Powers,J.C. and Gupton,B.F.
Reaction of serine proteases with aza-amino acid and aza-peptide derivatives
Methods Enzymol46, 208-216. PubMed Europe PubMed DOI V I -
[YEAR:5-10-1976]Birktoft,J.J., Kraut,J. and Freer,S.T.
A detailed structural comparison between the charge relay system in chymotrypsinogen and in alpha-chymotrypsin
Biochemistry15, 4481-4485. PubMed Europe PubMed -
Blow,D.M.
Structure and mechanism of chymotrypsin
Acc Chem Res9, 145-152. -
Rao,K.N. and Lombardi,B.
Substrate solubilization for the Hummel alpha-chymotrypsin assay
Anal Biochem65, 548-551. PubMed Europe PubMed A -
[YEAR:5-7-1974]Robillard,G. and Shulman,R.G.
High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. II. Polarization of histidine 57 by substrate analogues and competitive inhibitors
J Mol Biol86, 541-558. PubMed Europe PubMed -
Tomlinson,G., Shaw,M.C. and Viswanatha,T.
Affinity chromatography of chymotrypsin(s)
Methods Enzymol34, 415-420. PubMed Europe PubMed DOI -
[YEAR:25-2-1973]Fersht,A.R. and Sperling,J.
The charge relay system in chymotrypsin and chymotrypsinogen
J Mol Biol74, 137-149. PubMed Europe PubMed -
Jameson,G.W., Roberts,D.V., Adams,R.W., Kyle,W.S. and Elmore,D.T.
Determination of the operational molarity of solutions of bovine alpha-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration
Biochem J131, 107-117. PubMed Europe PubMed I -
Kurachi,K., Powers,J.C. and Wilcox,P.E.
Kinetics of the reaction of chymotrypsin A-alpha with peptide chloromethyl ketones in relation to its subsite specificity
Biochemistry12, 771-777. PubMed Europe PubMed I -
Tatsuta,K., Mikami,N., Fujimoto,K., Umezawa,S. and Umezawa,H.
The structure of chymostatin, a chymotrypsin inhibitor
J Antibiot (Tokyo)26, 625-646. PubMed Europe PubMed I -
Ako,H., Ryan,C.A. and Foster,R.J.
The purification by affinity chromatography of a proteinase inhibitor binding species of anhydrochymotrypsin
Biochem Biophys Res Commun46, 1639-1645. PubMed Europe PubMed -
Melville,J.C. and Ryan,C.A.
Chymotrypsin inhibitor I from potatoes. Large scale preparation and characterization of its subunit components
J Biol Chem247, 3445-3453. PubMed Europe PubMed -
Blow,D.M.
6. The structure of chymotrypsin
Enzymes3, 185-212. DOI S -
Kraut,J.
7. Chymotrypsin: chemical properties and catalysis
Enzymes3, 213-248. DOI -
Segal,D.M., Powers,J.C., Cohen,G.H., Davies,D.R. and Wilcox,P.E.
Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethylketones as site-specific inhibitors
Biochemistry10, 3728-3738. PubMed Europe PubMed S I -
[YEAR:27-4-1971]Uren,J.R.
Affinity chromatography of proteolytic enzymes
Biochim Biophys Acta236, 67-73. PubMed Europe PubMed -
Wunsch,E., Hogel-Betz,A. and Jaeger,E.
[Chromophoric substrates. IV. A new substrate for the quantitative determination of chymotrypsin A]
HOPPE-SEYLERS'S Z PHYSIOL CHEM352, 1553-1559. PubMed Europe PubMed DOI A -
Freer,S.T., Kraut,J., Robertus,J.D., Wright,H.T. and Xuong,N.H.
Chymotrypsinogen: 2.5-angstrom crystal structure, comparison with alpha-chymotrypsin, and implications for zymogen activation
Biochemistry9, 1997-2009. PubMed Europe PubMed S -
[YEAR:14-12-1970]Henderson,R.
Structure of crystalline alpha-chymotrypsin. IV. The structure of indoleacryloyl-alpha-chymotrypsin and its relevance to the hydrolytic mechanism of the enzyme
J Mol Biol54, 341-354. PubMed Europe PubMed -
Melville,J.C. and Ryan,C.A.
