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Literature for peptidase M85.001: NleC peptidase (Escherichia coli)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, P Specificity. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Freitas,I.L., Macedo,M.F., Oliveira,L., Oliveira,P., do Vale,A. and dos Santos,N.M.S.<br>AIP56, an AB toxin secreted by Photobacterium damselae subsp. piscicida, has tropism for myeloid cells<br>Front Immunol (2024) 15, 1527088-1527088. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2023
  2. Lisboa,J., Pereira,C., Pinto,R.D., Rodrigues,I.S., Pereira,L.M.G., Pinheiro,B., Oliveira,P., Pereira,P.J.B., Azevedo,J.E., Durand,D., Benz,R., do Vale,A. and dos Santos,N.M.S.<br>Unconventional structure and mechanisms for membrane interaction and translocation of the NF-kappaB-targeting toxin AIP56<br>Nat Commun (2023) 14, 7431-7431. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Rudenko,O., Baseggio,L., McGuigan,F. and Barnes,A.C.<br>Transforming the untransformable with knockout minicircles: High-efficiency transformation and vector-free allelic exchange knockout in the fish pathogen Photobacterium damselae<br>Microbiologyopen (2023) 12, e1374-e1374. PubMed  Europe PubMed DOI  PMC  EPMC
  4. Verster,K.I., Cinege,G., Lipinszki,Z., Magyar,L.B., Kurucz,E., Tarnopol,R.L., Abraham,E., Darula,Z., Karageorgi,M., Tamsil,J.A., Akalu,S.M., Ando,I. and Whiteman,N.K.<br>Evolution of insect innate immunity through domestication of bacterial toxins<br>Proc Natl Acad Sci U S A (2023) 120, e2218334120-e2218334120. PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2019
  5. Pereira,C., Rodrigues,I.S., Pereira,L.M.G., Lisboa,J., Pinto,R., Araujo,L., Oliveira,P., Benz,R., M S Dos Santos,N. and do Vale,A.<br>Role of AIP56 disulphide bond and its reduction by cytosolic redox systems for efficient intoxication<br>Cell Microbiol (2019) , e13109-e13109. PubMed  Europe PubMed DOI
  6. Rodrigues,I.S., Pereira,L.M.G., Lisboa,J., Pereira,C., Oliveira,P., dos Santos,N.M.S. and do Vale,A.<br>Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida<br>Sci Rep (2019) 9, 9019-9019. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2017
  7. do Vale,A., Pereira,C., Osorio,C.R. and dos Santos,N.M.S.<br>The apoptogenic toxin AIP56 is secreted by the Type II secretion system of Photobacterium damselae subsp. piscicida<br>Toxins (Basel) (2017) 9 PubMed  Europe PubMed DOI
  8. Stolle,A.S., Norkowski,S., Korner,B., Schmitz,J., Luken,L., Frankenberg,M., Ruter,C. and Schmidt,M.A.<br>T3SS-Independent uptake of the short-trip toxin-related recombinant NleC effector of enteropathogenic Escherichia coli leads to NF-kappaB p65 cleavage<br>Front Cell Infect Microbiol (2017) 7, 119-119. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2015
  9. Giogha,C., Wong Fok Lung,T., Muhlen,S., Pearson,J.S. and Hartland,E.L.<br>Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli<br>Cell Microbiol (2015) 17, 1766-1778. PubMed  Europe PubMed DOI
  10. Hodgson,A., Wier,E.M., Fu,K., Sun,X., Yu,H., Zheng,W., Sham,H.P., Johnson,K., Bailey,S., Vallance,B.A. and Wan,F.<br>Metalloprotease NleC suppresses host NF-kappaB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction<br>PLoS Pathog (2015) 11, e1004705-e1004705. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2014
  11. Li,W., Liu,Y., Sheng,X., Yin,P., Hu,F., Liu,Y., Chen,C., Li,Q., Yan,C. and Wang,J.<br>Structure and mechanism of a type III secretion protease, NleC<br>Acta Crystallogr D Biol Crystallogr (2014) 70, 40-47. PubMed  Europe PubMed DOI  S
