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Literature for subfamily P2A

Summary Distribution Literature

(Topics flags: S Structure, M Mutation, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Joshi,K. and Miao,Y.
    Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor
    J Phys Chem B (2026) 130, 56-67. PubMed  Europe PubMed DOI
    2. 2025
  2. Alsharif,H.A. and Bhatnagar,S.
    Cell-Specific Functions of the BAI/ADGRB Subfamily of Adhesion G-Protein Coupled Receptors
    Compr Physiol (2025) 15, e70068-e70068. PubMed  Europe PubMed DOI
  3. Chung,Y.K., Ihling,C.H., Zielke,L., Mathiasen,S., Sinz,A. and Langenhan,T.
    Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors
    Nat Commun (2025) 16, 8736-8736. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Seufert,F., Perez-Hernandez,G., Pandy-Szekeres,G., Guixa-Gonzalez,R., Langenhan,T., Gloriam,D.E. and Hildebrand,P.W.
    Generic residue numbering of the GAIN domain of adhesion GPCRs
    Nat Commun (2025) 16, 246-246. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2023
  5. Fu,C., Huang,W., Tang,Q., Niu,M., Guo,S., Langenhan,T., Song,G. and Yan,J.
    Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs
    Nano Lett (2023) 23, 9179-9186. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Scholz,N., Dahse,A.K., Kemkemer,M., Bormann,A., Auger,G.M., Vieira Contreras,F., Ernst,L.F., Staake,H., Korner,M.B., Buhlan,M., Meyer-Molck,A., Chung,Y.K., Blanco-Redondo,B., Klose,F., Jarboui,M.A., Ljaschenko,D., Bigl,M. and Langenhan,T.
    Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
    Nature (2023) 615, 945-953. PubMed  Europe PubMed DOI
  7. Seufert,F., Chung,Y.K., Hildebrand,P.W. and Langenhan,T.
    7TM domain structures of adhesion GPCRs: what's new and what's missing?
    Trends Biochem Sci (2023) 48, 726-739. PubMed  Europe PubMed DOI  V
  8. Thor,D. and Liebscher,I.
    Adhesion G protein-coupled receptors-Structure and functions
    Prog Mol Biol Transl Sci (2023) 195, 1-25. PubMed  Europe PubMed DOI
    9. 2022
  9. Barros-Alvarez,X., Nwokonko,R.M., Vizurraga,A., Matzov,D., He,F., Papasergi-Scott,M.M., Robertson,M.J., Panova,O., Yardeni,E.H., Seven,A.B., Kwarcinski,F.E., Su,H., Peroto,M.C., Meyerowitz,J.G., Shalev-Benami,M., Tall,G.G. and Skiniotis,G.
    The tethered peptide activation mechanism of adhesion GPCRs
    Nature (2022) 604, 757-762. PubMed  Europe PubMed DOI
    10. 2020
  10. Noguera,M.E., Jakoncic,J. and Ermacora,M.R.
    High-resolution structure of intramolecularly proteolyzed human mucin-1 SEA domain
    Biochim Biophys Acta Proteins Proteom (2020) 1868, 140361-140361. PubMed  Europe PubMed DOI
    11. 2019
  11. Bassilana,F., Nash,M. and Ludwig,M.G.
    Adhesion G protein-coupled receptors: opportunities for drug discovery
    Nat Rev Drug Discov (2019) 18, 869-884. PubMed  Europe PubMed DOI
  12. Folts,C.J., Giera,S., Li,T. and Piao,X.
    Adhesion G protein-coupled receptors as drug targets for neurological diseases
    Trends Pharmacol Sci (2019) 40, 278-293. PubMed  Europe PubMed DOI  PMC  EPMC  S
  13. Kashyap,P., Ng,C., Wang,Z., Li,B., Arif Pavel,M., Martin,H. and Yu,Y.
    A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site
    Biochem Biophys Res Commun (2019) 512, 812-818. PubMed  Europe PubMed DOI  M
    14. 2018
  14. Arakaki,A.K.S., Pan,W.A. and Trejo,J.
    GPCRs in cancer: protease-activated receptors, endocytic adaptors and signaling
    Int J Mol Sci (2018) 19 PubMed  Europe PubMed DOI
  15. Purcell,R.H. and Hall,R.A.
    Adhesion G protein-coupled receptors as drug targets
    Annu Rev Pharmacol Toxicol (2018) 58, 429-449. PubMed  Europe PubMed DOI
  16. Zhang,Q., Zheng,Y.W., Coughlin,S.R. and Shu,X.
    A rapid fluorogenic GPCR-beta-arrestin interaction assay
    Protein Sci (2018) 27, 874-879. PubMed  Europe PubMed DOI
    17. 2017
  17. Lin,H.H., Hsiao,C.C., Pabst,C., Hebert,J., Schoneberg,T. and Hamann,J.
    Adhesion GPCRs in regulating immune responses and inflammation
    Adv Immunol (2017) 136, 163-201. PubMed  Europe PubMed DOI
  18. Salzman,G.S., Zhang,S., Gupta,A., Koide,A., Koide,S. and Arac,D.
    Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region
    Proc Natl Acad Sci U S A (2017) 114, 10095-10100. PubMed  Europe PubMed DOI
    19. 2016
  19. Arac,D., Strater,N. and Seiradake,E.
    Understanding the structural basis of adhesion GPCR functions