Chymotrypsin inhibitor I from potatoes; a multisite inhibitor composed of subunits
Arch Biochem Biophys138, 700-702. PubMed Europe PubMed -
Umezawa,H., Aoyagi,T., Morishima,H., Kunimoto,S., Matsuzaki,M., Hamada,M. and Takeuchi,T.
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes
J Antibiot (Tokyo)23, 425-427. PubMed Europe PubMed I -
Wilcox,P.E.
Chymotrypsinogens - chymotrypsins
Methods Enzymol19, 64-108. DOI V -
Blow,D.M., Birktoft,J.J. and Hartley,B.S.
Role of a buried acid group in the mechanism of action of chymotrypsin
Nature221, 337-340. PubMed Europe PubMed DOI -
Brot,F.E. and Bender,M.L.
Use of the specificity constant of alpha-chymotrypsin
J Am Chem Soc91, 7187-7197. -
[YEAR:4-2-1969]Gratecos,D., Guy,O., Rovery,M. and Desnuelle,P.
On the two anionic chymotrypsinogens of porcine pancreas
Biochim Biophys Acta175, 82-96. PubMed Europe PubMed -
Steitz,T.A., Henderson,R. and Blow,D.M.
Structure of crystalline alpha-chymotrypsin. 3. Crystallographic studies of substrates and inhibitors bound to the active site of alpha-chymotrypsin
J Mol Biol46, 337-348. PubMed Europe PubMed S -
Elmore,D.T. and Smyth,J.J.
A new method for determining the absolute molarity of solutions of trypsin and chymotrypsin by using p-nitrophenyl N2-acetyl-N1-benzylcarbazate
Biochem J107, 103-107. PubMed Europe PubMed I -
Sigler,P.B., Blow,D.M., Matthews,B.W. and Henderson,R.
Structure of crystalline alpha-chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism
J Mol Biol35, 143-164. PubMed Europe PubMed -
Matthews,B.W., Sigler,P.B., Henderson,R. and Blow,D.M.
Three-dimensional structure of tosyl-alpha-chymotrypsin
Nature214, 652-656. PubMed Europe PubMed DOI S -
Rovery,M.
[25] Chromatography of trypsin to remove chymotrypsin, and of chymotrypsin to remove trypsin
Methods Enzymol11, 231-236. DOI -
Smillie,L.B. and Hartley,B.S.
The disulphide bridges of bovine chymotrypsinogen B
Biochem J105, 1125-1133. PubMed Europe PubMed -
Bender,M.L., Begue-Canton,M.L., Blakeley,R.L., Brubacher,L.J., Feder,J., Gunter,C.R., Kezdy,F.J., Killheffer,J.V., Jr., Marshall,T.H., Miller,C.G., Roeske,R.W. and Stoops,J.K.
The determination of the concentration of hydrolytic enzyme solutions: alpha-chymotrypsin, trypsin, papain, elastase, subtilisin, and acetylcholinesterase
J Am Chem Soc88, 5890-5913. PubMed Europe PubMed -
Brown,J.R. and Hartley,B.S.
Location of disulphide bridges by diagonal paper electrophoresis. The disulphide bridges of bovine chymotrypsinogen A
Biochem J101, 214-228. PubMed Europe PubMed -
[YEAR:25-11-1966]Feinstein,G. and Feeney,R.E.
Interaction of inactive derivatives of chymotrypsin and trypsin with protein inhibitors
J Biol Chem241, 5183-5189. PubMed Europe PubMed -
Gold,A.M. and Fahrney,D.
The kinetic equivalence of reactivated phenylmethanesulfonyl-alpha-chymotrypsin and native alpha-chymotrypsin. A reexamination
Biochemistry5, 2911-2913. PubMed Europe PubMed I -
Rapp,J.R., Niemann,C. and Hein,G.E.
The primary specificity of chymotrypsin. Further evidence for "wrong-way" binding
Biochemistry5, 4100-4105. -
Sigler,P.B., Jeffery,B.A., Matthews,B.W. and Blow,D.M.
An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin
J Mol Biol15, 175-192. PubMed Europe PubMed S -
Abrash,H.I. and Niemann,C.
Interaction of aromatic compounds with alpha-chymotrypsin. II. Combination of the isomeric indole carboxamides and carboxylate ions with the active site
Biochemistry4, 99-104. PubMed Europe PubMed -
Gold,A.M.
