Literature for peptidase M67.005: histone H2A deubiquitinase MYSM1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Shi,X., Xu,J., Liu,L., Zhao,S., Qian,Y., Fang,Z., Lin,L., Zhao,X., Xie,S., Shi,F. and Han,J. Deubiquitinase MYSM1 drives myocardial ischemia/reperfusion injury by stabilizing STAT1 in cardiomyocytes Theranostics (2025) 15, 1606-1621. PubMed Europe PubMed DOI PMC EPMC K
Yu,W., Ma,L., Li,R., Zhu,D., Qu,C., Han,J., Tian,Y., Tian,H. and Liang,J. MYSM1 promotes lung adenocarcinoma progression via TRAF2/3-mediated activation of MAPK and non-canonical NF-kappaB pathways NPJ Precis Oncol (2025) 9, 337-337. PubMed Europe PubMed DOI PMC EPMC
Zhong,X., Xu,J., Shi,X., Lyu,Y., Qian,Y., Fang,Z., Wang,Z., Xing,J., Ye,B., Xu,J. and Han,J. MYSM1 Mediates Cardiac Parthanatos and Hypertrophy by Deubiquitinating PARP1 Hypertension (2025) PubMed Europe PubMed DOI K

2024

Luan,R., He,M., Li,H., Bai,Y., Wang,A., Sun,G., Zhou,B., Wang,M., Wang,C., Wang,S., Zeng,K., Feng,J., Lin,L., Wei,Y., Kato,S., Zhang,Q. and Zhao,Y. MYSM1 acts as a novel co-activator of ERalpha to confer antiestrogen resistance in breast cancer EMBO Mol Med (2024) 16, 10-39. PubMed Europe PubMed DOI PMC EPMC
Mousa,M., Liang,Y., Tung,L.T., Wang,H., Krawczyk,C., Langlais,D. and Nijnik,A. Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation Immunology (2024) 172, 109-126. PubMed Europe PubMed DOI
Shi,X., Xu,J., Zhong,X., Qian,Y., Lin,L., Fang,Z., Ye,B., Lyu,Y., Zhang,R., Zheng,Z. and Han,J. Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes Cell Commun Signal (2024) 22, 593-593. PubMed Europe PubMed DOI PMC EPMC K

2021

Chen,X., Wang,W., Li,Y., Huo,Y., Zhang,H., Feng,F., Xi,W., Zhang,T., Gao,J., Yang,F., Chen,S., Yang,A. and Wang,T. MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling J Exp Clin Cancer Res (2021) 40, 341-341. PubMed Europe PubMed DOI PMC EPMC

2020

Fiore,A., Liang,Y., Lin,Y.H., Tung,J., Wang,H., Langlais,D. and Nijnik,A. Deubiquitinase MYSM1 in the hematopoietic system and beyond: a current review Int J Mol Sci (2020) 21, 3007-3007. PubMed Europe PubMed DOI V
Li,N., Xu,Y., Yu,T., Yao,R., Chen,J., Luo,C. and Wang,J. Further delineation of bone marrow failure syndrome caused by novel compound heterozygous variants of MYSM1 Gene (2020) 757, 144938-144938. PubMed Europe PubMed DOI R
Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H. Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Tian,M., Liu,W., Zhang,Q., Huang,Y., Li,W., Wang,W., Zhao,P., Huang,S., Song,Y., Shereen,M.A., Qin,M., Liu,Y., Wu,K. and Wu,J. MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway Cell Rep (2020) 33, 108297-108297. PubMed Europe PubMed DOI

2018

Panda,S. and Gekara,N.O. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex Nat Commun (2018) 9, 4654-4654. PubMed Europe PubMed DOI PMC EPMC
Zhao,X., Huang,X.H., Dong,X.H., Wang,Y.H., Yang,H.X., Wang,Y., He,Y., Liu,S., Zhou,J., Wang,C. and Jiang,X.X. Deubiquitinase Mysm1 regulates macrophage survival and polarization Mol Biol Rep (2018) 45, 2393-2401. PubMed Europe PubMed DOI

