Literature for peptidase M67.001: PSMD14 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, I Inhibitor, K Knockout, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U., Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M., Richter,M., Schneider,A., Meiners,S., Gaute,M. and Braun,T. The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes Sci Adv (2025) 11, eado3852-eado3852. PubMed Europe PubMed DOI PMC EPMC
Gao,J., Nardone,C., Yip,M.C.J., Chino,H., Gu,X., Mirman,Z., Rale,M.J., Paulo,J.A., Elledge,S.J. and Shao,S. Structure of the TXNL1-bound proteasome Nat Struct Mol Biol (2025) PubMed Europe PubMed DOI
Lu,J., Wu,H., Zhan,P., Lu,Y., Fang,Q., Luo,C., Wang,F., Wen,J., Xie,C. and Yin,Z. PSMD14-mediated deubiquitination of CARM1 facilitates the proliferation and metastasis of hepatocellular carcinoma by inducing the transcriptional activation of FERMT1 Cell Death Dis (2025) 16, 141-141. PubMed Europe PubMed DOI PMC EPMC
Lu,R.S., Ren,L.K., Fei,X.B., Liu,S.B., Gao,Y.J., Hou,J.Y., Wang,C., Liu,P., Zhu,C.H., Wang,X. and Pan,Y.Z. PSMD14-Mediated LDHA Deubiquitination Upregulates ACLY Expression via H3K18 Lactylation to Promote Lipid Synthesis and Pancreatic Cancer Progression Adv Sci (Weinh) (2025) , e05762-e05762. PubMed Europe PubMed DOI
Peddada,N., Zhong,X., Yin,Y., Lazaro,D.R., Wang,J., Lyon,S., Choi,J.H., Bai,X.C., Moresco,E.M.Y. and Beutler,B. Structural insights into the ubiquitin-independent midnolin-proteasome pathway Proc Natl Acad Sci U S A (2025) 122, e2505345122-e2505345122. PubMed Europe PubMed DOI

2024

Arkinson,C., Gee,C.L., Zhang,Z., Dong,K.C. and Martin,A. Structural landscape of AAA+ ATPase motor states in the substrate-degrading human 26S proteasome reveals conformation-specific binding of TXNL1 bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Guo,X., Mutch,M., Torres,A.Y., Nano,M., Rauth,N., Harwood,J., McDonald,D., Chen,Z., Montell,C., Dai,W. and Montell,D.J. The Zn(2+) transporter ZIP7 enhances endoplasmic-reticulum-associated protein degradation and prevents neurodegeneration in Drosophila Dev Cell (2024) 59, 1655-1667. PubMed Europe PubMed DOI
Htet,Z.M., Dong,K.C. and Martin,A. The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Lai,J., Kong,W., Fu,Q., Jiang,Z., Sun,B., Ye,X., Kong,J., Wei,S. and Jiang,L. PSMD14 is a novel prognostic marker and therapeutic target in osteosarcoma Diagn Pathol (2024) 19, 79-79. PubMed Europe PubMed DOI PMC EPMC K
Yang,P., Yang,X., Wang,D., Yang,H., Li,Z., Zhang,C., Zhang,S., Zhu,J., Li,X., Su,P. and Zhuang,T. PSMD14 stabilizes estrogen signaling and facilitates breast cancer progression via deubiquitinating ERalpha Oncogene (2024) 43, 248-264. PubMed Europe PubMed DOI PMC EPMC K
Yuan,Y., Li,Y., Wu,X., Bo,J., Zhang,L., Zhang,J., Hu,Y., Chen,Y., Zeng,Y., Wei,X. and Zhang,H. POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis Cancer Lett (2024) 582, 216526-216526. PubMed Europe PubMed DOI
Zhou,B., Luo,Y., Bi,H., Zhang,N., Ma,M., Dong,Z., Ji,N., Zhang,S., Wang,X., Liu,Y., Guo,X., Wei,W., Xie,C., Wu,L., Wan,X., Zheng,M.H., Zhao,B., Li,Y., Hu,C. and Lu,Y. Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11 Cell Metab (2024) 36, 2228-2244. PubMed Europe PubMed DOI