Sulfonyl fluorides as inhibitors of esterases. 3. Identification of serine as the site of sulfonylation in phenylmethanesulfonyl alpha-chymotrypsin
Biochemistry4, 897-901. PubMed Europe PubMed I -
Hartley,B.S., Brown,J.R., Kauffman,D.L. and Smillie,L.B.
Evolutionary similarities between pancreatic proteolytic enzymes
Nature207, 1157-1159. PubMed Europe PubMed DOI -
Jones,J.B., Niemann,C. and Hein,G.E.
The primary specificity of alpha-chymotrypsin. Interaction with acylated derivatives of D-valine methyl ester and D-norvaline methyl ester
Biochemistry4, 1735-1739. -
Jones,J.B., Kunitake,T., Niemann,C. and Hein,G.E.
The primary specificity of alpha-chymotrypsin. Acylated amino acid esters with normal alkyl side chains
J Am Chem Soc87, 1777-1781. PubMed Europe PubMed -
Lawson,W.B. and Schramm,H.J.
Modification of a methionine residue near the active site of chymotrypsin by p-nitrophenyl bromoacetyl-alpha-aminoisobutyrate
Biochemistry4, 377-386. PubMed Europe PubMed -
Bender,M.L., Killheffer,J.V., Jr. and Kezdy,F.J.
The active site of chymotrypsin
J Am Chem Soc86, 5331-5333. -
Bender,M.L., Clement,G.E., Kezdy,F.J. and Heck,H.D.
The correlation of the pH (pD) dependence and the stepwise mechanism of alpha-chymotrypsin-catalyzed reactions
J Am Chem Soc86, 3680-3690. -
Bender,M.L., Kezdy,F.J. and Gunter,C.R.
The anatomy of an enzymatic catalysis: alpha-chymotrypsin
J Am Chem Soc86, 3714-3721. -
Bender,M.L. and Kezdy,F.J.
The current status of the alpha-chymotrypsin mechanism
J Am Chem Soc86, 3704-3714. -
Cheung,H.T., Murthy,T.S. and Blout,E.R.
The synthesis of an octapeptide corresponding to a sequence around the "reactive serine" of chymotrypsin
J Am Chem Soc86, 4200-4202. -
Cohen,S.G. and Crossley,J.
Kinetics of hydrolysis of dicarboxylic esters and their alpha-acetamido derivatives by alpha-chymotrypsin
J Am Chem Soc86, 4999-5003. -
Cohen,S.G. and Weinstein,S.Y.
Hydrolysis of D-(-)-ethyl alpha-benzoyloxypropionate and L-(-)-ethyl alpha-acetoxy-beta-phenylpropionate by alpha-chymotrypsin
J Am Chem Soc86, 5326-5330. -
Cohen,S.G. and Crossley,J.
Kinetics of hydrolysis of diethyl glutarate and beta-substituted diethyl glutarates by alpha-chymotrypsin
J Am Chem Soc86, 1217-1220. -
Erlanger,B.F. and Edel,F.
The utilization of a specific chromogenic inactivator in an "all or none" assay for chymotrypsin
Biochemistry3, 346-349. PubMed Europe PubMed -
Erlanger,B.F., Cooper,A.G. and Bendich,A.J.
On the heterogeneity of three-times-crystallised alpha-chymotrypsin
Biochemistry3, 1880-1883. PubMed Europe PubMed -
Hartley,B.S.
Amino-acid sequence of bovine chymotrypsinogen-A
Nature201, 1284-1287. PubMed Europe PubMed DOI -
Kezdy,F.J., Clement,G.E. and Bender,M.L.
The observation of acyl-enzyme intermediates in the alpha-chymotrypsin-catalyzed reactions of N-acetyl-L-tryptophan derivatives at low pH
J Am Chem Soc86, 3690-3696. -
Kezdy,F.J. and Bender,M.L.
The observation of acyl-enzyme intermediates in the alpha-chymotrypsin-catalyzed hydrolysis of specific ester substrates at low pH
J Am Chem Soc86, 937-938. -
Kezdy,F.J. and Bender,M.L.
The acylation of alpha-chymotrypsin by N-acetyl-L-tryptophan
J Am Chem Soc86, 938-940. -
Lagunoff,D. and Benditt,E.P.
