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Literature for peptidase P02.036: polycystin-1

Summary Alignment Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Busch,T., Neubauer,B., Sediq,S., Zeisler,P.C., Tholen,S., Schilling,O., Westermann,L. and Kottgen,M.
    SDF2 and SDF2L1 are essential co-factors of DNAJB11 for Polycystin-1 processing
    J Biol Chem (2025) , 110823-110823. PubMed  Europe PubMed DOI
  2. Gresko,N.P., Padovano,V., Berg,P., Ong,A.C.M., Somlo,S., Scholz,N., Langenhan,T. and Caplan,M.J.
    Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Ha,K., Mundt-Machado,N., Bisignano,P., Pinedo,A., Raleigh,D.R., Loeb,G., Reiter,J.F., Cao,E. and Delling,M.
    Cilia-enriched oxysterol 7beta,27-DHC is required for polycystin ion channel activation
    Nat Commun (2024) 15, 6468-6468. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Liu,R., Jiao,Y.R., Huang,M., Zou,N.Y., He,C., Huang,M., Chen,K.X., He,W.Z., Liu,L., Sun,Y.C., Xia,Z.Y., Quarles,L.D., Yang,H.L., Wang,W.S., Xiao,Z.S., Luo,X.H. and Li,C.J.
    Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healing
    Theranostics (2024) 14, 2544-2559. PubMed  Europe PubMed DOI  PMC  EPMC
  5. Zhang,C., Rehman,M., Tian,X., Pei,S.L.C., Gu,J., Bell,T.A., III, Dong,K., Tham,M.S., Cai,Y., Wei,Z., Behrens,F., Jetten,A.M., Zhao,H., Lek,M. and Somlo,S.
    Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease
    Nat Commun (2024) 15, 3698-3698. PubMed  Europe PubMed DOI  PMC  EPMC  K
    6. 2023
  6. Ghosh Roy,S., Li,Z., Guo,Z., Tran Long,K., Rehrl,S., Tian,X., Dong,K. and Besse,W.
    Dnajb11 -Kidney supDevelops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice
    J Am Soc Nephrol (2023) 34, 1521-1534. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Lin,C.C., Menezes,L.F., Qiu,J., Pearson,E., Zhou,F., Ishimoto,Y., Anderson,D.E. and Germino,G.G.
    In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model
    PLoS ONE (2023) 18, e0289778-e0289778. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Mbiakop,U.C. and Jaggar,J.H.
    Vascular polycystin proteins in health and disease
    Microcirculation (2023) , e12834-e12834. PubMed  Europe PubMed DOI
  9. Pellegrini,H., Sharpe,E.H., Liu,G., Nishiuchi,E., Doerr,N., Kipp,K.R., Chin,T., Schimmel,M.F. and Weimbs,T.
    Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction
    J Biol Chem (2023) 299, 105158-105158. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2022
  10. Pawnikar,S., Magenheimer,B.S., Munoz,E.N., Maser,R.L. and Miao,Y.
    Mechanism of tethered agonist-mediated signaling by polycystin-1
    Proc Natl Acad Sci U S A (2022) 119, e2113786119-e2113786119. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Ram,G., Vats,T., Kumar,A., Singh,G. and Giri,S.K.
    Cross Talk Between Renal Transporters and Polycystin-1 as a Potential Molecular Target Involved in Autosomal Dominant Polycystic Kidney Disease
    Iran J Kidney Dis (2021) 15, 177-189. PubMed  Europe PubMed
    12. 2020
  12. Aranguiz,P., Romero,P., Vasquez,F., Flores-Vergara,R., Aravena,D., Sanchez,G., Gonzalez,M., Olmedo,I. and Pedrozo,Z.
    Polycystin-1 mitigates damage and regulates CTGF expression through AKT activation during cardiac ischemia/reperfusion
    Biochim Biophys Acta Mol Basis Dis (2020) 1867, 165986-165986. PubMed  Europe PubMed DOI
  13. Lea,W.A., McGreal,K., Sharma,M., Parnell,S.C., Zelenchuk,L., Charlesworth,M.C., Madden,B.J., Johnson,K.L., McCormick,D.J., Hogan,M.C. and Ward,C.J.
    Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs)
    Sci Rep (2020) 10, 1500-1500. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Peintner,L., Venkatraman,A., Waeldin,A., Hofherr,A., Busch,T., Voronov,A., Viau,A., Kuehn,E.W., Kottgen,M. and Borner,C.
    Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner
    Autophagy (2020) , 1-17. PubMed  Europe PubMed DOI  I
    15. 2019
  15. Kashyap,P., Ng,C., Wang,Z., Li,B., Arif Pavel,M., Martin,H. and Yu,Y.
    A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site
    Biochem Biophys Res Commun (2019) 512, 812-818. PubMed  Europe PubMed DOI  M
    16. 2018
  16. Katsianou,M.A., Skondra,F.G., Gargalionis,A.N., Piperi,C. and Basdra,E.K.
    The role of transient receptor potential polycystin channels in bone diseases
    Ann Transl Med (2018) 6, 246-246. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Padovano,V. and Caplan,M.J.