    Handb Exp Pharmacol (2016) 234, 67-82. PubMed  Europe PubMed DOI
  20. de Graaf,C., Nijmeijer,S., Wolf,S. and Ernst,O.P.
    7TM Domain structure of adhesion GPCRs
    Handb Exp Pharmacol (2016) 234, 43-66. PubMed  Europe PubMed DOI  S
  21. Hamann,J. and Petrenko,A.G.
    Introduction: history of the adhesion GPCR field
    Handb Exp Pharmacol (2016) 234, 1-11. PubMed  Europe PubMed DOI  S
  22. Kishore,A. and Hall,R.A.
    Versatile signaling activity of adhesion GPCRs
    Handb Exp Pharmacol (2016) 234, 127-146. PubMed  Europe PubMed DOI
  23. Krishnan,A., Nijmeijer,S., de Graaf,C. and Schioth,H.B.
    Classification, nomenclature, and structural aspects of adhesion GPCRs
    Handb Exp Pharmacol (2016) 234, 15-41. PubMed  Europe PubMed DOI
  24. Nieberler,M., Kittel,R.J., Petrenko,A.G., Lin,H.H. and Langenhan,T.
    Control of adhesion GPCR function through proteolytic processing
    Handb Exp Pharmacol (2016) 234, 83-109. PubMed  Europe PubMed DOI
  25. Trudel,M., Yao,Q. and Qian,F.
    The role of G-protein-coupled receptor proteolysis site cleavage of polycystin-1 in renal physiology and polycystic kidney disease
    Cells (2016) 5 PubMed  Europe PubMed DOI
    26. 2015
  26. Schoneberg,T., Liebscher,I., Luo,R., Monk,K.R. and Piao,X.
    Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation
    J Recept Signal Transduct Res (2015) 35, 220-223. PubMed  Europe PubMed DOI
    27. 2014
  27. Liao,Y., Pei,J., Cheng,H. and Grishin,N.V.
    An ancient autoproteolytic domain found in GAIN, ZU5 and nucleoporin98
    J Mol Biol (2014) 426, 3935-3945. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Liebscher,I., Ackley,B., Arac,D., Ariestanti,D.M., Aust,G., Bae,B.I., Bista,B.R., Bridges,J.P., Duman,J.G., Engel,F.B., Giera,S., Goffinet,A.M., Hall,R.A., Hamann,J., Hartmann,N., Lin,H.H., Liu,M., Luo,R., Mogha,A., Monk,K.R., Peeters,M.C., Promel,S., Ressl,S., Schioth,H.B., Sigoillot,S.M., Song,H., Talbot,W.S., Tall,G.G., White,J.P., Wolfrum,U., Xu,L. and Piao,X.
    New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors
    Ann N Y Acad Sci (2014) 1333, 43-64. PubMed  Europe PubMed DOI
    29. 2013
  29. Langenhan,T., Aust,G. and Hamann,J.
    Sticky signaling - adhesion class g protein-coupled receptors take the stage
    Sci Signal (2013) 6, re3-re3. PubMed  Europe PubMed DOI
    30. 2012
  30. Arac,D., Boucard,A.A., Bolliger,M.F., Nguyen,J., Soltis,S.M., Sudhof,T.C. and Brunger,A.T.
    A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
    EMBO J (2012) 31, 1364-1378. PubMed  Europe PubMed DOI  S
  31. Arac,D., Aust,G., Calebiro,D., Engel,F.B., Formstone,C., Goffinet,A., Hamann,J., Kittel,R.J., Liebscher,I., Lin,H.H., Monk,K.R., Petrenko,A., Piao,X., Promel,S., Schioth,H.B., Schwartz,T.W., Stacey,M., Ushkaryov,Y.A., Wobus,M., Wolfrum,U., Xu,L. and Langenhan,T.
    Dissecting signaling and functions of adhesion G protein-coupled receptors
    Ann N Y Acad Sci (2012) 1276, 1-25. PubMed  Europe PubMed DOI
  32. Tesmer,J.J.
    A GAIN in understanding autoproteolytic G protein-coupled receptors and polycystic kidney disease proteins
    EMBO J (2012) 31, 1334-1335. PubMed  Europe PubMed DOI  V
    33. 2011
  33. Lin,H.H., Stacey,M., Yona,S. and Chang,G.W.
    GPS proteolytic cleavage of adhesion-GPCRs
    Adv Exp Med Biol (2011) 706, 49-58. DOI  V
    34. 2010
  34. Deyev,I.E. and Petrenko,A.G.
    Regulation of CIRL-1 proteolysis and trafficking
    Biochimie (2010) 92, 418-422. PubMed  Europe PubMed DOI
    35. 2007
  35. Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A., Fredriksson,R. and Schioth,H.B.
    Identification of novel splice variants of Adhesion G protein-coupled receptors
    Gene (2007) 387, 38-48. PubMed  Europe PubMed DOI
  36. Bjarnadottir,T.K., Fredriksson,R. and Schioth,H.B.
    The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues
    Cell Mol Life Sci (2007) 64, 2104-2119. PubMed  Europe PubMed DOI
    37. 2002
  37. [YEAR:29-11-2002]Krasnoperov,V., Lu,Y., Buryanovsky,L., Neubert,T.A., Ichtchenko,K. and Petrenko,A.G.
    Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif
    J Biol Chem (29-11-2002) 277, 46518-46526. PubMed  Europe PubMed DOI
    38. 2000
  38. Stacey,M., Lin,H.H., Gordon,S. and McKnight,A.J.
    LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors
    Trends Biochem Sci (2000) 25, 284-289. PubMed  Europe PubMed DOI

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