Benzosalicylanilide ester substrates of proteolytic enzymes. Kinetic and histochemical studies. I. Chymotrypsin
Biochemistry3, 1427-1431. PubMed Europe PubMed -
Meloun,B. and Pospisilova,D.
The histidine residue involved in the proteolytic activity of alpha-chymotrypsin
Biochim Biophys Acta92, 152-153. PubMed Europe PubMed -
Ong,E.B., Shaw,E. and Schoellmann,G.
An active center histidine peptide of alpha-chymotrypsin
J Am Chem Soc86, 1271-1272. -
Walsh,K.A., Kauffman,D.L., Kumar,K.S. and Neurath,H.
ON THE STRUCTURE AND FUNCTION OF BOVINE TRYPSINOGEN AND TRYPSIN
Proc Natl Acad Sci U S A51, 301-308. PubMed Europe PubMed -
Walsh,K.A. and Neurath,H.
Trypsinogen and chymotrypsinogen as homologous proteins
Proc Natl Acad Sci U S A52, 884-889. PubMed Europe PubMed -
Wolf,J.P., III, Wallace,R.A., Peterson,R.L. and Niemann,C.
The alpha-chymotrypsin-catalyzed hydrolysis of a series of acylated glycine methyl esters. II. Behavior at low and high substrate concentrations
Biochemistry3, 940-944. PubMed Europe PubMed -
Zerner,B., Bond,R.P.M. and Bender,M.L.
Kinetic evidence for the formation of acyl-enzyme intermediates in the alpha-chymotrypsin-catalyzed hydrolyses of specific substrates
J Am Chem Soc86, 3674-3679. -
Zerner,B. and Bender,M.L.
The kinetic consequences of the acyl-enzyme mechanism for the reactions of specific substrates with chymotrypsin
J Am Chem Soc86, 3669-3674. -
Abrash,H.I. and Niemann,C.
Steric hindrance in alpha-chymotrypsin-catalyzed reactions
Biochemistry2, 947-953. PubMed Europe PubMed -
Bender,M.L. and Clement,G.E.
Kinetic evidence for an acyl-enzyme intermediate in the alpha-chymotrypsin-catalyzed hydrolysis of N-acetyl-L-tryptophan ethyl ester
Biochem Biophys Res Commun12, 339-344. PubMed Europe PubMed -
Fahrney,D.E. and Gold,A.M.
Sulfonyl fluorides as inhibitors of esterases. I. Rates of reaction with acetylcholinesterase, alpha-chymotrypsin, and trypsin
J Am Chem Soc85, 997-1000. DOI I -
[YEAR:18-1-1963]Gold,A.M. and Fahrney,D.E.
The mechanism of reactivation of phenylmethanesulfonyl alpha-chymotrypsin
Biochem Biophys Res Commun10, 55-59. PubMed Europe PubMed I -
Keil,B., Prusik,Z. and Sorm,F.
Disulphide bridges and a suggested structure of chymotrypsinogen
Biochim Biophys Acta78, 559-561. PubMed Europe PubMed -
Schoellmann,G. and Shaw,E.
Direct evidence for the presence of histidine in the active center of chymotrypsin
Biochemistry2, 252-255. PubMed Europe PubMed I -
Wallace,R.A., Kurtz,A.N. and Niemann,C.
Interaction of aromatic compounds with alpha-chymotrypsin
Biochemistry2, 824-836. PubMed Europe PubMed -
Zerner,B. and Bender,M.L.
Acyl-enzyme intermediates in the alpha-chymotrypsin-catalyzed hydrolysis of "specific" substrates. The relative rates of hydrolysis of ethyl, methyl and p-nitrophenyl esters of N-acetyl-L-tryptophan
J Am Chem Soc85, 356-358. DOI -
Balls,A.K.
Early experiments in the quest of an active center in chymotrypsin
J Gen Physiol45, 47-56. PubMed Europe PubMed -
Bender,M.L., Schonbaum,G.R. and Zerner,B.
The pH dependence of some alpha-chymotrypsin-catalyzed hydrolyses
J Am Chem Soc84, 2562-2570. -
Bender,M.L., Schonbaum,G.R. and Zerner,B.