  12. Pereira,L.M., Pinto,R.D., Silva,D.S., Moreira,A.R., Beitzinger,C., Oliveira,P., Sampaio,P., Benz,R., Azevedo,J.E., Dos Santos,N.M. and do Vale,A.<br>Intracellular trafficking of AIP56, an NF-kappaB-cleaving toxin from Photobacterium damselae subsp. piscicida<br>Infect Immun (2014) 82, 5270-5285. PubMed  Europe PubMed DOI
  13. Turco,M.M. and Sousa,M.C.<br>The structure and specificity of the type III secretion system effector NleC suggest a DNA mimicry mechanism of substrate recognition<br>Biochemistry (2014) 53, 5131-5139. PubMed  Europe PubMed DOI  P  S
    14. 2013
  14. Silva,D.S., Pereira,L.M., Moreira,A.R., Ferreira-da-Silva,F., Brito,R.M., Faria,T.Q., Zornetta,I., Montecucco,C., Oliveira,P., Azevedo,J.E., Pereira,P.J., Macedo-Ribeiro,S., do Vale,A. and Dos Santos,N.M.<br>The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-kappab P65<br>PLoS Pathog (2013) 9, e1003128-e1003128. PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2011
  15. Baruch,K., Gur-Arie,L., Nadler,C., Koby,S., Yerushalmi,G., Ben-Neriah,Y., Yogev,O., Shaulian,E., Guttman,C., Zarivach,R. and Rosenshine,I.<br>Metalloprotease type III effectors that specifically cleave JNK and NF-kappaB<br>EMBO J (2011) 30, 221-231. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Costa-Ramos,C., Vale,A., Ludovico,P., Dos Santos,N.M. and Silva,M.T.<br>The bacterial exotoxin AIP56 induces fish macrophage and neutrophil apoptosis using mechanisms of the extrinsic and intrinsic pathways<br>Fish Shellfish Immunol (2011) 30, 173-181. PubMed  Europe PubMed DOI
  17. Muhlen,S., Ruchaud-Sparagano,M.H. and Kenny,B.<br>Proteasome-independent degradation of canonical NFkappaB complex components by the NleC protein of pathogenic Escherichia coli<br>J Biol Chem (2011) 286, 5100-5107. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Pearson,J.S., Riedmaier,P., Marches,O., Frankel,G. and Hartland,E.L.<br>A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-kappaB for degradation<br>Mol Microbiol (2011) 80, 219-230. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Sham,H.P., Shames,S.R., Croxen,M.A., Ma,C., Chan,J.M., Khan,M.A., Wickham,M.E., Deng,W., Finlay,B.B. and Vallance,B.A.<br>Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-kappaB and p38 mitogen-activated protein kinase activation<br>Infect Immun (2011) 79, 3552-3562. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Shames,S.R., Bhavsar,A.P., Croxen,M.A., Law,R.J., Mak,S.H., Deng,W., Li,Y., Bidshari,R., de Hoog,C.L., Foster,L.J. and Finlay,B.B.<br>The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300<br>Cell Microbiol (2011) 13, 1542-1557. PubMed  Europe PubMed DOI
    21. 2010
  21. Silva,M.T., Dos Santos,N.M. and do Vale,A.<br>AIP56: a novel bacterial apoptogenic toxin<br>Toxins (Basel) (2010) 2, 905-918. PubMed  Europe PubMed DOI  PMC  EPMC
  22. Yen,H., Ooka,T., Iguchi,A., Hayashi,T., Sugimoto,N. and Tobe,T.<br>NleC, a type III secretion protease, compromises NF-kappaB activation by targeting p65/RelA<br>PLoS Pathog (2010) 6, e1001231-e1001231. PubMed  Europe PubMed DOI  PMC  EPMC
    23. 2005
  23. do Vale,A., Silva,M.T., Dos Santos,N.M., Nascimento,D.S., Reis-Rodrigues,P., Costa-Ramos,C., Ellis,A.E. and Azevedo,J.E.<br>AIP56, a novel plasmid-encoded virulence factor of Photobacterium damselae subsp. piscicida with apoptogenic activity against sea bass macrophages and neutrophils<br>Mol Microbiol (2005) 58, 1025-1038. PubMed  Europe PubMed DOI
  24. Marches,O., Wiles,S., Dziva,F., La Ragione,R.M., Schuller,S., Best,A., Phillips,A.D., Hartland,E.L., Woodward,M.J., Stevens,M.P. and Frankel,G.<br>Characterization of two non-locus of enterocyte effacement-encoded type III-translocated effectors, NleC and NleD, in attaching and effacing pathogens<br>Infect Immun (2005) 73, 8411-8417. PubMed  Europe PubMed DOI  PMC  EPMC

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