Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase M67.004: Brcc36 isopeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Chandler,F., Reddy,P.A.N., Bhutda,S., Ross,R.L., Datta,A., Walden,M., Walker,K., Di Donato,S., Cassel,J.A., Prakesch,M.A., Aman,A., Datti,A., Campbell,L.J., Foglizzo,M., Bell,L., Stein,D.N., Ault,J.R., Al-Awar,R.S., Calabrese,A.N., Sicheri,F., Del Galdo,F., Salvino,J.M., Greenberg,R.A. and Zeqiraj,E.<br>Molecular glues that inhibit deubiquitylase activity and inflammatory signaling<br>Nat Struct Mol Biol (2025) PubMed  Europe PubMed DOI
  2. Guo,X., Xi,L., Liu,Y., Lv,W., Li,T., Ju,A., Fan,Z., Shen,Y., Qian,Z., Wang,W., Liang,Z., Song,W., Chang,K., Ma,S., Zhang,J., Han,T., You,K., Xu,C., Wang,L., Guo,W. and Ren,W.<br>Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression<br>Adv Sci (Weinh) (2025) , e10310-e10310. PubMed  Europe PubMed DOI  K
    3. 2024
  3. Feng,X., He,S., Chen,Y. and Zhang,L.<br>Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression<br>Genes Genomics (2024) 46, 637-646. PubMed  Europe PubMed DOI  K
  4. Huang,Q., Zheng,S., Gu,H., Yang,Z., Lu,Y., Yu,X. and Guo,G.<br>The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells<br>Acta Biochim Biophys Sin (Shanghai) (2024) 56, 564-575. PubMed  Europe PubMed DOI
  5. Huang,X., Tan,J., Ji,Y., Luo,J., Zhao,Y. and Zhao,J.<br>BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome<br>CNS Neurosci Ther (2024) 30, e14697-e14697. PubMed  Europe PubMed DOI  PMC  EPMC  K
  6. Li,Y., Jiang,C., Liu,Q., Zhou,P., Tian,D., Zeng,Y. and Xiang,M.<br>USP15 facilitates the progression of bladder cancer by amplifying the activation of the NF-kappaB signaling pathway<br>Aging (Albany NY) (2024) 16, 6757-6772. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Liu,J., Isaji,T., Komatsu,S., Sun,Y., Xu,X., Fukuda,T., Fujimura,T., Takahashi,S. and Gu,J.<br>BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia<br>Cancer Sci (2024) 115, 1196-1208. PubMed  Europe PubMed DOI
  8. Wang,B., Li,M., Cao,D., Sun,Q., Yu,W., Ma,J., Ren,H., Xu,G. and Zhou,L.<br>Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon<br>Cell Mol Life Sci (2024) 81, 349-349. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Wang,H., Shu,L., Lv,C., Liu,N., Long,Y., Peng,X., Ling,H., Tao,T., Tang,J., Cheng,Y., Liu,S., Xiao,D. and Tao,Y.<br>BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis<br>Adv Sci (Weinh) (2024) 11, e2304263-e2304263. PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2023
  10. Yalcinkaya,M., Liu,W., Thomas,L.A., Olszewska,M., Xiao,T., Abramowicz,S., Papapetrou,E.P., Westerterp,M., Wang,N., Tabas,I. and Tall,A.R.<br>BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis<br>Circulation (2023) 148, 1764-1777. PubMed  Europe PubMed DOI  I
  11. Zhang,W., Liu,K., Ren,G.M., Wang,Y., Wang,T., Liu,X., Li,D.X., Xiao,Y., Chen,X., Li,Y.T., Zhan,Y.Q., Xiang,S.S., Chen,H., Gao,H.Y., Zhao,K., Yu,M., Ge,C.H., Li,C.Y., Ge,Z.Q., Yang,X.M. and Yin,R.H.<br>BRISC is required for optimal activation of NF-kappaB in Kupffer cells induced by LPS and contributes to acute liver injury<br>Cell Death Dis (2023) 14, 743-743. PubMed  Europe PubMed DOI  PMC  EPMC
    12. 2022
  12. Jiang,Q., Foglizzo,M., Morozov,Y.I., Yang,X., Datta,A., Tian,L., Thada,V., Li,W., Zeqiraj,E. and Greenberg,R.A.<br>Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition<br>J Cell Biol (2022) 221 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Li,Q., Ma,Y., Chang,F., Xu,Y., Deng,J., Duan,J., Jiang,W., He,Q., Xu,L., Zhong,L., Shao,G. and Li,L.<br>The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis<br>Commun Biol (2022) 5, 1335-1335. PubMed  Europe PubMed DOI  PMC  EPMC