Spectrophotometric investigations of the mechanism of alpha-chymotrypsin-catalyzed hydrolyses. Detection of the acyl-enzyme intermediate
J Am Chem Soc84, 2540-2550. -
Bender,M.L.
The mechanism of alpha-chymotrypsin-catalyzed hydrolyses
J Am Chem Soc84, 2582-2590. -
Hartley,B.S.
On the structure of chymotrypsin
Brookhaven Symp Biol15, 85-100. PubMed Europe PubMed -
Hein,G.E. and Niemann,C.
Steric course and specificity of alpha-chymotrypsin-catalyzed reactions. II
J Am Chem Soc84, 4495-4503. -
Kassell,B. and Laskowski,M., Sr.
A comparison of the terminal amino acids of chymotrypsinogen B and alpha-chymotrypsinogen
J Biol Chem237, 413-417. PubMed Europe PubMed -
Kezdy,F.J. and Bender,M.L.
The kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of p-nitrophenyl acetate
Biochemistry1, 1097-1106. PubMed Europe PubMed -
Waite,H.R. and Niemann,C.
The alpha-chymotrypsin-catalyzed hydrolysis of a series of acylated-L-valine esters
Biochemistry1, 250-253. PubMed Europe PubMed -
Bruice,T.C.
The mechanisms for chymotrypsin
Proc Natl Acad Sci U S A47, 1924-1928. PubMed Europe PubMed -
Cohen,S.G., Sprinzak,Y. and Khedouri,E.
Requirements for stereospecificity in hydrolysis by alpha-chymotrypsin. III. The acylamido group
J Am Chem Soc83, 4225-4228. -
Kurtz,A.N. and Niemann,C.
The interaction of alpha-chymotrypsin with 1-acyl-2-(alpha-aminoacyl)hydrazines
Biochim Biophys Acta53, 324-331. PubMed Europe PubMed I -
Schonbaum,G.R., Zerner,B. and Bender,M.L.
The spectrophotometric determination of the operational normality of an alpha-chymotrypsin solution
J Biol Chem236, 2930-2935. PubMed Europe PubMed A -
Bender,M.L. and Glasson,W.A.
The kinetics of the alpha-chymotrypsin-catalyzed hydrolysis and methanolysis of acetyl-L-phenylalanine methyl ester. Evidence for the specific binding of water on the enzyme surface
J Am Chem Soc82, 3336-3342. -
Yamashita,T.
Action of chymotrypsin on synthetic substrates. V. Action of alpha-chymotrypsin on glycyl-l-aminoacyl-l-tyrosinamides
J Biochem48, 846-852. -
Hartley,B.S.
The chemical structure of chymotrypsin
J Cell Comp Physiol54, 203-205. PubMed Europe PubMed -
Hummel,B.C.
A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin
Can J Biochem Physiol37, 1393-1399. PubMed Europe PubMed A -
Martin,C.J., Golubow,J. and Axelrod,A.E.
A rapid and sensitive spectrophotometric method for the assay of chymotrypsin
J Biol Chem234, 294-298. PubMed Europe PubMed -
Yamashita,T. and Izumiya,N.
Action of chymotrypsin on synthetic substrates. III. Action of alpha-chymotrypsin on aminoacyl-L-tyrosine amides and ethyl esters
J Biochem46, 991-1000. -
Wilcox,P.E., Kraut,J., Wade,R.D. and Neurath,H.
The molecular weight of alpha-chymotrypsinogen
Biochim Biophys Acta24, 72-78. PubMed Europe PubMed -
Bluhm,M.M. and Kendrew,J.C.
The crystal forms and molecular weight of alpha-chymotrypsinogen. An X-ray study
Biochim Biophys Acta Gen Subj20, 562-563. PubMed Europe PubMed -
Cunningham,L.W. and Brown,C.S.
The influence of pH on the kinetic constants of alpha-chymotrypsin-catalyzed esterolysis
J Biol Chem221, 287-299. PubMed Europe PubMed -
Davis,N.C.
Action of proteolytic enzymes on some peptides and derivatives containing histidine
J Biol Chem223, 935-947. PubMed Europe PubMed P -
Bettelheim,F.R. and Neurath,H.
The rapid activation of chymotrypsinogen
J Biol Chem212, 241-253. PubMed Europe PubMed -
Foster,R.J. and Niemann,C.
