Literature for peptidase M67.005: histone H2A deubiquitinase MYSM1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, R Splicing, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Shi,X., Xu,J., Liu,L., Zhao,S., Qian,Y., Fang,Z., Lin,L., Zhao,X., Xie,S., Shi,F. and Han,J.
    Deubiquitinase MYSM1 drives myocardial ischemia/reperfusion injury by stabilizing STAT1 in cardiomyocytes
    Theranostics (2025) 15, 1606-1621. PubMed  Europe PubMed DOI  PMC  EPMC  K
  2. Yu,W., Ma,L., Li,R., Zhu,D., Qu,C., Han,J., Tian,Y., Tian,H. and Liang,J.
    MYSM1 promotes lung adenocarcinoma progression via TRAF2/3-mediated activation of MAPK and non-canonical NF-kappaB pathways
    NPJ Precis Oncol (2025) 9, 337-337. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Zhong,X., Xu,J., Shi,X., Lyu,Y., Qian,Y., Fang,Z., Wang,Z., Xing,J., Ye,B., Xu,J. and Han,J.
    MYSM1 Mediates Cardiac Parthanatos and Hypertrophy by Deubiquitinating PARP1
    Hypertension (2025) PubMed  Europe PubMed DOI  K
  4. 2024
  5. Luan,R., He,M., Li,H., Bai,Y., Wang,A., Sun,G., Zhou,B., Wang,M., Wang,C., Wang,S., Zeng,K., Feng,J., Lin,L., Wei,Y., Kato,S., Zhang,Q. and Zhao,Y.
    MYSM1 acts as a novel co-activator of ERalpha to confer antiestrogen resistance in breast cancer
    EMBO Mol Med (2024) 16, 10-39. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Mousa,M., Liang,Y., Tung,L.T., Wang,H., Krawczyk,C., Langlais,D. and Nijnik,A.
    Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation
    Immunology (2024) 172, 109-126. PubMed  Europe PubMed DOI
  7. Shi,X., Xu,J., Zhong,X., Qian,Y., Lin,L., Fang,Z., Ye,B., Lyu,Y., Zhang,R., Zheng,Z. and Han,J.
    Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
    Cell Commun Signal (2024) 22, 593-593. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. 2021
  9. Chen,X., Wang,W., Li,Y., Huo,Y., Zhang,H., Feng,F., Xi,W., Zhang,T., Gao,J., Yang,F., Chen,S., Yang,A. and Wang,T.
    MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
    J Exp Clin Cancer Res (2021) 40, 341-341. PubMed  Europe PubMed DOI  PMC  EPMC
  10. 2020
  11. Fiore,A., Liang,Y., Lin,Y.H., Tung,J., Wang,H., Langlais,D. and Nijnik,A.
    Deubiquitinase MYSM1 in the hematopoietic system and beyond: a current review
    Int J Mol Sci (2020) 21, 3007-3007. PubMed  Europe PubMed DOI  V
  12. Li,N., Xu,Y., Yu,T., Yao,R., Chen,J., Luo,C. and Wang,J.
    Further delineation of bone marrow failure syndrome caused by novel compound heterozygous variants of MYSM1
    Gene (2020) 757, 144938-144938. PubMed  Europe PubMed DOI  R
  13. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
    Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
  14. Tian,M., Liu,W., Zhang,Q., Huang,Y., Li,W., Wang,W., Zhao,P., Huang,S., Song,Y., Shereen,M.A., Qin,M., Liu,Y., Wu,K. and Wu,J.
    MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway
    Cell Rep (2020) 33, 108297-108297. PubMed  Europe PubMed DOI
  15. 2018
  16. Panda,S. and Gekara,N.O.
    The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
    Nat Commun (2018) 9, 4654-4654. PubMed  Europe PubMed DOI  PMC  EPMC
  17. Zhao,X., Huang,X.H., Dong,X.H., Wang,Y.H., Yang,H.X., Wang,Y., He,Y., Liu,S., Zhou,J., Wang,C. and Jiang,X.X.
    Deubiquitinase Mysm1 regulates macrophage survival and polarization
    Mol Biol Rep (2018) 45, 2393-2401. PubMed  Europe PubMed DOI
  18. 2016
  19. Jiang,X.X., Liu,Y., Li,H., Gao,Y., Mu,R., Guo,J., Zhang,J., Yang,Y.M., Xiao,F., Liu,B., Wang,C., Shen,B., Chen,S.Y., Li,Z. and Yang,G.