  14. Liu,D., Jin,S. and Cui,J.<br>The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D<br>Autophagy (2022) 18, 2001-2002. PubMed  Europe PubMed DOI
  15. Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.<br>TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation<br>Proc Natl Acad Sci U S A (2022) 119, e2113454119-e2113454119. PubMed  Europe PubMed DOI  PMC  EPMC
  16. Liu,D., Zhao,Z., She,Y., Zhang,L., Chen,X., Ma,L. and Cui,J.<br>TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation<br>Proc Natl Acad Sci U S A (2022) 119 PubMed  Europe PubMed DOI  PMC  EPMC
  17. Pan,X., Wu,S., Wei,W., Chen,Z., Wu,Y. and Gong,K.<br>Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease<br>Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Zhang,C.H., Qin,K., Tian,S.L., Han,Y., Xu,S.Y. and Shao,X.Y.<br>Identification and Verification of the Ability of Cdk5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro<br>Bull Exp Biol Med (2022) 172, 701-708. PubMed  Europe PubMed DOI
    19. 2021
  19. Huang,X., Gan,H., Tan,J., Wang,T., Zhao,J. and Zhao,Y.<br>BRCC3 promotes activation of the NLRP6 inflammasome following cerebral ischemia/reperfusion (I/R) injury in rats<br>Neurosci Lett (2021) 756, 135954-135954. PubMed  Europe PubMed DOI  K
  20. Ren,G.M., Li,J., Zhang,X.C., Wang,Y., Xiao,Y., Zhang,X.Y., Liu,X., Zhang,W., Ma,W.B., Zhang,J., Li,Y.T., Tao,S.S., Wang,T., Liu,K., Chen,H., Zhan,Y.Q., Yu,M., Li,C.Y., Ge,C.H., Tian,B.X., Dou,G.F., Yang,X.M. and Yin,R.H.<br>Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases<br>Sci Immunol (2021) 6 PubMed  Europe PubMed DOI  I
  21. Zhang,L., Huang,F., Liu,J., Xu,Y., Miao,Y., Yuan,Y., Chen,X., Zhang,H.G., Wang,J., Zheng,H. and Zuo,Y.<br>HSV-1-encoded ICP0 degrades the host deubiquitinase BRCC36 to antagonize interferon antiviral response<br>Mol Immunol (2021) 135, 28-35. PubMed  Europe PubMed DOI
  22. Zhang,W., Tao,S.S., Wang,T., Zhang,J., Liu,X., Li,Y.T., Chen,H., Zhan,Y.Q., Yu,M., Ge,C.H., Li,C.Y., Ren,G.M., Yang,X.M. and Yin,R.H.<br>ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2<br>FEBS Lett (2021) 595, 169-182. PubMed  Europe PubMed DOI
  23. Zhou,L., Liu,T., Huang,B., Luo,M., Chen,Z., Zhao,Z., Wang,J., Leung,D., Yang,X., Chan,K.W., Liu,Y., Xiong,L., Chen,P., Wang,H., Ye,L., Liang,H., Masters,S.L., Lew,A.M., Gong,S., Bai,F., Yang,J., Pui-Wah,L.e., Yang,W., Zhang,Y., Lau,Y.L., Geng,L., Zhang,Y. and Cui,J.<br>Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development<br>J Allergy Clin Immunol (2021) 147, 267-279. PubMed  Europe PubMed DOI
    24. 2020
  24. Cheng,Q., Feng,Q., Xu,Y., Zuo,Y., Liu,J., Yuan,Y., Miao,Y., Liu,Y., Lei,L., Guo,T., Zhang,L., Wu,D. and Zheng,H.<br>BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability<br>Eur J Immunol (2020) PubMed  Europe PubMed DOI
  25. Cheng,X., Xu,S., Zhang,C., Qin,K., Yan,J. and Shao,X.<br>The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models<br>Biochem Biophys Res Commun (2020) 522, 647-654. PubMed  Europe PubMed DOI
  26. Meyer,T., Jahn,N., Lindner,S., Röhner,L., Dolnik,A., Weber,D., Scheffold,A., Köpff,S., Paschka,P., Gaidzik,V.I., Heckl,D., Wiese,S., Ebert,B.L., Döhner,H., Bullinger,L., Döhner,K. and Krönke,J.<br>Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1)<br>Leukemia (2020) 34, 404-415. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Rabl,J.<br>BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling<br>Biomolecules (2020) 10, 1503-1503. PubMed  Europe PubMed DOI  PMC  EPMC