    The polycystin complex reveals its complexity
    Biochemistry (2018) 57, 6917-6918. PubMed  Europe PubMed DOI
  18. Su,Q., Hu,F., Ge,X., Lei,J., Yu,S., Wang,T., Zhou,Q., Mei,C. and Shi,Y.
    Structure of the human PKD1-PKD2 complex
    Science (2018) 361 PubMed  Europe PubMed DOI  S
    19. 2016
  19. Trudel,M., Yao,Q. and Qian,F.
    The role of G-protein-coupled receptor proteolysis site cleavage of polycystin-1 in renal physiology and polycystic kidney disease
    Cells (2016) 5 PubMed  Europe PubMed DOI
    20. 2015
  20. Gainullin,V.G., Hopp,K., Ward,C.J., Hommerding,C.J. and Harris,P.C.
    Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner
    J Clin Invest (2015) 125, 607-620. PubMed  Europe PubMed DOI
    21. 2012
  21. Oatley,P., Stewart,A.P., Sandford,R. and Edwardson,J.M.
    Atomic force microscopy imaging reveals the domain structure of polycystin-1
    Biochemistry (2012) 51, 2879-2888. PubMed  Europe PubMed DOI  S
  22. Qian,F.
    Polycystin-1
    [ISSN:978-0-12-407742-3] (2012) 3, 3728-3736. DOI
    23. 2010
  23. Chapin,H.C., Rajendran,V. and Caplan,M.J.
    Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site
    Mol Biol Cell (2010) 21, 4338-4348. PubMed  Europe PubMed DOI
    24. 2009
  24. Bertuccio,C.A., Chapin,H.C., Cai,Y., Mistry,K., Chauvet,V., Somlo,S. and Caplan,M.J.
    Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression
    J Biol Chem (2009) 284, 21011-21026. PubMed  Europe PubMed DOI  PMC  EPMC
    25. 2008
  25. Kolpakova-Hart,E., McBratney-Owen,B., Hou,B., Fukai,N., Nicolae,C., Zhou,J. and Olsen,B.R.
    Growth of cranial synchondroses and sutures requires polycystin-1
    Dev Biol (2008) 321, 407-419. PubMed  Europe PubMed DOI  PMC  EPMC  K
    26. 2007
  26. Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A., Fredriksson,R. and Schioth,H.B.
    Identification of novel splice variants of Adhesion G protein-coupled receptors
    Gene (2007) 387, 38-48. PubMed  Europe PubMed DOI
  27. Wei,W., Hackmann,K., Xu,H., Germino,G. and Qian,F.
    Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene
    J Biol Chem (2007) 282, 21729-21737. PubMed  Europe PubMed DOI
  28. Yu,S., Hackmann,K., Gao,J., Gao,J., He,X., Piontek,K., Garcia-Gonzalez,M.A., Garcia Gonzalez,M.A., Menezes,L.F., Xu,H., Germino,G.G., Zuo,J. and Qian,F.
    Essential role of cleavage of polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure
    Proc Natl Acad Sci U S A (2007) 104, 18688-18693. PubMed  Europe PubMed DOI  PMC  EPMC
    29. 2004
  29. Chauvet,V., Tian,X., Husson,H., Grimm,D.H., Wang,T., Hiesberger,T., Hieseberger,T., Igarashi,P., Bennett,A.M., Ibraghimov-Beskrovnaya,O., Somlo,S. and Caplan,M.J.
    Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
    J Clin Invest (2004) 114, 1433-1443. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2002
  30. Qian,F., Boletta,A., Bhunia,A.K., Xu,H., Liu,L., Ahrabi,A.K., Watnick,T.J., Zhou,F. and Germino,G.G.
    Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
    Proc Natl Acad Sci U S A (2002) 99, 16981-16986. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 1999
  31. Bycroft,M., Bateman,A., Clarke,J., Hamill,S.J., Sandford,R., Thomas,R.L. and Chothia,C.
    The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease
    EMBO J (1999) 18, 297-305. PubMed  Europe PubMed DOI  PMC  EPMC  S
  32. [YEAR:26-8-1999]Ponting,C.P., Hofmann,K. and Bork,P.
    A latrophilin/CL-1-like GPS domain in polycystin-1
    Curr Biol (26-8-1999) 9, R585-R588. PubMed  Europe PubMed
    33. 1997
  33. Lu,W., Peissel,B., Babakhanlou,H., Pavlova,A., Geng,L., Fan,X., Larson,C., Brent,G. and Zhou,J.
    Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
    Nat Genet (1997) 17, 179-181. PubMed  Europe PubMed DOI

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