2023

Bustamante,H.A., Albornoz,N., Morselli,E., Soza,A. and Burgos,P.V. Novel insights into the non-canonical roles of PSMD14/POH1/Rpn11 in proteostasis and in the modulation of cancer progression Cell Signal (2023) 101, 110490-110490. PubMed Europe PubMed DOI
Guo,X., Mutch,M., Torres,A.Y., Nano,M., McDonald,D., Chen,Z., Montell,C., Dai,W. and Montell,D.J. Rescue of proteotoxic stress and neurodegeneration by the Zn (2+) transporter ZIP7 bioRxiv (2023) PubMed Europe PubMed DOI PMC EPMC
Jing,T., Xu,X., Wu,C., Wei,D., Yuan,L., Huang,Y., Liu,Y. and Wang,B. POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target Cancer Lett (2023) 577, 216444-216444. PubMed Europe PubMed DOI
Liu,Z., Wang,X., Li,C. and Zhao,R. The function and mechanism of PSMD14 in promoting progression and resistance to anlotinib in osteosarcoma Cancer Cell Int (2023) 23, 309-309. PubMed Europe PubMed DOI PMC EPMC K
Xie,G., Dong,K.C., Worden,E.J. and Martin,A. High-Throughput Assay for Characterizing Rpn11 Deubiquitinase Activity Methods Mol Biol (2023) 2591, 79-100. PubMed Europe PubMed DOI
Xiong,Y.M., Zhou,F., Zhou,J.W., Liu,F., Zhou,S.Q., Li,B., Liu,Z.J. and Qin,Y. Aberrant Expressions of PSMD14 in Tumor Tissue are the Potential Prognostic Biomarkers for Hepatocellular Carcinoma after Curative Resection Curr Genomics (2023) 24, 368-384. PubMed Europe PubMed DOI PMC EPMC
Zhao,Z., Xu,H., Wei,Y., Sun,L. and Song,Y. Deubiquitylase PSMD14 inhibits autophagy to promote ovarian cancer progression via stabilization of LRPPRC Biochim Biophys Acta Mol Basis Dis (2023) 1869, 166594-166594. PubMed Europe PubMed DOI K

2022

Li,J., Li,Y., Xu,F., Sun,B., Yang,L. and Wang,H. Deubiquitinating enzyme PSMD14 facilitates gastric carcinogenesis through stabilizing PTBP1 Exp Cell Res (2022) 415, 113148-113148. PubMed Europe PubMed DOI K
Luu,A.K., Cadieux,M., Wong,M., Macdonald,R., Jones,R., Choi,D., Oblak,M., Brisson,B., Sauer,S., Chafitz,J., Warshawsky,D., Wood,G.A. and Viloria-Petit,A.M. Proteomic Assessment of Extracellular Vesicles from Canine Tissue Explants as a Pipeline to Identify Molecular Targets in Osteosarcoma: PSMD14/Rpn11 as a Proof of Principle Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC I
Schnoell,J., Scheiflinger,A., Al-Gboore,S., Kadletz-Wanke,L., Kenner,L., Heiduschka,G. and Jank,B.J. The prognostic role of PSMD14 in head and neck squamous cell carcinoma J Cancer Res Clin Oncol (2022) PubMed Europe PubMed DOI
Spataro,V. and Buetti-Dinh,A. POH1/Rpn11/PSMD14: a journey from basic research in fission yeast to a prognostic marker and a druggable target in cancer cells Br J Cancer (2022) PubMed Europe PubMed DOI I
Yuan,Z., Hu,B., Xiao,H., Tan,X., Li,Y., Tang,K., Zhang,Y., Cai,K. and Ding,B. The E3 Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release MBio (2022) , e0316821-e0316821. PubMed Europe PubMed DOI PMC EPMC