    MYSM1/miR-150/FLT3 inhibits B1a cell proliferation
    Oncotarget (2016) 7, 68086-68096. PubMed  Europe PubMed DOI  PMC  EPMC
  20. 2015
  21. Belle,J.I., Langlais,D., Petrov,J.C., Pardo,M., Jones,R.G., Gros,P. and Nijnik,A.
    p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency
    Blood (2015) 125, 2344-2348. PubMed  Europe PubMed DOI
  22. Jiang,X.X., Chou,Y., Jones,L., Wang,T., Sanchez,S., Huang,X.F., Zhang,L., Wang,C. and Chen,S.Y.
    Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1
    Sci Rep (2015) 5, 13755-13755. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Panda,S., Nilsson,J.A. and Gekara,N.O.
    Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes
    Immunity (2015) 43, 647-659. PubMed  Europe PubMed DOI
  24. 2014
  25. Won,H., Nandakumar,V., Yates,P., Sanchez,S., Jones,L., Huang,X.F. and Chen,S.Y.
    Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1
    Blood (2014) 124, 2647-2656. PubMed  Europe PubMed DOI  PMC  EPMC
  26. 2013
  27. Alsultan,A., Shamseldin,H.E., Osman,M.E., Aljabri,M. and Alkuraya,F.S.
    MYSM1 is mutated in a family with transient transfusion-dependent anemia, mild thrombocytopenia, and low NK
    Blood (2013) 122, 3844-3845. PubMed  Europe PubMed DOI
  28. Nandakumar,V., Chou,Y., Zang,L., Huang,X.F. and Chen,S.Y.
    Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1
    Proc Natl Acad Sci U S A (2013) 110, E3927-E3936. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Wang,T., Nandakumar,V., Jiang,X.X., Jones,L., Yang,A.G., Huang,X.F. and Chen,S.Y.
    The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation
    Blood (2013) 122, 2812-2822. DOI  PMC  EPMC
  30. 2012
  31. Nijnik,A., Clare,S., Hale,C., Raisen,C., McIntyre,R.E., Yusa,K., Everitt,A.R., Mottram,L., Podrini,C., Lucas,M., Estabel,J., Goulding,D., Adams,N., Ramirez-Solis,R., White,J.K., Adams,D.J., Hancock,R.E. and Dougan,G.
    The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation
    Blood (2012) 119, 1370-1379. PubMed  Europe PubMed DOI
  32. 2011
  33. Jiang,X.X., Nguyen,Q., Chou,Y., Wang,T., Nandakumar,V., Yates,P., Jones,L., Wang,L., Won,H., Lee,H.R., Jung,J.U., Müschen,M., Huang,X.F. and Chen,S.Y.
    Control of B cell development by the histone H2A deubiquitinase MYSM1
    Immunity (2011) 35, 883-896. PubMed  Europe PubMed DOI  PMC  EPMC
  34. 2009
  35. Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
    Defining the human deubiquitinating enzyme interaction landscape
    Cell (2009) 138, 389-403. PubMed  Europe PubMed DOI  PMC  EPMC  V
  36. 2008
  37. Pijnappel,W.W. and Timmers,H.T.
    Dubbing SAGA unveils new epigenetic crosstalk
    Mol Cell (2008) 29, 152-154. PubMed  Europe PubMed DOI
  38. Zhao,Y., Lang,G., Ito,S., Bonnet,J., Metzger,E., Sawatsubashi,S., Suzuki,E., Le Guezennec,X., Stunnenberg,H.G., Krasnov,A., Georgieva,S.G., Schule,R., Takeyama,K., Kato,S., Tora,L. and Devys,D.
    A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing
    Mol Cell (2008) 29, 92-101. PubMed  Europe PubMed DOI
  39. 2007
  40. Yoneyama,M., Tochio,N., Umehara,T., Koshiba,S., Inoue,M., Yabuki,T., Aoki,M., Seki,E., Matsuda,T., Watanabe,S., Tomo,Y., Nishimura,Y., Harada,T., Terada,T., Shirouzu,M., Hayashizaki,Y., Ohara,O., Tanaka,A., Kigawa,T. and Yokoyama,S.
    Structural and functional differences of SWIRM domain subtypes
    J Mol Biol (2007) 369, 222-238. PubMed  Europe PubMed DOI  S
  41. Zhu,P., Zhou,W., Wang,J., Puc,J., Ohgi,K.A., Erdjument-Bromage,H., Tempst,P., Glass,C.K. and Rosenfeld,M.G.
    A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation
    Mol Cell (2007) 27, 609-621. PubMed  Europe PubMed DOI  PMC  EPMC
  42. 2001
  43. Nagase,T., Kikuno,R. and Ohara,O.
    Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins
    DNA Res (2001) 8, 179-187. PubMed  Europe PubMed DOI