Literature for subfamily P2A

Summary Distribution Literature

(Topics flags: S Structure, M Mutation, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Joshi,K. and Miao,Y. Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor J Phys Chem B (2026) 130, 56-67. PubMed Europe PubMed DOI

2025

Alsharif,H.A. and Bhatnagar,S. Cell-Specific Functions of the BAI/ADGRB Subfamily of Adhesion G-Protein Coupled Receptors Compr Physiol (2025) 15, e70068-e70068. PubMed Europe PubMed DOI
Chung,Y.K., Ihling,C.H., Zielke,L., Mathiasen,S., Sinz,A. and Langenhan,T. Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors Nat Commun (2025) 16, 8736-8736. PubMed Europe PubMed DOI PMC EPMC
Seufert,F., Perez-Hernandez,G., Pandy-Szekeres,G., Guixa-Gonzalez,R., Langenhan,T., Gloriam,D.E. and Hildebrand,P.W. Generic residue numbering of the GAIN domain of adhesion GPCRs Nat Commun (2025) 16, 246-246. PubMed Europe PubMed DOI PMC EPMC

2023

Fu,C., Huang,W., Tang,Q., Niu,M., Guo,S., Langenhan,T., Song,G. and Yan,J. Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs Nano Lett (2023) 23, 9179-9186. PubMed Europe PubMed DOI PMC EPMC
Scholz,N., Dahse,A.K., Kemkemer,M., Bormann,A., Auger,G.M., Vieira Contreras,F., Ernst,L.F., Staake,H., Korner,M.B., Buhlan,M., Meyer-Molck,A., Chung,Y.K., Blanco-Redondo,B., Klose,F., Jarboui,M.A., Ljaschenko,D., Bigl,M. and Langenhan,T. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation Nature (2023) 615, 945-953. PubMed Europe PubMed DOI
Seufert,F., Chung,Y.K., Hildebrand,P.W. and Langenhan,T. 7TM domain structures of adhesion GPCRs: what's new and what's missing? Trends Biochem Sci (2023) 48, 726-739. PubMed Europe PubMed DOI V
Thor,D. and Liebscher,I. Adhesion G protein-coupled receptors-Structure and functions Prog Mol Biol Transl Sci (2023) 195, 1-25. PubMed Europe PubMed DOI

2022

Barros-Alvarez,X., Nwokonko,R.M., Vizurraga,A., Matzov,D., He,F., Papasergi-Scott,M.M., Robertson,M.J., Panova,O., Yardeni,E.H., Seven,A.B., Kwarcinski,F.E., Su,H., Peroto,M.C., Meyerowitz,J.G., Shalev-Benami,M., Tall,G.G. and Skiniotis,G. The tethered peptide activation mechanism of adhesion GPCRs Nature (2022) 604, 757-762. PubMed Europe PubMed DOI

2020

Noguera,M.E., Jakoncic,J. and Ermacora,M.R. High-resolution structure of intramolecularly proteolyzed human mucin-1 SEA domain Biochim Biophys Acta Proteins Proteom (2020) 1868, 140361-140361. PubMed Europe PubMed DOI

2019

Bassilana,F., Nash,M. and Ludwig,M.G. Adhesion G protein-coupled receptors: opportunities for drug discovery Nat Rev Drug Discov (2019) 18, 869-884. PubMed Europe PubMed DOI
Folts,C.J., Giera,S., Li,T. and Piao,X. Adhesion G protein-coupled receptors as drug targets for neurological diseases Trends Pharmacol Sci (2019) 40, 278-293. PubMed Europe PubMed DOI PMC EPMC S
Kashyap,P., Ng,C., Wang,Z., Li,B., Arif Pavel,M., Martin,H. and Yu,Y. A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site Biochem Biophys Res Commun (2019) 512, 812-818. PubMed Europe PubMed DOI M

2018

Arakaki,A.K.S., Pan,W.A. and Trejo,J. GPCRs in cancer: protease-activated receptors, endocytic adaptors and signaling Int J Mol Sci (2018) 19 PubMed Europe PubMed DOI
Purcell,R.H. and Hall,R.A. Adhesion G protein-coupled receptors as drug targets Annu Rev Pharmacol Toxicol (2018) 58, 429-449. PubMed Europe PubMed DOI
Zhang,Q., Zheng,Y.W., Coughlin,S.R. and Shu,X. A rapid fluorogenic GPCR-beta-arrestin interaction assay Protein Sci (2018) 27, 874-879. PubMed Europe PubMed DOI

2017

Lin,H.H., Hsiao,C.C., Pabst,C., Hebert,J., Schoneberg,T. and Hamann,J. Adhesion GPCRs in regulating immune responses and inflammation Adv Immunol (2017) 136, 163-201. PubMed Europe PubMed DOI
Salzman,G.S., Zhang,S., Gupta,A., Koide,A., Koide,S. and Arac,D. Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region Proc Natl Acad Sci U S A (2017) 114, 10095-10100. PubMed Europe PubMed DOI