2021

Barban do Patrocinio,A., Cabral,F.J., de Paiva,T.H., Magalhaes,L.G., Paula,L.A.L., Brigato,O.M., Guerra-Sa,R. and Rodrigues,V. Deubiquitinating enzymes as possible drug targets for schistosomiasis Acta Trop (2021) 217, 105856-105856. PubMed Europe PubMed DOI I
Molho,M., Lin,W. and Nagy,P.D. A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication PLoS Pathog (2021) 17, e1009680-e1009680. PubMed Europe PubMed DOI PMC EPMC K
Moon,S., Muniyappan,S., Lee,S.B. and Lee,B.H. Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases Int J Mol Sci (2021) 22, 6213-6213. PubMed Europe PubMed DOI PMC EPMC I

2020

Bustamante,H.A., Cereceda,K., Gonzalez,A.E., Valenzuela,G.E., Cheuquemilla,Y., Hernandez,S., Arias-Munoz,E., Cerda-Troncoso,C., Bandau,S., Soza,A., Kausel,G., Kerr,B., Mardones,G.A., Cancino,J., Hay,R.T., Rojas-Fernandez,A. and Burgos,P.V. The proteasomal deubiquitinating enzyme PSMD14 regulates macroautophagy by controlling golgi-to-er retrograde transport Cells (2020) 9 PubMed Europe PubMed DOI
Chen,X., Dorris,Z., Shi,D., Huang,R.K., Khant,H., Fox,T., de Val,N., Williams,D., Zhang,P. and Walters,K.J. Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome Structure (2020) 28, 1206-1217. PubMed Europe PubMed DOI
Lv,J., Zhang,S., Wu,H., Lu,J., Lu,Y., Wang,F., Zhao,W., Zhan,P., Lu,J., Fang,Q., Xie,C. and Yin,Z. Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2 Cancer Lett (2020) 469, 22-34. PubMed Europe PubMed DOI
Shin,J.Y., Muniyappan,S., Tran,N.N., Park,H., Lee,S.B. and Lee,B.H. Deubiquitination Reactions on the Proteasome for Proteasome Versatility Int J Mol Sci (2020) 21, 5312-5312. PubMed Europe PubMed DOI
Yang,H.J., Asakawa,H., Ohtsuki,C., Haraguchi,T. and Hiraoka,Y. Transient Breakage of the Nucleocytoplasmic Barrier Controls Spore Maturation via Mobilizing the Proteasome Subunit Rpn11 in the Fission Yeast Schizosaccharomyces pombe J Fungi (Basel) (2020) 6, 242-242. PubMed Europe PubMed DOI
Yokoyama,S., Iwakami,Y., Hang,Z., Kin,R., Zhou,Y., Yasuta,Y., Takahashi,A., Hayakawa,Y. and Sakurai,H. Targeting PSMD14 inhibits melanoma growth through SMAD3 stabilization Sci Rep (2020) 10, 19214-19214. PubMed Europe PubMed DOI PMC EPMC K
Zhang,L., Xu,H., Ma,C., Zhang,J., Zhao,Y., Yang,X., Wang,S. and Li,D. Upregulation of deubiquitinase c in lung adenocarcinoma (LUAD) and its prognostic significance J Cancer (2020) 11, 2962-2971. PubMed Europe PubMed DOI PMC EPMC