2016

Jiang,X.X., Liu,Y., Li,H., Gao,Y., Mu,R., Guo,J., Zhang,J., Yang,Y.M., Xiao,F., Liu,B., Wang,C., Shen,B., Chen,S.Y., Li,Z. and Yang,G. MYSM1/miR-150/FLT3 inhibits B1a cell proliferation Oncotarget (2016) 7, 68086-68096. PubMed Europe PubMed DOI PMC EPMC

2015

Belle,J.I., Langlais,D., Petrov,J.C., Pardo,M., Jones,R.G., Gros,P. and Nijnik,A. p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency Blood (2015) 125, 2344-2348. PubMed Europe PubMed DOI
Jiang,X.X., Chou,Y., Jones,L., Wang,T., Sanchez,S., Huang,X.F., Zhang,L., Wang,C. and Chen,S.Y. Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1 Sci Rep (2015) 5, 13755-13755. PubMed Europe PubMed DOI PMC EPMC
Panda,S., Nilsson,J.A. and Gekara,N.O. Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes Immunity (2015) 43, 647-659. PubMed Europe PubMed DOI

2014

Won,H., Nandakumar,V., Yates,P., Sanchez,S., Jones,L., Huang,X.F. and Chen,S.Y. Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1 Blood (2014) 124, 2647-2656. PubMed Europe PubMed DOI PMC EPMC

2013

Alsultan,A., Shamseldin,H.E., Osman,M.E., Aljabri,M. and Alkuraya,F.S. MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK Blood (2013) 122, 3844-3845. PubMed Europe PubMed DOI
Nandakumar,V., Chou,Y., Zang,L., Huang,X.F. and Chen,S.Y. Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1 Proc Natl Acad Sci U S A (2013) 110, E3927-E3936. PubMed Europe PubMed DOI PMC EPMC
Wang,T., Nandakumar,V., Jiang,X.X., Jones,L., Yang,A.G., Huang,X.F. and Chen,S.Y. The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation Blood (2013) 122, 2812-2822. DOI PMC EPMC

2012

Nijnik,A., Clare,S., Hale,C., Raisen,C., McIntyre,R.E., Yusa,K., Everitt,A.R., Mottram,L., Podrini,C., Lucas,M., Estabel,J., Goulding,D., Adams,N., Ramirez-Solis,R., White,J.K., Adams,D.J., Hancock,R.E. and Dougan,G. The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation Blood (2012) 119, 1370-1379. PubMed Europe PubMed DOI

2011

Jiang,X.X., Nguyen,Q., Chou,Y., Wang,T., Nandakumar,V., Yates,P., Jones,L., Wang,L., Won,H., Lee,H.R., Jung,J.U., Müschen,M., Huang,X.F. and Chen,S.Y. Control of B cell development by the histone H2A deubiquitinase MYSM1 Immunity (2011) 35, 883-896. PubMed Europe PubMed DOI PMC EPMC

2009

Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W. Defining the human deubiquitinating enzyme interaction landscape Cell (2009) 138, 389-403. PubMed Europe PubMed DOI PMC EPMC V

2008

Pijnappel,W.W. and Timmers,H.T. Dubbing SAGA unveils new epigenetic crosstalk Mol Cell (2008) 29, 152-154. PubMed Europe PubMed DOI
Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S., Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A., Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and Devys,D. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing Mol Cell (2008) 29, 92-101. PubMed Europe PubMed DOI

2007

Yoneyama,M., Tochio,N., Umehara,T., Koshiba,S., Inoue,M., Yabuki,T., Aoki,M., Seki,E., Matsuda,T., Watanabe,S., Tomo,Y., Nishimura,Y., Harada,T., Terada,T., Shirouzu,M., Hayashizaki,Y., Ohara,O., Tanaka,A., Kigawa,T. and Yokoyama,S. Structural and functional differences of SWIRM domain subtypes J Mol Biol (2007) 369, 222-238. PubMed Europe PubMed DOI S
Zhu,P., Zhou,W., Wang,J., Puc,J., Ohgi,K.A., Erdjument-Bromage,H., Tempst,P., Glass,C.K. and Rosenfeld,M.G. A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation Mol Cell (2007) 27, 609-621. PubMed Europe PubMed DOI PMC EPMC

2001

Nagase,T., Kikuno,R. and Ohara,O. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins DNA Res (2001) 8, 179-187. PubMed Europe PubMed DOI