Re-evaluation of the kinetic constants of previously investigated specific substrates of alpha-chymotrypsin
J Am Chem Soc77, 1886-1892. -
Laskowski,M.
Chymotrypsinogens and chymotrypsins
Methods Enzymol2, 8-26. DOI -
Sakota,N., Yu,T., Okada,Y. and Yamada,H.
A new crystalline form of chymotrypsin
J Biochem42, 609-611. -
Schwert,G.W. and Takenaka,Y.
A spectrophotometric determination of trypsin and chymotrypsin
Biochim Biophys Acta16, 570-575. PubMed Europe PubMed A -
Gladner,J.A. and Neurath,H.
Carboxyl terminal groups of proteolytic enzymes. II. Chymotrypsins
J Biol Chem206, 911-924. PubMed Europe PubMed -
Gladner,J.A. and Neurath,H.
C-terminal groups in chymotrypsinogen and DFP-alpha-chymotrypsin in relation to the activation process
Biochim Biophys Acta9, 335-336. PubMed Europe PubMed -
Hartley,B.S. and Kilby,B.A.
The inhibition of chymotrypsin by diethyl p-nitrophenyl phosphate
Biochem J50, 672-678. PubMed Europe PubMed I -
Loewus,M.W. and Briggs,D.R.
The number of catalytically active sites present on the chymotrypsin molecule
J Biol Chem199, 857-864. PubMed Europe PubMed -
Huang,H.T. and Niemann,C.
The evaluation of the enzyme-inhibitor dissociation constant of alpha-chymotrypsin and acetyl-D-tryptophan methyl ester
J Am Chem Soc73, 3228-3231. -
Sanger,F. and Tuppy,H.
Amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates
Biochem J49, 481-490. PubMed Europe PubMed P -
Seligman,A.M. and Wolf,G.
Synthesis of peptides and esters of phenylalanine as chromogenic substrates for chymotrypsin
J Am Chem Soc73, 2086-2089. A -
Iselin,B.M., Huang,H.T., MacAllister,R.V. and Niemann,C.
A new series of substrates for the evaluation of chymotrypsin activity
J Am Chem Soc72, 1729-1731. A -
Neurath,H. and Schwert,G.W.
The mode of action of the crystalline pancreatic proteolytic enzymes
Chem Rev46, 69-153. PubMed Europe PubMed V -
Kaufman,S. and Neurath,H.
Structural requirements of specific inhibitors for alpha-chymotrypsin
J Biol Chem181, 623-633. PubMed Europe PubMed -
Kaufman,S., Schwert,G.W. and Neurath,H.
The specific peptidase and esterase activities of chymotrypsin
Arch Biochem17, 203-205. PubMed Europe PubMed -
[YEAR:20-11-1948]Kunitz,M.
Crystallization of salt-free chymotrypsinogen and chymotrypsin from solution in dilute ethyl alcohol
J Gen Physiol32, 265-269. PubMed Europe PubMed DOI -
Sizer,I.W.
Essential groups of crystalline chymotrypsin
J Biol Chem160, 547-554. PubMed Europe PubMed -
Butler,J.A.V.
On the formation of chymotrypsin from chymotrypsinogen
J Am Chem Soc63, 2968-2970. -
[YEAR:20-11-1938]Kunitz,M.
Formation of new crystalline enzymes from chymotrypsin: isolation of beta and gamma chymotrypsin
J Gen Physiol22, 207-237. PubMed Europe PubMed DOI -
Bergmann,M. and Fruton,J.S.
On proteolytic enzymes. XIII. Synthetic substrates for chymotrypsin
J Biol Chem118, 405-415. -
Kunitz,M. and Northrop,J.H.
Crystalline chymo-trypsin and chymo-trypsinogen. I. Isolation, crystallization, and general properties of a new proteolytic enzyme and its precursor
J Gen Physiol18, 433-458. PubMed Europe PubMed DOI -
[YEAR:20-3-1935]Kunitz,M.
A method for determining the rennet activity of chymo-trypsin
J Gen Physiol18, 459-466. PubMed Europe PubMed DOI -
Kunitz,M. and Northrop,J.H.
Isolation of a crystalline protein from pancreas and its conversion into a new crystalline proteolytic enzyme by trypsin
Science78, 558-559. PubMed Europe PubMed DOI
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