2016

Arac,D., Strater,N. and Seiradake,E. Understanding the structural basis of adhesion GPCR functions Handb Exp Pharmacol (2016) 234, 67-82. PubMed Europe PubMed DOI
de Graaf,C., Nijmeijer,S., Wolf,S. and Ernst,O.P. 7TM Domain structure of adhesion GPCRs Handb Exp Pharmacol (2016) 234, 43-66. PubMed Europe PubMed DOI S
Hamann,J. and Petrenko,A.G. Introduction: history of the adhesion GPCR field Handb Exp Pharmacol (2016) 234, 1-11. PubMed Europe PubMed DOI S
Kishore,A. and Hall,R.A. Versatile signaling activity of adhesion GPCRs Handb Exp Pharmacol (2016) 234, 127-146. PubMed Europe PubMed DOI
Krishnan,A., Nijmeijer,S., de Graaf,C. and Schioth,H.B. Classification, nomenclature, and structural aspects of adhesion GPCRs Handb Exp Pharmacol (2016) 234, 15-41. PubMed Europe PubMed DOI
Nieberler,M., Kittel,R.J., Petrenko,A.G., Lin,H.H. and Langenhan,T. Control of adhesion GPCR function through proteolytic processing Handb Exp Pharmacol (2016) 234, 83-109. PubMed Europe PubMed DOI
Trudel,M., Yao,Q. and Qian,F. The role of G-protein-coupled receptor proteolysis site cleavage of polycystin-1 in renal physiology and polycystic kidney disease Cells (2016) 5 PubMed Europe PubMed DOI

2015

Schoneberg,T., Liebscher,I., Luo,R., Monk,K.R. and Piao,X. Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation J Recept Signal Transduct Res (2015) 35, 220-223. PubMed Europe PubMed DOI

2014

Liao,Y., Pei,J., Cheng,H. and Grishin,N.V. An ancient autoproteolytic domain found in GAIN, ZU5 and nucleoporin98 J Mol Biol (2014) 426, 3935-3945. PubMed Europe PubMed DOI PMC EPMC
Liebscher,I., Ackley,B., Arac,D., Ariestanti,D.M., Aust,G., Bae,B.I., Bista,B.R., Bridges,J.P., Duman,J.G., Engel,F.B., Giera,S., Goffinet,A.M., Hall,R.A., Hamann,J., Hartmann,N., Lin,H.H., Liu,M., Luo,R., Mogha,A., Monk,K.R., Peeters,M.C., Promel,S., Ressl,S., Schioth,H.B., Sigoillot,S.M., Song,H., Talbot,W.S., Tall,G.G., White,J.P., Wolfrum,U., Xu,L. and Piao,X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors Ann N Y Acad Sci (2014) 1333, 43-64. PubMed Europe PubMed DOI

2013

Langenhan,T., Aust,G. and Hamann,J. Sticky signaling - adhesion class g protein-coupled receptors take the stage Sci Signal (2013) 6, re3-re3. PubMed Europe PubMed DOI

2012

Arac,D., Boucard,A.A., Bolliger,M.F., Nguyen,J., Soltis,S.M., Sudhof,T.C. and Brunger,A.T. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis EMBO J (2012) 31, 1364-1378. PubMed Europe PubMed DOI S
Arac,D., Aust,G., Calebiro,D., Engel,F.B., Formstone,C., Goffinet,A., Hamann,J., Kittel,R.J., Liebscher,I., Lin,H.H., Monk,K.R., Petrenko,A., Piao,X., Promel,S., Schioth,H.B., Schwartz,T.W., Stacey,M., Ushkaryov,Y.A., Wobus,M., Wolfrum,U., Xu,L. and Langenhan,T. Dissecting signaling and functions of adhesion G protein-coupled receptors Ann N Y Acad Sci (2012) 1276, 1-25. PubMed Europe PubMed DOI
Tesmer,J.J. A GAIN in understanding autoproteolytic G protein-coupled receptors and polycystic kidney disease proteins EMBO J (2012) 31, 1334-1335. PubMed Europe PubMed DOI V

2011

Lin,H.H., Stacey,M., Yona,S. and Chang,G.W. GPS proteolytic cleavage of adhesion-GPCRs Adv Exp Med Biol (2011) 706, 49-58. DOI V

2010

Deyev,I.E. and Petrenko,A.G. Regulation of CIRL-1 proteolysis and trafficking Biochimie (2010) 92, 418-422. PubMed Europe PubMed DOI

2007

Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A., Fredriksson,R. and Schioth,H.B. Identification of novel splice variants of Adhesion G protein-coupled receptors Gene (2007) 387, 38-48. PubMed Europe PubMed DOI
Bjarnadottir,T.K., Fredriksson,R. and Schioth,H.B. The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues Cell Mol Life Sci (2007) 64, 2104-2119. PubMed Europe PubMed DOI

2002

[YEAR:29-11-2002]Krasnoperov,V., Lu,Y., Buryanovsky,L., Neubert,T.A., Ichtchenko,K. and Petrenko,A.G. Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif J Biol Chem (29-11-2002) 277, 46518-46526. PubMed Europe PubMed DOI

2000

Stacey,M., Lin,H.H., Gordon,S. and McKnight,A.J. LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors Trends Biochem Sci (2000) 25, 284-289. PubMed Europe PubMed DOI