  28. Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.<br>Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation<br>Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC  V
    29. 2019
  29. Cai,L., Huo,Z., Yang,H., He,F., Cao,Z., Wu,F., Liu,L. and Sun,B.<br>Gene co-expression network analysis identifies BRCC3 as a key regulator in osteogenic differentiation of osteoblasts through a ß-catenin signaling dependent pathway<br>Iran J Basic Med Sci (2019) 22, 173-178. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Donaghy,R., Han,X., Rozenova,K., Lv,K., Jiang,Q., Doepner,M., Greenberg,R.A. and Tong,W.<br>The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination<br>Blood (2019) 133, 1560-1571. PubMed  Europe PubMed DOI  PMC  EPMC
  31. Rabl,J., Bunker,R.D., Schenk,A.D., Cavadini,S., Gill,M.E., Abdulrahman,W., Andrés-Pons,A., Luijsterburg,M.S., Ibrahim,A.F., Branigan,E., Aguirre,J.D., Marceau,A.H., Guérillon,C., Bouwmeester,T., Hassiepen,U., Peters,A.H., Renatus,M., Gelman,L., Rubin,S.M., Mailand,N., van,A.t., Hay,R.T. and Thomä,N.H.<br>Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation<br>Mol Cell (2019) 75, 483-497. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Rao,Z., Chen,X., Wu,J., Xiao,M., Zhang,J., Wang,B., Fang,L., Zhang,H., Wang,X., Yang,S. and Chen,Y.<br>Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination<br>Front Immunol (2019) 10, 2783-2783. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Ren,G., Zhang,X., Xiao,Y., Zhang,W., Wang,Y., Ma,W., Wang,X., Song,P., Lai,L., Chen,H., Zhan,Y., Zhang,J., Yu,M., Ge,C., Li,C., Yin,R. and Yang,X.<br>ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination<br>EMBO J (2019) 38, e100376-e100376. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Singh,M., Kumari,B. and Yadav,U.C.S.<br>Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36<br>Inflamm Res (2019) 68, 999-1010. PubMed  Europe PubMed DOI
  35. Walden,M., Tian,L., Ross,R.L., Sykora,U.M., Byrne,D.P., Hesketh,E.L., Masandi,S.K., Cassel,J., George,R., Ault,J.R., El,O.u., Pawlowski,K., Salvino,J.M., Eyers,P.A., Ranson,N.A., Del,G.a., Greenberg,R.A. and Zeqiraj,E.<br>Metabolic control of BRISC-SHMT2 assembly regulates immune signalling<br>Nature (2019) 570, 194-199. PubMed  Europe PubMed DOI  PMC  EPMC
  36. Wang,C.Y., Deneen,B. and Tzeng,S.F.<br>BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte differentiation by dynamically regulating lysine 63-linked ubiquitination<br>Glia (2019) 67, 1775-1792. PubMed  Europe PubMed DOI
    37. 2018
  37. Liu,Q., Wu,Y., Qin,Y., Hu,J., Xie,W., Qin,F.X. and Cui,J.<br>Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses<br>Sci Adv (2018) 4, eaar2824-eaar2824. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Xu,M., Moresco,J.J., Chang,M., Mukim,A., Smith,D., Diedrich,J.K., Yates JR 3rd and Jones,K.A.<br>SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy<br>PLoS Pathog (2018) 14, e1007071-e1007071. PubMed  Europe PubMed DOI
  39. Zhang,F. and Zhou,Q.<br>Knockdown of BRCC3 exerts an anti-tumor effect on cervical cancer in vitro<br>Mol Med Rep (2018) 18, 4886-4894. PubMed  Europe PubMed DOI  PMC  EPMC
    40. 2017
  40. Chi,W., Hua,X., Chen,X., Bian,F., Yuan,X., Zhang,L., Wang,X., Chen,D., Deng,R., Li,Z., Liu,Y., De Paiva,C.S., Pflugfelder,S.C. and Li,D.Q.<br>Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye<br>J Autoimmun (2017) 80, 65-76. PubMed  Europe PubMed DOI