2019

Bramasole,L., Sinha,A., Harshuk,D., Cirigliano,A., Gurevich,S., Yu,Z., Carmeli,R.L., Glickman,M.H., Rinaldi,T. and Pick,E. The proteasome lid triggers COP9 signalosome activity during the transition of Sachharomyces cerevisiae cells into quiescence Biomolecules (2019) 9, 449-449. PubMed Europe PubMed DOI M
Hameed,D.S., Sapmaz,A., Burggraaff,L., Amore,A., Slingerland,C.J., van Westen,G.J.P. and Ovaa,H. Development of ubiquitin-based probe for metalloprotease deubiquitinases Angew Chem Int Ed Engl (2019) 58, 14477-14482. PubMed Europe PubMed DOI
Seo,D., Jung,S.M., Park,J.S., Lee,J., Ha,J., Kim,M. and Park,S.H. The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway EBioMedicine (2019) 49, 55-71. PubMed Europe PubMed DOI
Wang,B., Xu,X., Yang,Z., Zhang,L., Liu,Y., Ma,A., Xu,G., Tang,M., Jing,T., Wu,L. and Liu,Y. POH1 contributes to hyperactivation of TGF-beta signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-beta receptors and caveolin-1 EBioMedicine (2019) 41, 320-332. PubMed Europe PubMed DOI
Zhi,T., Jiang,K., Xu,X., Yu,T., Zhou,F., Wang,Y., Liu,N. and Zhang,J. ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1 Neuro Oncol (2019) 21, 462-473. PubMed Europe PubMed DOI

2018

Kolog Gulko,M., Heinrich,G., Gross,C., Popova,B., Valerius,O., Neumann,P., Ficner,R. and Braus,G.H. Sem1 links proteasome stability and specificity to multicellular development PLoS Genet (2018) 14, e1007141-e1007141. PubMed Europe PubMed DOI
Kumar,V., Naumann,M. and Stein,M. Computational Studies on the Inhibitor Selectivity of Human JAMM Deubiquitinylases Rpn11 and CSN5 Front Chem (2018) 6, 480-480. PubMed Europe PubMed DOI PMC EPMC I
Li,J., Zhang,Y., Da Silva Sil Dos Santos,B., Wang,F., Ma,Y., Perez,C., Yang,Y., Peng,J., Cohen,S.M., Chou,T.F., Hilton,S.T. and Deshaies,R.J. Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11 Cell Chem Biol (2018) 25, 1350-1358. PubMed Europe PubMed DOI I
Zhang,L., Liu,Y., Wang,B., Xu,G., Yang,Z., Tang,M., Ma,A., Jing,T., Xu,X., Zhang,X. and Liu,Y. POH1 deubiquitinates pro-interleukin-1beta and restricts inflammasome activity Nat Commun (2018) 9, 4225-4225. PubMed Europe PubMed DOI PMC EPMC

2017

Cohen,S.M. A bioinorganic approach to fragment-based drug discovery targeting metalloenzymes Acc Chem Res (2017) 50, 2007-2016. PubMed Europe PubMed DOI I
De Poot,S.A.H., Tian,G. and Finley,D. Meddling with fate: the proteasomal deubiquitinating enzymes J Mol Biol (2017) 429, 3525-3545. PubMed Europe PubMed DOI
Lauinger,L., Li,J., Shostak,A., Cemel,I.A., Ha,N., Zhang,Y., Merkl,P.E., Obermeyer,S., Stankovic-Valentin,N., Schafmeier,T., Wever,W.J., Bowers,A.A., Carter,K.P., Palmer,A.E., Tschochner,H., Melchior,F., Deshaies,R.J., Brunner,M. and Diernfellner,A. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases Nat Chem Biol (2017) 13, 709-714. PubMed Europe PubMed DOI I
Li,J., Yakushi,T., Parlati,F., Mackinnon,A.L., Perez,C., Ma,Y., Carter,K.P., Colayco,S., Magnuson,G., Brown,B., Nguyen,K., Vasile,S., Suyama,E., Smith,L.H., Sergienko,E., Pinkerton,A.B., Chung,T.D.Y., Palmer,A.E., Pass,I., Hess,S., Cohen,S.M. and Deshaies,R.J. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 Nat Chem Biol (2017) 13, 486-493. PubMed Europe PubMed DOI I
Perez,C., Li,J., Parlati,F., Rouffet,M., Ma,Y., Mackinnon,A.L., Chou,T.F., Deshaies,R.J. and Cohen,S.M. Discovery of an inhibitor of the proteasome subunit Rpn11 J Med Chem (2017) 60, 1343-1361. PubMed Europe PubMed DOI I
Song,Y., Li,S., Ray,A., Das,D.S., Qi,J., Samur,M.K., Tai,Y.T., Munshi,N., Carrasco,R.D., Chauhan,D. and Anderson,K.C. Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance Oncogene (2017) 36, 5631-5638. PubMed Europe PubMed DOI I
Worden,E.J., Dong,K.C. and Martin,A. An AAA motor-driven mechanical switch in Rpn11 controls deubiquitination at the 26S proteasome Mol Cell (2017) 67, 799-811. PubMed Europe PubMed DOI S

