Literature for peptidase P02.036: polycystin-1

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Gresko,N.P., Padovano,V., Berg,P., Ong,A.C.M., Somlo,S., Scholz,N., Langenhan,T. and Caplan,M.J.
   Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli
   bioRxiv PubMed  Europe PubMed DOI
2024
2. Ha,K., Mundt-Machado,N., Bisignano,P., Pinedo,A., Raleigh,D.R., Loeb,G., Reiter,J.F., Cao,E. and Delling,M.
   Cilia-enriched oxysterol 7beta,27-DHC is required for polycystin ion channel activation
   Nat Commun15, 6468-6468. PubMed  Europe PubMed DOI
3. Zhang,C., Rehman,M., Tian,X., Pei,S.L.C., Gu,J., Bell,T.A., III, Dong,K., Tham,M.S., Cai,Y., Wei,Z., Behrens,F., Jetten,A.M., Zhao,H., Lek,M. and Somlo,S.
   Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease
   Nat Commun15, 3698-3698. PubMed  Europe PubMed DOI  K
2023
4. Ghosh Roy,S., Li,Z., Guo,Z., Tran Long,K., Rehrl,S., Tian,X., Dong,K. and Besse,W.
   Dnajb11 -Kidney supDevelops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice
   J Am Soc Nephrol34, 1521-1534. PubMed  Europe PubMed DOI
5. Lin,C.C., Menezes,L.F., Qiu,J., Pearson,E., Zhou,F., Ishimoto,Y., Anderson,D.E. and Germino,G.G.
   In vivo Polycystin-1 interactome using a novel Pkd1 knock-in mouse model
   PLoS ONE18, e0289778-e0289778. PubMed  Europe PubMed DOI
6. Mbiakop,U.C. and Jaggar,J.H.
   Vascular polycystin proteins in health and disease
   Microcirculatione12834-e12834. PubMed  Europe PubMed DOI
7. Pellegrini,H., Sharpe,E.H., Liu,G., Nishiuchi,E., Doerr,N., Kipp,K.R., Chin,T., Schimmel,M.F. and Weimbs,T.
   Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction
   J Biol Chem299, 105158-105158. PubMed  Europe PubMed DOI
2022
8. Pawnikar,S., Magenheimer,B.S., Munoz,E.N., Maser,R.L. and Miao,Y.
   Mechanism of tethered agonist-mediated signaling by polycystin-1
   Proc Natl Acad Sci U S A119, e2113786119-e2113786119. PubMed  Europe PubMed DOI
2021
9. Ram,G., Vats,T., Kumar,A., Singh,G. and Giri,S.K.
   Cross Talk Between Renal Transporters and Polycystin-1 as a Potential Molecular Target Involved in Autosomal Dominant Polycystic Kidney Disease
   Iran J Kidney Dis15, 177-189. PubMed  Europe PubMed
2020
10. Aranguiz,P., Romero,P., Vasquez,F., Flores-Vergara,R., Aravena,D., Sanchez,G., Gonzalez,M., Olmedo,I. and Pedrozo,Z.
    Polycystin-1 mitigates damage and regulates CTGF expression through AKT activation during cardiac ischemia/reperfusion
    Biochim Biophys Acta Mol Basis Dis1867, 165986-165986. PubMed  Europe PubMed DOI
11. Lea,W.A., McGreal,K., Sharma,M., Parnell,S.C., Zelenchuk,L., Charlesworth,M.C., Madden,B.J., Johnson,K.L., McCormick,D.J., Hogan,M.C. and Ward,C.J.
    Analysis of the polycystin complex (PCC) in human urinary exosome-like vesicles (ELVs)
    Sci Rep10, 1500-1500. PubMed  Europe PubMed DOI
12. Peintner,L., Venkatraman,A., Waeldin,A., Hofherr,A., Busch,T., Voronov,A., Viau,A., Kuehn,E.W., Kottgen,M. and Borner,C.
    Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner
    Autophagy1-17. PubMed  Europe PubMed DOI  I
2019
13. Kashyap,P., Ng,C., Wang,Z., Li,B., Arif Pavel,M., Martin,H. and Yu,Y.
    A PKD1L3 splice variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site
    Biochem Biophys Res Commun512, 812-818. PubMed  Europe PubMed DOI  M
2018
14. Katsianou,M.A., Skondra,F.G., Gargalionis,A.N., Piperi,C. and Basdra,E.K.
    The role of transient receptor potential polycystin channels in bone diseases
    Ann Transl Med6, 246-246. PubMed  Europe PubMed DOI
15. Padovano,V. and Caplan,M.J.
    The polycystin complex reveals its complexity
    Biochemistry57, 6917-6918. PubMed  Europe PubMed DOI
16. Su,Q., Hu,F., Ge,X., Lei,J., Yu,S., Wang,T., Zhou,Q., Mei,C. and Shi,Y.
    Structure of the human PKD1-PKD2 complex
    Science361, PubMed  Europe PubMed DOI  S
2016
17. Trudel,M., Yao,Q. and Qian,F.
    The role of G-protein-coupled receptor proteolysis site cleavage of polycystin-1 in renal physiology and polycystic kidney disease
    Cells5, PubMed  Europe PubMed DOI
2015
18. Gainullin,V.G., Hopp,K., Ward,C.J., Hommerding,C.J. and Harris,P.C.
    Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner
    J Clin Invest125, 607-620. PubMed  Europe PubMed DOI
2012
19. Oatley,P., Stewart,A.P., Sandford,R. and Edwardson,J.M.
    Atomic force microscopy imaging reveals the domain structure of polycystin-1
    Biochemistry51, 2879-2888. PubMed  Europe PubMed DOI  S
20. Qian,F.
    Polycystin-1
    [ISSN:978-0-12-407742-3]3, 3728-3736. DOI
2010
21. Chapin,H.C., Rajendran,V. and Caplan,M.J.
    Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site
    Mol Biol Cell21, 4338-4348. PubMed  Europe PubMed DOI
2009
22. Bertuccio,C.A., Chapin,H.C., Cai,Y., Mistry,K., Chauvet,V., Somlo,S. and Caplan,M.J.
    Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression
    J Biol Chem284, 21011-21026. PubMed  Europe PubMed DOI
2008
23. Kolpakova-Hart,E., McBratney-Owen,B., Hou,B., Fukai,N., Nicolae,C., Zhou,J. and Olsen,B.R.
    Growth of cranial synchondroses and sutures requires polycystin-1
    Dev Biol321, 407-419. PubMed  Europe PubMed DOI  K
2007
24. Bjarnadottir,T.K., Geirardsdottir,K., Ingemansson,M., Mirza,M.A., Fredriksson,R. and Schioth,H.B.
    Identification of novel splice variants of Adhesion G protein-coupled receptors
    Gene387, 38-48. PubMed  Europe PubMed DOI
25. Wei,W., Hackmann,K., Xu,H., Germino,G. and Qian,F.
    Characterization of cis-autoproteolysis of polycystin-1, the product of human polycystic kidney disease 1 gene
    J Biol Chem282, 21729-21737. PubMed  Europe PubMed DOI
26. Yu,S., Hackmann,K., Gao,J., Gao,J., He,X., Piontek,K., Garcia-Gonzalez,M.A., Garcia Gonzalez,M.A., Menezes,L.F., Xu,H., Germino,G.G., Zuo,J. and Qian,F.
    Essential role of cleavage of polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure
    Proc Natl Acad Sci U S A104, 18688-18693. PubMed  Europe PubMed DOI
2004
27. Chauvet,V., Tian,X., Husson,H., Grimm,D.H., Wang,T., Hiesberger,T., Hieseberger,T., Igarashi,P., Bennett,A.M., Ibraghimov-Beskrovnaya,O., Somlo,S. and Caplan,M.J.
    Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
    J Clin Invest114, 1433-1443. PubMed  Europe PubMed DOI
2002
28. Qian,F., Boletta,A., Bhunia,A.K., Xu,H., Liu,L., Ahrabi,A.K., Watnick,T.J., Zhou,F. and Germino,G.G.
    Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
    Proc Natl Acad Sci U S A99, 16981-16986. PubMed  Europe PubMed DOI
1999
29. Bycroft,M., Bateman,A., Clarke,J., Hamill,S.J., Sandford,R., Thomas,R.L. and Chothia,C.
    The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease
    EMBO J18, 297-305. PubMed  Europe PubMed DOI  S
30. [YEAR:26-8-1999]Ponting,C.P., Hofmann,K. and Bork,P.
    A latrophilin/CL-1-like GPS domain in polycystin-1
    Curr Biol9, R585-R588. PubMed  Europe PubMed
1997
31. Lu,W., Peissel,B., Babakhanlou,H., Pavlova,A., Geng,L., Fan,X., Larson,C., Brent,G. and Zhou,J.
    Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
    Nat Genet17, 179-181. PubMed  Europe PubMed DOI