  41. Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A.<br>Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases<br>Nat Chem Biol (2017) 13, 709-714. PubMed  Europe PubMed DOI  I
  42. Tripathi,E. and Smith,S.<br>Cell cycle-regulated ubiquitination of tankyrase 1 by RNF8 and ABRO1/BRCC36 controls the timing of sister telomere resolution<br>EMBO J (2017) 36, 503-519. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2016
  43. Ng,H.M., Wei,L., Lan,L. and Huen,M.S.<br>The Lys63-deubiquitylating enzyme BRCC36 limits DNA break processing and repair<br>J Biol Chem (2016) 291, 16197-16207. PubMed  Europe PubMed DOI
  44. Sun,Z.Z., Zhang,T., Ning,K., Zhu,R., Liu,F., Tang,S.C., Jiang,B. and Hua,D.<br>B7-H3 upregulates BRCC3 expression, antagonizing DNA damage caused by 5-Fu<br>Oncol Rep (2016) 36, 231-238. PubMed  Europe PubMed DOI
    45. 2015
  45. Huang,D., Nagata,Y., Grossmann,V., Radivoyevitch,T., Okuno,Y., Nagae,G., Hosono,N., Schnittger,S., Sanada,M., Przychodzen,B., Kon,A., Polprasert,C., Shen,W., Clemente,M.J., Phillips,J.G., Alpermann,T., Yoshida,K., Nadarajah,N., Sekeres,M.A., Oakley,K., Nguyen,N., Shiraishi,Y., Shiozawa,Y., Chiba,K., Tanaka,H., Koeffler,H.P., Klein,H.U., Dugas,M., Aburatani,H., Miyano,S., Haferlach,C., Kern,W., Haferlach,T., Du,Y., Ogawa,S. and Makishima,H.<br>BRCC3 mutations in myeloid neoplasms<br>Haematologica (2015) 100, 1051-1057. PubMed  Europe PubMed DOI  PMC  EPMC
  46. Tu,Z., Xu,B., Qu,C., Tao,Y., Chen,C., Hua,W., Feng,G., Chang,H., Liu,Z., Li,G., Jiang,C., Yi,W., Zeng,M. and Xia,Y.<br>BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro<br>Radiat Oncol (2015) 10, 123-123. PubMed  Europe PubMed DOI  PMC  EPMC
  47. Yan,K., Li,L., Wang,X., Hong,R., Zhang,Y., Yang,H., Lin,M., Zhang,S., He,Q., Zheng,D., Tang,J., Yin,Y. and Shao,G.<br>The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells<br>J Cell Biol (2015) 210, 209-224. PubMed  Europe PubMed DOI  PMC  EPMC
  48. Zeqiraj,E., Tian,L., Piggott,C.A., Pillon,M.C., Duffy,N.M., Ceccarelli,D.F., Keszei,A.F., Lorenzen,K., Kurinov,I., Orlicky,S., Gish,G.D., Heck,A.J., Guarne,A., Greenberg,R.A. and Sicheri,F.<br>Higher-order assembly of BRCC36-KIAA0157 is required for DUB activity and biological function<br>Mol Cell (2015) 59, 970-983. PubMed  Europe PubMed DOI  PMC  EPMC  S
    49. 2014
  49. Chai,K.M., Wang,C.Y., Liaw,H.J., Fang,K.M., Yang,C.S. and Tzeng,S.F.<br>Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide<br>Oncotarget (2014) 5, 10901-10915. PubMed  Europe PubMed DOI  PMC  EPMC
  50. Janczar,S., Fogtman,A., Koblowska,M., Baranska,D., Pastorczak,A., Wegner,O., Kostrzewska,M., Laguna,P., Borowiec,M. and Mlynarski,W.<br>Novel severe hemophilia A and moyamoya (SHAM) syndrome caused by Xq28 deletions encompassing F8 and BRCC3 genes<br>Blood (2014) 123, 4002-4004. PubMed  Europe PubMed DOI
    51. 2013
  51. Okamoto,K., Bartocci,C., Ouzounov,I., Diedrich,J.K., Yates,J.R., III and Denchi,E.L.<br>A two-step mechanism for TRF2-mediated chromosome-end protection<br>Nature (2013) 494, 502-505. PubMed  Europe PubMed DOI
  52. [YEAR:24-1-2013]Py,B.F., Kim,M.S., Vakifahmetoglu-Norberg,H. and Yuan,J.<br>Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity<br>Mol Cell (24-1-2013) 49, 331-338. PubMed  Europe PubMed
  53. Zheng,H., Gupta,V., Patterson-Fortin,J., Bhattacharya,S., Katlinski,K., Wu,J., Varghese,B., Carbone,C.J., Aressy,B., Fuchs,S.Y. and Greenberg,R.A.<br>A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses<br>Cell Rep (2013) 5, 180-193. DOI  PMC  EPMC
    54. 2012
