Literature for peptidase M67.005: histone H2A deubiquitinase MYSM1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Shi,X., Xu,J., Liu,L., Zhao,S., Qian,Y., Fang,Z., Lin,L., Zhao,X., Xie,S., Shi,F. and Han,J.
    Deubiquitinase MYSM1 drives myocardial ischemia/reperfusion injury by stabilizing STAT1 in cardiomyocytes
    Theranostics15, 1606-1621. PubMed  Europe PubMed DOI  K
  2. Zhong,X., Xu,J., Shi,X., Lyu,Y., Qian,Y., Fang,Z., Wang,Z., Xing,J., Ye,B., Xu,J. and Han,J.
    MYSM1 Mediates Cardiac Parthanatos and Hypertrophy by Deubiquitinating PARP1
    Hypertension PubMed  Europe PubMed DOI  K
  3. 2024
  4. Luan,R., He,M., Li,H., Bai,Y., Wang,A., Sun,G., Zhou,B., Wang,M., Wang,C., Wang,S., Zeng,K., Feng,J., Lin,L., Wei,Y., Kato,S., Zhang,Q. and Zhao,Y.
    MYSM1 acts as a novel co-activator of ERalpha to confer antiestrogen resistance in breast cancer
    EMBO Mol Med16, 10-39. PubMed  Europe PubMed DOI
  5. Mousa,M., Liang,Y., Tung,L.T., Wang,H., Krawczyk,C., Langlais,D. and Nijnik,A.
    Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation
    Immunology172, 109-126. PubMed  Europe PubMed DOI
  6. Shi,X., Xu,J., Zhong,X., Qian,Y., Lin,L., Fang,Z., Ye,B., Lyu,Y., Zhang,R., Zheng,Z. and Han,J.
    Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
    Cell Commun Signal22, 593-593. PubMed  Europe PubMed DOI  K
  7. 2021
  8. Chen,X., Wang,W., Li,Y., Huo,Y., Zhang,H., Feng,F., Xi,W., Zhang,T., Gao,J., Yang,F., Chen,S., Yang,A. and Wang,T.
    MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    J Exp Clin Cancer Res40, 341-341. PubMed  Europe PubMed DOI
  9. 2020
  10. Fiore,A., Liang,Y., Lin,Y.H., Tung,J., Wang,H., Langlais,D. and Nijnik,A.
    Deubiquitinase MYSM1 in the hematopoietic system and beyond: a current review
    Int J Mol Sci21, 3007-3007. PubMed  Europe PubMed DOI  V
  11. Li,N., Xu,Y., Yu,T., Yao,R., Chen,J., Luo,C. and Wang,J.
    Further delineation of bone marrow failure syndrome caused by novel compound heterozygous variants of MYSM1
    Gene757, 144938-144938. PubMed  Europe PubMed DOI  R
  12. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci21, PubMed  Europe PubMed DOI  V
  13. Tian,M., Liu,W., Zhang,Q., Huang,Y., Li,W., Wang,W., Zhao,P., Huang,S., Song,Y., Shereen,M.A., Qin,M., Liu,Y., Wu,K. and Wu,J.
    MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway
    Cell Rep33, 108297-108297. PubMed  Europe PubMed DOI
  14. 2018
  15. Panda,S. and Gekara,N.O.
    The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
    Nat Commun9, 4654-4654. PubMed  Europe PubMed DOI
  16. Zhao,X., Huang,X.H., Dong,X.H., Wang,Y.H., Yang,H.X., Wang,Y., He,Y., Liu,S., Zhou,J., Wang,C. and Jiang,X.X.
    Deubiquitinase Mysm1 regulates macrophage survival and polarization
    Mol Biol Rep45, 2393-2401. PubMed  Europe PubMed DOI
  17. 2016
  18. Jiang,X.X., Liu,Y., Li,H., Gao,Y., Mu,R., Guo,J., Zhang,J., Yang,Y.M., Xiao,F., Liu,B., Wang,C., Shen,B., Chen,S.Y., Li,Z. and Yang,G.