2016

Dambacher,C.M., Worden,E.J., Herzik,M.A., Martin,A. and Lander,G.C. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition elife (2016) 5, e13027-e13027. PubMed Europe PubMed DOI S
Ronau,J.A., Beckmann,J.F. and Hochstrasser,M. Substrate specificity of the ubiquitin and Ubl proteases Cell Res (2016) 26, 441-456. PubMed Europe PubMed DOI

2015

Mansour,W., Nakasone,M.A., von Delbruck,M., Yu,Z., Krutauz,D., Reis,N., Kleifeld,O., Sommer,T., Fushman,D. and Glickman,M.H. Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6 J Biol Chem (2015) 290, 4688-4704. PubMed Europe PubMed DOI
Prasanth,K.R., Barajas,D. and Nagy,P.D. The proteasomal Rpn11 metalloprotease suppresses tombusvirus RNA recombination and promotes viral replication via facilitating assembly of the viral replicase complex J Virol (2015) 89, 2750-2763. PubMed Europe PubMed DOI

2014

Birol,M. and Echalier,A. Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins Curr Protein Pept Sci (2014) 15, 504-517. PubMed Europe PubMed DOI
Kulichkova,V.A., Zaykova,Y.Y., Ermolaeva,Y.B., Vinogradova,E.V., Huang,L., Tomilin,A.N., Barlev,N.A. and Tsimokha,A.S. Creation of a HEK293 cell line stably expressing the proteasome subunit PSMD14 fused with fluorescent protein EGFP and HTBT tag Cell Tissue Biol (2014) 8, 330-336. DOI E
Pathare,G.R., Nagy,I., Sledz,P., Anderson,D.J., Zhou,H.J., Pardon,E., Steyaert,J., Forster,F., Bracher,A. and Baumeister,W. Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11 Proc Natl Acad Sci U S A (2014) 111, 2984-2989. PubMed Europe PubMed DOI S
Pick,E. and Bramasole,L. Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN Biochem Soc Trans (2014) 42, 1786-1791. PubMed Europe PubMed DOI
Wauer,T. and Komander,D. The JAMM in the proteasome Nat Struct Mol Biol (2014) 21, 346-348. PubMed Europe PubMed DOI
Worden,E.J., Padovani,C. and Martin,A. Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation Nat Struct Mol Biol (2014) 21, 220-227. PubMed Europe PubMed DOI S

2013

Matyskiela,M.E., Lander,G.C. and Martin,A. Conformational switching of the 26S proteasome enables substrate degradation Nat Struct Mol Biol (2013) 20, 781-788. PubMed Europe PubMed DOI S

2012

Butler,L.R., Densham,R.M., Jia,J., Garvin,A.J., Stone,H.R., Shah,V., Weekes,D., Festy,F., Beesley,J. and Morris,J.R. The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response EMBO J (2012) 31, 3918-3934. PubMed Europe PubMed DOI
Livnat-Levanon,N., Glaser,F. and Glickman,M.H. Poh1 peptidase [ISSN:978-0-12-407743-0] (2012) 3, 1560-1566. DOI

2011

Lee,M.J., Lee,B.H., Hanna,J., King,R.W. and Finley,D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes Mol Cell Proteomics (2011) 10, R110-R110. PubMed Europe PubMed DOI P