  54. [YEAR:19-10-2012]Juliana,C., Fernandes-Alnemri,T., Kang,S., Farias,A., Qin,F. and Alnemri,E.S.<br>Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation<br>J Biol Chem (19-10-2012) 287, 36617-36622. PubMed  Europe PubMed
    55. 2011
  55. Cilenti,L., Balakrishnan,M.P., Wang,X.L., Ambivero,C., Sterlicchi,M., Del Monte,F., Ma,X.L. and Zervos,A.S.<br>Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination<br>J Mol Cell Cardiol (2011) 50, 652-661. PubMed  Europe PubMed DOI
  56. Coleman,K.A. and Greenberg,R.A.<br>The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection<br>J Biol Chem (2011) 286, 13669-13680. PubMed  Europe PubMed DOI  PMC  EPMC
  57. Hu,X., Kim,J.A., Castillo,A., Huang,M., Liu,J. and Wang,B.<br>NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes<br>J Biol Chem (2011) 286, 11734-11745. PubMed  Europe PubMed DOI  PMC  EPMC
  58. Miskinyte,S., Butler,M.G., Hervé,D., Sarret,C., Nicolino,M., Petralia,J.D., Bergametti,F., Arnould,M., Pham,V.N., Gore,A.V., Spengos,K., Gazal,S., Woimant,F., Steinberg,G.K., Weinstein,B.M. and Tournier-Lasserve,E.<br>Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya<br>Am J Hum Genet (2011) 88, 718-728. PubMed  Europe PubMed DOI  PMC  EPMC
    59. 2010
  59. Cooper,E.M., Boeke,J.D. and Cohen,R.E.<br>Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin<br>J Biol Chem (2010) 285, 10344-10352. PubMed  Europe PubMed DOI
  60. [YEAR:1-10-2010]Feng,L., Wang,J. and Chen,J.<br>The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments<br>J Biol Chem (1-10-2010) 285, 30982-30988. PubMed  Europe PubMed
  61. Patterson-Fortin,J., Shao,G., Bretscher,H., Messick,T.E. and Greenberg,R.A.<br>Differential regulation of JAMM domain deubiquitinating enzyme activity within the rap80 complex<br>J Biol Chem (2010) 285, 30971-30981. PubMed  Europe PubMed DOI
    62. 2009
  62. Cooper,E.M., Cutcliffe,C., Kristiansen,T.Z., Pandey,A., Pickart,C.M. and Cohen,R.E.<br>K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1<br>EMBO J (2009) 28, 621-631. PubMed  Europe PubMed DOI  PMC  EPMC
  63. Shao,G., Lilli,D.R., Patterson-Fortin,J., Coleman,K.A., Morrissey,D.E. and Greenberg,R.A.<br>The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks<br>Proc Natl Acad Sci U S A (2009) 106, 3166-3171. PubMed  Europe PubMed DOI  PMC  EPMC
  64. Shao,G., Patterson-Fortin,J., Messick,T.E., Feng,D., Shanbhag,N., Wang,Y. and Greenberg,R.A.<br>MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks<br>Genes Dev (2009) 23, 740-754. PubMed  Europe PubMed DOI  PMC  EPMC
    65. 2007
  65. Boudreau,H.E., Broustas,C.G., Gokhale,P.C., Kumar,D., Mewani,R.R., Rone,J.D., Haddad,B.R. and Kasid,U.<br>Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation<br>Int J Mol Med (2007) 19, 29-39. PubMed  Europe PubMed
  66. Wang,B. and Elledge,S.J.<br>Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage<br>Proc Natl Acad Sci U S A (2007) 104, 20759-20763. PubMed  Europe PubMed DOI  PMC  EPMC
    67. 2006
  67. Chen,X., Arciero,C.A., Wang,C., Broccoli,D. and Godwin,A.K.<br>BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation<br>Cancer Res (2006) 66, 5039-5046. PubMed  Europe PubMed DOI
    68. 2003
  68. Dong,Y., Hakimi,M.A., Chen,X., Kumaraswamy,E., Cooch,N.S., Godwin,A.K. and Shiekhattar,R.<br>Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair<br>Mol Cell (2003) 12, 1087-1099. DOI
    69. 1992
  69. Kenwrick,S., Levinson,B., Taylor,S., Shapiro,A. and Gitschier,J.<br>Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene<br>Hum Mol Genet (1992) 1, 179-186. PubMed  Europe PubMed DOI

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use