    MYSM1/miR-150/FLT3 inhibits B1a cell proliferation
    Oncotarget7, 68086-68096. PubMed  Europe PubMed DOI
  19. 2015
  20. Belle,J.I., Langlais,D., Petrov,J.C., Pardo,M., Jones,R.G., Gros,P. and Nijnik,A.
    p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency
    Blood125, 2344-2348. PubMed  Europe PubMed DOI
  21. Jiang,X.X., Chou,Y., Jones,L., Wang,T., Sanchez,S., Huang,X.F., Zhang,L., Wang,C. and Chen,S.Y.
    Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1
    Sci Rep5, 13755-13755. PubMed  Europe PubMed DOI
  22. Panda,S., Nilsson,J.A. and Gekara,N.O.
    Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes
    Immunity43, 647-659. PubMed  Europe PubMed DOI
  23. 2014
  24. Won,H., Nandakumar,V., Yates,P., Sanchez,S., Jones,L., Huang,X.F. and Chen,S.Y.
    Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1
    Blood124, 2647-2656. PubMed  Europe PubMed DOI
  25. 2013
  26. Alsultan,A., Shamseldin,H.E., Osman,M.E., Aljabri,M. and Alkuraya,F.S.
    MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK
    Blood122, 3844-3845. PubMed  Europe PubMed DOI
  27. Nandakumar,V., Chou,Y., Zang,L., Huang,X.F. and Chen,S.Y.
    Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1
    Proc Natl Acad Sci U S A110, E3927-E3936. PubMed  Europe PubMed DOI
  28. Wang,T., Nandakumar,V., Jiang,X.X., Jones,L., Yang,A.G., Huang,X.F. and Chen,S.Y.
    The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation
    Blood122, 2812-2822. DOI
  29. 2012
  30. Nijnik,A., Clare,S., Hale,C., Raisen,C., McIntyre,R.E., Yusa,K., Everitt,A.R., Mottram,L., Podrini,C., Lucas,M., Estabel,J., Goulding,D., Adams,N., Ramirez-Solis,R., White,J.K., Adams,D.J., Hancock,R.E. and Dougan,G.
    The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
    Blood119, 1370-1379. PubMed  Europe PubMed DOI
  31. 2011
  32. Jiang,X.X., Nguyen,Q., Chou,Y., Wang,T., Nandakumar,V., Yates,P., Jones,L., Wang,L., Won,H., Lee,H.R., Jung,J.U., Müschen,M., Huang,X.F. and Chen,S.Y.
    Control of B cell development by the histone H2A deubiquitinase MYSM1
    Immunity35, 883-896. PubMed  Europe PubMed DOI
  33. 2009
  34. Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
    Defining the human deubiquitinating enzyme interaction landscape
    Cell138, 389-403. PubMed  Europe PubMed DOI  V
  35. 2008
  36. Pijnappel,W.W. and Timmers,H.T.
    Dubbing SAGA unveils new epigenetic crosstalk
    Mol Cell29, 152-154. PubMed  Europe PubMed DOI
  37. Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S., Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A., Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and Devys,D.
    A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
    Mol Cell29, 92-101. PubMed  Europe PubMed DOI
  38. 2007
  39. Yoneyama,M., Tochio,N., Umehara,T., Koshiba,S., Inoue,M., Yabuki,T., Aoki,M., Seki,E., Matsuda,T., Watanabe,S., Tomo,Y., Nishimura,Y., Harada,T., Terada,T., Shirouzu,M., Hayashizaki,Y., Ohara,O., Tanaka,A., Kigawa,T. and Yokoyama,S.
    Structural and functional differences of SWIRM domain subtypes
    J Mol Biol369, 222-238. PubMed  Europe PubMed DOI  S
  40. Zhu,P., Zhou,W., Wang,J., Puc,J., Ohgi,K.A., Erdjument-Bromage,H., Tempst,P., Glass,C.K. and Rosenfeld,M.G.
    A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
    Mol Cell27, 609-621. PubMed  Europe PubMed DOI
  41. 2001
  42. Nagase,T., Kikuno,R. and Ohara,O.
    Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins
    DNA Res8, 179-187. PubMed  Europe PubMed DOI