2010

Byrne,A., McLaren,R.P., Mason,P., Chai,L., Dufault,M.R., Huang,Y., Liang,B., Gans,J.D., Zhang,M., Carter,K., Gladysheva,T.B., Teicher,B.A., Biemann,H.P., Booker,M., Goldberg,M.A., Klinger,K.W., Lillie,J., Madden,S.L. and Jiang,Y. Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence Exp Cell Res (2010) 316, 258-271. PubMed Europe PubMed DOI
Chandra,A., Chen,L. and Madura,K. Synthetic lethality of rpn11-1 rpn10Delta is linked to altered proteasome assembly and activity Curr Genet (2010) 56, 543-557. PubMed Europe PubMed DOI K
Chandra,A., Chen,L., Liang,H. and Madura,K. Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors J Biol Chem (2010) 285, 8330-8339. PubMed Europe PubMed DOI PMC EPMC

2009

Cooper,E.M., Cutcliffe,C., Kristiansen,T.Z., Pandey,A., Pickart,C.M. and Cohen,R.E. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1 EMBO J (2009) 28, 621-631. PubMed Europe PubMed DOI PMC EPMC
Tonoki,A., Kuranaga,E., Tomioka,T., Hamazaki,J., Murata,S., Tanaka,K. and Miura,M. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process Mol Cell Biol (2009) 29, 1095-1106. PubMed Europe PubMed DOI PMC EPMC

2008

Koulich,E., Li,X. and DeMartino,G.N. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome Mol Biol Cell (2008) 19, 1072-1082. PubMed Europe PubMed DOI PMC EPMC
Rinaldi,T., Hofmann,L., Gambadoro,A., Cossard,R., Livnat-Levanon,N., Glickman,M.H., Frontali,L. and Delahodde,A. Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function Mol Biol Cell (2008) 19, 1022-1031. PubMed Europe PubMed DOI PMC EPMC

2007

Gallery,M., Blank,J.L., Lin,Y., Gutierrez,J.A., Pulido,J.C., Rappoli,D., Badola,S., Rolfe,M. and Macbeth,K.J. The JAMM motif of human deubiquitinase Poh1 is essential for cell viability Mol Cancer Ther (2007) 6, 262-268. PubMed Europe PubMed DOI

2006

[YEAR:6-10-2006]Hanna,J., Hathaway,N.A., Tone,Y., Crosas,B., Elsasser,S., Kirkpatrick,D.S., Leggett,D.S., Gygi,S.P., King,R.W. and Finley,D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation Cell (6-10-2006) 127, 99-111. PubMed Europe PubMed DOI

2004

Guterman,A. and Glickman,M.H. Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome J Biol Chem (2004) 279, 1729-1738. PubMed Europe PubMed DOI
[YEAR:1-7-2004]Rinaldi,T., Pick,E., Gambadoro,A., Zilli,S., Maytal-Kivity,V., Frontali,L. and Glickman,M.H. Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain Biochem J (1-7-2004) 381, 275-285. PubMed Europe PubMed DOI PMC EPMC

2003

Lundgren,J., Masson,P., Realini,C.A. and Young,P. Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13 Mol Cell Biol (2003) 23, 5320-5330. PubMed Europe PubMed DOI PMC EPMC

2002

[YEAR:20-9-2002]Maytal-Kivity,V., Reis,N., Hofmann,K. and Glickman,M.H. MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function BMC Biochem (20-9-2002) 3, 28-28. PubMed Europe PubMed PMC EPMC
[YEAR:30-4-2002]Nabhan,J.F., Hamdan,F.F. and Ribeiro,P. A Schistosoma mansoni Pad1 homologue stabilizes c-Jun Mol Biochem Parasitol (30-4-2002) 121, 163-172. PubMed Europe PubMed
[YEAR:6-3-2002]Rinaldi,T., Ricordy,R., Bolotin-Fukuhara,M. and Frontali,L. Mitochondrial effects of the pleiotropic proteasomal mutation mpr1/rpn11: uncoupling from cell cycle defects in extragenic revertants Gene (6-3-2002) 286, 43-51. PubMed Europe PubMed DOI
Spataro,V., Simmen,K. and Realini,C.A. The essential 26S proteasome subunit Rpn11 confers multidrug resistance to mammalian cells Anticancer Res (2002) 22, 3905-3909. PubMed Europe PubMed
[YEAR:18-10-2002]Verma,R., Aravind,L., Oania,R., McDonald,W.H., Yates,J.R., III, Koonin,E.V. and Deshaies,R.J. Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome Science (18-10-2002) 298, 611-615. PubMed Europe PubMed DOI
[YEAR:26-9-2002]Wilkinson,K.D. Cell biology: unchaining the condemned Nature (26-9-2002) 419, 351-353. PubMed Europe PubMed DOI
[YEAR:26-9-2002]Yao,T. and Cohen,R.E. A cryptic protease couples deubiquitination and degradation by the proteasome Nature (26-9-2002) 419, 403-407. PubMed Europe PubMed DOI

2001

Krasko,A., Kurelec,B., Batel,R., Muller,I.M. and Muller,W.E. Potential multidrug resistance gene POHL: an ecologically relevant indicator in marine sponges Environ Toxicol Chem (2001) 20, 198-204. PubMed Europe PubMed

1999

[YEAR:29-9-1999]Wilkinson,C.R., Penney,M., McGurk,G., Wallace,M. and Gordon,C. The 26S proteasome of the fission yeast Schizosaccharomyces pombe Philos Trans R Soc Lond B Biol Sci (29-9-1999) 354, 1523-1532. PubMed Europe PubMed DOI PMC EPMC

1998

Arioka,M., Kouhashi,M., Yoda,K., Takatsuki,A., Yamasaki,M. and Kitamoto,K. Multidrug resistance phenotype conferred by overexpressing bfr2+/pad1+/sks1+ or pap1+ genes and mediated by bfr1+ gene product, a structural and functional homologue of P-glycoprotein in Schizosaccharomyces pombe Biosci Biotechnol Biochem (1998) 62, 390-392. PubMed Europe PubMed DOI
Glickman,M.H., Rubin,D.M., Fried,V.A. and Finley,D. The regulatory particle of the Saccharomyces cerevisiae proteasome Mol Cell Biol (1998) 18, 3149-3162. PubMed Europe PubMed PMC EPMC
[YEAR:11-9-1998]Penney,M., Wilkinson,C., Wallace,M., Javerzat,J.P., Ferrell,K., Seeger,M., Dubiel,W., McKay,S., Allshire,R. and Gordon,C. The Pad1+ gene encodes a subunit of the 26 S proteasome in fission yeast J Biol Chem (11-9-1998) 273, 23938-23945. PubMed Europe PubMed DOI
Rinaldi,T., Ricci,C., Porro,D., Bolotin-Fukuhara,M. and Frontali,L. A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology Mol Biol Cell (1998) 9, 2917-2931. PubMed Europe PubMed PMC EPMC

1997

Lam,Y.A., Xu,W., DeMartino,G.N. and Cohen,R.E. Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome Nature (1997) 385, 737-740. PubMed Europe PubMed DOI
[YEAR:28-11-1997]Spataro,V., Toda,T., Craig,R., Seeger,M., Dubiel,W., Harris,A.L. and Norbury,C. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit J Biol Chem (28-11-1997) 272, 30470-30475. PubMed Europe PubMed DOI

1995

Shimanuki,M., Saka,Y., Yanagida,M. and Toda,T. A novel essential fission yeast gene pad1+ positively regulates pap1(+)-dependent transcription and is implicated in the maintenance of chromosome structure J Cell Sci (1995) 108, 569-579. PubMed Europe PubMed